Details for: HTR5A

Gene ID: 3361

Symbol: HTR5A

Ensembl ID: ENSG00000157219

Description: 5-hydroxytryptamine receptor 5A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.23
    Marker Score: 53036
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.34
    Marker Score: 2352
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2220
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.19
    Marker Score: 1137
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71816
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48035
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.95
    Marker Score: 1003.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.91
    Marker Score: 1851
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.89
    Marker Score: 844
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1396
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 496
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.85
    Marker Score: 3448
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 403
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.72
    Marker Score: 1161.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.71
    Marker Score: 1475
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7
    Marker Score: 844
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 519
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.64
    Marker Score: 1209
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.59
    Marker Score: 740
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.59
    Marker Score: 913
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.57
    Marker Score: 21833
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.57
    Marker Score: 4892
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.53
    Marker Score: 5004
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.5
    Marker Score: 2060
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.49
    Marker Score: 848
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.46
    Marker Score: 944
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.45
    Marker Score: 4675
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.44
    Marker Score: 1707
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.41
    Marker Score: 659
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.41
    Marker Score: 246
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.41
    Marker Score: 216
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4
    Marker Score: 24611
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.39
    Marker Score: 124
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.38
    Marker Score: 5934
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.38
    Marker Score: 3567
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.34
    Marker Score: 198
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.32
    Marker Score: 2474
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.32
    Marker Score: 245
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.29
    Marker Score: 987
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.29
    Marker Score: 174
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.27
    Marker Score: 300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.26
    Marker Score: 248
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.25
    Marker Score: 115
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.25
    Marker Score: 3727
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.23
    Marker Score: 4655
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.22
    Marker Score: 90
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.22
    Marker Score: 7932
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.21
    Marker Score: 99
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.2
    Marker Score: 842.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.19
    Marker Score: 457
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.18
    Marker Score: 67
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.17
    Marker Score: 82.5
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.16
    Marker Score: 166
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.16
    Marker Score: 190
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.16
    Marker Score: 382
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.15
    Marker Score: 132
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.15
    Marker Score: 435
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.15
    Marker Score: 38
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.14
    Marker Score: 94
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.14
    Marker Score: 37
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.14
    Marker Score: 41
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.13
    Marker Score: 59
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.13
    Marker Score: 42
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.13
    Marker Score: 68
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.12
    Marker Score: 43.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.12
    Marker Score: 144
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.12
    Marker Score: 40
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.11
    Marker Score: 98
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.11
    Marker Score: 201
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.11
    Marker Score: 647
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.11
    Marker Score: 309
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.1
    Marker Score: 37.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.1
    Marker Score: 450
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.09
    Marker Score: 54.5
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.09
    Marker Score: 49
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.09
    Marker Score: 104
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.09
    Marker Score: 744
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.09
    Marker Score: 35
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.08
    Marker Score: 51
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.08
    Marker Score: 218
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.08
    Marker Score: 142
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.08
    Marker Score: 29

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Other Information

**Key characteristics:** * HTR5A is a transmembrane protein with seven transmembrane domains. * It is a member of the G protein-coupled receptor (GPCR) family. * It is expressed in the central nervous system, particularly in the hippocampus, cerebral cortex, and forebrain. * It is a key regulator of synaptic plasticity and learning and memory. **Pathways and functions:** * HTR5A is a ligand-gated ion channel that is expressed in the plasma membrane of neurons and glial cells. * When HTR5A binds to its ligand, 5-hydroxytryptamine (5HT), it opens the channel and allows sodium ions to flow out of the cell. * This depolarizes the cell and inhibits the activity of postsynaptic receptors. * This inhibition of postsynaptic receptors is thought to be important for learning and memory. **Clinical significance:** * Mutations in HTR5A have been linked to a number of psychiatric disorders, including schizophrenia and autism. * These mutations can lead to an increase in anxiety and fear, as well as problems with learning and memory. * Therefore, HTR5A is a promising target for the treatment of psychiatric disorders. **Additional information:** * HTR5A is a relatively new receptor, and there is still much that is unknown about its function. * However, it is clear that HTR5A is an important player in synaptic plasticity and learning and memory.

Genular Protein ID: 2786711513

Symbol: 5HT5A_HUMAN

Name: 5-hydroxytryptamine receptor 5A

UniProtKB Accession Codes:

P47898 Q2M2D2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 4 EMDB 3 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7988681

Title: Cloning and characterisation of the human 5-HT5A serotonin receptor.

PubMed ID: 7988681

DOI: 10.1016/0014-5793(94)01209-1

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 357
  • Mass: 40255
  • Checksum: 92F8A78C69169790
  • Sequence:
    • MDLPVNLTSF SLSTPSPLET NHSLGKDDLR PSSPLLSVFG VLILTLLGFL VAATFAWNLL 
VLATILRVRT FHRVPHNLVA SMAVSDVLVA ALVMPLSLVH ELSGRRWQLG RRLCQLWIAC 
DVLCCTASIW NVTAIALDRY WSITRHMEYT LRTRKCVSNV MIALTWALSA VISLAPLLFG 
WGETYSEGSE ECQVSREPSY AVFSTVGAFY LPLCVVLFVY WKIYKAAKFR VGSRKTNSVS 
PISEAVEVKD SAKQPQMVFT VRHATVTFQP EGDTWREQKE QRAALMVGIL IGVFVLCWIP 
FFLTELISPL CSCDIPAIWK SIFLWLGYSN SFFNPLIYTA FNKNYNSAFK NFFSRQH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.