Details for: HTR5A

Gene ID: 3361

Symbol: HTR5A

Ensembl ID: ENSG00000157219

Description: 5-hydroxytryptamine receptor 5A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.3308
    Cell Significance Index: 3.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2724
    Cell Significance Index: 54.6500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2096
    Cell Significance Index: 3.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1914
    Cell Significance Index: 68.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0689
    Cell Significance Index: 3.6200
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.0557
    Cell Significance Index: 0.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0208
    Cell Significance Index: 14.3800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0182
    Cell Significance Index: 0.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0068
    Cell Significance Index: 0.4600
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0011
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0026
    Cell Significance Index: -4.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0028
    Cell Significance Index: -5.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0028
    Cell Significance Index: -4.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0037
    Cell Significance Index: -5.0200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0052
    Cell Significance Index: -0.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0053
    Cell Significance Index: -1.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0081
    Cell Significance Index: -5.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0093
    Cell Significance Index: -5.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0105
    Cell Significance Index: -0.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0106
    Cell Significance Index: -5.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0117
    Cell Significance Index: -5.3000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0120
    Cell Significance Index: -0.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0163
    Cell Significance Index: -0.7200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0228
    Cell Significance Index: -0.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0251
    Cell Significance Index: -0.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0301
    Cell Significance Index: -5.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0330
    Cell Significance Index: -5.9500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0337
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0346
    Cell Significance Index: -5.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0409
    Cell Significance Index: -5.9500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0487
    Cell Significance Index: -1.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0521
    Cell Significance Index: -1.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0525
    Cell Significance Index: -6.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0659
    Cell Significance Index: -4.0500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0695
    Cell Significance Index: -1.0600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0726
    Cell Significance Index: -1.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0735
    Cell Significance Index: -2.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0779
    Cell Significance Index: -2.5500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0811
    Cell Significance Index: -2.0800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0880
    Cell Significance Index: -2.1100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0900
    Cell Significance Index: -1.7800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0995
    Cell Significance Index: -2.1500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0995
    Cell Significance Index: -1.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1002
    Cell Significance Index: -3.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1039
    Cell Significance Index: -5.8300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1080
    Cell Significance Index: -1.4000
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1206
    Cell Significance Index: -1.0900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1207
    Cell Significance Index: -3.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1213
    Cell Significance Index: -6.3200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1254
    Cell Significance Index: -1.0400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1265
    Cell Significance Index: -2.6400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1365
    Cell Significance Index: -1.8200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1470
    Cell Significance Index: -3.6600
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1543
    Cell Significance Index: -1.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1552
    Cell Significance Index: -7.8400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1558
    Cell Significance Index: -1.7600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1587
    Cell Significance Index: -5.0200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1780
    Cell Significance Index: -3.5500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1839
    Cell Significance Index: -3.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1872
    Cell Significance Index: -5.3700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1962
    Cell Significance Index: -8.0400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2184
    Cell Significance Index: -5.3300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2190
    Cell Significance Index: -5.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2217
    Cell Significance Index: -5.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2217
    Cell Significance Index: -5.9400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2241
    Cell Significance Index: -4.5600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2248
    Cell Significance Index: -2.9400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2286
    Cell Significance Index: -2.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2301
    Cell Significance Index: -4.4900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2302
    Cell Significance Index: -4.9200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2362
    Cell Significance Index: -2.9900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2492
    Cell Significance Index: -2.9800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2639
    Cell Significance Index: -3.2100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2649
    Cell Significance Index: -2.5200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.2687
    Cell Significance Index: -2.9500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2765
    Cell Significance Index: -4.7800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2783
    Cell Significance Index: -3.4700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2813
    Cell Significance Index: -5.5000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2868
    Cell Significance Index: -3.6200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2916
    Cell Significance Index: -3.6800
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.2949
    Cell Significance Index: -3.1700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2974
    Cell Significance Index: -4.3900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2979
    Cell Significance Index: -3.8600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3016
    Cell Significance Index: -4.8900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3018
    Cell Significance Index: -2.0500
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.3021
    Cell Significance Index: -3.2700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.3061
    Cell Significance Index: -3.7100
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.3156
    Cell Significance Index: -2.7800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3261
    Cell Significance Index: -4.4000
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.3287
    Cell Significance Index: -4.0000
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.3307
    Cell Significance Index: -3.4000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3307
    Cell Significance Index: -4.3400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.3310
    Cell Significance Index: -5.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3430
    Cell Significance Index: -5.7400
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.3436
    Cell Significance Index: -5.1400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3473
    Cell Significance Index: -5.8500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3532
    Cell Significance Index: -5.9400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.3559
    Cell Significance Index: -3.6300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -0.3579
    Cell Significance Index: -3.7400
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.3585
    Cell Significance Index: -4.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Receptor Structure:** HTR5A is a G-protein coupled receptor (GPCR) that belongs to the 5-HT receptor family. Its structure consists of seven transmembrane domains, which are crucial for ligand binding and signal transduction. 2. **Ligand Binding:** HTR5A is selectively activated by 5-hydroxytryptamine (5-HT), the primary neurotransmitter of the serotonergic system. This interaction triggers a cascade of downstream signaling events, influencing various cellular processes. 3. **Signal Transduction:** Upon ligand binding, HTR5A activates G-proteins, which in turn modulate adenylate cyclase activity, influencing cAMP levels and downstream signaling pathways. 4. **Expression and Localization:** HTR5A is widely expressed in various tissues, including the brain, gut, and immune cells, such as B cells and plasma cells. **Pathways and Functions:** 1. **Adenylate Cyclase-Activating Signaling Pathway:** Activation of HTR5A leads to the stimulation of adenylate cyclase, resulting in increased cAMP levels and subsequent activation of downstream signaling pathways. 2. **Neurotransmitter Regulation:** HTR5A plays a crucial role in regulating neurotransmitter release, particularly in the serotonergic system, influencing mood, cognition, and behavior. 3. **Immune Regulation:** HTR5A is expressed in immune cells, where it modulates immune responses, influencing cytokine production and cell activation. 4. **Neuroinflammation:** HTR5A has been implicated in neuroinflammatory processes, including the regulation of microglial activation and cytokine production. **Clinical Significance:** 1. **Mood Disorders:** HTR5A has been linked to various mood disorders, including depression and anxiety, where it is thought to play a role in regulating serotonergic neurotransmission. 2. **Neurodegenerative Diseases:** HTR5A has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where it is thought to influence neuroinflammation and neurotransmitter regulation. 3. **Immune-Related Disorders:** HTR5A has been linked to immune-related disorders, including rheumatoid arthritis and multiple sclerosis, where it is thought to modulate immune responses and inflammation. 4. **Cancer:** HTR5A has been implicated in cancer, particularly in the regulation of tumor growth and metastasis, where it is thought to influence cell proliferation and apoptosis. In conclusion, the 5-hydroxytryptamine receptor 5A (HTR5A) is a complex gene with far-reaching implications in immunological disorders. Further research is necessary to fully elucidate its mechanisms of action, exploring its potential as a therapeutic target for various diseases.

Genular Protein ID: 2786711513

Symbol: 5HT5A_HUMAN

Name: N/A

UniProtKB Accession Codes:

P47898 Q2M2D2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 4 EMDB 3 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7988681

Title: Cloning and characterisation of the human 5-HT5A serotonin receptor.

PubMed ID: 7988681

DOI: 10.1016/0014-5793(94)01209-1

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 9865521

Title: The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells.

PubMed ID: 9865521

DOI: 10.1016/s0014-2999(98)00744-4

PubMed ID: 35835867

Title: Inactive and active state structures template selective tools for the human 5-HT5A receptor.

PubMed ID: 35835867

DOI: 10.1038/s41594-022-00796-6

PubMed ID: 35610220

Title: Structural insights into the ligand binding and Gi coupling of serotonin receptor 5-HT5A.

PubMed ID: 35610220

DOI: 10.1038/s41421-022-00412-3

Sequence Information:

  • Length: 357
  • Mass: 40255
  • Checksum: 92F8A78C69169790
  • Sequence:
    • MDLPVNLTSF SLSTPSPLET NHSLGKDDLR PSSPLLSVFG VLILTLLGFL VAATFAWNLL 
VLATILRVRT FHRVPHNLVA SMAVSDVLVA ALVMPLSLVH ELSGRRWQLG RRLCQLWIAC 
DVLCCTASIW NVTAIALDRY WSITRHMEYT LRTRKCVSNV MIALTWALSA VISLAPLLFG 
WGETYSEGSE ECQVSREPSY AVFSTVGAFY LPLCVVLFVY WKIYKAAKFR VGSRKTNSVS 
PISEAVEVKD SAKQPQMVFT VRHATVTFQP EGDTWREQKE QRAALMVGIL IGVFVLCWIP 
FFLTELISPL CSCDIPAIWK SIFLWLGYSN SFFNPLIYTA FNKNYNSAFK NFFSRQH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.