Details for: IFI16

Gene ID: 3428

Symbol: IFI16

Ensembl ID: ENSG00000163565

Description: interferon gamma inducible protein 16

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.8
    Marker Score: 33337.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.91
    Marker Score: 28806
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.89
    Marker Score: 4199
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.87
    Marker Score: 97770
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.78
    Marker Score: 7058
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.77
    Marker Score: 7654.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.75
    Marker Score: 2933.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.72
    Marker Score: 5434
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.7
    Marker Score: 975
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.63
    Marker Score: 1305
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.54
    Marker Score: 3495
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.41
    Marker Score: 2076
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.39
    Marker Score: 1361
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.37
    Marker Score: 4127.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.35
    Marker Score: 2473
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.35
    Marker Score: 27294
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.34
    Marker Score: 2765
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.34
    Marker Score: 6825
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.29
    Marker Score: 9372
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.27
    Marker Score: 3850
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 2.25
    Marker Score: 19052
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.24
    Marker Score: 2254.5
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.21
    Marker Score: 1476
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.18
    Marker Score: 16192
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.17
    Marker Score: 2337
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.16
    Marker Score: 2791
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 2.16
    Marker Score: 423
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.15
    Marker Score: 9287
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.14
    Marker Score: 119419
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.12
    Marker Score: 23921
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.12
    Marker Score: 3005
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.12
    Marker Score: 493
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.11
    Marker Score: 3841
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.1
    Marker Score: 1645
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.07
    Marker Score: 5416
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.07
    Marker Score: 1853
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 2.07
    Marker Score: 672
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.06
    Marker Score: 1842
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.04
    Marker Score: 879
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.03
    Marker Score: 830
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.03
    Marker Score: 1116
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.02
    Marker Score: 1183
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2
    Marker Score: 2292
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.99
    Marker Score: 1427
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.99
    Marker Score: 617
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.98
    Marker Score: 1792
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.95
    Marker Score: 1951.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.95
    Marker Score: 1642
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.95
    Marker Score: 414
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.94
    Marker Score: 2810
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.94
    Marker Score: 5264
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.92
    Marker Score: 432
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.91
    Marker Score: 1301
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.9
    Marker Score: 5326
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.9
    Marker Score: 19205.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.88
    Marker Score: 1426
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.88
    Marker Score: 1082
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.88
    Marker Score: 1813.5
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.87
    Marker Score: 918
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.85
    Marker Score: 1106
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.84
    Marker Score: 643
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.84
    Marker Score: 454
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.83
    Marker Score: 421
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.82
    Marker Score: 1323
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.82
    Marker Score: 3417
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.82
    Marker Score: 3314
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.8
    Marker Score: 4895.5
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.8
    Marker Score: 436
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.79
    Marker Score: 894
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.78
    Marker Score: 2151
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.78
    Marker Score: 982
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.78
    Marker Score: 1296
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.77
    Marker Score: 2010.5
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.77
    Marker Score: 1078
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.75
    Marker Score: 419
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.75
    Marker Score: 2872
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.74
    Marker Score: 409
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.74
    Marker Score: 4337
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.74
    Marker Score: 1155
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.73
    Marker Score: 416
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.73
    Marker Score: 44268
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.73
    Marker Score: 1918
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.73
    Marker Score: 2542
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.72
    Marker Score: 2124
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.72
    Marker Score: 10997
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.72
    Marker Score: 696
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.72
    Marker Score: 373
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.71
    Marker Score: 455
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.71
    Marker Score: 1999
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 1.71
    Marker Score: 424
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.69
    Marker Score: 871
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.67
    Marker Score: 414
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.67
    Marker Score: 719.5
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 1.66
    Marker Score: 440
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.65
    Marker Score: 1084
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 1.65
    Marker Score: 428
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.65
    Marker Score: 4266
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.65
    Marker Score: 16558
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.64
    Marker Score: 957
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.63
    Marker Score: 1183.5

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Other Information

**Key characteristics:** * IFI16 is a protein of the interferon gamma (IF) family. * It is a key activator of the innate immune response. * It plays a role in the regulation of inflammation and tissue repair. * It is highly expressed in cells of the lung, immune cells, and endothelial cells. **Pathways and functions:** * IFI16 is involved in the activation of innate immune responses. * It binds to the IFNAR1 receptor and activates the IKK1/NF-κB pathway. * This pathway leads to the production of cytokines and chemokines, which recruit immune cells to the site of infection. * IFI16 also plays a role in the regulation of autophagy, the process by which cells break down and recycle their own components. **Clinical significance:** * Mutations in the IFI16 gene have been linked to a number of human diseases, including asthma, rheumatoid arthritis, and cancer. * IFI16 is a potential target for the treatment of inflammatory diseases. * By understanding the role of IFI16 in innate immune responses, it may be possible to develop new therapies for these diseases. **Additional information:** * IFI16 is a highly conserved protein that is found in mammals. * It is expressed in high levels in humans, with the highest expression in cells of the lung, immune cells, and endothelial cells. * IFI16 is a pleiotropic protein that can have both pro-inflammatory and anti-inflammatory effects. * It is a key regulator of inflammation and tissue repair.

Genular Protein ID: 3184311682

Symbol: IF16_HUMAN

Name: Interferon-inducible myeloid differentiation transcriptional activator

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1526658

Title: A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells.

PubMed ID: 1526658

DOI: 10.1007/bf00218044

PubMed ID: 7959953

Title: Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization.

PubMed ID: 7959953

DOI: 10.1007/bf00177824

PubMed ID: 30104205

Title: Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16.

PubMed ID: 30104205

DOI: 10.15252/embr.201845737

PubMed ID: 12894224

Title: Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence.

PubMed ID: 12894224

DOI: 10.1038/sj.onc.1206754

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9718316

Title: Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing.

PubMed ID: 9718316

DOI: 10.1021/bi981069a

PubMed ID: 7536752

Title: IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines.

PubMed ID: 7536752

DOI: 10.1002/jcb.240570106

PubMed ID: 7806273

Title: The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression.

PubMed ID: 7806273

DOI: 10.1007/bf00188431

PubMed ID: 9766636

Title: The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations.

PubMed ID: 9766636

DOI: 10.1002/jlb.64.4.546

PubMed ID: 9642285

Title: The human interferon-inducible protein, IFI 16, is a repressor of transcription.

PubMed ID: 9642285

DOI: 10.1074/jbc.273.27.17172

PubMed ID: 11146555

Title: Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16.

PubMed ID: 11146555

DOI: 10.1038/sj.onc.1204005

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 14654789

Title: A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway.

PubMed ID: 14654789

DOI: 10.1038/sj.onc.1207057

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20388717

Title: In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification.

PubMed ID: 20388717

DOI: 10.1074/jbc.m110.106955

PubMed ID: 20890285

Title: IFI16 is an innate immune sensor for intracellular DNA.

PubMed ID: 20890285

DOI: 10.1038/ni.1932

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21575908

Title: IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.

PubMed ID: 21575908

DOI: 10.1016/j.chom.2011.04.008

PubMed ID: 21573174

Title: IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway.

PubMed ID: 21573174

DOI: 10.1371/journal.pone.0019532

PubMed ID: 22046441

Title: IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes.

PubMed ID: 22046441

DOI: 10.1371/journal.pone.0027040

PubMed ID: 22618232

Title: Preferential binding of IFI16 protein to cruciform structure and superhelical DNA.

PubMed ID: 22618232

DOI: 10.1016/j.bbrc.2012.05.065

PubMed ID: 22291595

Title: The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication.

PubMed ID: 22291595

DOI: 10.1371/journal.ppat.1002498

PubMed ID: 23027953

Title: Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein.

PubMed ID: 23027953

DOI: 10.1073/pnas.1211302109

PubMed ID: 22691496

Title: Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16.

PubMed ID: 22691496

DOI: 10.1073/pnas.1203447109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24198334

Title: Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA.

PubMed ID: 24198334

DOI: 10.1073/pnas.1316194110

PubMed ID: 24413532

Title: Differential regulation of estrogen receptor alpha expression in breast cancer cells by metastasis-associated protein 1.

PubMed ID: 24413532

DOI: 10.1158/0008-5472.can-13-2020

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24531343

Title: The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.

PubMed ID: 24531343

DOI: 10.1038/ni.2829

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 21397192

Title: Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53.

PubMed ID: 21397192

DOI: 10.1016/j.str.2010.12.015

PubMed ID: 22483801

Title: Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.

PubMed ID: 22483801

DOI: 10.1016/j.immuni.2012.02.014

Sequence Information:

  • Length: 785
  • Mass: 88256
  • Checksum: 216CD103D8F5206A
  • Sequence:
  • MGKKYKNIVL LKGLEVINDY HFRMVKSLLS NDLKLNLKMR EEYDKIQIAD LMEEKFRGDA 
    GLGKLIKIFE DIPTLEDLAE TLKKEKLKVK GPALSRKRKK EVDATSPAPS TSSTVKTEGA 
    EATPGAQKRK KSTKEKAGPK GSKVSEEQTQ PPSPAGAGMS TAMGRSPSPK TSLSAPPNSS 
    STENPKTVAK CQVTPRRNVL QKRPVIVKVL STTKPFEYET PEMEKKIMFH ATVATQTQFF 
    HVKVLNTSLK EKFNGKKIII ISDYLEYDSL LEVNEESTVS EAGPNQTFEV PNKIINRAKE 
    TLKIDILHKQ ASGNIVYGVF MLHKKTVNQK TTIYEIQDDR GKMDVVGTGQ CHNIPCEEGD 
    KLQLFCFRLR KKNQMSKLIS EMHSFIQIKK KTNPRNNDPK SMKLPQEQRQ LPYPSEASTT 
    FPESHLRTPQ MPPTTPSSSF FTKKSEDTIS KMNDFMRMQI LKEGSHFPGP FMTSIGPAES 
    HPHTPQMPPS TPSSSFLTTK SEDTISKMND FMRMQILKEG SHFPGPFMTS IGPAESHPHT 
    PQMPPSTPSS SFLTTLKPRL KTEPEEVSIE DSAQSDLKEV MVLNATESFV YEPKEQKKMF 
    HATVATENEV FRVKVFNIDL KEKFTPKKII AIANYVCRNG FLEVYPFTLV ADVNADRNME 
    IPKGLIRSAS VTPKINQLCS QTKGSFVNGV FEVHKKNVRG EFTYYEIQDN TGKMEVVVHG 
    RLTTINCEEG DKLKLTCFEL APKSGNTGEL RSVIHSHIKV IKTRKNKKDI LNPDSSMETS 
    PDFFF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.