Details for: IFI16
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.8
Marker Score: 33337.5 - Cell Name: mature T cell (CL0002419)
Fold Change: 2.91
Marker Score: 28806 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.89
Marker Score: 4199 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.87
Marker Score: 97770 - Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 2.78
Marker Score: 7058 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.77
Marker Score: 7654.5 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.75
Marker Score: 2933.5 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.72
Marker Score: 5434 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 2.7
Marker Score: 975 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.63
Marker Score: 1305 - Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 2.54
Marker Score: 3495 - Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 2.41
Marker Score: 2076 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.39
Marker Score: 1361 - Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.37
Marker Score: 4127.5 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.35
Marker Score: 2473 - Cell Name: blood cell (CL0000081)
Fold Change: 2.35
Marker Score: 27294 - Cell Name: late pro-B cell (CL0002048)
Fold Change: 2.34
Marker Score: 2765 - Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 2.34
Marker Score: 6825 - Cell Name: pro-T cell (CL0000827)
Fold Change: 2.29
Marker Score: 9372 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.27
Marker Score: 3850 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 2.25
Marker Score: 19052 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 2.24
Marker Score: 2254.5 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 2.21
Marker Score: 1476 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.18
Marker Score: 16192 - Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 2.17
Marker Score: 2337 - Cell Name: basal cell (CL0000646)
Fold Change: 2.16
Marker Score: 2791 - Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 2.16
Marker Score: 423 - Cell Name: decidual cell (CL2000002)
Fold Change: 2.15
Marker Score: 9287 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.14
Marker Score: 119419 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.12
Marker Score: 23921 - Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.12
Marker Score: 3005 - Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 2.12
Marker Score: 493 - Cell Name: microglial cell (CL0000129)
Fold Change: 2.11
Marker Score: 3841 - Cell Name: type I NK T cell (CL0000921)
Fold Change: 2.1
Marker Score: 1645 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.07
Marker Score: 5416 - Cell Name: endothelial cell (CL0000115)
Fold Change: 2.07
Marker Score: 1853 - Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 2.07
Marker Score: 672 - Cell Name: naive B cell (CL0000788)
Fold Change: 2.06
Marker Score: 1842 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.04
Marker Score: 879 - Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.03
Marker Score: 830 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 2.03
Marker Score: 1116 - Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 2.02
Marker Score: 1183 - Cell Name: lung macrophage (CL1001603)
Fold Change: 2
Marker Score: 2292 - Cell Name: theca cell (CL0000503)
Fold Change: 1.99
Marker Score: 1427 - Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.99
Marker Score: 617 - Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.98
Marker Score: 1792 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.95
Marker Score: 1951.5 - Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 1.95
Marker Score: 1642 - Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 1.95
Marker Score: 414 - Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 1.94
Marker Score: 2810 - Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.94
Marker Score: 5264 - Cell Name: PP cell (CL0000696)
Fold Change: 1.92
Marker Score: 432 - Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.91
Marker Score: 1301 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.9
Marker Score: 5326 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.9
Marker Score: 19205.5 - Cell Name: memory B cell (CL0000787)
Fold Change: 1.88
Marker Score: 1426 - Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.88
Marker Score: 1082 - Cell Name: pro-B cell (CL0000826)
Fold Change: 1.88
Marker Score: 1813.5 - Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 1.87
Marker Score: 918 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.85
Marker Score: 1106 - Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 1.84
Marker Score: 643 - Cell Name: adventitial cell (CL0002503)
Fold Change: 1.84
Marker Score: 454 - Cell Name: keratocyte (CL0002363)
Fold Change: 1.83
Marker Score: 421 - Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 1.82
Marker Score: 1323 - Cell Name: supporting cell (CL0000630)
Fold Change: 1.82
Marker Score: 3417 - Cell Name: secretory cell (CL0000151)
Fold Change: 1.82
Marker Score: 3314 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.8
Marker Score: 4895.5 - Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 1.8
Marker Score: 436 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.79
Marker Score: 894 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.78
Marker Score: 2151 - Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 1.78
Marker Score: 982 - Cell Name: Unknown (CL0000548)
Fold Change: 1.78
Marker Score: 1296 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.77
Marker Score: 2010.5 - Cell Name: germinal center B cell (CL0000844)
Fold Change: 1.77
Marker Score: 1078 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.75
Marker Score: 419 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.75
Marker Score: 2872 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.74
Marker Score: 409 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.74
Marker Score: 4337 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.74
Marker Score: 1155 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.73
Marker Score: 416 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.73
Marker Score: 44268 - Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 1.73
Marker Score: 1918 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.73
Marker Score: 2542 - Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.72
Marker Score: 2124 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.72
Marker Score: 10997 - Cell Name: melanocyte (CL0000148)
Fold Change: 1.72
Marker Score: 696 - Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 1.72
Marker Score: 373 - Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 1.71
Marker Score: 455 - Cell Name: stromal cell (CL0000499)
Fold Change: 1.71
Marker Score: 1999 - Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 1.71
Marker Score: 424 - Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 1.69
Marker Score: 871 - Cell Name: oocyte (CL0000023)
Fold Change: 1.67
Marker Score: 414 - Cell Name: inflammatory cell (CL0009002)
Fold Change: 1.67
Marker Score: 719.5 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 1.66
Marker Score: 440 - Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 1.65
Marker Score: 1084 - Cell Name: muscle precursor cell (CL0000680)
Fold Change: 1.65
Marker Score: 428 - Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.65
Marker Score: 4266 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.65
Marker Score: 16558 - Cell Name: pericyte (CL0000669)
Fold Change: 1.64
Marker Score: 957 - Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.63
Marker Score: 1183.5
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Other Information
Genular Protein ID: 3184311682
Symbol: IF16_HUMAN
Name: Interferon-inducible myeloid differentiation transcriptional activator
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1526658
Title: A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells.
PubMed ID: 1526658
DOI: 10.1007/bf00218044
PubMed ID: 7959953
Title: Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization.
PubMed ID: 7959953
DOI: 10.1007/bf00177824
PubMed ID: 30104205
Title: Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16.
PubMed ID: 30104205
PubMed ID: 12894224
Title: Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence.
PubMed ID: 12894224
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9718316
Title: Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing.
PubMed ID: 9718316
DOI: 10.1021/bi981069a
PubMed ID: 7536752
Title: IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines.
PubMed ID: 7536752
PubMed ID: 7806273
Title: The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression.
PubMed ID: 7806273
DOI: 10.1007/bf00188431
PubMed ID: 9766636
Title: The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations.
PubMed ID: 9766636
DOI: 10.1002/jlb.64.4.546
PubMed ID: 9642285
Title: The human interferon-inducible protein, IFI 16, is a repressor of transcription.
PubMed ID: 9642285
PubMed ID: 11146555
Title: Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16.
PubMed ID: 11146555
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 14654789
Title: A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway.
PubMed ID: 14654789
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20388717
Title: In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification.
PubMed ID: 20388717
PubMed ID: 20890285
Title: IFI16 is an innate immune sensor for intracellular DNA.
PubMed ID: 20890285
DOI: 10.1038/ni.1932
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21575908
Title: IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
PubMed ID: 21575908
PubMed ID: 21573174
Title: IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway.
PubMed ID: 21573174
PubMed ID: 22046441
Title: IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes.
PubMed ID: 22046441
PubMed ID: 22618232
Title: Preferential binding of IFI16 protein to cruciform structure and superhelical DNA.
PubMed ID: 22618232
PubMed ID: 22291595
Title: The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication.
PubMed ID: 22291595
PubMed ID: 23027953
Title: Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein.
PubMed ID: 23027953
PubMed ID: 22691496
Title: Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16.
PubMed ID: 22691496
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24198334
Title: Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA.
PubMed ID: 24198334
PubMed ID: 24413532
Title: Differential regulation of estrogen receptor alpha expression in breast cancer cells by metastasis-associated protein 1.
PubMed ID: 24413532
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24531343
Title: The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.
PubMed ID: 24531343
DOI: 10.1038/ni.2829
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25114211
Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
PubMed ID: 25114211
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 21397192
Title: Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53.
PubMed ID: 21397192
PubMed ID: 22483801
Title: Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.
PubMed ID: 22483801
Sequence Information:
- Length: 785
- Mass: 88256
- Checksum: 216CD103D8F5206A
- Sequence:
MGKKYKNIVL LKGLEVINDY HFRMVKSLLS NDLKLNLKMR EEYDKIQIAD LMEEKFRGDA GLGKLIKIFE DIPTLEDLAE TLKKEKLKVK GPALSRKRKK EVDATSPAPS TSSTVKTEGA EATPGAQKRK KSTKEKAGPK GSKVSEEQTQ PPSPAGAGMS TAMGRSPSPK TSLSAPPNSS STENPKTVAK CQVTPRRNVL QKRPVIVKVL STTKPFEYET PEMEKKIMFH ATVATQTQFF HVKVLNTSLK EKFNGKKIII ISDYLEYDSL LEVNEESTVS EAGPNQTFEV PNKIINRAKE TLKIDILHKQ ASGNIVYGVF MLHKKTVNQK TTIYEIQDDR GKMDVVGTGQ CHNIPCEEGD KLQLFCFRLR KKNQMSKLIS EMHSFIQIKK KTNPRNNDPK SMKLPQEQRQ LPYPSEASTT FPESHLRTPQ MPPTTPSSSF FTKKSEDTIS KMNDFMRMQI LKEGSHFPGP FMTSIGPAES HPHTPQMPPS TPSSSFLTTK SEDTISKMND FMRMQILKEG SHFPGPFMTS IGPAESHPHT PQMPPSTPSS SFLTTLKPRL KTEPEEVSIE DSAQSDLKEV MVLNATESFV YEPKEQKKMF HATVATENEV FRVKVFNIDL KEKFTPKKII AIANYVCRNG FLEVYPFTLV ADVNADRNME IPKGLIRSAS VTPKINQLCS QTKGSFVNGV FEVHKKNVRG EFTYYEIQDN TGKMEVVVHG RLTTINCEEG DKLKLTCFEL APKSGNTGEL RSVIHSHIKV IKTRKNKKDI LNPDSSMETS PDFFF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.