Details for: IGFALS

Gene ID: 3483

Symbol: IGFALS

Ensembl ID: ENSG00000099769

Description: insulin like growth factor binding protein acid labile subunit

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.32
    Marker Score: 2333
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.17
    Marker Score: 491
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7644
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4822
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48059
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5347
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.84
    Marker Score: 592
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.83
    Marker Score: 382
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.75
    Marker Score: 1155
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 350
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.49
    Marker Score: 1019
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.43
    Marker Score: 975
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.31
    Marker Score: 173
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.31
    Marker Score: 322
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.29
    Marker Score: 483
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.25
    Marker Score: 80
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.25
    Marker Score: 103.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.25
    Marker Score: 468
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.24
    Marker Score: 895
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.24
    Marker Score: 182
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.23
    Marker Score: 55
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.23
    Marker Score: 133
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.21
    Marker Score: 215
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.21
    Marker Score: 108
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.21
    Marker Score: 3262
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.19
    Marker Score: 188
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.19
    Marker Score: 505
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.18
    Marker Score: 428.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.17
    Marker Score: 117
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.17
    Marker Score: 404
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.17
    Marker Score: 339
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.16
    Marker Score: 538
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.15
    Marker Score: 111
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.14
    Marker Score: 100
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.14
    Marker Score: 173
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.14
    Marker Score: 146
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.13
    Marker Score: 115
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.13
    Marker Score: 59
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.13
    Marker Score: 48
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.12
    Marker Score: 123
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.12
    Marker Score: 738
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.11
    Marker Score: 60
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.11
    Marker Score: 154
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.1
    Marker Score: 100
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.1
    Marker Score: 39
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.09
    Marker Score: 56
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.09
    Marker Score: 349
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.09
    Marker Score: 278
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.09
    Marker Score: 109
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.09
    Marker Score: 59
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.09
    Marker Score: 37
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.08
    Marker Score: 127
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.08
    Marker Score: 84
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.08
    Marker Score: 50
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.07
    Marker Score: 308
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.07
    Marker Score: 120
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.07
    Marker Score: 103
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.07
    Marker Score: 13
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.07
    Marker Score: 662
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.06
    Marker Score: 154
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.06
    Marker Score: 59
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.05
    Marker Score: 211

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Other Information

**Key characteristics** * The IGFALS gene is located on chromosome 15q21.1. * It is a large gene, encoding for a protein of approximately 180 kDa. * IGFALS is a glycoprotein that is expressed in the extracellular matrix. * It is a key regulator of cell adhesion to extracellular matrix proteins. * It is also a regulator of cell migration and differentiation. **Pathways and functions** * IGFALS is a key regulator of cell adhesion to extracellular matrix proteins. * It is expressed in a variety of cell types, including blood vessel endothelial cells, peptic cells, goblet cells, enterocytes, and brain cells. * IGFALS is thought to play a role in the regulation of cell migration and differentiation. * It is also a key regulator of angiogenesis. **Clinical significance** * Mutations in the IGFALS gene have been linked to a number of human diseases, including cancer and diabetes. * IGFALS is a potential therapeutic target for these diseases. * Small molecule inhibitors of IGFALS have been shown to be effective in treating cancer and other diseases that are characterized by abnormal cell growth. **Additional information** * The IGFALS gene is expressed in high levels in many types of cancer cells. * IGFALS is a key regulator of cell migration and invasion. * It is a target for therapy in cancer. * Mutations in the IGFALS gene have been linked to a number of human diseases, including cancer and diabetes.

Genular Protein ID: 1258197969

Symbol: ALS_HUMAN

Name: Insulin-like growth factor-binding protein complex acid labile subunit

UniProtKB Accession Codes:

P35858 B4DZY8 E9PGU3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EMBL 5 EMDB 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1379671

Title: Structure and functional expression of the acid-labile subunit of the insulin-like growth factor-binding protein complex.

PubMed ID: 1379671

DOI: 10.1210/mend.6.6.1379671

PubMed ID: 10650966

Title: Conservation of a growth hormone-responsive promoter element in the human and mouse acid-labile subunit genes.

PubMed ID: 10650966

DOI: 10.1210/endo.141.2.7333

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 2473065

Title: High molecular weight insulin-like growth factor binding protein complex. Purification and properties of the acid-labile subunit from human serum.

PubMed ID: 2473065

DOI: 10.1016/s0021-9258(18)80143-0

PubMed ID: 14762184

Title: Deficiency of the circulating insulin-like growth factor system associated with inactivation of the acid-labile subunit gene.

PubMed ID: 14762184

DOI: 10.1056/nejmoa013100

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16507628

Title: Total absence of functional acid labile subunit, resulting in severe insulin-like growth factor deficiency and moderate growth failure.

PubMed ID: 16507628

DOI: 10.1210/jc.2005-2842

PubMed ID: 17726072

Title: Phenotypic effects of null and haploinsufficiency of acid-labile subunit in a family with two novel IGFALS gene mutations.

PubMed ID: 17726072

DOI: 10.1210/jc.2007-1152

PubMed ID: 18303074

Title: Primary acid-labile subunit deficiency due to recessive IGFALS mutations results in postnatal growth deficit associated with low circulating insulin growth factor (IGF)-I, IGF binding protein-3 levels, and hyperinsulinemia.

PubMed ID: 18303074

DOI: 10.1210/jc.2007-2678

PubMed ID: 19129715

Title: Three novel IGFALS gene mutations resulting in total ALS and severe circulating IGF-I/IGFBP-3 deficiency in children of different ethnic origins.

PubMed ID: 19129715

DOI: 10.1159/000183899

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20389102

Title: Acid-labile subunit deficiency and growth failure: description of two novel cases.

PubMed ID: 20389102

DOI: 10.1159/000308164

PubMed ID: 21396577

Title: Acid-labile subunit (ALS) deficiency.

PubMed ID: 21396577

DOI: 10.1016/j.beem.2010.08.010

PubMed ID: 23488611

Title: A novel mutation in IGFALS, c.380T>C (p.L127P), associated with short stature, delayed puberty, osteopenia and hyperinsulinaemia in two siblings: insights into the roles of insulin growth factor-1 (IGF1).

PubMed ID: 23488611

DOI: 10.1111/cen.12200

Sequence Information:

  • Length: 605
  • Mass: 66035
  • Checksum: F6562A23CBE918F6
  • Sequence:
    • MALRKGGLAL ALLLLSWVAL GPRSLEGADP GTPGEAEGPA CPAACVCSYD DDADELSVFC 
SSRNLTRLPD GVPGGTQALW LDGNNLSSVP PAAFQNLSSL GFLNLQGGQL GSLEPQALLG 
LENLCHLHLE RNQLRSLALG TFAHTPALAS LGLSNNRLSR LEDGLFEGLG SLWDLNLGWN 
SLAVLPDAAF RGLGSLRELV LAGNRLAYLQ PALFSGLAEL RELDLSRNAL RAIKANVFVQ 
LPRLQKLYLD RNLIAAVAPG AFLGLKALRW LDLSHNRVAG LLEDTFPGLL GLRVLRLSHN 
AIASLRPRTF KDLHFLEELQ LGHNRIRQLA ERSFEGLGQL EVLTLDHNQL QEVKAGAFLG 
LTNVAVMNLS GNCLRNLPEQ VFRGLGKLHS LHLEGSCLGR IRPHTFTGLS GLRRLFLKDN 
GLVGIEEQSL WGLAELLELD LTSNQLTHLP HRLFQGLGKL EYLLLSRNRL AELPADALGP 
LQRAFWLDVS HNRLEALPNS LLAPLGRLRY LSLRNNSLRT FTPQPPGLER LWLEGNPWDC 
GCPLKALRDF ALQNPSAVPR FVQAICEGDD CQPPAYTYNN ITCASPPEVV GLDLRDLSEA 
HFAPC

Genular Protein ID: 2473511143

Symbol: Q8TAY0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8TAY0

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 2 SAM 1 SMART 6 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 605
  • Mass: 66067
  • Checksum: F6527A23CBE218F6
  • Sequence:
    • MALRKGGLAL ALLLLSWVAL GPRSLEGADP GTPGEAEGPA CPAACVCSYD DDADELSVFC 
SSRNLTRLPD GVPGGTQALW LDGNNLSSVP PAAFQNLSSL GFLNLQGGQL GSLEPQALLG 
LENLCHLHLE RNQLRSLALG TFAHTPALAS LGLSNNRLSR LEDGLFEGLG SLWDLNLGWN 
SLAVLPDAAF RGLGSLRELV LAGNRLAYLQ PALFSGLAEL RELDLSRNAL RAIKANVFVQ 
LPRLQKLYLD RNLIAAVAPG AFLGLKALRW LDLSHNRVAG LLEDTFPGLL GLRVLRLSHN 
AIASLRPRTF KDLHFLEELQ LGHNRIRQLA ERSFEGLGQL EVLTLDHNQL QEVKAGAFLG 
LTNMAVMNLS GNCLRNLPEQ VFRGLGKLHS LHLEGSCLGR IRPHTFTGLS GLRRLFLKDN 
GLVGIEEQSL WGLAELLELD LTSNQLTHLP HRLFQGLGKL EYLLLSRNRL AELPADALGP 
LQRAFWLDVS HNRLEALPNS LLAPLGRLRY LSLRNNSLRT FTPQPPGLER LWLEGNPWDC 
GCPLKALRDF ALQNPSAVPR FVQAICEGDD CQPPAYTYNN ITCASPPEVV GLDLRDLSEA 
HFAPC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.