Details for: LCE1C

Gene ID: 353133

Symbol: LCE1C

Ensembl ID: ENSG00000197084

Description: late cornified envelope 1C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 15.9916
    Cell Significance Index: -7.5500
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 6.6459
    Cell Significance Index: 62.5200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.8243
    Cell Significance Index: 1.8600
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.5570
    Cell Significance Index: 7.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.4641
    Cell Significance Index: 13.6700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3394
    Cell Significance Index: 4.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0517
    Cell Significance Index: 2.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0445
    Cell Significance Index: 19.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0736
    Cell Significance Index: -7.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0948
    Cell Significance Index: -7.5100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1129
    Cell Significance Index: -1.2900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1348
    Cell Significance Index: -4.9500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1511
    Cell Significance Index: -3.0100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1633
    Cell Significance Index: -2.3200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1776
    Cell Significance Index: -3.5100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1778
    Cell Significance Index: -2.3200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1962
    Cell Significance Index: -4.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2131
    Cell Significance Index: -5.8000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2243
    Cell Significance Index: -6.2700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2351
    Cell Significance Index: -2.4300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2473
    Cell Significance Index: -3.5400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2492
    Cell Significance Index: -2.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2556
    Cell Significance Index: -6.8500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2928
    Cell Significance Index: -7.4600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3124
    Cell Significance Index: -3.4600
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.3241
    Cell Significance Index: -3.5500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.3428
    Cell Significance Index: -3.6400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.3442
    Cell Significance Index: -3.6900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3650
    Cell Significance Index: -6.2400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.3853
    Cell Significance Index: -4.6200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3948
    Cell Significance Index: -4.5800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.4057
    Cell Significance Index: -6.8900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.4190
    Cell Significance Index: -4.7200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.4281
    Cell Significance Index: -5.5000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.4347
    Cell Significance Index: -6.9900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.4637
    Cell Significance Index: -5.4800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.4665
    Cell Significance Index: -6.8000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.4675
    Cell Significance Index: -6.4200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4716
    Cell Significance Index: -7.8900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.4732
    Cell Significance Index: -5.7100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.4853
    Cell Significance Index: -7.3700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.4889
    Cell Significance Index: -5.0700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.4989
    Cell Significance Index: -5.2500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.5118
    Cell Significance Index: -8.2900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.5185
    Cell Significance Index: -6.1700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5365
    Cell Significance Index: -7.5200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.5492
    Cell Significance Index: -6.3200
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.5538
    Cell Significance Index: -4.0300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.5634
    Cell Significance Index: -7.4200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.5776
    Cell Significance Index: -6.8200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.5786
    Cell Significance Index: -8.4000
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.5911
    Cell Significance Index: -7.5700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.5965
    Cell Significance Index: -8.1800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.5975
    Cell Significance Index: -6.1000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.6020
    Cell Significance Index: -7.9000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.6071
    Cell Significance Index: -5.7000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.6090
    Cell Significance Index: -7.8800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.6142
    Cell Significance Index: -7.7500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.6212
    Cell Significance Index: -8.1100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.6219
    Cell Significance Index: -6.5600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.6239
    Cell Significance Index: -7.5900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.6250
    Cell Significance Index: -7.9200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.6263
    Cell Significance Index: -7.4900
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.6344
    Cell Significance Index: -7.6700
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.6372
    Cell Significance Index: -8.0700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.6471
    Cell Significance Index: -7.0500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.6505
    Cell Significance Index: -3.8600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.6534
    Cell Significance Index: -7.3000
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.6582
    Cell Significance Index: -7.5500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.6635
    Cell Significance Index: -8.1600
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.6672
    Cell Significance Index: -7.6900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.6699
    Cell Significance Index: -6.8500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.6723
    Cell Significance Index: -8.7900
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.6743
    Cell Significance Index: -7.5500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.6802
    Cell Significance Index: -8.7600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.6806
    Cell Significance Index: -8.0900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.6880
    Cell Significance Index: -8.1300
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: -0.6917
    Cell Significance Index: -7.5600
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.7011
    Cell Significance Index: -7.5600
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.7115
    Cell Significance Index: -7.5300
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.7121
    Cell Significance Index: -7.4900
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.7153
    Cell Significance Index: -8.3100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.7178
    Cell Significance Index: -4.6700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.7196
    Cell Significance Index: -7.8400
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.7222
    Cell Significance Index: -7.5700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7274
    Cell Significance Index: -7.5300
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.7293
    Cell Significance Index: -7.9900
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.7400
    Cell Significance Index: -7.9900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.7826
    Cell Significance Index: -8.4100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.7843
    Cell Significance Index: -8.0000
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.7933
    Cell Significance Index: -7.5600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.7981
    Cell Significance Index: -7.9000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.8090
    Cell Significance Index: -6.8400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.8133
    Cell Significance Index: -8.6400
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.8241
    Cell Significance Index: -8.1300
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.8269
    Cell Significance Index: -8.0900
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.8284
    Cell Significance Index: -7.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.8386
    Cell Significance Index: -9.5300
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.8422
    Cell Significance Index: -7.5900
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.8531
    Cell Significance Index: -8.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LCE1C is a protein-coding gene that belongs to the LCE family, which consists of four genes (LCE1A, LCE1B, LCE1C, and LCE1D). These genes are characterized by their expression in epithelial tissues and their involvement in keratinization, a process by which epithelial cells acquire a more rigid and resistant state. LCE1C is specifically expressed in cells that undergo keratinization, such as stratified epithelial cells and neurons. Its expression is also observed in progenitor cells, oligodendrocyte precursor cells, and microglial cells, indicating a broader role in cell development and differentiation. **Pathways and Functions:** LCE1C is involved in several key pathways, including: 1. **Keratinization:** LCE1C plays a crucial role in the formation of the cornified envelope, a complex structure composed of cross-linked keratin filaments that provides mechanical strength to epithelial tissues. 2. **Developmental biology:** LCE1C is expressed in progenitor cells and oligodendrocyte precursor cells, suggesting its involvement in the development and differentiation of these cell types. 3. **Protein binding:** LCE1C is capable of binding to various proteins, including keratins and other LCE family members, which may regulate its expression and function. **Functions:** The functions of LCE1C can be summarized as follows: 1. **Keratinization:** LCE1C contributes to the formation of the cornified envelope by regulating the expression of keratin genes and promoting the cross-linking of keratin filaments. 2. **Cell differentiation:** LCE1C may influence the differentiation of progenitor cells and oligodendrocyte precursor cells, promoting their acquisition of specific cell types. 3. **Epithelial homeostasis:** LCE1C may maintain epithelial homeostasis by regulating the expression of genes involved in cell proliferation, differentiation, and survival. **Clinical Significance:** Dysregulation of LCE1C has been implicated in various diseases, including: 1. **Skin disorders:** Mutations in LCE1C have been associated with skin disorders such as epidermolysis bullosa simplex, a condition characterized by blistering skin lesions. 2. **Neurological disorders:** LCE1C has been linked to neurological disorders, including Alzheimer's disease and amyotrophic lateral sclerosis, where aberrant keratinization and protein binding may contribute to disease pathogenesis. In conclusion, LCE1C is a gene that plays a critical role in keratinization, epithelial development, and cell differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of this gene.

Genular Protein ID: 290527288

Symbol: LCE1C_HUMAN

Name: Late cornified envelope protein 1C

UniProtKB Accession Codes:

Q5T751

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 1 ExpressionAtlas 1 GO 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15854049

Title: Late cornified envelope family in differentiating epithelia -- response to calcium and ultraviolet irradiation.

PubMed ID: 15854049

DOI: 10.1111/j.0022-202x.2005.23699.x

PubMed ID: 36804407

Title: CYSRT1: An Antimicrobial Epidermal Protein that Can Interact with Late Cornified Envelope Proteins.

PubMed ID: 36804407

DOI: 10.1016/j.jid.2023.01.022

Sequence Information:

  • Length: 118
  • Mass: 11543
  • Checksum: B1163143D1292259
  • Sequence:
    • MSCQQSQQQC QPPPKCTPKC PPKCPTPKCP PKCPPKCPPV SSCCSVSSGG CCGSSSGGSC 
GSSSGGCCSS GGGGCCLSHH RRRRSHCHRP QSSGCCSQPS GGSSCCGGGS GQHSGGCC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.