Details for: IL12B

Gene ID: 3593

Symbol: IL12B

Ensembl ID: ENSG00000113302

Description: interleukin 12B

Associated with

  • Cytokine signaling in immune system
    (R-HSA-1280215)
  • Immune system
    (R-HSA-168256)
  • Interleukin-4 and interleukin-13 signaling
    (R-HSA-6785807)
  • Interleukin-10 signaling
    (R-HSA-6783783)
  • Interleukin-12 family signaling
    (R-HSA-447115)
  • Interleukin-12 signaling
    (R-HSA-9020591)
  • Interleukin-23 signaling
    (R-HSA-9020933)
  • Signaling by interleukins
    (R-HSA-449147)
  • Cell migration
    (GO:0016477)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cellular response to type ii interferon
    (GO:0071346)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Cytokine activity
    (GO:0005125)
  • Cytokine binding
    (GO:0019955)
  • Cytokine receptor activity
    (GO:0004896)
  • Cytosol
    (GO:0005829)
  • Defense response to gram-negative bacterium
    (GO:0050829)
  • Defense response to protozoan
    (GO:0042832)
  • Defense response to virus
    (GO:0051607)
  • Endoplasmic reticulum lumen
    (GO:0005788)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Growth factor activity
    (GO:0008083)
  • Identical protein binding
    (GO:0042802)
  • Interleukin-12 alpha subunit binding
    (GO:0042164)
  • Interleukin-12 complex
    (GO:0043514)
  • Interleukin-12 receptor binding
    (GO:0005143)
  • Interleukin-12-mediated signaling pathway
    (GO:0035722)
  • Interleukin-23 complex
    (GO:0070743)
  • Interleukin-23 receptor binding
    (GO:0045519)
  • Late endosome lumen
    (GO:0031906)
  • Natural killer cell activation
    (GO:0030101)
  • Natural killer cell activation involved in immune response
    (GO:0002323)
  • Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
    (GO:1903588)
  • Negative regulation of inflammatory response to antigenic stimulus
    (GO:0002862)
  • Negative regulation of interleukin-10 production
    (GO:0032693)
  • Negative regulation of interleukin-17 production
    (GO:0032700)
  • Negative regulation of protein secretion
    (GO:0050709)
  • Negative regulation of smooth muscle cell proliferation
    (GO:0048662)
  • Negative regulation of vascular endothelial growth factor signaling pathway
    (GO:1900747)
  • Positive regulation of activated t cell proliferation
    (GO:0042104)
  • Positive regulation of activation of janus kinase activity
    (GO:0010536)
  • Positive regulation of cell adhesion
    (GO:0045785)
  • Positive regulation of defense response to virus by host
    (GO:0002230)
  • Positive regulation of granulocyte macrophage colony-stimulating factor production
    (GO:0032725)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of interleukin-17 production
    (GO:0032740)
  • Positive regulation of lymphocyte proliferation
    (GO:0050671)
  • Positive regulation of memory t cell differentiation
    (GO:0043382)
  • Positive regulation of mononuclear cell proliferation
    (GO:0032946)
  • Positive regulation of natural killer cell activation
    (GO:0032816)
  • Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
    (GO:0002860)
  • Positive regulation of natural killer cell proliferation
    (GO:0032819)
  • Positive regulation of nk t cell activation
    (GO:0051135)
  • Positive regulation of nk t cell proliferation
    (GO:0051142)
  • Positive regulation of non-canonical nf-kappab signal transduction
    (GO:1901224)
  • Positive regulation of osteoclast differentiation
    (GO:0045672)
  • Positive regulation of smooth muscle cell apoptotic process
    (GO:0034393)
  • Positive regulation of t-helper 1 type immune response
    (GO:0002827)
  • Positive regulation of t-helper 17 cell lineage commitment
    (GO:2000330)
  • Positive regulation of t-helper 17 type immune response
    (GO:2000318)
  • Positive regulation of t cell mediated cytotoxicity
    (GO:0001916)
  • Positive regulation of t cell proliferation
    (GO:0042102)
  • Positive regulation of tissue remodeling
    (GO:0034105)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Positive regulation of tyrosine phosphorylation of stat protein
    (GO:0042531)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein binding
    (GO:0005515)
  • Protein heterodimerization activity
    (GO:0046982)
  • Receptor complex
    (GO:0043235)
  • Regulation of cytokine production
    (GO:0001817)
  • Regulation of tyrosine phosphorylation of stat protein
    (GO:0042509)
  • Response to uv-b
    (GO:0010224)
  • Sexual reproduction
    (GO:0019953)
  • T-helper 1 type immune response
    (GO:0042088)
  • T-helper cell differentiation
    (GO:0042093)
  • T cell proliferation
    (GO:0042098)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 4.55
    Marker Score: 2519
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3177
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.85
    Marker Score: 3184
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.53
    Marker Score: 2111
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.22
    Marker Score: 776
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.17
    Marker Score: 686
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7514
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.13
    Marker Score: 595
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.04
    Marker Score: 2125
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.01
    Marker Score: 1911
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48055
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.94
    Marker Score: 716
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.79
    Marker Score: 456
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 403
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.77
    Marker Score: 462
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.75
    Marker Score: 313
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.73
    Marker Score: 920
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.71
    Marker Score: 687
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 520
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.63
    Marker Score: 9847
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.62
    Marker Score: 694
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.58
    Marker Score: 615
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.53
    Marker Score: 1107
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.48
    Marker Score: 762
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.44
    Marker Score: 292
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 250
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.38
    Marker Score: 445
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.38
    Marker Score: 378
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.36
    Marker Score: 189
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.29
    Marker Score: 259
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.28
    Marker Score: 135
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.23
    Marker Score: 221
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.2
    Marker Score: 89
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.19
    Marker Score: 124
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.16
    Marker Score: 110
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.14
    Marker Score: 46
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.14
    Marker Score: 182
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.14
    Marker Score: 244
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.13
    Marker Score: 42
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.12
    Marker Score: 91
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.12
    Marker Score: 118
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.11
    Marker Score: 57
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1
    Marker Score: 33
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.08
    Marker Score: 191
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.07
    Marker Score: 44
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.07
    Marker Score: 67
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.07
    Marker Score: 20.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.06
    Marker Score: 81
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.06
    Marker Score: 20.5
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.06
    Marker Score: 16.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.05
    Marker Score: 14.5
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.05
    Marker Score: 19.5
  • Cell Name: myeloid dendritic cell, human (CL0001057)
    Fold Change: 0.05
    Marker Score: 17.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.05
    Marker Score: 2713
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.05
    Marker Score: 290.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.04
    Marker Score: 182
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.04
    Marker Score: 20.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.04
    Marker Score: 51
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.04
    Marker Score: 48
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.04
    Marker Score: 38
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.04
    Marker Score: 20.5
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.04
    Marker Score: 69
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.04
    Marker Score: 228
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.04
    Marker Score: 88
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.03
    Marker Score: 49
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.03
    Marker Score: 20.5
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.03
    Marker Score: 19.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.03
    Marker Score: 17.5
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.03
    Marker Score: 19.5
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.03
    Marker Score: 16.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.03
    Marker Score: 1489
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.03
    Marker Score: 30

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Other Information

**Key characteristics:** - Type: Cytokine - Ensembl ID: ENSG00000113302 - Protein: IL12B_HUMAN (Interleukin-12 subunit beta) - Molecular weight: 125 kDa **Pathways and functions:** - IL12B is primarily produced by activated macrophages and dendritic cells in response to infection or inflammation. - It binds to its receptor, IL12 receptor (IL12R), expressed on various immune cells, including T cells, B cells, and macrophages. - Upon binding, IL12B recruits the IL12 receptor-mediated signaling pathway, leading to the activation of downstream targets. - These downstream targets include: - Activation of STAT3 signaling pathway: IL12B and its receptor interact with STAT3, leading to the phosphorylation and nuclear translocation of STAT3. - Activation of NF-κB pathway: IL12B also activates the NF-κB pathway, promoting the production of inflammatory cytokines and chemokines. - Activation of MAPK pathway: IL12B can activate the MAPK pathway, leading to the phosphorylation of MAPK proteins and the activation of downstream targets. - Activation of JAK/STAT pathway: IL12B can also activate the JAK/STAT pathway, leading to the phosphorylation of STAT proteins and the activation of downstream targets. - IL12B plays a critical role in various immune responses, including inflammation, cell proliferation, and differentiation. It is involved in the regulation of immune responses against extracellular bacteria and fungi, promoting the development of adaptive immune responses and the regulation of inflammatory responses. **Clinical significance:** - IL12B is a therapeutic target for various inflammatory diseases, including rheumatoid arthritis, inflammatory bowel disease, and asthma. - Blockade of IL12 signaling has been shown to be effective in reducing inflammation and disease activity. - IL12B is also a potential therapeutic target for cancer, where it is expressed by tumor cells and promotes tumor growth and metastasis.

Genular Protein ID: 2358513950

Symbol: IL12B_HUMAN

Name: Interleukin-12 subunit beta

UniProtKB Accession Codes:

P29460

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 ELM 1 EMBL 11 Ensembl 1 EvolutionaryTrace 1 GO 70 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 15 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1674604

Title: Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.

PubMed ID: 1674604

DOI: 10.1073/pnas.88.10.4143

PubMed ID: 1673147

Title: Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.

PubMed ID: 1673147

PubMed ID: 11197695

Title: Complete primary structure, chromosomal localization, and definition of polymorphisms of the gene encoding the human interleukin 12 p40 subunit.

PubMed ID: 11197695

DOI: 10.1038/sj.gene.6363720

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2204066

Title: Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.

PubMed ID: 2204066

DOI: 10.1073/pnas.87.17.6808

PubMed ID: 2070420

Title: Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor.

PubMed ID: 2070420

DOI: 10.1016/0092-8674(91)90131-h

PubMed ID: 7836910

Title: Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production.

PubMed ID: 7836910

DOI: 10.1084/jem.181.2.537

PubMed ID: 10207176

Title: Recombinant human interleukin-12 is the second example of a C-mannosylated protein.

PubMed ID: 10207176

DOI: 10.1093/glycob/9.5.435

PubMed ID: 9854038

Title: Inherited interleukin 12 deficiency in a child with bacille Calmette-Guerin and Salmonella enteritidis disseminated infection.

PubMed ID: 9854038

DOI: 10.1172/jci4950

PubMed ID: 11114383

Title: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.

PubMed ID: 11114383

DOI: 10.1016/s1074-7613(00)00070-4

PubMed ID: 11753820

Title: Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindreds.

PubMed ID: 11753820

DOI: 10.1086/338625

PubMed ID: 17587057

Title: Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.

PubMed ID: 17587057

DOI: 10.1007/s00439-007-0397-0

PubMed ID: 18800148

Title: Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis.

PubMed ID: 18800148

DOI: 10.1038/jid.2008.233

PubMed ID: 10899108

Title: Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12.

PubMed ID: 10899108

DOI: 10.1093/emboj/19.14.3530

PubMed ID: 18708069

Title: Crystal structures of the pro-inflammatory cytokine interleukin-23 and its complex with a high-affinity neutralizing antibody.

PubMed ID: 18708069

DOI: 10.1016/j.jmb.2008.08.001

PubMed ID: 18680750

Title: The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12.

PubMed ID: 18680750

DOI: 10.1016/j.jmb.2008.07.051

Sequence Information:

  • Length: 328
  • Mass: 37169
  • Checksum: 118FA801B8F5BB2F
  • Sequence:
    • MCHQQLVISW FSLVFLASPL VAIWELKKDV YVVELDWYPD APGEMVVLTC DTPEEDGITW 
TLDQSSEVLG SGKTLTIQVK EFGDAGQYTC HKGGEVLSHS LLLLHKKEDG IWSTDILKDQ 
KEPKNKTFLR CEAKNYSGRF TCWWLTTIST DLTFSVKSSR GSSDPQGVTC GAATLSAERV 
RGDNKEYEYS VECQEDSACP AAEESLPIEV MVDAVHKLKY ENYTSSFFIR DIIKPDPPKN 
LQLKPLKNSR QVEVSWEYPD TWSTPHSYFS LTFCVQVQGK SKREKKDRVF TDKTSATVIC 
RKNASISVRA QDRYYSSSWS EWASVPCS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.