Details for: IL12B

Gene ID: 3593

Symbol: IL12B

Ensembl ID: ENSG00000113302

Description: interleukin 12B

Associated with

  • Cytokine signaling in immune system
    (R-HSA-1280215)
  • Immune system
    (R-HSA-168256)
  • Interleukin-4 and interleukin-13 signaling
    (R-HSA-6785807)
  • Interleukin-10 signaling
    (R-HSA-6783783)
  • Interleukin-12 family signaling
    (R-HSA-447115)
  • Interleukin-12 signaling
    (R-HSA-9020591)
  • Interleukin-23 signaling
    (R-HSA-9020933)
  • Signaling by interleukins
    (R-HSA-449147)
  • Cell migration
    (GO:0016477)
  • Cell surface receptor signaling pathway via jak-stat
    (GO:0007259)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cellular response to type ii interferon
    (GO:0071346)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Cytokine activity
    (GO:0005125)
  • Cytokine binding
    (GO:0019955)
  • Cytokine receptor activity
    (GO:0004896)
  • Cytosol
    (GO:0005829)
  • Defense response to gram-negative bacterium
    (GO:0050829)
  • Defense response to protozoan
    (GO:0042832)
  • Defense response to virus
    (GO:0051607)
  • Endoplasmic reticulum lumen
    (GO:0005788)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Growth factor activity
    (GO:0008083)
  • Identical protein binding
    (GO:0042802)
  • Interleukin-12 alpha subunit binding
    (GO:0042164)
  • Interleukin-12 complex
    (GO:0043514)
  • Interleukin-12 receptor binding
    (GO:0005143)
  • Interleukin-12-mediated signaling pathway
    (GO:0035722)
  • Interleukin-23 complex
    (GO:0070743)
  • Interleukin-23 receptor binding
    (GO:0045519)
  • Late endosome lumen
    (GO:0031906)
  • Natural killer cell activation
    (GO:0030101)
  • Natural killer cell activation involved in immune response
    (GO:0002323)
  • Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
    (GO:1903588)
  • Negative regulation of inflammatory response to antigenic stimulus
    (GO:0002862)
  • Negative regulation of interleukin-10 production
    (GO:0032693)
  • Negative regulation of interleukin-17 production
    (GO:0032700)
  • Negative regulation of protein secretion
    (GO:0050709)
  • Negative regulation of smooth muscle cell proliferation
    (GO:0048662)
  • Negative regulation of vascular endothelial growth factor signaling pathway
    (GO:1900747)
  • Positive regulation of activated t cell proliferation
    (GO:0042104)
  • Positive regulation of cell adhesion
    (GO:0045785)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of defense response to virus by host
    (GO:0002230)
  • Positive regulation of granulocyte macrophage colony-stimulating factor production
    (GO:0032725)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of interleukin-17 production
    (GO:0032740)
  • Positive regulation of lymphocyte proliferation
    (GO:0050671)
  • Positive regulation of memory t cell differentiation
    (GO:0043382)
  • Positive regulation of mononuclear cell proliferation
    (GO:0032946)
  • Positive regulation of natural killer cell activation
    (GO:0032816)
  • Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
    (GO:0002860)
  • Positive regulation of natural killer cell proliferation
    (GO:0032819)
  • Positive regulation of nk t cell activation
    (GO:0051135)
  • Positive regulation of nk t cell proliferation
    (GO:0051142)
  • Positive regulation of non-canonical nf-kappab signal transduction
    (GO:1901224)
  • Positive regulation of osteoclast differentiation
    (GO:0045672)
  • Positive regulation of smooth muscle cell apoptotic process
    (GO:0034393)
  • Positive regulation of t-helper 1 type immune response
    (GO:0002827)
  • Positive regulation of t-helper 17 cell lineage commitment
    (GO:2000330)
  • Positive regulation of t-helper 17 type immune response
    (GO:2000318)
  • Positive regulation of t cell mediated cytotoxicity
    (GO:0001916)
  • Positive regulation of t cell proliferation
    (GO:0042102)
  • Positive regulation of tissue remodeling
    (GO:0034105)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein binding
    (GO:0005515)
  • Protein heterodimerization activity
    (GO:0046982)
  • Receptor complex
    (GO:0043235)
  • Regulation of cytokine production
    (GO:0001817)
  • Response to uv-b
    (GO:0010224)
  • Sexual reproduction
    (GO:0019953)
  • T-helper 1 type immune response
    (GO:0042088)
  • T-helper cell differentiation
    (GO:0042093)
  • T cell proliferation
    (GO:0042098)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 3.9384
    Cell Significance Index: -1.6000
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 2.4629
    Cell Significance Index: 22.2700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2973
    Cell Significance Index: 4.6000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2967
    Cell Significance Index: 4.3300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1841
    Cell Significance Index: 1.3900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1694
    Cell Significance Index: 2.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1454
    Cell Significance Index: 3.9000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0649
    Cell Significance Index: 1.6200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0586
    Cell Significance Index: 0.5800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0308
    Cell Significance Index: 0.3900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0165
    Cell Significance Index: 0.2000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0010
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0007
    Cell Significance Index: 1.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0005
    Cell Significance Index: -0.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0016
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0028
    Cell Significance Index: -0.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0033
    Cell Significance Index: -6.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0034
    Cell Significance Index: -1.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0043
    Cell Significance Index: -1.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0047
    Cell Significance Index: -1.6800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0066
    Cell Significance Index: -0.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0090
    Cell Significance Index: -1.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0093
    Cell Significance Index: -1.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0107
    Cell Significance Index: -1.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0111
    Cell Significance Index: -3.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0135
    Cell Significance Index: -1.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0145
    Cell Significance Index: -1.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0147
    Cell Significance Index: -1.5000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0196
    Cell Significance Index: -0.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0215
    Cell Significance Index: -2.2400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0224
    Cell Significance Index: -0.5600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0271
    Cell Significance Index: -0.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0296
    Cell Significance Index: -1.5400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0298
    Cell Significance Index: -0.3900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0327
    Cell Significance Index: -0.4800
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0342
    Cell Significance Index: -0.4800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0355
    Cell Significance Index: -0.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0360
    Cell Significance Index: -2.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0372
    Cell Significance Index: -2.4000
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0446
    Cell Significance Index: -0.4100
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0472
    Cell Significance Index: -0.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0477
    Cell Significance Index: -2.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0520
    Cell Significance Index: -1.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0540
    Cell Significance Index: -1.5900
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0544
    Cell Significance Index: -0.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0574
    Cell Significance Index: -2.0100
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0587
    Cell Significance Index: -0.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0593
    Cell Significance Index: -2.7900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0615
    Cell Significance Index: -1.0400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0630
    Cell Significance Index: -1.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0675
    Cell Significance Index: -2.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0688
    Cell Significance Index: -2.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0692
    Cell Significance Index: -1.8200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0722
    Cell Significance Index: -1.3400
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.0741
    Cell Significance Index: -0.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0756
    Cell Significance Index: -4.2400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0782
    Cell Significance Index: -1.5600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0806
    Cell Significance Index: -0.9800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0818
    Cell Significance Index: -2.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0850
    Cell Significance Index: -3.7600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0855
    Cell Significance Index: -2.4400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0860
    Cell Significance Index: -1.0500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0877
    Cell Significance Index: -2.1300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0886
    Cell Significance Index: -1.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0903
    Cell Significance Index: -3.4200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0906
    Cell Significance Index: -2.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0925
    Cell Significance Index: -2.0300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0925
    Cell Significance Index: -1.3300
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0960
    Cell Significance Index: -1.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0997
    Cell Significance Index: -1.3600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0998
    Cell Significance Index: -1.0600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1032
    Cell Significance Index: -2.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1057
    Cell Significance Index: -2.0900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1060
    Cell Significance Index: -2.2500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1062
    Cell Significance Index: -2.0900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1069
    Cell Significance Index: -1.8000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1083
    Cell Significance Index: -1.8400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1098
    Cell Significance Index: -1.8100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1104
    Cell Significance Index: -1.3700
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.1124
    Cell Significance Index: -1.4400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1126
    Cell Significance Index: -1.9300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1131
    Cell Significance Index: -1.3400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1148
    Cell Significance Index: -1.5300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.1153
    Cell Significance Index: -1.3400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1156
    Cell Significance Index: -2.3200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1165
    Cell Significance Index: -2.0200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1171
    Cell Significance Index: -1.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1173
    Cell Significance Index: -3.3800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1234
    Cell Significance Index: -4.5300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1237
    Cell Significance Index: -2.9700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1238
    Cell Significance Index: -1.7000
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.1241
    Cell Significance Index: -1.4500
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1303
    Cell Significance Index: -1.6500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1305
    Cell Significance Index: -1.7900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.1314
    Cell Significance Index: -1.6500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1316
    Cell Significance Index: -1.2500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1330
    Cell Significance Index: -1.4400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1338
    Cell Significance Index: -1.5900
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1347
    Cell Significance Index: -1.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IL12B exhibits several key characteristics that define its function in the immune system: 1. **Cellular specificity**: IL12B is primarily expressed on antigen-presenting cells (APCs), such as dendritic cells and macrophages, which are essential for initiating and regulating immune responses. 2. **Th1 cell differentiation**: IL12B promotes the differentiation of naive T cells into Th1 cells, which are critical for cell-mediated immunity and the defense against intracellular pathogens. 3. **IFN-γ production**: IL12B induces the production of IFN-γ, a key cytokine that plays a central role in the regulation of immune responses and the defense against viral and bacterial infections. 4. **Immune cell activation**: IL12B activates various immune cells, including natural killer cells, macrophages, and T cells, leading to their proliferation, differentiation, and functional activation. **Pathways and Functions** IL12B interacts with multiple signaling pathways that regulate immune responses, including: 1. **JAK/STAT pathway**: IL12B binds to the IL-12 receptor, which activates the JAK/STAT pathway, leading to the phosphorylation and activation of transcription factors, such as STAT1 and STAT4. 2. **NF-κB pathway**: IL12B also activates the NF-κB pathway, which regulates the expression of genes involved in inflammation, immune cell activation, and cell survival. 3. **Cytokine signaling pathway**: IL12B interacts with other cytokines, such as IL-10 and IL-17, to regulate immune responses and modulate the activity of immune cells. IL12B's functions in the immune system include: 1. **Defense against infections**: IL12B plays a crucial role in the defense against viral, bacterial, and protozoan infections by promoting the activation and proliferation of immune cells. 2. **Immune cell regulation**: IL12B regulates the activity of various immune cells, including T cells, natural killer cells, and macrophages, to ensure proper immune function and prevent immune dysregulation. 3. **Autoimmune disease modulation**: IL12B modulates the activity of immune cells involved in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. **Clinical Significance** IL12B's dysregulation has been implicated in various diseases, including: 1. **Autoimmune diseases**: Alterations in IL12B expression and function have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: IL12B's role in cancer immunotherapy has been explored, as it can modulate the activity of immune cells to target cancer cells. 3. **Infectious diseases**: IL12B's dysregulation has been implicated in the pathogenesis of infectious diseases, such as tuberculosis and malaria. In conclusion, IL12B is a critical cytokine that plays a pivotal role in the regulation of immune responses, particularly in the context of Th1 cell differentiation, activation, and proliferation. Its dysregulation has been implicated in various diseases, highlighting the importance of IL12B's function in maintaining immune homeostasis and preventing immune dysregulation.

Genular Protein ID: 2358513950

Symbol: IL12B_HUMAN

Name: Interleukin-12 subunit beta

UniProtKB Accession Codes:

P29460

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 ELM 1 EMBL 11 EMDB 1 Ensembl 1 EvolutionaryTrace 1 GO 68 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 17 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1674604

Title: Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.

PubMed ID: 1674604

DOI: 10.1073/pnas.88.10.4143

PubMed ID: 1673147

Title: Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.

PubMed ID: 1673147

PubMed ID: 11197695

Title: Complete primary structure, chromosomal localization, and definition of polymorphisms of the gene encoding the human interleukin 12 p40 subunit.

PubMed ID: 11197695

DOI: 10.1038/sj.gene.6363720

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2204066

Title: Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.

PubMed ID: 2204066

DOI: 10.1073/pnas.87.17.6808

PubMed ID: 2070420

Title: Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor.

PubMed ID: 2070420

DOI: 10.1016/0092-8674(91)90131-h

PubMed ID: 7836910

Title: Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production.

PubMed ID: 7836910

DOI: 10.1084/jem.181.2.537

PubMed ID: 10207176

Title: Recombinant human interleukin-12 is the second example of a C-mannosylated protein.

PubMed ID: 10207176

DOI: 10.1093/glycob/9.5.435

PubMed ID: 9854038

Title: Inherited interleukin 12 deficiency in a child with bacille Calmette-Guerin and Salmonella enteritidis disseminated infection.

PubMed ID: 9854038

DOI: 10.1172/jci4950

PubMed ID: 11114383

Title: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.

PubMed ID: 11114383

DOI: 10.1016/s1074-7613(00)00070-4

PubMed ID: 11753820

Title: Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindreds.

PubMed ID: 11753820

DOI: 10.1086/338625

PubMed ID: 17587057

Title: Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.

PubMed ID: 17587057

DOI: 10.1007/s00439-007-0397-0

PubMed ID: 18800148

Title: Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis.

PubMed ID: 18800148

DOI: 10.1038/jid.2008.233

PubMed ID: 10899108

Title: Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12.

PubMed ID: 10899108

DOI: 10.1093/emboj/19.14.3530

PubMed ID: 18708069

Title: Crystal structures of the pro-inflammatory cytokine interleukin-23 and its complex with a high-affinity neutralizing antibody.

PubMed ID: 18708069

DOI: 10.1016/j.jmb.2008.08.001

PubMed ID: 18680750

Title: The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12.

PubMed ID: 18680750

DOI: 10.1016/j.jmb.2008.07.051

Sequence Information:

  • Length: 328
  • Mass: 37169
  • Checksum: 118FA801B8F5BB2F
  • Sequence:
    • MCHQQLVISW FSLVFLASPL VAIWELKKDV YVVELDWYPD APGEMVVLTC DTPEEDGITW 
TLDQSSEVLG SGKTLTIQVK EFGDAGQYTC HKGGEVLSHS LLLLHKKEDG IWSTDILKDQ 
KEPKNKTFLR CEAKNYSGRF TCWWLTTIST DLTFSVKSSR GSSDPQGVTC GAATLSAERV 
RGDNKEYEYS VECQEDSACP AAEESLPIEV MVDAVHKLKY ENYTSSFFIR DIIKPDPPKN 
LQLKPLKNSR QVEVSWEYPD TWSTPHSYFS LTFCVQVQGK SKREKKDRVF TDKTSATVIC 
RKNASISVRA QDRYYSSSWS EWASVPCS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.