Details for: IL17A

Gene ID: 3605

Symbol: IL17A

Ensembl ID: ENSG00000112115

Description: interleukin 17A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 11.15
    Marker Score: 6177
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8279
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4
    Marker Score: 2104
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.9
    Marker Score: 2217.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6845
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3178
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.94
    Marker Score: 811
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 876
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.32
    Marker Score: 870
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7691
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.06
    Marker Score: 1009
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251817
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71835
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48060
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.94
    Marker Score: 718
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 495
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.83
    Marker Score: 1570
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.77
    Marker Score: 449
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.72
    Marker Score: 1162
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.67
    Marker Score: 506
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 511
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.6
    Marker Score: 366
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 480
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.43
    Marker Score: 874.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.41
    Marker Score: 369
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.39
    Marker Score: 236
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 376
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.36
    Marker Score: 246
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.31
    Marker Score: 4858
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.31
    Marker Score: 178
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.3
    Marker Score: 238
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.27
    Marker Score: 1619
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.22
    Marker Score: 49
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.18
    Marker Score: 86
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.16
    Marker Score: 66
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.14
    Marker Score: 227
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.12
    Marker Score: 57
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.11
    Marker Score: 57
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.11
    Marker Score: 107
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.11
    Marker Score: 47
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.1
    Marker Score: 68
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.1
    Marker Score: 225
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.09
    Marker Score: 610
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.09
    Marker Score: 68
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.09
    Marker Score: 60
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.08
    Marker Score: 89
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.08
    Marker Score: 169
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.07
    Marker Score: 81
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.07
    Marker Score: 456
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.07
    Marker Score: 77
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.06
    Marker Score: 53
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.06
    Marker Score: 106
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.06
    Marker Score: 38
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.05
    Marker Score: 36.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.05
    Marker Score: 80
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.05
    Marker Score: 59
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.04
    Marker Score: 53
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.04
    Marker Score: 31
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 71
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.02
    Marker Score: 14

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Other Information

**Key characteristics:** - IL17A is a cytokine of the interleukin-17 (IL-17) family. - It is produced by a variety of cell types, including immune cells, endothelial cells, and stromal cells. - It is a potent activator of the NLRP3 inflammasome, which is involved in the regulation of inflammation. - It also plays a role in the regulation of cell survival, proliferation, and differentiation. **Pathways and functions:** - IL17A signaling is initiated by the binding of its receptor, IL17RA, to its receptor complex on immune cells. - This binding triggers the activation of the NLRP3 inflammasome, leading to the production of pro-inflammatory cytokines and chemokines. - IL17A also plays a role in the regulation of cell survival, proliferation, and differentiation. - It can promote the survival of immune cells, inhibit the proliferation of tumor cells, and promote the differentiation of naive T cells into effector T cells. - It also plays a role in the regulation of inflammation. **Clinical significance:** - IL17A is involved in a wide range of human diseases, including asthma, inflammatory bowel disease, psoriasis, and cancer. - Dysregulation of IL17A signaling has been implicated in the pathogenesis of these diseases. - Blockade of IL17A signaling has been shown to be effective in ameliorating disease symptoms. **Conclusion:** IL17A is a key cytokine that plays a critical role in the regulation of innate and adaptive immune responses. Its expression and activity are often altered in human diseases, suggesting that IL17A may be a potential therapeutic target for these diseases.

Genular Protein ID: 3320649509

Symbol: IL17_HUMAN

Name: Interleukin-17A

UniProtKB Accession Codes:

Q16552 Q5T2P0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 10 EMDB 2 Ensembl 1 EvolutionaryTrace 1 GO 40 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PDB 35 PDBsum 29 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8676080

Title: T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines.

PubMed ID: 8676080

DOI: 10.1084/jem.183.6.2593

PubMed ID: 7499828

Title: Human IL-17: a novel cytokine derived from T cells.

PubMed ID: 7499828

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 17763419

Title: Distinct regulation of interleukin-17 in human T helper lymphocytes.

PubMed ID: 17763419

DOI: 10.1002/art.22866

PubMed ID: 17355969

Title: Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells.

PubMed ID: 17355969

DOI: 10.1074/jbc.m700499200

PubMed ID: 17911633

Title: Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F.

PubMed ID: 17911633

DOI: 10.4049/jimmunol.179.8.5462

PubMed ID: 18684971

Title: The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex.

PubMed ID: 18684971

DOI: 10.4049/jimmunol.181.4.2799

PubMed ID: 19825828

Title: Act1, a U-box E3 ubiquitin ligase for IL-17 signaling.

PubMed ID: 19825828

DOI: 10.1126/scisignal.2000382

PubMed ID: 21350122

Title: Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity.

PubMed ID: 21350122

DOI: 10.1126/science.1200439

PubMed ID: 24120361

Title: An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis.

PubMed ID: 24120361

DOI: 10.1016/j.immuni.2013.09.002

PubMed ID: 27795421

Title: Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance.

PubMed ID: 27795421

DOI: 10.1128/jvi.01529-16

PubMed ID: 32187518

Title: Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling.

PubMed ID: 32187518

DOI: 10.1016/j.immuni.2020.02.004

PubMed ID: 19835883

Title: Structure of IL-17A in complex with a potent, fully human neutralizing antibody.

PubMed ID: 19835883

DOI: 10.1016/j.jmb.2009.10.008

PubMed ID: 23695682

Title: Crystal structures of interleukin 17A and its complex with IL-17 receptor A.

PubMed ID: 23695682

DOI: 10.1038/ncomms2880

PubMed ID: 28827714

Title: The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition properties.

PubMed ID: 28827714

DOI: 10.1038/s41598-017-08360-9

Sequence Information:

  • Length: 155
  • Mass: 17504
  • Checksum: 2BCAE9CB2F4886D1
  • Sequence:
    • MTPGKTSLVS LLLLLSLEAI VKAGITIPRN PGCPNSEDKN FPRTVMVNLN IHNRNTNTNP 
KRSSDYYNRS TSPWNLHRNE DPERYPSVIW EAKCRHLGCI NADGNVDYHM NSVPIQQEIL 
VLRREPPHCP NSFRLEKILV SVGCTCVTPI VHHVA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.