Details for: MAGEA3

Gene ID: 4102

Symbol: MAGEA3

Ensembl ID: ENSG00000221867

Description: MAGE family member A3

Associated with

  • Caspase binding
    (GO:0089720)
  • Endoplasmic reticulum
    (GO:0005783)
  • Histone deacetylase binding
    (GO:0042826)
  • Negative regulation of autophagy
    (GO:0010507)
  • Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043154)
  • Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
    (GO:1902236)
  • Negative regulation of protein processing
    (GO:0010955)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.33
    Marker Score: 384
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 1.24
    Marker Score: 550
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.21
    Marker Score: 554
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7690
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 1.13
    Marker Score: 538
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.05
    Marker Score: 554
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30370
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1532
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5315
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.86
    Marker Score: 519
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.84
    Marker Score: 551
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.81
    Marker Score: 555
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.8
    Marker Score: 552
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.8
    Marker Score: 728
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.79
    Marker Score: 462
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.69
    Marker Score: 549
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.62
    Marker Score: 554
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.61
    Marker Score: 541
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.6
    Marker Score: 513
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.56
    Marker Score: 545
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.55
    Marker Score: 555
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.51
    Marker Score: 804
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.5
    Marker Score: 535
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.5
    Marker Score: 547
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.5
    Marker Score: 553
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.47
    Marker Score: 521
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.45
    Marker Score: 527.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.44
    Marker Score: 551
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.43
    Marker Score: 555
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.39
    Marker Score: 627.5
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.38
    Marker Score: 652
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.36
    Marker Score: 466
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.35
    Marker Score: 502
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.28
    Marker Score: 863
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.28
    Marker Score: 482
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.25
    Marker Score: 281
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.25
    Marker Score: 515
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.24
    Marker Score: 547
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.23
    Marker Score: 551
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.2
    Marker Score: 540
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.19
    Marker Score: 378
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.17
    Marker Score: 327
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.16
    Marker Score: 555
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.14
    Marker Score: 544
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.13
    Marker Score: 553
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.1
    Marker Score: 187
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.05
    Marker Score: 314
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.05
    Marker Score: 802

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - MAGEA3 is a protein of the immunoglobulin superfamily. - It is expressed in a variety of cell types. - It is a key regulator of apoptosis, autophagy, and protein processing. **Pathways and functions:** - MAGEA3 is involved in the regulation of apoptosis, which is the process by which cells die on their own. - It does this by binding to the caspase-9 protein, which is an enzyme that is responsible for the initiation of apoptosis. - MAGEA3 also binds to the endoplasmic reticulum, which is a network of protein-folding and trafficking vesicles. - This binding inhibits the activity of the endoplasmic reticulum, which leads to the release of pro-apoptotic factors into the cytoplasm. - MAGEA3 also regulates autophagy, the process by which cells break down and recycle their own components. - It does this by binding to the autophagy-related protein ATG5 and inhibiting its activity. - Finally, MAGEA3 also regulates protein processing by binding to the cysteine-type endopeptidase activity involved in apoptotic process. **Clinical significance:** MAGEA3 is a gene that is frequently mutated in cancer. This mutation can lead to the activation of apoptosis, which can help to suppress tumor growth. However, in some cases, mutations in MAGEA3 can also lead to the activation of autophagy, which can lead to the destruction of the tumor. This can make MAGEA3 a potential target for cancer therapy.

Genular Protein ID: 1403723414

Symbol: MAGA3_HUMAN

Name: Antigen MZ2-D

UniProtKB Accession Codes:

P43357 Q6FHI6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 5 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8113684

Title: Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.

PubMed ID: 8113684

DOI: 10.1084/jem.179.3.921

PubMed ID: 8037761

Title: Cloning and analysis of MAGE-1-related genes.

PubMed ID: 8037761

DOI: 10.1006/bbrc.1994.1963

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10854409

Title: Comparative genome sequence analysis of the Bpa/Str region in mouse and man.

PubMed ID: 10854409

DOI: 10.1101/gr.10.6.758

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17942928

Title: MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines.

PubMed ID: 17942928

DOI: 10.1158/0008-5472.can-07-1478

PubMed ID: 20864041

Title: MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.

PubMed ID: 20864041

DOI: 10.1016/j.molcel.2010.08.029

PubMed ID: 29779948

Title: The eukaryotic proteome is shaped by E3 ubiquitin ligases targeting C-terminal degrons.

PubMed ID: 29779948

DOI: 10.1016/j.cell.2018.04.028

PubMed ID: 31267705

Title: Regulation of MAGE-A3/6 by the CRL4-DCAF12 ubiquitin ligase and nutrient availability.

PubMed ID: 31267705

DOI: 10.15252/embr.201847352

Sequence Information:

  • Length: 314
  • Mass: 34747
  • Checksum: 3F5EB13D1C9946A1
  • Sequence:
    • MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQEAAS SSSTLVEVTL GEVPAAESPD 
PPQSPQGASS LPTTMNYPLW SQSYEDSSNQ EEEGPSTFPD LESEFQAALS RKVAELVHFL 
LLKYRAREPV TKAEMLGSVV GNWQYFFPVI FSKASSSLQL VFGIELMEVD PIGHLYIFAT 
CLGLSYDGLL GDNQIMPKAG LLIIVLAIIA REGDCAPEEK IWEELSVLEV FEGREDSILG 
DPKKLLTQHF VQENYLEYRQ VPGSDPACYE FLWGPRALVE TSYVKVLHHM VKISGGPHIS 
YPPLHEWVLR EGEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.