Details for: MAGEA3

Gene ID: 4102

Symbol: MAGEA3

Ensembl ID: ENSG00000221867

Description: MAGE family member A3

Associated with

  • Caspase binding
    (GO:0089720)
  • Endoplasmic reticulum
    (GO:0005783)
  • Histone deacetylase binding
    (GO:0042826)
  • Negative regulation of autophagy
    (GO:0010507)
  • Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043154)
  • Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
    (GO:1902236)
  • Negative regulation of protein processing
    (GO:0010955)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.5935
    Cell Significance Index: 5.1000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0499
    Cell Significance Index: 0.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0036
    Cell Significance Index: 0.4100
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0093
    Cell Significance Index: -0.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0173
    Cell Significance Index: -2.3800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0222
    Cell Significance Index: -0.2800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0322
    Cell Significance Index: -0.8000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0638
    Cell Significance Index: -0.6300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0660
    Cell Significance Index: -0.7800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0747
    Cell Significance Index: -0.4000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0891
    Cell Significance Index: -0.9400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1032
    Cell Significance Index: -0.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1041
    Cell Significance Index: -2.7800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1138
    Cell Significance Index: -2.9000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1359
    Cell Significance Index: -1.6300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1395
    Cell Significance Index: -1.8300
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1397
    Cell Significance Index: -1.4300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1504
    Cell Significance Index: -1.5600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1514
    Cell Significance Index: -2.3000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1550
    Cell Significance Index: -1.7700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1560
    Cell Significance Index: -3.1100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1608
    Cell Significance Index: -1.5100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1611
    Cell Significance Index: -2.5900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1655
    Cell Significance Index: -2.3200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1699
    Cell Significance Index: -1.8500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1703
    Cell Significance Index: -2.4200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1707
    Cell Significance Index: -1.9800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1734
    Cell Significance Index: -2.0400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1743
    Cell Significance Index: -2.9800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1766
    Cell Significance Index: -2.9700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1791
    Cell Significance Index: -2.9000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1825
    Cell Significance Index: -2.6600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1838
    Cell Significance Index: -2.4000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1871
    Cell Significance Index: -2.5700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1910
    Cell Significance Index: -2.0500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1916
    Cell Significance Index: -2.2800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1960
    Cell Significance Index: -2.1200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1964
    Cell Significance Index: -2.5900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1973
    Cell Significance Index: -2.2700
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.2082
    Cell Significance Index: -2.4000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2105
    Cell Significance Index: -2.9200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2125
    Cell Significance Index: -2.7300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.2139
    Cell Significance Index: -2.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2147
    Cell Significance Index: -3.0800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2149
    Cell Significance Index: -2.3800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2159
    Cell Significance Index: -2.7800
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2203
    Cell Significance Index: -2.6800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2217
    Cell Significance Index: -3.1100
  • Cell Name: brush cell of tracheobronchial tree (CL0002075)
    Fold Change: -0.2217
    Cell Significance Index: -2.0000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2294
    Cell Significance Index: -3.0000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2325
    Cell Significance Index: -2.4700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2338
    Cell Significance Index: -3.1800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2341
    Cell Significance Index: -2.6200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2348
    Cell Significance Index: -3.1200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2351
    Cell Significance Index: -2.8900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2352
    Cell Significance Index: -3.0700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2380
    Cell Significance Index: -2.4300
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.2403
    Cell Significance Index: -2.6900
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.2423
    Cell Significance Index: -2.3900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2431
    Cell Significance Index: -2.8700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2437
    Cell Significance Index: -2.8800
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.2452
    Cell Significance Index: -3.1400
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -0.2521
    Cell Significance Index: -2.5000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2550
    Cell Significance Index: -3.0000
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2602
    Cell Significance Index: -2.8400
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.2612
    Cell Significance Index: -2.4800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.2651
    Cell Significance Index: -2.9100
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.2651
    Cell Significance Index: -2.8800
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.2683
    Cell Significance Index: -2.9800
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2721
    Cell Significance Index: -2.9500
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.2783
    Cell Significance Index: -2.9100
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.2818
    Cell Significance Index: -2.9200
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2821
    Cell Significance Index: -2.9100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2828
    Cell Significance Index: -2.3900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2831
    Cell Significance Index: -2.8900
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.2834
    Cell Significance Index: -2.1400
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.2838
    Cell Significance Index: -2.9400
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.2962
    Cell Significance Index: -2.4500
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.2985
    Cell Significance Index: -2.7700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3059
    Cell Significance Index: -2.9000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.3143
    Cell Significance Index: -2.9400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.3159
    Cell Significance Index: -3.0000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3186
    Cell Significance Index: -3.0200
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.3202
    Cell Significance Index: -2.9300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.3292
    Cell Significance Index: -3.0700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.3337
    Cell Significance Index: -2.9400
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.3443
    Cell Significance Index: -3.0100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.3583
    Cell Significance Index: -5.2400
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.3620
    Cell Significance Index: -2.8800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3704
    Cell Significance Index: -3.0200
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.3975
    Cell Significance Index: -1.8300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.4217
    Cell Significance Index: -2.6200
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.4627
    Cell Significance Index: -2.9100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.6259
    Cell Significance Index: -2.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** MAGEA3 is expressed in multiple cell types, including male germ cells, neuronal receptor cells, and epithelial cells, which indicates its role in immune regulation and tissue homeostasis. 2. **Protein Binding:** MAGEA3 interacts with various proteins, including histone deacetylases, caspases, and RNA polymerase II, suggesting its involvement in chromatin remodeling, apoptosis, and transcription regulation. 3. **Negative Regulation of Apoptosis:** MAGEA3 acts as a negative regulator of apoptosis, which is essential for maintaining tissue homeostasis and preventing excessive cell death. 4. **Histone Deacetylase Binding:** MAGEA3 binds to histone deacetylases, which are enzymes involved in chromatin remodeling and gene expression regulation. **Pathways and Functions:** 1. **Negative Regulation of Autophagy:** MAGEA3 regulates autophagy, a process involved in cellular degradation and recycling, which is essential for maintaining cellular homeostasis. 2. **Negative Regulation of Cysteine-Type Endopeptidase Activity:** MAGEA3 inhibits the activity of cysteine-type endopeptidases, which are involved in apoptosis and cellular degradation. 3. **Negative Regulation of Endoplasmic Reticulum Stress-Induced Intrinsic Apoptotic Signaling Pathway:** MAGEA3 regulates the endoplasmic reticulum stress response, which is a critical mechanism for maintaining cellular homeostasis. 4. **Negative Regulation of Protein Processing:** MAGEA3 regulates protein processing, which is essential for maintaining cellular homeostasis and preventing excessive protein degradation. **Clinical Significance:** 1. **Cancer Association:** MAGEA3 is overexpressed in various cancers, including melanoma, suggesting its potential role as a tumor suppressor gene. 2. **Immune Regulation:** MAGEA3 plays a crucial role in regulating the immune response, which is essential for preventing excessive inflammation and tissue damage. 3. **Neurological Disorders:** MAGEA3 is expressed in neuronal cells, suggesting its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Autoimmune Diseases:** MAGEA3 may play a role in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, due to its involvement in immune regulation and tissue homeostasis. In conclusion, the MAGEA3 gene is a complex immunomodulator that plays a significant role in regulating various cellular processes, including apoptosis, autophagy, and transcription. Its clinical significance extends to cancer, neurological disorders, and autoimmune diseases, highlighting the need for further research into the mechanisms of MAGEA3 and its potential therapeutic applications.

Genular Protein ID: 1403723414

Symbol: MAGA3_HUMAN

Name: Antigen MZ2-D

UniProtKB Accession Codes:

P43357 Q6FHI6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 5 SIGNOR 1 SMART 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8113684

Title: Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.

PubMed ID: 8113684

DOI: 10.1084/jem.179.3.921

PubMed ID: 8037761

Title: Cloning and analysis of MAGE-1-related genes.

PubMed ID: 8037761

DOI: 10.1006/bbrc.1994.1963

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10854409

Title: Comparative genome sequence analysis of the Bpa/Str region in mouse and man.

PubMed ID: 10854409

DOI: 10.1101/gr.10.6.758

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17942928

Title: MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines.

PubMed ID: 17942928

DOI: 10.1158/0008-5472.can-07-1478

PubMed ID: 20864041

Title: MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.

PubMed ID: 20864041

DOI: 10.1016/j.molcel.2010.08.029

PubMed ID: 29779948

Title: The eukaryotic proteome is shaped by E3 ubiquitin ligases targeting C-terminal degrons.

PubMed ID: 29779948

DOI: 10.1016/j.cell.2018.04.028

PubMed ID: 31267705

Title: Regulation of MAGE-A3/6 by the CRL4-DCAF12 ubiquitin ligase and nutrient availability.

PubMed ID: 31267705

DOI: 10.15252/embr.201847352

Sequence Information:

  • Length: 314
  • Mass: 34747
  • Checksum: 3F5EB13D1C9946A1
  • Sequence:
    • MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQEAAS SSSTLVEVTL GEVPAAESPD 
PPQSPQGASS LPTTMNYPLW SQSYEDSSNQ EEEGPSTFPD LESEFQAALS RKVAELVHFL 
LLKYRAREPV TKAEMLGSVV GNWQYFFPVI FSKASSSLQL VFGIELMEVD PIGHLYIFAT 
CLGLSYDGLL GDNQIMPKAG LLIIVLAIIA REGDCAPEEK IWEELSVLEV FEGREDSILG 
DPKKLLTQHF VQENYLEYRQ VPGSDPACYE FLWGPRALVE TSYVKVLHHM VKISGGPHIS 
YPPLHEWVLR EGEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.