Details for: SMCP

Gene ID: 4184

Symbol: SMCP

Ensembl ID: ENSG00000163206

Description: sperm mitochondria associated cysteine rich protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 7.99
    Marker Score: 4424
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.66
    Marker Score: 30045
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.34
    Marker Score: 1898
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.19
    Marker Score: 4395
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3181
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.43
    Marker Score: 1279
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.98
    Marker Score: 2217
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.63
    Marker Score: 682
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.05
    Marker Score: 694
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48059
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 501
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 714
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 403
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1189
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.7
    Marker Score: 669
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.67
    Marker Score: 538
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.48
    Marker Score: 194
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 283
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.46
    Marker Score: 872
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.34
    Marker Score: 687
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.31
    Marker Score: 534
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.28
    Marker Score: 585
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.26
    Marker Score: 4056
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.22
    Marker Score: 197
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.2
    Marker Score: 123
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.19
    Marker Score: 147
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.19
    Marker Score: 182
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.18
    Marker Score: 106
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.17
    Marker Score: 194
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.17
    Marker Score: 81
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.14
    Marker Score: 77
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.13
    Marker Score: 146
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.11
    Marker Score: 114
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.09
    Marker Score: 537
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.07
    Marker Score: 46
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.07
    Marker Score: 120
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 71
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.04
    Marker Score: 46
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 87
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.03
    Marker Score: 64
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.02
    Marker Score: 34
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.02
    Marker Score: 33
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.01
    Marker Score: 59
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.01
    Marker Score: 33
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 37.5
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.01
    Marker Score: 136
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.01
    Marker Score: 27
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.01
    Marker Score: 14

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Other Information

**Key characteristics:** * The SMCP gene is located on chromosome 17q21.1. * It is a large gene that encodes a protein of 1,033 amino acids. * The protein is expressed in a variety of cell types, including erythrocytes, progenitor cells, megakaryocytes, double-negative thymocytes, blood vessel endothelial cells, hematopoietic stem cells, plasma cells, megakaryocyte-erythroid progenitor cells, goblet cells, and precursor B cells. * The protein is a cysteine-rich protein that is involved in the assembly of the sperm mitochondrial outer membrane. **Pathways and functions:** * The SMCP gene is involved in the biogenesis of the sperm mitochondria. * The protein is a key component of the mitochondrial outer membrane, where it is involved in the assembly of the sperm mitochondrial outer membrane. * The SMCP gene is also involved in the regulation of mitochondrial function. * Knockout studies in mice have shown that the SMCP gene is essential for the survival and function of sperm cells. **Clinical significance:** * Mutations in the SMCP gene have been linked to male infertility in humans. * SMCP is a potential target for the development of new treatments for male infertility.

Genular Protein ID: 2900343931

Symbol: MCSP_HUMAN

Name: Sperm mitochondrial-associated cysteine-rich protein

UniProtKB Accession Codes:

P49901 Q96A42

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 STRING 1 SignaLink 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8833144

Title: Isolation, expression, and chromosomal localization of the human mitochondrial capsule selenoprotein gene (MCSP).

PubMed ID: 8833144

DOI: 10.1006/geno.1996.0104

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 116
  • Mass: 12767
  • Checksum: 242191C60AEE03B2
  • Sequence:
    • MCDQTKHSKC CPAKGNQCCP PQQNQCCQSK GNQCCPPKQN QCCQPKGSQC CPPKHNHCCQ 
PKPPCCIQAR CCGLETKPEV SPLNMESEPN SPQTQDKGCQ TQQQPHSPQN ESRPSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.