Details for: SMCP

Gene ID: 4184

Symbol: SMCP

Ensembl ID: ENSG00000163206

Description: sperm mitochondria associated cysteine rich protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4.2237
    Cell Significance Index: 72.2000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.8775
    Cell Significance Index: 39.4600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 2.8625
    Cell Significance Index: 37.0400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 1.8413
    Cell Significance Index: 19.5600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.0866
    Cell Significance Index: 26.3200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.2866
    Cell Significance Index: 3.6000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.2824
    Cell Significance Index: 4.1000
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.2520
    Cell Significance Index: 2.3100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2096
    Cell Significance Index: 3.3300
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.1333
    Cell Significance Index: 1.5900
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.1227
    Cell Significance Index: 1.1100
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.1124
    Cell Significance Index: 1.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1089
    Cell Significance Index: 1.5600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0688
    Cell Significance Index: 0.8700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0404
    Cell Significance Index: 0.4700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0386
    Cell Significance Index: 0.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0302
    Cell Significance Index: 0.8100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0265
    Cell Significance Index: 0.4300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0238
    Cell Significance Index: 0.2900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.0199
    Cell Significance Index: 0.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0144
    Cell Significance Index: 1.9800
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.0073
    Cell Significance Index: 0.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0032
    Cell Significance Index: 0.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0009
    Cell Significance Index: 0.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0004
    Cell Significance Index: 0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0000
    Cell Significance Index: 0.0300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0004
    Cell Significance Index: -0.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0006
    Cell Significance Index: -0.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0006
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0007
    Cell Significance Index: -0.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0007
    Cell Significance Index: -0.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0010
    Cell Significance Index: -0.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0013
    Cell Significance Index: -0.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0013
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0024
    Cell Significance Index: -0.2800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0039
    Cell Significance Index: -0.1000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0045
    Cell Significance Index: -0.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0051
    Cell Significance Index: -0.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0064
    Cell Significance Index: -0.3600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0064
    Cell Significance Index: -0.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0066
    Cell Significance Index: -0.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0070
    Cell Significance Index: -0.4300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0070
    Cell Significance Index: -0.0900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0073
    Cell Significance Index: -0.1800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0075
    Cell Significance Index: -0.1100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0079
    Cell Significance Index: -0.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0081
    Cell Significance Index: -0.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0083
    Cell Significance Index: -0.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0083
    Cell Significance Index: -0.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0094
    Cell Significance Index: -0.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0095
    Cell Significance Index: -0.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0099
    Cell Significance Index: -0.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0101
    Cell Significance Index: -0.3300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0101
    Cell Significance Index: -0.1200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0102
    Cell Significance Index: -0.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0104
    Cell Significance Index: -0.3300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0104
    Cell Significance Index: -0.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0116
    Cell Significance Index: -0.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0126
    Cell Significance Index: -0.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0127
    Cell Significance Index: -0.3300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0132
    Cell Significance Index: -0.1400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0132
    Cell Significance Index: -0.2000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0133
    Cell Significance Index: -0.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0133
    Cell Significance Index: -0.2600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0134
    Cell Significance Index: -0.1900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0135
    Cell Significance Index: -0.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0142
    Cell Significance Index: -0.7200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0144
    Cell Significance Index: -0.3600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0148
    Cell Significance Index: -0.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0152
    Cell Significance Index: -0.2600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0155
    Cell Significance Index: -0.3100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0156
    Cell Significance Index: -0.2000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0157
    Cell Significance Index: -0.3400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0160
    Cell Significance Index: -0.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0160
    Cell Significance Index: -0.3400
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0164
    Cell Significance Index: -0.1800
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0165
    Cell Significance Index: -0.1800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0166
    Cell Significance Index: -0.2100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0177
    Cell Significance Index: -0.3500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0177
    Cell Significance Index: -0.3700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0179
    Cell Significance Index: -0.3600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0183
    Cell Significance Index: -0.3600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0186
    Cell Significance Index: -0.1900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0188
    Cell Significance Index: -0.3200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0194
    Cell Significance Index: -0.1700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0199
    Cell Significance Index: -0.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0200
    Cell Significance Index: -0.4800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0200
    Cell Significance Index: -0.2800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0202
    Cell Significance Index: -0.2700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0203
    Cell Significance Index: -0.3000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0204
    Cell Significance Index: -0.2900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0208
    Cell Significance Index: -0.3600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0214
    Cell Significance Index: -0.3500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0215
    Cell Significance Index: -0.8800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0217
    Cell Significance Index: -0.3300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0218
    Cell Significance Index: -0.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SMCP is a cysteine-rich protein specifically localized to the mitochondria of sperm cells, where it plays a crucial role in maintaining mitochondrial homeostasis and regulating sperm motility. Its expression is not limited to sperm, however, as it has been identified in various other cell types, including erythrocytes, progenitor cells, megakaryocytes, and endothelial cells. The protein's unique structure, comprising a cysteine-rich domain, enables it to interact with multiple partners, influencing cell signaling, adhesion, and migration. **Pathways and Functions:** The SMCP gene is involved in several key pathways, including: 1. **Flagellated sperm motility:** SMCP regulates sperm motility by maintaining mitochondrial function and integrity, ensuring proper energy production and ATP synthesis. 2. **Cytoplasmic signaling:** SMCP interacts with various signaling molecules, influencing cell proliferation, differentiation, and survival in hematopoietic cells and endothelial cells. 3. **Protein binding:** SMCP's cysteine-rich domain facilitates binding to other proteins, modulating their activity and localization in different cellular contexts. 4. **Penetration of zona pellucida:** SMCP may play a role in sperm-egg interaction, facilitating the penetration of the zona pellucida during fertilization. **Clinical Significance:** The SMCP gene's diverse expression and functional roles have significant implications for various diseases and disorders, including: 1. **Infertility:** Abnormalities in SMCP expression or function may contribute to male infertility, affecting sperm motility and fertility. 2. **Hematological disorders:** Mutations in the SMCP gene may be associated with hematological conditions, such as anemia, leukemia, or lymphoma, due to its role in regulating cell proliferation and survival. 3. **Endothelial dysfunction:** SMCP's involvement in endothelial cell function may contribute to vascular diseases, such as atherosclerosis or hypertension, characterized by impaired endothelial cell signaling and function. 4. **Cancer:** SMCP's expression in cancer cells, including goblet cells, may play a role in tumor progression, metastasis, or therapeutic resistance. In conclusion, the SMCP gene is a complex and multifaceted molecule with far-reaching implications for our understanding of immunological processes and disease mechanisms. Further research into its functions and clinical significance is essential to unravel the intricate relationships between SMCP, cellular signaling, and disease pathology.

Genular Protein ID: 2900343931

Symbol: MCSP_HUMAN

Name: Sperm mitochondrial-associated cysteine-rich protein

UniProtKB Accession Codes:

P49901 Q96A42

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8833144

Title: Isolation, expression, and chromosomal localization of the human mitochondrial capsule selenoprotein gene (MCSP).

PubMed ID: 8833144

DOI: 10.1006/geno.1996.0104

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 116
  • Mass: 12767
  • Checksum: 242191C60AEE03B2
  • Sequence:
    • MCDQTKHSKC CPAKGNQCCP PQQNQCCQSK GNQCCPPKQN QCCQPKGSQC CPPKHNHCCQ 
PKPPCCIQAR CCGLETKPEV SPLNMESEPN SPQTQDKGCQ TQQQPHSPQN ESRPSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.