Details for: TRNE

Gene ID: 4556

Symbol: TRNE

Ensembl ID: ENSG00000210194

Description: tRNA-Glu

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 8.6719
    Cell Significance Index: 393.0700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 6.8549
    Cell Significance Index: 97.5800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 4.4127
    Cell Significance Index: 66.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.0772
    Cell Significance Index: 190.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.9785
    Cell Significance Index: 85.8200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.8625
    Cell Significance Index: 39.5800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.4267
    Cell Significance Index: 60.6100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 2.2468
    Cell Significance Index: 24.3500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.1792
    Cell Significance Index: 19.2000
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.9272
    Cell Significance Index: 12.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8445
    Cell Significance Index: 43.8700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.5395
    Cell Significance Index: 9.3000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.1980
    Cell Significance Index: 2.3300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.1848
    Cell Significance Index: 2.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0623
    Cell Significance Index: -9.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0970
    Cell Significance Index: -16.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0975
    Cell Significance Index: -11.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1370
    Cell Significance Index: -3.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1683
    Cell Significance Index: -10.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1883
    Cell Significance Index: -6.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1936
    Cell Significance Index: -6.2000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2374
    Cell Significance Index: -2.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2480
    Cell Significance Index: -15.2100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3023
    Cell Significance Index: -6.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3220
    Cell Significance Index: -6.9800
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.3443
    Cell Significance Index: -3.0100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3479
    Cell Significance Index: -5.5200
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.3945
    Cell Significance Index: -3.7500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.4071
    Cell Significance Index: -5.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4786
    Cell Significance Index: -6.5300
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.4942
    Cell Significance Index: -4.3200
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.5244
    Cell Significance Index: -6.5800
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.5331
    Cell Significance Index: -6.6200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.5392
    Cell Significance Index: -5.5800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.5489
    Cell Significance Index: -5.3100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.5604
    Cell Significance Index: -5.8100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5811
    Cell Significance Index: -14.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6067
    Cell Significance Index: -17.8700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.7194
    Cell Significance Index: -18.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7715
    Cell Significance Index: -16.4300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.7942
    Cell Significance Index: -7.3000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.8173
    Cell Significance Index: -6.7600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.8472
    Cell Significance Index: -11.7500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.8588
    Cell Significance Index: -10.2200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.8726
    Cell Significance Index: -11.2100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.8983
    Cell Significance Index: -9.5400
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.9278
    Cell Significance Index: -10.2300
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.9517
    Cell Significance Index: -9.9500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.9947
    Cell Significance Index: -10.8800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.9950
    Cell Significance Index: -14.6900
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -1.0070
    Cell Significance Index: -10.9400
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -1.0216
    Cell Significance Index: -11.3100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -1.0375
    Cell Significance Index: -10.6000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -1.0465
    Cell Significance Index: -14.5200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -1.0522
    Cell Significance Index: -12.2100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -1.0534
    Cell Significance Index: -9.8900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -1.0769
    Cell Significance Index: -11.3600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -1.0885
    Cell Significance Index: -12.1100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.1007
    Cell Significance Index: -21.5200
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -1.1261
    Cell Significance Index: -12.3000
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -1.1262
    Cell Significance Index: -12.1900
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -1.1278
    Cell Significance Index: -12.3800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -1.1384
    Cell Significance Index: -19.4600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -1.1421
    Cell Significance Index: -10.5700
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -1.1605
    Cell Significance Index: -12.8900
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -1.1614
    Cell Significance Index: -11.9800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -1.1803
    Cell Significance Index: -12.0500
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -1.1865
    Cell Significance Index: -12.2900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -1.1871
    Cell Significance Index: -14.9100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.1908
    Cell Significance Index: -17.1000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -1.1919
    Cell Significance Index: -15.5600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -1.1940
    Cell Significance Index: -12.0300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -1.2128
    Cell Significance Index: -15.9600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -1.2164
    Cell Significance Index: -10.9800
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -1.2200
    Cell Significance Index: -14.8300
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -1.2306
    Cell Significance Index: -12.0400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -1.2609
    Cell Significance Index: -11.7400
  • Cell Name: stem cell (CL0000034)
    Fold Change: -1.2672
    Cell Significance Index: -9.2100
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -1.2746
    Cell Significance Index: -14.6800
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -1.2889
    Cell Significance Index: -13.6400
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -1.2977
    Cell Significance Index: -12.0900
  • Cell Name: T cell (CL0000084)
    Fold Change: -1.3111
    Cell Significance Index: -15.4800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -1.3134
    Cell Significance Index: -14.2200
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -1.3328
    Cell Significance Index: -14.2400
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -1.3379
    Cell Significance Index: -14.2800
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -1.3522
    Cell Significance Index: -12.6700
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -1.3558
    Cell Significance Index: -14.7000
  • Cell Name: club cell (CL0000158)
    Fold Change: -1.3676
    Cell Significance Index: -14.9000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -1.3988
    Cell Significance Index: -19.2100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -1.4042
    Cell Significance Index: -14.6600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -1.4117
    Cell Significance Index: -17.6400
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -1.4188
    Cell Significance Index: -15.2600
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -1.4244
    Cell Significance Index: -14.9300
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -1.4318
    Cell Significance Index: -14.7400
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -1.4405
    Cell Significance Index: -13.7800
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -1.4445
    Cell Significance Index: -14.2500
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -1.4458
    Cell Significance Index: -14.3400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -1.4498
    Cell Significance Index: -18.9600
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -1.4561
    Cell Significance Index: -14.3700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -1.4822
    Cell Significance Index: -17.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRNE is a tRNA (transfer RNA) gene that encodes for the amino acid glutamate. As a tRNA, it is involved in the translation process, where it recognizes and binds to specific codons on messenger RNA (mRNA) to facilitate the incorporation of glutamate into proteins. The expression of TRNE is highly restricted to specific cell types, including CD4-positive and CD8-positive T cells, innate lymphoid cells, and epithelial cells of the gut and salivary gland. This restricted expression pattern suggests that TRNE plays a role in the regulation of immune cell function and the maintenance of tissue homeostasis. **Pathways and Functions:** TRNE is involved in several key signaling pathways that regulate immune responses and cellular homeostasis. One of the primary pathways is the mTOR (mechanistic target of rapamycin) pathway, which regulates protein synthesis and cell growth. TRNE's expression in immune cells suggests that it may play a role in the regulation of T cell proliferation and differentiation. Additionally, TRNE is also involved in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional components, which is critical for maintaining cellular homeostasis. TRNE's functional role in the immune system is multifaceted. It is involved in the regulation of: * Immune cell function: TRNE plays a role in the regulation of T cell proliferation, differentiation, and survival, which are critical for the development and maintenance of immune responses. * Cellular homeostasis: TRNE is involved in the regulation of autophagy, which is essential for maintaining cellular homeostasis and preventing tissue damage. * Tissue repair: TRNE is expressed in epithelial cells of the gut and salivary gland, where it may play a role in the regulation of tissue repair and maintenance. **Clinical Significance:** Dysregulation of TRNE has been implicated in various immune-related disorders, including: * Autoimmune diseases: TRNE's role in regulating immune cell function and tissue homeostasis makes it a potential target for the treatment of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. * Cancer: TRNE's involvement in the regulation of autophagy and cellular homeostasis makes it a potential target for the treatment of cancer, particularly in the context of immunotherapy. * Gastrointestinal disorders: TRNE's expression in epithelial cells of the gut makes it a potential target for the treatment of gastrointestinal disorders, such as inflammatory bowel disease and irritable bowel syndrome. In conclusion, TRNE is a critical gene that plays a pivotal role in the regulation of immune responses and maintenance of cellular homeostasis. Its expression profile and functional role in the immune system make it a promising target for the treatment of immune-related disorders. Further research is needed to fully elucidate the mechanisms by which TRNE regulates immune responses and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.