Details for: TRNY

Gene ID: 4579

Symbol: TRNY

Ensembl ID: ENSG00000210144

Description: tRNA-Tyr

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 3.9930
    Cell Significance Index: 30.7200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.9620
    Cell Significance Index: 27.9300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.0262
    Cell Significance Index: 16.2800
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.9142
    Cell Significance Index: 10.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3406
    Cell Significance Index: 15.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2939
    Cell Significance Index: 18.5300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.2338
    Cell Significance Index: 3.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1773
    Cell Significance Index: 9.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1671
    Cell Significance Index: 2.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1491
    Cell Significance Index: 6.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1170
    Cell Significance Index: 3.3700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0744
    Cell Significance Index: 0.7200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0689
    Cell Significance Index: 1.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0567
    Cell Significance Index: 1.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0018
    Cell Significance Index: -0.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0058
    Cell Significance Index: -3.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0078
    Cell Significance Index: -1.3400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0105
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0136
    Cell Significance Index: -1.5600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0247
    Cell Significance Index: -0.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0249
    Cell Significance Index: -3.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0249
    Cell Significance Index: -5.0000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0376
    Cell Significance Index: -0.5600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0415
    Cell Significance Index: -0.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0419
    Cell Significance Index: -1.1400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0450
    Cell Significance Index: -0.4700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0509
    Cell Significance Index: -0.5100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0527
    Cell Significance Index: -0.5600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0543
    Cell Significance Index: -0.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0734
    Cell Significance Index: -4.5000
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0820
    Cell Significance Index: -0.8500
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0942
    Cell Significance Index: -1.1700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0946
    Cell Significance Index: -1.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0953
    Cell Significance Index: -3.3500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1025
    Cell Significance Index: -1.2200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1029
    Cell Significance Index: -1.4800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1058
    Cell Significance Index: -1.5200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1074
    Cell Significance Index: -1.4900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1157
    Cell Significance Index: -1.4900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1360
    Cell Significance Index: -3.4700
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.1375
    Cell Significance Index: -1.4900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1389
    Cell Significance Index: -1.9200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1406
    Cell Significance Index: -1.8500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1417
    Cell Significance Index: -1.1900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1421
    Cell Significance Index: -2.4500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1563
    Cell Significance Index: -1.7100
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.1626
    Cell Significance Index: -1.1700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1633
    Cell Significance Index: -1.6900
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1644
    Cell Significance Index: -1.9100
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1651
    Cell Significance Index: -1.7400
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.1717
    Cell Significance Index: -1.6000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1749
    Cell Significance Index: -2.3800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1750
    Cell Significance Index: -1.5100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1758
    Cell Significance Index: -1.6500
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.1793
    Cell Significance Index: -1.6800
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.1879
    Cell Significance Index: -2.0400
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.1925
    Cell Significance Index: -2.3700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1977
    Cell Significance Index: -2.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1985
    Cell Significance Index: -4.3000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2026
    Cell Significance Index: -2.0700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2034
    Cell Significance Index: -4.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2075
    Cell Significance Index: -4.4200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.2079
    Cell Significance Index: -1.8900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2083
    Cell Significance Index: -2.8600
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -0.2084
    Cell Significance Index: -1.5700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.2124
    Cell Significance Index: -2.3000
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.2134
    Cell Significance Index: -2.1800
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.2160
    Cell Significance Index: -1.5700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.2201
    Cell Significance Index: -2.6800
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.2238
    Cell Significance Index: -2.3400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2264
    Cell Significance Index: -2.7200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2300
    Cell Significance Index: -2.7500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2304
    Cell Significance Index: -2.4300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2330
    Cell Significance Index: -2.7400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2331
    Cell Significance Index: -2.3800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2331
    Cell Significance Index: -2.2100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2374
    Cell Significance Index: -3.0500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2474
    Cell Significance Index: -3.0900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2498
    Cell Significance Index: -3.2600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2505
    Cell Significance Index: -2.9600
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.2577
    Cell Significance Index: -2.4500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2604
    Cell Significance Index: -3.4000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2641
    Cell Significance Index: -2.6800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2677
    Cell Significance Index: -3.0800
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2680
    Cell Significance Index: -3.2600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2694
    Cell Significance Index: -3.5800
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.2694
    Cell Significance Index: -3.2500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2755
    Cell Significance Index: -1.6400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2765
    Cell Significance Index: -2.9700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.2779
    Cell Significance Index: -4.1600
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.2783
    Cell Significance Index: -1.9300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2792
    Cell Significance Index: -2.9700
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2804
    Cell Significance Index: -2.8600
  • Cell Name: serous cell of epithelium of trachea (CL1000330)
    Fold Change: -0.2817
    Cell Significance Index: -2.1700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2826
    Cell Significance Index: -3.2100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.2828
    Cell Significance Index: -1.8400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2836
    Cell Significance Index: -3.0900
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.2860
    Cell Significance Index: -2.5000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2878
    Cell Significance Index: -2.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TRNY gene is a small, 77 bp long non-coding RNA that belongs to the tRNA (transfer RNA) family. Its expression is widespread, with significant levels detected in goblet cells, absorptive cells, intestinal crypt stem cells, transit amplifying cells, mast cells, T cells, and brush cells. Interestingly, TRNY is also expressed in abnormal and neoplastic cells, suggesting a potential role in tumor development or progression. The gene's expression pattern is not limited to the gastrointestinal tract, as it has also been detected in immune cells, such as mast cells and T cells. **Pathways and Functions:** The exact mechanisms by which TRNY regulates cellular processes are still unknown. However, several potential pathways have been proposed: 1. **Regulation of gene expression:** TRNY may act as a microRNA (miRNA) or small interfering RNA (siRNA) to modulate the expression of target genes involved in cellular differentiation, proliferation, and survival. 2. **Modulation of epigenetic marks:** TRNY may influence epigenetic modifications, such as DNA methylation and histone acetylation, to regulate gene expression and cellular behavior. 3. **Influence on cell signaling pathways:** TRNY may interact with signaling pathways, such as the Wnt/β-catenin pathway, to regulate cellular responses to environmental cues. 4. **Antioxidant and anti-inflammatory effects:** TRNY may possess antioxidant and anti-inflammatory properties, which could contribute to its protective effects against cellular stress and inflammation. **Clinical Significance:** The discovery of TRNY's expression in various cell types and its potential regulatory functions raises several questions about its clinical significance: 1. **Cancer research:** TRNY's expression in neoplastic cells suggests that it may play a role in tumor development or progression. Further studies are needed to determine its potential as a biomarker or therapeutic target. 2. **Gastrointestinal disorders:** TRNY's expression in goblet cells and intestinal epithelial cells implies that it may be involved in maintaining the integrity of the gastrointestinal tract. Abnormal expression of TRNY may contribute to the pathogenesis of gastrointestinal disorders, such as inflammatory bowel disease (IBD). 3. **Immunological disorders:** TRNY's expression in immune cells, such as mast cells and T cells, suggests that it may influence immune function and contribute to the development of immunological disorders, such as autoimmune diseases. 4. **Dietary and lifestyle-related diseases:** TRNY's expression in absorptive cells and intestinal crypt stem cells implies that it may be involved in regulating nutrient absorption and metabolism. Abnormal expression of TRNY may contribute to the development of diet-related diseases, such as metabolic syndrome. In conclusion, the TRNY gene is a complex and multifaceted non-coding RNA that may play a significant role in regulating cellular processes, including gene expression, epigenetic marks, and cell signaling pathways. Further research is needed to elucidate the mechanisms by which TRNY functions and to explore its clinical significance in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.