Details for: OR2C1

Gene ID: 4993

Symbol: OR2C1

Ensembl ID: ENSG00000168158

Description: olfactory receptor family 2 subfamily C member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 5.38
    Marker Score: 2983
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3184
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.97
    Marker Score: 1686
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.62
    Marker Score: 3610.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2006
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.83
    Marker Score: 966
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.63
    Marker Score: 1181
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.28
    Marker Score: 865
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 495
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.18
    Marker Score: 495
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4825.5
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.11
    Marker Score: 511
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 517
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 1
    Marker Score: 470
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.97
    Marker Score: 565
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.95
    Marker Score: 381
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.95
    Marker Score: 1539
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 332.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.83
    Marker Score: 548
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 714
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 404
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 470
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.68
    Marker Score: 543
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.57
    Marker Score: 179
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 283
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.46
    Marker Score: 834
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.4
    Marker Score: 235
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.29
    Marker Score: 545
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.26
    Marker Score: 4118
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.23
    Marker Score: 77
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.2
    Marker Score: 405
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.18
    Marker Score: 1140
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.16
    Marker Score: 124
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.15
    Marker Score: 90
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.14
    Marker Score: 73
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.12
    Marker Score: 1266
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.09
    Marker Score: 544
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.06
    Marker Score: 31
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.06
    Marker Score: 51
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.05
    Marker Score: 24.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.05
    Marker Score: 54
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.05
    Marker Score: 56
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.04
    Marker Score: 76
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.03
    Marker Score: 80
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.03
    Marker Score: 39
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.03
    Marker Score: 22.5
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.02
    Marker Score: 29
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.02
    Marker Score: 31
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.02
    Marker Score: 27.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.02
    Marker Score: 49
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.01
    Marker Score: 28
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.01
    Marker Score: 49
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.01
    Marker Score: 26
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.01
    Marker Score: 27
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.01
    Marker Score: 25.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 27.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.01
    Marker Score: 25
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.01
    Marker Score: 27
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.01
    Marker Score: 48
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.01
    Marker Score: 27
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 256
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0
    Marker Score: 34

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Other Information

**Key Characteristics:** OR2C1 is a G protein-coupled receptor (GPCR) that belongs to the olfactory receptor family, which is responsible for detecting odorant molecules in the air we breathe. The OR2C1 receptor is characterized by its ability to bind to specific odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. The OR2C1 gene is highly conserved across species, suggesting its critical role in the evolution of olfaction. **Pathways and Functions:** The OR2C1 receptor is involved in several signaling pathways that are crucial for the perception of smell. These pathways include: 1. **G protein-coupled receptor activity**: OR2C1 binds to odorant molecules, triggering the activation of G proteins, which in turn activate downstream signaling pathways. 2. **Detection of chemical stimulus involved in sensory perception of smell**: OR2C1 is responsible for detecting chemical stimuli that are associated with specific odors, allowing us to perceive and distinguish between different smells. 3. **Expression and translocation of olfactory receptors**: OR2C1 is involved in the expression and translocation of olfactory receptors to the plasma membrane, where they can bind to odorant molecules. 4. **Olfactory signaling pathway**: OR2C1 is part of the olfactory signaling pathway, which involves the coordination of multiple receptors and signaling molecules to process and interpret odorant signals. **Clinical Significance:** The OR2C1 gene has significant implications for our understanding of olfactory disorders and the development of novel therapeutic strategies. Some potential clinical applications of OR2C1 include: 1. **Olfactory disorders**: OR2C1 mutations have been associated with olfactory disorders, such as anosmia (loss of smell) and hyposmia (reduced sense of smell). Understanding the role of OR2C1 in these disorders may lead to the development of new treatments. 2. **Smell disorders in neurological disorders**: OR2C1 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, which often involve olfactory dysfunction. Studying the role of OR2C1 in these disorders may provide new insights into the mechanisms underlying smell disorders. 3. **Personalized medicine**: OR2C1 may play a role in the development of personalized medicine approaches, where genetic information is used to tailor treatments to an individual's specific genetic profile. In conclusion, the OR2C1 gene is a critical component of the olfactory system, involved in the detection of chemical stimuli and the perception of smell. Further research on OR2C1 has significant implications for our understanding of olfactory disorders and the development of novel therapeutic strategies.

Genular Protein ID: 3872124048

Symbol: OR2C1_HUMAN

Name: Olfactory receptor 2C2

UniProtKB Accession Codes:

O95371 A0AVA4 Q6IF34 Q6IF55

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 8 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9847080

Title: Construction of an approximately 700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3.

PubMed ID: 9847080

DOI: 10.1101/gr.8.11.1172

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 312
  • Mass: 34412
  • Checksum: 33A2697D06ED8E9E
  • Sequence:
    • MDGVNDSSLQ GFVLMGISDH PQLEMIFFIA ILFSYLLTLL GNSTIILLSR LEARLHTPMY 
FFLSNLSSLD LAFATSSVPQ MLINLWGPGK TISYGGCITQ LYVFLWLGAT ECILLVVMAF 
DRYVAVCRPL RYTAIMNPQL CWLLAVIACL GGLGNSVIQS TFTLQLPLCG HRRVEGFLCE 
VPAMIKLACG DTSLNQAVLN GVCTFFTAVP LSIIVISYCL IAQAVLKIRS AEGRRKAFNT 
CLSHLLVVFL FYGSASYGYL LPAKNSKQDQ GKFISLFYSL VTPMVNPLIY TLRNMEVKGA 
LRRLLGKGRE VG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.