Details for: OR2C1

Gene ID: 4993

Symbol: OR2C1

Ensembl ID: ENSG00000168158

Description: olfactory receptor family 2 subfamily C member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 5.6078
    Cell Significance Index: 90.8300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.1140
    Cell Significance Index: 53.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.1827
    Cell Significance Index: 69.9100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 2.1237
    Cell Significance Index: 27.4800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.8010
    Cell Significance Index: 27.1400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 1.3814
    Cell Significance Index: 14.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7424
    Cell Significance Index: 33.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4471
    Cell Significance Index: 26.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3993
    Cell Significance Index: 64.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3158
    Cell Significance Index: 6.7300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1832
    Cell Significance Index: 2.6600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.1665
    Cell Significance Index: 2.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1556
    Cell Significance Index: 15.4000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1224
    Cell Significance Index: 1.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1094
    Cell Significance Index: 2.7400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1040
    Cell Significance Index: 1.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1003
    Cell Significance Index: 10.9200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.0792
    Cell Significance Index: 0.9200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0444
    Cell Significance Index: 0.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0377
    Cell Significance Index: 2.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0339
    Cell Significance Index: 0.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0283
    Cell Significance Index: 5.3900
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.0060
    Cell Significance Index: 0.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0059
    Cell Significance Index: 0.0900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.0051
    Cell Significance Index: 0.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0030
    Cell Significance Index: 0.3400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0025
    Cell Significance Index: 0.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0020
    Cell Significance Index: 0.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0005
    Cell Significance Index: 0.1400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0002
    Cell Significance Index: -0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0003
    Cell Significance Index: -0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0006
    Cell Significance Index: -0.4400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0007
    Cell Significance Index: -0.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0008
    Cell Significance Index: -0.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0009
    Cell Significance Index: -0.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0010
    Cell Significance Index: -0.5200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0014
    Cell Significance Index: -0.0400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0026
    Cell Significance Index: -0.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0032
    Cell Significance Index: -0.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0036
    Cell Significance Index: -0.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0039
    Cell Significance Index: -0.5300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0044
    Cell Significance Index: -0.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0046
    Cell Significance Index: -0.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0071
    Cell Significance Index: -0.4800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0074
    Cell Significance Index: -0.1600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0085
    Cell Significance Index: -0.1000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0087
    Cell Significance Index: -0.1100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0087
    Cell Significance Index: -0.1200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0089
    Cell Significance Index: -0.2900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0095
    Cell Significance Index: -0.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0096
    Cell Significance Index: -0.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0098
    Cell Significance Index: -0.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0104
    Cell Significance Index: -0.3300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0109
    Cell Significance Index: -0.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0113
    Cell Significance Index: -0.5000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0118
    Cell Significance Index: -0.1600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0121
    Cell Significance Index: -0.0800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0122
    Cell Significance Index: -0.1600
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0122
    Cell Significance Index: -0.1200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0126
    Cell Significance Index: -0.3200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0129
    Cell Significance Index: -0.3100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0130
    Cell Significance Index: -0.3300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0130
    Cell Significance Index: -0.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0140
    Cell Significance Index: -0.5300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0146
    Cell Significance Index: -0.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0150
    Cell Significance Index: -0.3200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0154
    Cell Significance Index: -0.3100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0155
    Cell Significance Index: -0.2200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0163
    Cell Significance Index: -0.3300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0166
    Cell Significance Index: -0.1800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0172
    Cell Significance Index: -0.3400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0177
    Cell Significance Index: -0.1900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0178
    Cell Significance Index: -0.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0179
    Cell Significance Index: -0.3800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0179
    Cell Significance Index: -0.5100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0180
    Cell Significance Index: -0.4500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0185
    Cell Significance Index: -0.3200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0192
    Cell Significance Index: -0.4000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0193
    Cell Significance Index: -0.3100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0199
    Cell Significance Index: -0.2700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0207
    Cell Significance Index: -0.2800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0211
    Cell Significance Index: -0.2800
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0217
    Cell Significance Index: -0.2200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0219
    Cell Significance Index: -0.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0221
    Cell Significance Index: -0.5100
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0224
    Cell Significance Index: -0.2000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0225
    Cell Significance Index: -0.4400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0231
    Cell Significance Index: -0.5600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0233
    Cell Significance Index: -0.1900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0236
    Cell Significance Index: -0.2800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0244
    Cell Significance Index: -0.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR2C1 is a G protein-coupled receptor (GPCR) that belongs to the olfactory receptor family, which is responsible for detecting odorant molecules in the air we breathe. The OR2C1 receptor is characterized by its ability to bind to specific odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. The OR2C1 gene is highly conserved across species, suggesting its critical role in the evolution of olfaction. **Pathways and Functions:** The OR2C1 receptor is involved in several signaling pathways that are crucial for the perception of smell. These pathways include: 1. **G protein-coupled receptor activity**: OR2C1 binds to odorant molecules, triggering the activation of G proteins, which in turn activate downstream signaling pathways. 2. **Detection of chemical stimulus involved in sensory perception of smell**: OR2C1 is responsible for detecting chemical stimuli that are associated with specific odors, allowing us to perceive and distinguish between different smells. 3. **Expression and translocation of olfactory receptors**: OR2C1 is involved in the expression and translocation of olfactory receptors to the plasma membrane, where they can bind to odorant molecules. 4. **Olfactory signaling pathway**: OR2C1 is part of the olfactory signaling pathway, which involves the coordination of multiple receptors and signaling molecules to process and interpret odorant signals. **Clinical Significance:** The OR2C1 gene has significant implications for our understanding of olfactory disorders and the development of novel therapeutic strategies. Some potential clinical applications of OR2C1 include: 1. **Olfactory disorders**: OR2C1 mutations have been associated with olfactory disorders, such as anosmia (loss of smell) and hyposmia (reduced sense of smell). Understanding the role of OR2C1 in these disorders may lead to the development of new treatments. 2. **Smell disorders in neurological disorders**: OR2C1 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, which often involve olfactory dysfunction. Studying the role of OR2C1 in these disorders may provide new insights into the mechanisms underlying smell disorders. 3. **Personalized medicine**: OR2C1 may play a role in the development of personalized medicine approaches, where genetic information is used to tailor treatments to an individual's specific genetic profile. In conclusion, the OR2C1 gene is a critical component of the olfactory system, involved in the detection of chemical stimuli and the perception of smell. Further research on OR2C1 has significant implications for our understanding of olfactory disorders and the development of novel therapeutic strategies.

Genular Protein ID: 3872124048

Symbol: OR2C1_HUMAN

Name: Olfactory receptor 2C2

UniProtKB Accession Codes:

O95371 A0AVA4 Q6IF34 Q6IF55

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9847080

Title: Construction of an approximately 700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3.

PubMed ID: 9847080

DOI: 10.1101/gr.8.11.1172

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 312
  • Mass: 34412
  • Checksum: 33A2697D06ED8E9E
  • Sequence:
    • MDGVNDSSLQ GFVLMGISDH PQLEMIFFIA ILFSYLLTLL GNSTIILLSR LEARLHTPMY 
FFLSNLSSLD LAFATSSVPQ MLINLWGPGK TISYGGCITQ LYVFLWLGAT ECILLVVMAF 
DRYVAVCRPL RYTAIMNPQL CWLLAVIACL GGLGNSVIQS TFTLQLPLCG HRRVEGFLCE 
VPAMIKLACG DTSLNQAVLN GVCTFFTAVP LSIIVISYCL IAQAVLKIRS AEGRRKAFNT 
CLSHLLVVFL FYGSASYGYL LPAKNSKQDQ GKFISLFYSL VTPMVNPLIY TLRNMEVKGA 
LRRLLGKGRE VG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.