Details for: LUZP4

Gene ID: 51213

Symbol: LUZP4

Ensembl ID: ENSG00000102021

Description: leucine zipper protein 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.9348
    Cell Significance Index: 22.1600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1828
    Cell Significance Index: 28.6500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.6035
    Cell Significance Index: 6.7500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4446
    Cell Significance Index: 6.4800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.3757
    Cell Significance Index: 4.0400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.2523
    Cell Significance Index: 3.4600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.2035
    Cell Significance Index: 2.4100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1333
    Cell Significance Index: 1.9400
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.0681
    Cell Significance Index: 0.4000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0637
    Cell Significance Index: 0.7500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0441
    Cell Significance Index: 0.5500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0351
    Cell Significance Index: 0.8800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0217
    Cell Significance Index: 0.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0164
    Cell Significance Index: 0.4400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.0118
    Cell Significance Index: 0.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0103
    Cell Significance Index: 0.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0055
    Cell Significance Index: 0.1400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0045
    Cell Significance Index: 0.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0044
    Cell Significance Index: 0.1300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0037
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0035
    Cell Significance Index: 0.4000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0027
    Cell Significance Index: 0.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0017
    Cell Significance Index: 0.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0006
    Cell Significance Index: 0.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: 0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0002
    Cell Significance Index: -0.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.3000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0003
    Cell Significance Index: 0.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0004
    Cell Significance Index: -0.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0005
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0006
    Cell Significance Index: -0.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0006
    Cell Significance Index: -0.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0006
    Cell Significance Index: -0.3400
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: -0.0016
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0018
    Cell Significance Index: -0.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0020
    Cell Significance Index: -0.3000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0023
    Cell Significance Index: -0.4200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0027
    Cell Significance Index: -0.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0031
    Cell Significance Index: -0.3300
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0035
    Cell Significance Index: -0.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0038
    Cell Significance Index: -0.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0046
    Cell Significance Index: -0.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0047
    Cell Significance Index: -0.0800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0050
    Cell Significance Index: -0.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0053
    Cell Significance Index: -0.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0070
    Cell Significance Index: -0.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0072
    Cell Significance Index: -0.2300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0072
    Cell Significance Index: -0.1400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0074
    Cell Significance Index: -0.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0076
    Cell Significance Index: -0.2500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0077
    Cell Significance Index: -0.1300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0078
    Cell Significance Index: -0.0900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0081
    Cell Significance Index: -0.0900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0092
    Cell Significance Index: -0.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0094
    Cell Significance Index: -0.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0094
    Cell Significance Index: -0.2600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0099
    Cell Significance Index: -0.1200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0107
    Cell Significance Index: -0.1800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0108
    Cell Significance Index: -0.2700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0111
    Cell Significance Index: -0.2400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0113
    Cell Significance Index: -0.2200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0116
    Cell Significance Index: -0.2300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0123
    Cell Significance Index: -0.1700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0125
    Cell Significance Index: -0.1600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0127
    Cell Significance Index: -0.2700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0127
    Cell Significance Index: -0.5200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0130
    Cell Significance Index: -0.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0133
    Cell Significance Index: -0.3800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0134
    Cell Significance Index: -0.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0135
    Cell Significance Index: -0.3600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0136
    Cell Significance Index: -0.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0137
    Cell Significance Index: -0.2300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0142
    Cell Significance Index: -0.1900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0149
    Cell Significance Index: -0.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0159
    Cell Significance Index: -0.8000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0165
    Cell Significance Index: -0.2900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0167
    Cell Significance Index: -0.2200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0168
    Cell Significance Index: -0.3300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0176
    Cell Significance Index: -0.4300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0186
    Cell Significance Index: -0.1300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0187
    Cell Significance Index: -0.2400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0189
    Cell Significance Index: -0.2600
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0192
    Cell Significance Index: -0.2400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0193
    Cell Significance Index: -0.2100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0196
    Cell Significance Index: -0.3900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0200
    Cell Significance Index: -0.4800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0202
    Cell Significance Index: -0.2900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0211
    Cell Significance Index: -0.4300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0217
    Cell Significance Index: -0.2300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0218
    Cell Significance Index: -0.3100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0226
    Cell Significance Index: -0.3300
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0227
    Cell Significance Index: -0.2700
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0227
    Cell Significance Index: -0.2500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0228
    Cell Significance Index: -0.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Leucine Zipper Motif:** LUZP4 contains a conserved leucine zipper motif, a characteristic domain that allows for protein-protein interactions and RNA binding. 2. **RNA Binding:** LUZP4 has been shown to bind to RNA, specifically targeting mature RNA transcripts for transport to the cytoplasm and nucleus. 3. **Cellular Expression:** LUZP4 is significantly expressed in germ cells, immune cells, and hematopoietic progenitor cells, highlighting its importance in cellular development and function. 4. **Pathway Involvement:** LUZP4 is involved in various cellular pathways, including gene expression (transcription), RNA metabolism (processing and transport), and protein binding (cytoplasm and nucleus). **Pathways and Functions:** 1. **Gene Expression (Transcription):** LUZP4 plays a crucial role in regulating gene expression by facilitating the transport of mature RNA transcripts to the cytoplasm and nucleus. 2. **RNA Metabolism:** LUZP4 is involved in RNA processing, including 3'-end processing, and transport, ensuring the proper maturation and localization of RNA transcripts. 3. **Protein Binding:** LUZP4 interacts with RNA-binding proteins, facilitating the transport of mature RNA transcripts to the cytoplasm and nucleus. 4. **Immune Cell Development:** LUZP4 is significantly expressed in immune cells, suggesting its involvement in the development and function of these cells. **Clinical Significance:** 1. **Cancer Association:** LUZP4 has been implicated in various types of cancer, including leukemia and lymphoma, highlighting its potential role in tumorigenesis. 2. **Immune Cell Dysregulation:** Alterations in LUZP4 expression may contribute to immune cell dysfunction, leading to autoimmune diseases or impaired immune responses. 3. **RNA Transport Disorders:** LUZP4 dysfunction may result in RNA transport disorders, characterized by impaired RNA processing and localization, leading to various diseases. In conclusion, LUZP4 is a critical gene involved in RNA transport and expression, with significant implications for cellular development, immune cell function, and disease pathogenesis. Further research is necessary to elucidate the full extent of LUZP4's role in these processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 2544973666

Symbol: LUZP4_HUMAN

Name: Leucine zipper protein 4

UniProtKB Accession Codes:

Q9P127 B3KSD6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12032826

Title: A novel tumour associated leucine zipper protein targeting to sites of gene transcription and splicing.

PubMed ID: 12032826

DOI: 10.1038/sj.onc.1205481

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25662211

Title: Luzp4 defines a new mRNA export pathway in cancer cells.

PubMed ID: 25662211

DOI: 10.1093/nar/gkv070

Sequence Information:

  • Length: 313
  • Mass: 35937
  • Checksum: E041911D9BA1DC8B
  • Sequence:
    • MASFRKLTLS EKVPPNHPSR KKVNFLDMSL DDIIIYKELE GTNAEEEKNK RQNHSKKESP 
SRQQSKAHRH RHRRGYSRCR SNSEEGNHDK KPSQKPSGFK SGQHPLNGQP LIEQEKCSDN 
YEAQAEKNQG QSEGNQHQSE GNPDKSEESQ GQPEENHHSE RSRNHLERSL SQSDRSQGQL 
KRHHPQYERS HGQYKRSHGQ SERSHGHSER SHGHSERSHG HSERSHGHSK RSRSQGDLVD 
TQSDLIATQR DLIATQKDLI ATQRDLIATQ RDLIVTQRDL VATERDLINQ SGRSHGQSER 
HQRYSTGKNT ITT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.