Details for: RXFP3

Gene ID: 51289

Symbol: RXFP3

Ensembl ID: ENSG00000182631

Description: relaxin family peptide receptor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1549
    Cell Significance Index: 4.1500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1089
    Cell Significance Index: 1.5600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0179
    Cell Significance Index: 12.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0126
    Cell Significance Index: 3.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0069
    Cell Significance Index: -0.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0086
    Cell Significance Index: -4.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0135
    Cell Significance Index: -9.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0219
    Cell Significance Index: -4.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0224
    Cell Significance Index: -4.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0371
    Cell Significance Index: -2.0800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0401
    Cell Significance Index: -0.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0401
    Cell Significance Index: -1.1500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0607
    Cell Significance Index: -1.2000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0608
    Cell Significance Index: -1.5500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0709
    Cell Significance Index: -0.9000
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0716
    Cell Significance Index: -0.7500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0873
    Cell Significance Index: -1.1400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0889
    Cell Significance Index: -1.0500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0936
    Cell Significance Index: -1.1000
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0944
    Cell Significance Index: -0.8600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0945
    Cell Significance Index: -1.5300
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0956
    Cell Significance Index: -1.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0964
    Cell Significance Index: -2.4100
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0986
    Cell Significance Index: -1.2000
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0996
    Cell Significance Index: -1.0800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0998
    Cell Significance Index: -1.2800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1042
    Cell Significance Index: -2.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1047
    Cell Significance Index: -4.6300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1048
    Cell Significance Index: -1.3700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1103
    Cell Significance Index: -2.2000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1130
    Cell Significance Index: -1.5500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1132
    Cell Significance Index: -1.0200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1175
    Cell Significance Index: -1.2800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1183
    Cell Significance Index: -1.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1202
    Cell Significance Index: -4.5500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1314
    Cell Significance Index: -1.6200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1342
    Cell Significance Index: -2.8000
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1639
    Cell Significance Index: -1.4900
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.1655
    Cell Significance Index: -2.0800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1666
    Cell Significance Index: -2.0800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1669
    Cell Significance Index: -2.0700
  • Cell Name: H2 horizontal cell (CL0004218)
    Fold Change: -0.1760
    Cell Significance Index: -2.0800
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.1897
    Cell Significance Index: -2.3600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1925
    Cell Significance Index: -4.2200
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.1935
    Cell Significance Index: -2.0800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1948
    Cell Significance Index: -2.0500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1955
    Cell Significance Index: -4.1500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1970
    Cell Significance Index: -2.3800
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.1973
    Cell Significance Index: -2.3900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2060
    Cell Significance Index: -4.4500
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.2148
    Cell Significance Index: -1.1500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2167
    Cell Significance Index: -4.3500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2174
    Cell Significance Index: -2.6400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2180
    Cell Significance Index: -2.5000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2210
    Cell Significance Index: -2.6400
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2250
    Cell Significance Index: -2.4700
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.2356
    Cell Significance Index: -1.6900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2461
    Cell Significance Index: -2.3700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2508
    Cell Significance Index: -2.0700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2512
    Cell Significance Index: -2.3400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.2530
    Cell Significance Index: -2.6400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2638
    Cell Significance Index: -2.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2652
    Cell Significance Index: -4.4400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.2704
    Cell Significance Index: -2.0800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2779
    Cell Significance Index: -4.5800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2817
    Cell Significance Index: -4.8700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.2829
    Cell Significance Index: -3.0400
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.2965
    Cell Significance Index: -3.1700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2974
    Cell Significance Index: -7.2000
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.3167
    Cell Significance Index: -2.8300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.3233
    Cell Significance Index: -4.4400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3327
    Cell Significance Index: -3.5100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3334
    Cell Significance Index: -4.4300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3467
    Cell Significance Index: -6.7800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.3495
    Cell Significance Index: -3.3200
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.3522
    Cell Significance Index: -4.4600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3574
    Cell Significance Index: -3.3600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.3600
    Cell Significance Index: -3.8600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3638
    Cell Significance Index: -4.9100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3645
    Cell Significance Index: -4.4300
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.3668
    Cell Significance Index: -3.2700
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.3690
    Cell Significance Index: -4.2200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3702
    Cell Significance Index: -3.7800
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.3777
    Cell Significance Index: -4.1000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.3978
    Cell Significance Index: -4.7700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.4171
    Cell Significance Index: -4.4300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.4189
    Cell Significance Index: -5.0100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.4336
    Cell Significance Index: -4.4300
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.4678
    Cell Significance Index: -4.4000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.4845
    Cell Significance Index: -3.0900
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.4910
    Cell Significance Index: -4.5100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.5119
    Cell Significance Index: -4.5100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.5311
    Cell Significance Index: -3.3400
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.5453
    Cell Significance Index: -4.5100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.5659
    Cell Significance Index: -6.7300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.5749
    Cell Significance Index: -3.7400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.6353
    Cell Significance Index: -3.7700
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.6427
    Cell Significance Index: -5.0000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.6442
    Cell Significance Index: -6.9700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.6491
    Cell Significance Index: -7.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** RXFP3 is predominantly expressed in cells of the adrenal gland, medial ganglionic eminence-derived interneuron, GABAergic interneuron, dopaminergic neuron, acinar cell of the salivary gland, type B pancreatic cell, pancreatic A cell, pancreatic D cell, L2/3-6 intratelencephalic projecting glutamatergic neuron, and retinal progenitor cell. 2. **Ligand Binding:** RXFP3 binds to the ligand relaxin, which is a member of the relaxin family of peptides. 3. **G-Protein Coupled Receptor Activity:** RXFP3 exhibits G protein-coupled receptor activity, which involves the activation of G proteins, leading to downstream signaling events. **Pathways and Functions:** 1. **Neuropeptide Signaling Pathway:** RXFP3 is involved in the neuropeptide signaling pathway, which regulates various physiological processes, including reproduction, inflammation, and cell signaling. 2. **G-Protein Signaling Events:** RXFP3 activates G alpha (i) signaling events, which lead to the regulation of various cellular processes, including cell proliferation, differentiation, and survival. 3. **Plasma Membrane Signaling:** RXFP3 is located on the plasma membrane, where it can interact with its ligand and initiate signaling events. 4. **Positive Regulation of Cytokinesis:** RXFP3 is involved in the positive regulation of cytokinesis, which is the process of cell division. **Clinical Significance:** 1. **Reproductive Disorders:** RXFP3 has been implicated in various reproductive disorders, including premature labor, fetal growth restriction, and reproductive failure. 2. **Inflammatory Diseases:** RXFP3 has been shown to play a role in inflammatory diseases, including rheumatoid arthritis and multiple sclerosis. 3. **Endocrine Disorders:** RXFP3 has been implicated in endocrine disorders, including diabetes and thyroid dysfunction. 4. **Neurological Disorders:** RXFP3 has been shown to play a role in neurological disorders, including Parkinson's disease and schizophrenia. In conclusion, RXFP3 is a critical receptor involved in various physiological and pathological processes. Further research is needed to fully understand the role of RXFP3 in human disease and to develop therapeutic strategies for the treatment of related disorders.

Genular Protein ID: 3121898313

Symbol: RL3R1_HUMAN

Name: Relaxin-3 receptor 1

UniProtKB Accession Codes:

Q9NSD7 Q14DA5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10806363

Title: The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors.

PubMed ID: 10806363

DOI: 10.1016/s0378-1119(00)00123-2

PubMed ID: 14522968

Title: Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein coupled receptor GPCR135.

PubMed ID: 14522968

DOI: 10.1074/jbc.m308995200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 469
  • Mass: 51124
  • Checksum: 932E7B3001689F7B
  • Sequence:
    • MQMADAATIA TMNKAAGGDK LAELFSLVPD LLEAANTSGN ASLQLPDLWW ELGLELPDGA 
PPGHPPGSGG AESADTEARV RILISVVYWV VCALGLAGNL LVLYLMKSMQ GWRKSSINLF 
VTNLALTDFQ FVLTLPFWAV ENALDFKWPF GKAMCKIVSM VTSMNMYASV FFLTAMSVTR 
YHSVASALKS HRTRGHGRGD CCGRSLGDSC CFSAKALCVW IWALAALASL PSAIFSTTVK 
VMGEELCLVR FPDKLLGRDR QFWLGLYHSQ KVLLGFVLPL GIIILCYLLL VRFIADRRAA 
GTKGGAAVAG GRPTGASARR LSKVTKSVTI VVLSFFLCWL PNQALTTWSI LIKFNAVPFS 
QEYFLCQVYA FPVSVCLAHS NSCLNPVLYC LVRREFRKAL KSLLWRIASP SITSMRPFTA 
TTKPEHEDQG LQAPAPPHAA AEPDLLYYPP GVVVYSGGRY DLLPSSSAY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.