Details for: PPP2R2B

Gene ID: 5521

Symbol: PPP2R2B

Ensembl ID: ENSG00000156475

Description: protein phosphatase 2 regulatory subunit Bbeta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 7.08
    Marker Score: 4656
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.55
    Marker Score: 187574
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 4.84
    Marker Score: 11581
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.04
    Marker Score: 18681
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 3.3
    Marker Score: 1726
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.27
    Marker Score: 69774
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 3.02
    Marker Score: 5071
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.99
    Marker Score: 4020
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.92
    Marker Score: 8321
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.91
    Marker Score: 57823
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.84
    Marker Score: 21758
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.76
    Marker Score: 3344
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.75
    Marker Score: 41099
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.73
    Marker Score: 1599.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.72
    Marker Score: 2355
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.68
    Marker Score: 101624
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.6
    Marker Score: 10775
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.52
    Marker Score: 7194
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.47
    Marker Score: 13281
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.45
    Marker Score: 90439.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.34
    Marker Score: 979
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.34
    Marker Score: 9033.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.29
    Marker Score: 2830
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.28
    Marker Score: 678
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.23
    Marker Score: 1833
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.19
    Marker Score: 20628
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.16
    Marker Score: 829
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.13
    Marker Score: 4032
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127906
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.02
    Marker Score: 8228
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.02
    Marker Score: 20839
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.95
    Marker Score: 4489
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18297.5
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.89
    Marker Score: 644
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.88
    Marker Score: 6163
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16126
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.84
    Marker Score: 504
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.81
    Marker Score: 812
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.78
    Marker Score: 2223
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.78
    Marker Score: 1036
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.67
    Marker Score: 529
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.64
    Marker Score: 2537
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.58
    Marker Score: 1149
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.57
    Marker Score: 476
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.54
    Marker Score: 516
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.53
    Marker Score: 3115
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.52
    Marker Score: 3090
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.48
    Marker Score: 1478
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168043
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.36
    Marker Score: 1566
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.36
    Marker Score: 1527
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.34
    Marker Score: 853
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.33
    Marker Score: 797
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.27
    Marker Score: 5291
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.26
    Marker Score: 1569
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.24
    Marker Score: 838
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.23
    Marker Score: 456
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.15
    Marker Score: 1237
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.15
    Marker Score: 642
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4780
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.13
    Marker Score: 408
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.12
    Marker Score: 667
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.06
    Marker Score: 533
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.05
    Marker Score: 426
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 15936
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.01
    Marker Score: 352
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71773
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47999
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1
    Marker Score: 413
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.99
    Marker Score: 3502
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.97
    Marker Score: 732
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.95
    Marker Score: 832
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.93
    Marker Score: 1310
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5247
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 366
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.91
    Marker Score: 2146
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.9
    Marker Score: 389
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.87
    Marker Score: 176
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.87
    Marker Score: 2444
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5273
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.85
    Marker Score: 1252
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 645
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.84
    Marker Score: 1241
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.83
    Marker Score: 401
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.81
    Marker Score: 235
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.77
    Marker Score: 312
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1247
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.76
    Marker Score: 2412
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 689
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.75
    Marker Score: 273
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.75
    Marker Score: 218
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.75
    Marker Score: 633
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.74
    Marker Score: 440

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** PPPR2R2B is a protein phosphatase 2 regulatory subunit beta isoform, comprising 55 kDa subunits of the PP2A complex. It is significantly expressed in mature astrocytes, Purkinje cells, oligodendrocytes, inhibitory interneurons, rod bipolar cells, and various neurons in the cerebral cortex. The PPP2R2B gene is encoded by the ENSG00000156475 locus and is part of the PP2A complex, which plays a crucial role in regulating protein phosphatase activity. The unique characteristics of PPP2R2B, including its subunit composition and expression patterns, suggest a specialized role in regulating cellular processes. **Pathways and Functions:** The PPP2R2B gene is involved in several key pathways, including: 1. **Apoptotic Process:** PPP2R2B has been implicated in regulating apoptosis, a process crucial for eliminating damaged or unwanted cells. The PP2A complex, including PPP2R2B, can modulate pro-apoptotic and anti-apoptotic signaling pathways, influencing cell survival and death. 2. **Cytoskeleton:** PPP2R2B has been shown to regulate cytoskeletal dynamics, influencing cell shape, movement, and division. The PP2A complex can modulate the activity of cytoskeletal proteins, such as microtubule-associated proteins, to maintain cellular homeostasis. 3. **Protein Binding:** PPP2R2B can interact with various proteins, modulating their activity and function. The PP2A complex can regulate the activity of transcription factors, signaling molecules, and other proteins, influencing cellular processes such as proliferation, differentiation, and survival. 4. **Mitochondrial Outer Membrane:** PPP2R2B has been implicated in regulating the mitochondrial outer membrane, a critical component of the mitochondrial structure and function. The PP2A complex can modulate the activity of proteins involved in mitochondrial dynamics, influencing energy metabolism and cell survival. **Clinical Significance:** The PPP2R2B gene has been associated with various diseases, including: 1. **Neurodegenerative Disorders:** PPP2R2B has been implicated in neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. Mutations in the PPP2R2B gene have been linked to these disorders, suggesting a critical role in regulating cellular processes and maintaining neuronal health. 2. **Cancer:** PPP2R2B has been shown to regulate cell growth, proliferation, and survival in various cancer types. The PP2A complex, including PPP2R2B, can modulate signaling pathways involved in cancer development and progression. 3. **Neurological Disorders:** PPP2R2B has been implicated in various neurological disorders, including epilepsy, multiple sclerosis, and stroke. The PP2A complex can modulate signaling pathways involved in neuronal development, plasticity, and injury response. In conclusion, the PPP2R2B gene is a mysterious player in the intricate world of cellular regulation. Further research is needed to elucidate the precise functions of PPP2R2B and its role in various diseases. However, the existing evidence suggests that PPP2R2B is a critical component of the PP2A complex, influencing cellular processes such as apoptosis, cytoskeletal dynamics, and protein binding. Understanding the functions of PPP2R2B can provide valuable insights into the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 1476860171

Symbol: 2ABB_HUMAN

Name: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

UniProtKB Accession Codes:

Q00005 A6NEJ2 A8K102 B3KPD0 B7Z2F2 B7Z304 D3DQF7 D3DQF8 G3V149

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 21 EPD 1 Ensembl 8 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 RefSeq 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1849734

Title: Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform.

PubMed ID: 1849734

DOI: 10.1021/bi00229a001

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10581021

Title: Expansion of a novel CAG trinucleotide repeat in the 5' region of PPP2R2B is associated with SCA12.

PubMed ID: 10581021

DOI: 10.1038/70493

PubMed ID: 25816751

Title: HSF1 transcriptional activity is modulated by IER5 and PP2A/B55.

PubMed ID: 25816751

DOI: 10.1016/j.febslet.2015.03.019

PubMed ID: 26496226

Title: Immediate-early response 5 (IER5) interacts with protein phosphatase 2A and regulates the phosphorylation of ribosomal protein S6 kinase and heat shock factor 1.

PubMed ID: 26496226

DOI: 10.1016/j.febslet.2015.10.013

PubMed ID: 25356899

Title: De novo mutations in moderate or severe intellectual disability.

PubMed ID: 25356899

DOI: 10.1371/journal.pgen.1004772

Sequence Information:

  • Length: 443
  • Mass: 51710
  • Checksum: C383C834B2852B8F
  • Sequence:
    • MEEDIDTRKI NNSFLRDHSY ATEADIISTV EFNHTGELLA TGDKGGRVVI FQREQESKNQ 
VHRRGEYNVY STFQSHEPEF DYLKSLEIEE KINKIRWLPQ QNAAYFLLST NDKTVKLWKV 
SERDKRPEGY NLKDEEGRLR DPATITTLRV PVLRPMDLMV EATPRRVFAN AHTYHINSIS 
VNSDYETYMS ADDLRINLWN FEITNQSFNI VDIKPANMEE LTEVITAAEF HPHHCNTFVY 
SSSKGTIRLC DMRASALCDR HTKFFEEPED PSNRSFFSEI ISSISDVKFS HSGRYIMTRD 
YLTVKVWDLN MENRPIETYQ VHDYLRSKLC SLYENDCIFD KFECVWNGSD SVIMTGSYNN 
FFRMFDRNTK RDVTLEASRE NSKPRAILKP RKVCVGGKRR KDEISVDSLD FSKKILHTAW 
HPSENIIAVA ATNNLYIFQD KVN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.