Details for: OR4K1

Gene ID: 79544

Symbol: OR4K1

Ensembl ID: ENSG00000155249

Description: olfactory receptor family 4 subfamily K member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 21.7198
    Cell Significance Index: 553.3800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 14.6818
    Cell Significance Index: 237.7900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 8.1874
    Cell Significance Index: 139.9600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 3.8982
    Cell Significance Index: 41.4100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.5014
    Cell Significance Index: 7.2800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3642
    Cell Significance Index: 4.7800
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.0573
    Cell Significance Index: 0.6800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0428
    Cell Significance Index: 0.5100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0153
    Cell Significance Index: 0.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0119
    Cell Significance Index: 0.1700
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.0075
    Cell Significance Index: 0.0800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0072
    Cell Significance Index: 0.0900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0022
    Cell Significance Index: 0.0700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.2500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0004
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0005
    Cell Significance Index: -0.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0005
    Cell Significance Index: -0.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0025
    Cell Significance Index: -0.0800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0029
    Cell Significance Index: -0.0400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0030
    Cell Significance Index: -0.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0037
    Cell Significance Index: -0.1200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0038
    Cell Significance Index: -0.0400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0040
    Cell Significance Index: -0.0800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0041
    Cell Significance Index: -0.1700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0044
    Cell Significance Index: -0.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0050
    Cell Significance Index: -0.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0058
    Cell Significance Index: -0.2200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0060
    Cell Significance Index: -0.0700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0060
    Cell Significance Index: -0.0800
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0066
    Cell Significance Index: -0.0600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0067
    Cell Significance Index: -0.1400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0071
    Cell Significance Index: -0.1400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0074
    Cell Significance Index: -0.1600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0080
    Cell Significance Index: -0.1700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0080
    Cell Significance Index: -0.1600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0082
    Cell Significance Index: -0.1600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0083
    Cell Significance Index: -0.0700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0088
    Cell Significance Index: -0.0900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0091
    Cell Significance Index: -0.1800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0091
    Cell Significance Index: -0.2200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0093
    Cell Significance Index: -0.1600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0096
    Cell Significance Index: -0.1100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0100
    Cell Significance Index: -0.1100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0101
    Cell Significance Index: -0.1100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0104
    Cell Significance Index: -0.1200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0105
    Cell Significance Index: -0.1200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0118
    Cell Significance Index: -0.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0125
    Cell Significance Index: -0.1200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0127
    Cell Significance Index: -0.1600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0130
    Cell Significance Index: -0.1700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0136
    Cell Significance Index: -0.1700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0141
    Cell Significance Index: -0.1900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0147
    Cell Significance Index: -0.1200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0154
    Cell Significance Index: -0.1400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0154
    Cell Significance Index: -0.1700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0156
    Cell Significance Index: -0.1900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0160
    Cell Significance Index: -0.1500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0161
    Cell Significance Index: -0.1900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0163
    Cell Significance Index: -0.1800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0176
    Cell Significance Index: -0.2200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0179
    Cell Significance Index: -0.1700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0179
    Cell Significance Index: -0.2200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0179
    Cell Significance Index: -0.2100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0181
    Cell Significance Index: -0.2200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0183
    Cell Significance Index: -0.2200
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0184
    Cell Significance Index: -0.1800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0185
    Cell Significance Index: -0.2200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0187
    Cell Significance Index: -0.2000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0195
    Cell Significance Index: -0.2100
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0205
    Cell Significance Index: -0.1600
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0213
    Cell Significance Index: -0.1900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0216
    Cell Significance Index: -0.1900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0218
    Cell Significance Index: -0.2200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0219
    Cell Significance Index: -0.1300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0223
    Cell Significance Index: -0.2200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0229
    Cell Significance Index: -0.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0232
    Cell Significance Index: -0.1400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0242
    Cell Significance Index: -0.3100
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0250
    Cell Significance Index: -0.2700
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0252
    Cell Significance Index: -0.2200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0257
    Cell Significance Index: -0.2200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0260
    Cell Significance Index: -0.3400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0261
    Cell Significance Index: -0.1400
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0266
    Cell Significance Index: -0.2800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0267
    Cell Significance Index: -0.2500
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0267
    Cell Significance Index: -0.2500
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: -0.0270
    Cell Significance Index: -0.3000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0271
    Cell Significance Index: -0.1700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0283
    Cell Significance Index: -0.2200
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0287
    Cell Significance Index: -0.3100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0292
    Cell Significance Index: -0.1900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0303
    Cell Significance Index: -0.1400
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0322
    Cell Significance Index: -0.2900
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0329
    Cell Significance Index: -0.3000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0336
    Cell Significance Index: -0.3100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0341
    Cell Significance Index: -0.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Function:** OR4K1 is a G protein-coupled receptor that detects chemical stimuli, contributing to the sensory perception of smell. Its expression and translocation are critical for the proper functioning of olfactory receptors. 2. **Cell Type-Specific Expression:** OR4K1 is significantly expressed in various cell types, including glutamatergic neurons, erythrocytes, and oligodendrocyte precursor cells, indicating its broad functional range. 3. **G Protein-Coupled Receptor Activity:** OR4K1 is a member of the G protein-coupled receptor family, which is characterized by its ability to activate G proteins, leading to various signaling cascades. 4. **Plasma Membrane Localization:** The OR4K1 gene product is localized to the plasma membrane, where it can interact with ligands and initiate signaling pathways. **Pathways and Functions:** 1. **Detection of Chemical Stimuli:** OR4K1 detects chemical stimuli involved in sensory perception of smell, contributing to the olfactory system's ability to perceive odors. 2. **Expression and Translocation of Olfactory Receptors:** OR4K1 is involved in the expression and translocation of olfactory receptors, ensuring their proper functioning and localization to the plasma membrane. 3. **G Protein-Coupled Receptor Signaling Pathway:** OR4K1 activates G proteins, leading to various signaling cascades that regulate cellular responses to chemical stimuli. 4. **Olfactory Signaling Pathway:** OR4K1 is integrated into the olfactory signaling pathway, which involves the coordination of multiple olfactory receptors to process complex odorant molecules. **Clinical Significance:** 1. **Olfactory Dysfunction:** OR4K1 dysfunction has been implicated in olfactory dysfunction, a condition characterized by impaired olfactory perception. Understanding the gene's role in olfactory function can lead to the development of novel therapeutic strategies for treating olfactory disorders. 2. **Neurological Disorders:** OR4K1 has been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Further research is needed to elucidate the gene's role in these conditions and explore potential therapeutic applications. 3. **Cancer Research:** OR4K1 has been identified as a potential biomarker for cancer diagnosis and treatment. Its expression and translocation can be used to monitor cancer progression and response to therapy. 4. **Neurodevelopmental Disorders:** OR4K1 has been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. Further research is needed to understand the gene's role in these conditions and explore potential therapeutic strategies. In conclusion, the OR4K1 gene is a critical component of the human olfactory system, playing a vital role in sensory perception of smell. Its expression and translocation are essential for the proper functioning of olfactory receptors, and its dysfunction has been implicated in various clinical contexts. Further research is needed to fully elucidate the gene's role in human health and disease, with potential implications for the development of novel therapeutic strategies.

Genular Protein ID: 1128659245

Symbol: OR4K1_HUMAN

Name: Olfactory receptor 4K1

UniProtKB Accession Codes:

Q8NGD4 B9EKV9 Q8NGD6 Q96R73

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 6 Ensembl 6 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 311
  • Mass: 35201
  • Checksum: 97C9A3B6DC91A063
  • Sequence:
    • MAHTNESMVS EFVLLGLSNS WGLQLFFFAI FSIVYVTSVL GNVLIIVIIS FDSHLNSPMY 
FLLSNLSFID ICQSNFATPK MLVDFFIERK TISFEGCMAQ IFVLHSFVGS EMMLLVAMAY 
DRFIAICKPL HYSTIMNRRL CVIFVSISWA VGVLHSVSHL AFTVDLPFCG PNEVDSFFCD 
LPLVIELACM DTYEMEIMTL TNSGLISLSC FLALIISYTI ILIGVRCRSS SGSSKALSTL 
TAHITVVILF FGPCIYFYIW PFSRLPVDKF LSVFYTVCTP LLNPIIYSLR NEDVKAAMWK 
LRNRHVNSWK N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.