Details for: DPF3

Gene ID: 8110

Symbol: DPF3

Ensembl ID: ENSG00000205683

Description: double PHD fingers 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.93
    Marker Score: 87738
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.31
    Marker Score: 8298
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.61
    Marker Score: 1518
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.58
    Marker Score: 818
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.4
    Marker Score: 51119
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.16
    Marker Score: 6164
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.13
    Marker Score: 7562
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.12
    Marker Score: 7120
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.06
    Marker Score: 11077
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.03
    Marker Score: 1187
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.87
    Marker Score: 4301
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.87
    Marker Score: 70865
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.85
    Marker Score: 13933.5
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.68
    Marker Score: 8825
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.63
    Marker Score: 3844
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.61
    Marker Score: 6232.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.59
    Marker Score: 3811
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.52
    Marker Score: 1145
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169071
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.46
    Marker Score: 700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.45
    Marker Score: 1256
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.39
    Marker Score: 870
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.36
    Marker Score: 21334
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.33
    Marker Score: 872
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.27
    Marker Score: 762
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.24
    Marker Score: 694
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.2
    Marker Score: 503
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.19
    Marker Score: 17849
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.16
    Marker Score: 2362
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.16
    Marker Score: 1431
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.15
    Marker Score: 1227
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.09
    Marker Score: 10992
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.05
    Marker Score: 1264
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.04
    Marker Score: 2120
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.04
    Marker Score: 2861.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71812.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48037
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.99
    Marker Score: 1189.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.96
    Marker Score: 652.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.96
    Marker Score: 431
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.95
    Marker Score: 3386.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.94
    Marker Score: 281
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.94
    Marker Score: 3083
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.94
    Marker Score: 882.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5208
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.9
    Marker Score: 289
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.88
    Marker Score: 276
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.87
    Marker Score: 237
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.83
    Marker Score: 1111
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.82
    Marker Score: 391
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8
    Marker Score: 3370
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 607
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 316
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.78
    Marker Score: 3347
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.76
    Marker Score: 197
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 668
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.73
    Marker Score: 1711.5
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.7
    Marker Score: 356
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.68
    Marker Score: 1931
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.67
    Marker Score: 5131
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.65
    Marker Score: 6749
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.65
    Marker Score: 8596
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.61
    Marker Score: 459
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.6
    Marker Score: 3585
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.59
    Marker Score: 3193
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.59
    Marker Score: 3810
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.58
    Marker Score: 656
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 366
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.57
    Marker Score: 711
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.56
    Marker Score: 607
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.54
    Marker Score: 2204
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.53
    Marker Score: 175
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.53
    Marker Score: 526.5
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.51
    Marker Score: 197
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.51
    Marker Score: 865
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.49
    Marker Score: 216
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.48
    Marker Score: 3105
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.47
    Marker Score: 173
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.47
    Marker Score: 319
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.46
    Marker Score: 2769
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.45
    Marker Score: 236
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.44
    Marker Score: 616
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.42
    Marker Score: 387
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.42
    Marker Score: 1934
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.41
    Marker Score: 205
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.39
    Marker Score: 467
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.38
    Marker Score: 226
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.37
    Marker Score: 809

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Other Information

**Key Characteristics:** DPF3 is a small protein with a molecular weight of approximately 15 kDa, consisting of a PHD (proline-histidine-aspartate) finger domain and a zinc finger motif. The PHD finger domain is characterized by a unique arrangement of histidine and aspartate residues, which are crucial for protein-protein interactions. The zinc finger motif, on the other hand, is responsible for the protein's ability to bind to specific DNA sequences. DPF3 is highly expressed in various cell types, including cardiac myocytes, skeletal muscle fibers, brainstem motor neurons, and cerebral cortex neurons. **Pathways and Functions:** DPF3's biological functions can be attributed to its involvement in several key pathways: 1. **Chromatin remodeling and transcriptional control**: DPF3 interacts with the Swi/Snf complex, a chromatin-remodeling enzyme, to regulate transcriptional activity. This interaction allows DPF3 to modulate the expression of target genes involved in cell differentiation, DNA repair, and transcriptional regulation. 2. **DNA repair and double-strand break response**: DPF3 is involved in the positive regulation of double-strand break repair, ensuring the integrity of the genome. Its interaction with the NbfA complex, a DNA repair enzyme, facilitates the repair of DNA damage. 3. **Muscle development and differentiation**: DPF3 plays a crucial role in the regulation of myoblast differentiation, a process essential for muscle development. Its interaction with the Brahma complex, a chromatin-remodeling enzyme, regulates the expression of muscle-specific genes. 4. **Cell cycle regulation**: DPF3 is involved in the regulation of the cell cycle, specifically the transition from G0 to G1 and from G1 to S phase. Its interaction with the Nbaf complex, a cyclin-dependent kinase, regulates the progression of the cell cycle. 5. **Nervous system development and function**: DPF3 is expressed in brainstem motor neurons and cerebral cortex neurons, where it plays a role in the regulation of neuronal development and function. **Clinical Significance:** The study of DPF3's biological functions has significant implications for our understanding of various diseases and disorders, including: 1. **Muscle disorders**: Alterations in DPF3 expression have been linked to muscle disorders, such as muscular dystrophy. 2. **Cancer**: DPF3's involvement in DNA repair and transcriptional control makes it a potential target for cancer therapy. 3. **Neurological disorders**: DPF3's role in nervous system development and function suggests that it may be involved in the pathogenesis of neurological disorders, such as Alzheimer's disease. 4. **Cardiac disease**: DPF3's expression in cardiac myocytes and its involvement in cell cycle regulation make it a potential target for cardiac disease therapy. In conclusion, DPF3 is a multifaceted protein with a unique zinc finger motif, playing a crucial role in various cellular processes. Further research into DPF3's biological functions and pathways will provide valuable insights into its clinical significance and potential therapeutic applications.

Genular Protein ID: 826864343

Symbol: DPF3_HUMAN

Name: Zinc finger protein DPF3

UniProtKB Accession Codes:

Q92784 A8MSI3 B7Z276 F5H575 Q32UJ0 Q6P9E6 Q6ZT41 Q9H7Y5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CTD 1 ChiTaRS 1 ComplexPortal 12 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 7 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 RefSeq 6 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 18765789

Title: Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.

PubMed ID: 18765789

DOI: 10.1101/gad.471408

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8812431

Title: The d4 gene family in the human genome.

PubMed ID: 8812431

DOI: 10.1006/geno.1996.0440

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 32459350

Title: HRP2-DPF3a-BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription.

PubMed ID: 32459350

DOI: 10.1093/nar/gkaa441

PubMed ID: 20613843

Title: Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b.

PubMed ID: 20613843

DOI: 10.1038/nature09139

Sequence Information:

  • Length: 378
  • Mass: 43084
  • Checksum: 7E6A6FD07A0E4668
  • Sequence:
    • MATVIHNPLK ALGDQFYKEA IEHCRSYNSR LCAERSVRLP FLDSQTGVAQ NNCYIWMEKR 
HRGPGLAPGQ LYTYPARCWR KKRRLHPPED PKLRLLEIKP EVELPLKKDG FTSESTTLEA 
LLRGEGVEKK VDAREEESIQ EIQRVLENDE NVEEGNEEED LEEDIPKRKN RTRGRARGSA 
GGRRRHDAAS QEDHDKPYVC DICGKRYKNR PGLSYHYAHT HLASEEGDEA QDQETRSPPN 
HRNENHRPQK GPDGTVIPNN YCDFCLGGSN MNKKSGRPEE LVSCADCGRS GHPTCLQFTL 
NMTEAVKTYK WQCIECKSCI LCGTSENDDQ LLFCDDCDRG YHMYCLNPPV AEPPEGSWSC 
HLCWELLKEK ASAFGCQA

Genular Protein ID: 778234778

Symbol: F8W7T1_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8W7T1

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 SwissPalm 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 412
  • Mass: 46445
  • Checksum: BBE03D204CA249F8
  • Sequence:
    • MFYGRINGRN FAASSLPVAF AATPLMLFLP NPQLIFSFPI SSRNHITGLM PPGKLKLENL 
FHMCTRLGDQ FYKEAIEHCR SYNSRLCAER SVRLPFLDSQ TGVAQNNCYI WMEKRHRGPG 
LAPGQLYTYP ARCWRKKRRL HPPEDPKLRL LEIKPEVELP LKKDGFTSES TTLEALLRGE 
GVEKKVDARE EESIQEIQRV LENDENVEEG NEEEDLEEDI PKRKNRTRGR ARGSAGGRRR 
HDAASQEDHD KPYVCDICGK RYKNRPGLSY HYAHTHLASE EGDEAQDQET RSPPNHRNEN 
HRPQKGPDGT VIPNNYCDFC LGGSNMNKKS GRPEELVSCA DCGRSAHLGG EGRKEKEAAA 
AARTTEDLFG STSESDTSTF HGFDEDDLEE PRSCRGRRSG RGSPTADKKG SC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.