Details for: MYOM1

Gene ID: 8736

Symbol: MYOM1

Ensembl ID: ENSG00000101605

Description: myomesin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 5.31
    Marker Score: 118773
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.75
    Marker Score: 11883
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 3.98
    Marker Score: 3025.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.75
    Marker Score: 8236
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.59
    Marker Score: 12753
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.46
    Marker Score: 776
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.89
    Marker Score: 1022
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.77
    Marker Score: 23499
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.62
    Marker Score: 819.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.48
    Marker Score: 3014
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169266
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.46
    Marker Score: 479
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.45
    Marker Score: 1387
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.45
    Marker Score: 30949
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.43
    Marker Score: 14729
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.34
    Marker Score: 20923
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.14
    Marker Score: 992
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.14
    Marker Score: 831
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.14
    Marker Score: 2165.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.11
    Marker Score: 463
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.1
    Marker Score: 301
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.08
    Marker Score: 646
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.05
    Marker Score: 337
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48040
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.96
    Marker Score: 534
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.94
    Marker Score: 4072
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5311
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.92
    Marker Score: 3028
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.91
    Marker Score: 4908
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.89
    Marker Score: 522
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.88
    Marker Score: 3673.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.86
    Marker Score: 1162.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.82
    Marker Score: 1019
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8
    Marker Score: 3343
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.8
    Marker Score: 252
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.79
    Marker Score: 5076.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 595
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 311
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 697
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.76
    Marker Score: 500
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.75
    Marker Score: 284
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.72
    Marker Score: 342
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.71
    Marker Score: 4275
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.69
    Marker Score: 2798
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.67
    Marker Score: 1568
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.63
    Marker Score: 198
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.62
    Marker Score: 163
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.61
    Marker Score: 435
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.61
    Marker Score: 1068
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.61
    Marker Score: 355
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.61
    Marker Score: 158
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.61
    Marker Score: 345
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.61
    Marker Score: 10762
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.6
    Marker Score: 4593
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.6
    Marker Score: 686
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 377
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.55
    Marker Score: 20452
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.54
    Marker Score: 137
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.54
    Marker Score: 650
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.52
    Marker Score: 343
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.51
    Marker Score: 636
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.5
    Marker Score: 132
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.5
    Marker Score: 338
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.48
    Marker Score: 139
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.48
    Marker Score: 138
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.48
    Marker Score: 1850
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.48
    Marker Score: 217
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.47
    Marker Score: 17868
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.45
    Marker Score: 181
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.44
    Marker Score: 487
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.44
    Marker Score: 1811
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.43
    Marker Score: 159
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.42
    Marker Score: 175
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.42
    Marker Score: 3911
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.41
    Marker Score: 790
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.41
    Marker Score: 198
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.4
    Marker Score: 133
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.39
    Marker Score: 174
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.39
    Marker Score: 136
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.38
    Marker Score: 379
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.38
    Marker Score: 714
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.38
    Marker Score: 795
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.38
    Marker Score: 405
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.37
    Marker Score: 22970
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.37
    Marker Score: 106
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.37
    Marker Score: 528
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.35
    Marker Score: 99

Other Information

**Key Characteristics:** 1. **Muscle-specific expression:** MYOM1 is predominantly expressed in muscle cells, including cardiac myocytes, skeletal muscle fibers, and smooth muscle cells. 2. **Striated muscle organization:** MYOM1 is essential for the organization of striated muscle myosin thick filaments, which are critical for muscle contraction and relaxation. 3. **Regulatory functions:** MYOM1 is involved in the positive regulation of gene expression and protein secretion, indicating its role in modulating muscle development and function. 4. **Protein binding and homodimerization:** MYOM1 exhibits protein binding and homodimerization activity, suggesting its ability to interact with other proteins and form dimers, which may contribute to its regulatory functions. **Pathways and Functions:** 1. **Sarcomere organization:** MYOM1 is involved in the organization of sarcomeres, the functional units of striated muscle, which are critical for muscle contraction and relaxation. 2. **Muscle development:** MYOM1 plays a crucial role in muscle development, particularly during embryonic development and in the formation of striated muscle myosin thick filaments. 3. **Protein kinase A signaling:** MYOM1 interacts with protein kinase A (PKA), a key regulator of muscle contraction and relaxation, highlighting its importance in muscle function. 4. **Muscle contraction and relaxation:** MYOM1 is essential for the proper functioning of striated muscle myosin thick filaments, which are critical for muscle contraction and relaxation. **Clinical Significance:** Dysregulation of MYOM1 has been implicated in various muscular disorders, including cardiomyopathies and muscular dystrophies. Mutations in the MYOM1 gene have been associated with conditions such as hypertrophic cardiomyopathy, a common cause of sudden cardiac death in young athletes. Additionally, MYOM1 has been shown to play a role in the development of smooth muscle tumors, highlighting its importance in regulating muscle cell growth and differentiation. Further research is needed to fully elucidate the role of MYOM1 in muscle development and function and to explore its potential as a therapeutic target for muscular disorders. **Implications for Immunology:** While MYOM1 is primarily recognized as a muscle-specific gene, its expression in lymphocytes and immature innate lymphoid cells suggests a broader role in immune regulation. Further investigation into the immunological functions of MYOM1 may reveal novel mechanisms of immune cell development and function, with potential implications for the treatment of autoimmune disorders and cancer. In conclusion, MYOM1 is a multifaceted gene that plays a critical role in muscle development and function, with significant implications for our understanding of muscular disorders and immune regulation. Further research is needed to fully elucidate the functions of MYOM1 and to explore its potential as a therapeutic target for muscular and immune-related disorders.

Genular Protein ID: 3939799795

Symbol: MYOM1_HUMAN

Name: Myomesin-1

UniProtKB Accession Codes:

P52179 Q14BD6 Q6H969 Q6ZUU0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CORUM 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 6 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 9 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SASBDB 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7505783

Title: The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins.

PubMed ID: 7505783

DOI: 10.1242/jcs.106.1.319

PubMed ID: 15188056

Title: Characterization of MR-1, a novel myofibrillogenesis regulator in human muscle.

PubMed ID: 15188056

DOI: 10.1093/abbs/36.6.412

Sequence Information:

  • Length: 1685
  • Mass: 187627
  • Checksum: F0DBB25EB6323DF8
  • Sequence:
    • MSLPFYQRCH QHYDLSYRNK DVRSTVSHYQ REKKRSAVYT QGSTAYSSRS SAAHRRESEA 
FRRASASSSQ QQASQHALSS EVSRKAASAY DYGSSHGLTD SSLLLDDYSS KLSPKPKRAK 
HSLLSGEEKE NLPSDYMVPI FSGRQKHVSG ITDTEEERIK EAAAYIAQRN LLASEEGITT 
SKQSTASKQT TASKQSTASK QSTASKQSTA SRQSTASRQS VVSKQATSAL QQEETSEKKS 
RKVVIREKAE RLSLRKTLEE TETYHAKLNE DHLLHAPEFI IKPRSHTVWE KENVKLHCSI 
AGWPEPRVTW YKNQVPINVH ANPGKYIIES RYGMHTLEIN GCDFEDTAQY RASAMNVKGE 
LSAYASVVVK RYKGEFDETR FHAGASTMPL SFGVTPYGYA SRFEIHFDDK FDVSFGREGE 
TMSLGCRVVI TPEIKHFQPE IQWYRNGVPL SPSKWVQTLW SGERATLTFS HLNKEDEGLY 
TIRVRMGEYY EQYSAYVFVR DADAEIEGAP AAPLDVKCLE ANKDYIIISW KQPAVDGGSP 
ILGYFIDKCE VGTDSWSQCN DTPVKFARFP VTGLIEGRSY IFRVRAVNKM GIGFPSRVSE 
PVAALDPAEK ARLKSRPSAP WTGQIIVTEE EPSEGIVPGP PTDLSVTEAT RSYVVLSWKP 
PGQRGHEGIM YFVEKCEAGT ENWQRVNTEL PVKSPRFALF DLAEGKSYCF RVRCSNSAGV 
GEPSEATEVT VVGDKLDIPK APGKIIPSRN TDTSVVVSWE ESKDAKELVG YYIEASVAGS 
GKWEPCNNNP VKGSRFTCHG LVTGQSYIFR VRAVNAAGLS EYSQDSEAIE VKAAIGGGVS 
PDVCPALSDE PGGLTASRGR VHEASPPTFQ KDALLGSKPN KPSLPSSSQN LGQTEVSKVS 
ETVQEELTPP PQKAAPQGKS KSDPLKKKTD RAPPSPPCDI TCLESFRDSM VLGWKQPDKI 
GGAEITGYYV NYREVIDGVP GKWREANVKA VSEEAYKISN LKENMVYQFQ VAAMNMAGLG 
APSAVSECFK CEEWTIAVPG PPHSLKCSEV RKDSLVLQWK PPVHSGRTPV TGYFVDLKEA 
KAKEDQWRGL NEAAIKNVYL KVRGLKEGVS YVFRVRAINQ AGVGKPSDLA GPVVAETRPG 
TKEVVVNVDD DGVISLNFEC DKMTPKSEFS WSKDYVSTED SPRLEVESKG NKTKMTFKDL 
GMDDLGIYSC DVTDTDGIAS SYLIDEEELK RLLALSHEHK FPTVPVKSEL AVEILEKGQV 
RFWMQAEKLS GNAKVNYIFN EKEIFEGPKY KMHIDRNTGI IEMFMEKLQD EDEGTYTFQL 
QDGKATNHST VVLVGDVFKK LQKEAEFQRQ EWIRKQGPHF VEYLSWEVTG ECNVLLKCKV 
ANIKKETHIV WYKDEREISV DEKHDFKDGI CTLLITEFSK KDAGIYEVIL KDDRGKDKSR 
LKLVDEAFKE LMMEVCKKIA LSATDLKIQS TAEGIQLYSF VTYYVEDLKV NWSHNGSAIR 
YSDRVKTGVT GEQIWLQINE PTPNDKGKYV MELFDGKTGH QKTVDLSGQA YDEAYAEFQR 
LKQAAIAEKN RARVLGGLPD VVTIQEGKAL NLTCNVWGDP PPEVSWLKNE KALASDDHCN 
LKFEAGRTAY FTINGVSTAD SGKYGLVVKN KYGSETSDFT VSVFIPEEEA RMAALESLKG 
GKKAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.