Details for: LINC00424

Gene ID: 100874182

Symbol: LINC00424

Ensembl ID: ENSG00000226722

Description: long intergenic non-protein coding RNA 424

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.1422
    Cell Significance Index: 12.6500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 1.1354
    Cell Significance Index: 14.9000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.7698
    Cell Significance Index: 11.2200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.6039
    Cell Significance Index: 7.5900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.2329
    Cell Significance Index: 3.0400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.1543
    Cell Significance Index: 1.8800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0733
    Cell Significance Index: 0.8900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0562
    Cell Significance Index: 0.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0493
    Cell Significance Index: 1.3200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.0286
    Cell Significance Index: 0.2500
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.0267
    Cell Significance Index: 0.2800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.0151
    Cell Significance Index: 0.3000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0042
    Cell Significance Index: 0.0600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.0038
    Cell Significance Index: 0.0400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0022
    Cell Significance Index: 0.0300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0004
    Cell Significance Index: -0.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0004
    Cell Significance Index: -0.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0009
    Cell Significance Index: -0.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0016
    Cell Significance Index: -0.0900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0018
    Cell Significance Index: -0.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0019
    Cell Significance Index: -0.0600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0021
    Cell Significance Index: -0.0500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0023
    Cell Significance Index: -0.0200
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0024
    Cell Significance Index: -0.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0024
    Cell Significance Index: -0.1200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0025
    Cell Significance Index: -0.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0025
    Cell Significance Index: -0.0700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0029
    Cell Significance Index: -0.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0030
    Cell Significance Index: -0.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0034
    Cell Significance Index: -0.0900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0035
    Cell Significance Index: -0.0800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0035
    Cell Significance Index: -0.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0038
    Cell Significance Index: -0.1100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0040
    Cell Significance Index: -0.0700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0042
    Cell Significance Index: -0.0900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0042
    Cell Significance Index: -0.1000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0043
    Cell Significance Index: -0.0600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0046
    Cell Significance Index: -0.0900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0046
    Cell Significance Index: -0.0600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0053
    Cell Significance Index: -0.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0053
    Cell Significance Index: -0.1400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0053
    Cell Significance Index: -0.0700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0055
    Cell Significance Index: -0.0700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0059
    Cell Significance Index: -0.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0059
    Cell Significance Index: -0.2100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0060
    Cell Significance Index: -0.1200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0060
    Cell Significance Index: -0.0600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0066
    Cell Significance Index: -0.1300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0066
    Cell Significance Index: -0.0800
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0066
    Cell Significance Index: -0.0600
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0066
    Cell Significance Index: -0.0400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0067
    Cell Significance Index: -0.0900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0071
    Cell Significance Index: -0.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0071
    Cell Significance Index: -0.1400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0074
    Cell Significance Index: -0.0700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0077
    Cell Significance Index: -0.0600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0078
    Cell Significance Index: -0.0800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0079
    Cell Significance Index: -0.1000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0080
    Cell Significance Index: -0.1000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0080
    Cell Significance Index: -0.1000
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.0080
    Cell Significance Index: -0.1000
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0080
    Cell Significance Index: -0.0900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0081
    Cell Significance Index: -0.1000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0081
    Cell Significance Index: -0.1000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0081
    Cell Significance Index: -0.1100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0082
    Cell Significance Index: -0.1200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0083
    Cell Significance Index: -0.0900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0084
    Cell Significance Index: -0.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0084
    Cell Significance Index: -0.1400
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0085
    Cell Significance Index: -0.0800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0086
    Cell Significance Index: -0.1000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0086
    Cell Significance Index: -0.1000
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0087
    Cell Significance Index: -0.0500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0087
    Cell Significance Index: -0.1000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0089
    Cell Significance Index: -0.0700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0089
    Cell Significance Index: -0.0900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0090
    Cell Significance Index: -0.1100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0092
    Cell Significance Index: -0.1100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0092
    Cell Significance Index: -0.1100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0093
    Cell Significance Index: -0.1100
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0095
    Cell Significance Index: -0.1100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0096
    Cell Significance Index: -0.1100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0096
    Cell Significance Index: -0.1000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0100
    Cell Significance Index: -0.1300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0103
    Cell Significance Index: -0.1100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0104
    Cell Significance Index: -0.1100
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0106
    Cell Significance Index: -0.1100
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0108
    Cell Significance Index: -0.1000
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0108
    Cell Significance Index: -0.0800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0108
    Cell Significance Index: -0.1300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0110
    Cell Significance Index: -0.0900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0116
    Cell Significance Index: -0.1100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0120
    Cell Significance Index: -0.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-coding nature**: LINC00424 does not encode a protein, but instead, it regulates gene expression through various mechanisms, including RNA binding, chromatin remodeling, and transcriptional regulation. 2. **Long intergenic non-coding RNA**: LINC00424 is a type of lincRNA that is located between two protein-coding genes, where it can act as a bridge to regulate gene expression. 3. **Differential expression**: LINC00424 is significantly expressed in various cell types, including immune cells, suggesting its potential role in immune function and tissue homeostasis. 4. **Cell-type specific expression**: The expression of LINC00424 varies across different cell types, indicating its unique roles in different tissues and cellular contexts. **Pathways and Functions:** 1. **Regulation of gene expression**: LINC00424 modulates gene expression by regulating transcription factors, chromatin remodeling, and RNA binding proteins. 2. **Immune function**: LINC00424 is involved in regulating immune responses, including T cell activation, proliferation, and differentiation. 3. **Cellular differentiation**: LINC00424 plays a role in regulating cellular differentiation, particularly in the development of oligodendrocyte precursor cells and smooth muscle myoblasts. 4. **Tissue homeostasis**: LINC00424 contributes to maintaining tissue homeostasis by regulating the expression of genes involved in cell proliferation, differentiation, and survival. **Clinical Significance:** 1. **Immune-related disorders**: Alterations in LINC00424 expression have been linked to various immune-related disorders, including autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: LINC00424 has been implicated in cancer development and progression, particularly in hematological malignancies, such as acute myeloid leukemia and lymphoma. 3. **Neurological disorders**: LINC00424 expression has been associated with neurological disorders, including Alzheimer's disease, Parkinson's disease, and stroke. 4. **Regenerative medicine**: LINC00424 has potential applications in regenerative medicine, particularly in tissue engineering and stem cell therapy. In conclusion, LINC00424 is a complex and multifunctional lincRNA that plays a crucial role in regulating gene expression, immune function, and tissue homeostasis. Further studies are needed to fully elucidate the mechanisms of action and clinical significance of LINC00424, which may lead to the development of novel therapeutic strategies for immune-related disorders and other diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.