Details for: CGB2

Gene ID: 114336

Symbol: CGB2

Ensembl ID: ENSG00000104818

Description: chorionic gonadotropin subunit beta 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.6031
    Cell Significance Index: 4.3500
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.4373
    Cell Significance Index: 5.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1422
    Cell Significance Index: 1.9400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1305
    Cell Significance Index: 0.9900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: 0.0523
    Cell Significance Index: 0.5300
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0453
    Cell Significance Index: 0.5400
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.0266
    Cell Significance Index: 0.2500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0221
    Cell Significance Index: 0.2100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0140
    Cell Significance Index: 0.0800
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.0137
    Cell Significance Index: 0.1400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0087
    Cell Significance Index: 0.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0060
    Cell Significance Index: 0.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0026
    Cell Significance Index: 0.0700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0019
    Cell Significance Index: 0.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0006
    Cell Significance Index: -0.3500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0008
    Cell Significance Index: -0.0200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0032
    Cell Significance Index: -0.0300
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0033
    Cell Significance Index: -0.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0037
    Cell Significance Index: -0.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0041
    Cell Significance Index: -0.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0076
    Cell Significance Index: -0.1600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0084
    Cell Significance Index: -0.1100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0092
    Cell Significance Index: -0.1200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0108
    Cell Significance Index: -0.1200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0111
    Cell Significance Index: -0.1300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0124
    Cell Significance Index: -0.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0125
    Cell Significance Index: -0.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0154
    Cell Significance Index: -0.5400
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0158
    Cell Significance Index: -0.1800
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0188
    Cell Significance Index: -0.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0194
    Cell Significance Index: -0.5100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0194
    Cell Significance Index: -0.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0209
    Cell Significance Index: -0.6200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0239
    Cell Significance Index: -0.6000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0246
    Cell Significance Index: -0.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0251
    Cell Significance Index: -0.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0260
    Cell Significance Index: -0.5700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0288
    Cell Significance Index: -0.7200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0294
    Cell Significance Index: -0.8400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0315
    Cell Significance Index: -0.3600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0322
    Cell Significance Index: -0.8200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0353
    Cell Significance Index: -0.5100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0377
    Cell Significance Index: -0.6100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0419
    Cell Significance Index: -0.5400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0421
    Cell Significance Index: -0.4900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0424
    Cell Significance Index: -0.5200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0442
    Cell Significance Index: -0.6200
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0446
    Cell Significance Index: -0.4200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0452
    Cell Significance Index: -0.6200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0453
    Cell Significance Index: -0.5800
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0475
    Cell Significance Index: -0.4900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0496
    Cell Significance Index: -0.4700
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0505
    Cell Significance Index: -0.6400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0514
    Cell Significance Index: -0.8300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0521
    Cell Significance Index: -0.7200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0529
    Cell Significance Index: -0.5400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0534
    Cell Significance Index: -0.7200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0545
    Cell Significance Index: -0.5100
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.0548
    Cell Significance Index: -0.5100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0555
    Cell Significance Index: -0.6600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0558
    Cell Significance Index: -0.5700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0570
    Cell Significance Index: -0.5400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0577
    Cell Significance Index: -0.7400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0584
    Cell Significance Index: -0.7100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0591
    Cell Significance Index: -0.6800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0605
    Cell Significance Index: -0.7900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0625
    Cell Significance Index: -0.7500
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0628
    Cell Significance Index: -0.6200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0629
    Cell Significance Index: -0.6900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0637
    Cell Significance Index: -0.6900
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0642
    Cell Significance Index: -0.5900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0644
    Cell Significance Index: -0.4000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0646
    Cell Significance Index: -0.6600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0649
    Cell Significance Index: -0.6900
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0649
    Cell Significance Index: -0.6400
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0652
    Cell Significance Index: -0.7100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0659
    Cell Significance Index: -0.7000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0672
    Cell Significance Index: -0.7200
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0677
    Cell Significance Index: -0.7000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0678
    Cell Significance Index: -0.7700
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0679
    Cell Significance Index: -0.5400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0681
    Cell Significance Index: -0.5600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0688
    Cell Significance Index: -0.8300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0692
    Cell Significance Index: -0.6500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0694
    Cell Significance Index: -0.8300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0695
    Cell Significance Index: -0.8200
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0704
    Cell Significance Index: -0.7700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0706
    Cell Significance Index: -0.8200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0706
    Cell Significance Index: -1.1300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0707
    Cell Significance Index: -0.7700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0715
    Cell Significance Index: -0.7200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0744
    Cell Significance Index: -0.8000
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.0748
    Cell Significance Index: -0.7100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0766
    Cell Significance Index: -0.8300
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.0767
    Cell Significance Index: -0.4800
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0767
    Cell Significance Index: -0.8300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0771
    Cell Significance Index: -0.6000
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.0773
    Cell Significance Index: -0.5900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0773
    Cell Significance Index: -0.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The CGB2 gene is a member of the chorionic gonadotropin (hCG) subunit family, which consists of alpha and beta subunits. The beta subunit is responsible for the hormone-like activity of hCG, which is essential for maintaining pregnancy and regulating reproductive processes. The CGB2 gene is highly expressed in cells involved in hormone production and signaling, such as the intestinal epithelial cells and germ cells. **Pathways and Functions:** The CGB2 gene is involved in several key signaling pathways, including: 1. **G Protein-Coupled Receptor Signaling Pathway**: CGB2 interacts with G protein-coupled receptors (GPCRs) to modulate cellular responses to hormones and other signaling molecules. 2. **Hormone Activity**: The CGB2 protein exhibits hormone-like activity, which is essential for maintaining pregnancy and regulating reproductive processes. 3. **Cell Signaling**: CGB2 is involved in cell signaling pathways that regulate cell growth, differentiation, and survival. **Clinical Significance:** The CGB2 gene has significant clinical implications, particularly in the context of: 1. **Germ Cell Tumors**: Abnormal expression of CGB2 has been observed in germ cell tumors, highlighting its potential as a diagnostic biomarker. 2. **Intestinal Disorders**: Altered expression of CGB2 has been linked to intestinal disorders, such as colorectal cancer and inflammatory bowel disease. 3. **Reproductive Health**: CGB2 plays a crucial role in maintaining pregnancy, and abnormalities in its expression may contribute to reproductive health issues, such as infertility and miscarriage. In conclusion, the CGB2 gene is a vital component of various cellular processes, including hormone regulation, cell signaling, and differentiation. Its significant expression in various cell types and involvement in key signaling pathways highlight its clinical significance in the diagnosis and treatment of germ cell tumors, intestinal disorders, and reproductive health issues. Further research is necessary to fully elucidate the functional roles of CGB2 and its potential applications in clinical practice.

Genular Protein ID: 2844809072

Symbol: CGB2_HUMAN

Name: Choriogonadotropin subunit beta variant 2

UniProtKB Accession Codes:

Q6NT52 B9ZVM5 H9KV56

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 18048458

Title: Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues.

PubMed ID: 18048458

DOI: 10.1093/molehr/gam082

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11861891

Title: Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection.

PubMed ID: 11861891

DOI: 10.1093/oxfordjournals.molbev.a004085

PubMed ID: 16123088

Title: Expression of beta-subunit of HCG genes during normal and failed pregnancy.

PubMed ID: 16123088

DOI: 10.1093/humrep/dei261

Sequence Information:

  • Length: 163
  • Mass: 17374
  • Checksum: 823CEF334B9183F6
  • Sequence:
    • MSKGLLLLLL LSMGGTWASK EPLRPRCRPI NATLAVEKEG CPVCITVNTT ICAGYCPTMT 
RVLQGVLPAL PQVVCNYRDV RFESIRLPGC PRGVNPVVSY AVALSCQCAL CRRSTTDCGG 
PKDHPLTCDD PRFQASSSSK APPPSLPSPS RLPGPSDTPI LPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.