Details for: PCAT4

Gene ID: 118425

Symbol: PCAT4

Ensembl ID: ENSG00000251321

Description: prostate cancer associated transcript 4

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 8.1876
    Cell Significance Index: 115.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.3598
    Cell Significance Index: 16.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.3239
    Cell Significance Index: 83.4400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5503
    Cell Significance Index: 8.0200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.3798
    Cell Significance Index: 3.9300
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.2469
    Cell Significance Index: 2.6900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.2029
    Cell Significance Index: 4.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1165
    Cell Significance Index: 6.5400
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: 0.1052
    Cell Significance Index: 1.3100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.0945
    Cell Significance Index: 1.1800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0879
    Cell Significance Index: 0.8500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0487
    Cell Significance Index: 0.3800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0355
    Cell Significance Index: 0.4300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0353
    Cell Significance Index: 0.5600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0259
    Cell Significance Index: 0.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0096
    Cell Significance Index: 0.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0067
    Cell Significance Index: 0.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0024
    Cell Significance Index: 0.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -0.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0005
    Cell Significance Index: -0.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0007
    Cell Significance Index: -0.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0009
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0021
    Cell Significance Index: -0.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0022
    Cell Significance Index: -0.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0024
    Cell Significance Index: -1.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0031
    Cell Significance Index: -0.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0044
    Cell Significance Index: -0.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0050
    Cell Significance Index: -0.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0053
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0061
    Cell Significance Index: -1.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0063
    Cell Significance Index: -1.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0065
    Cell Significance Index: -0.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0065
    Cell Significance Index: -0.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0083
    Cell Significance Index: -0.2400
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0091
    Cell Significance Index: -0.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0092
    Cell Significance Index: -0.4800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0115
    Cell Significance Index: -0.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0118
    Cell Significance Index: -1.2300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0142
    Cell Significance Index: -0.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0159
    Cell Significance Index: -0.9800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0164
    Cell Significance Index: -0.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0167
    Cell Significance Index: -1.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0194
    Cell Significance Index: -1.4900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0208
    Cell Significance Index: -0.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0238
    Cell Significance Index: -1.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0253
    Cell Significance Index: -1.1200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0255
    Cell Significance Index: -0.9000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0272
    Cell Significance Index: -0.7300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0294
    Cell Significance Index: -0.3200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0295
    Cell Significance Index: -1.2100
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0300
    Cell Significance Index: -0.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0304
    Cell Significance Index: -1.1500
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0320
    Cell Significance Index: -0.4100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0333
    Cell Significance Index: -0.7300
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0338
    Cell Significance Index: -0.3700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0355
    Cell Significance Index: -0.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0361
    Cell Significance Index: -1.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0373
    Cell Significance Index: -1.2200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0382
    Cell Significance Index: -0.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0382
    Cell Significance Index: -1.7800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0385
    Cell Significance Index: -0.5100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0386
    Cell Significance Index: -0.4000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0386
    Cell Significance Index: -0.5700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0410
    Cell Significance Index: -1.0000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0411
    Cell Significance Index: -0.4800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0420
    Cell Significance Index: -0.5600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0421
    Cell Significance Index: -1.2000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0436
    Cell Significance Index: -0.5500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0442
    Cell Significance Index: -0.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0449
    Cell Significance Index: -1.2000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0449
    Cell Significance Index: -1.1200
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0451
    Cell Significance Index: -0.5700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0454
    Cell Significance Index: -0.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0463
    Cell Significance Index: -1.1900
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0466
    Cell Significance Index: -0.5900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0475
    Cell Significance Index: -0.4500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0480
    Cell Significance Index: -1.1500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0484
    Cell Significance Index: -0.6100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0543
    Cell Significance Index: -0.8800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0547
    Cell Significance Index: -0.9200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0553
    Cell Significance Index: -0.7100
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0560
    Cell Significance Index: -0.7100
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0570
    Cell Significance Index: -0.6600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0573
    Cell Significance Index: -1.1200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0583
    Cell Significance Index: -1.2600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0583
    Cell Significance Index: -1.2400
  • Cell Name: S cone cell (CL0003050)
    Fold Change: -0.0583
    Cell Significance Index: -0.6800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0590
    Cell Significance Index: -0.8400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0598
    Cell Significance Index: -1.2000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0603
    Cell Significance Index: -1.0400
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0608
    Cell Significance Index: -0.5500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0619
    Cell Significance Index: -0.5900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0620
    Cell Significance Index: -0.8100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0627
    Cell Significance Index: -1.2400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0630
    Cell Significance Index: -1.2400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0630
    Cell Significance Index: -1.3200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0632
    Cell Significance Index: -1.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PCAT4 is a long non-coding RNA (lncRNA) that is approximately 2.5 kilobases in length. It is predominantly expressed in cells of the immune system, including T cells, plasma cells, and B cells. Its expression is also observed in progenitor cells, blood vessel endothelial cells, and various types of cancer cells, including prostate cancer cells. PCAT4 has been shown to be highly stable and resistant to degradation, allowing it to maintain its expression levels over time. **Pathways and Functions:** The mechanisms by which PCAT4 regulates cellular processes are multifaceted and involve several signaling pathways. One of the primary functions of PCAT4 is to modulate the expression of genes involved in cell proliferation and differentiation. It achieves this by interacting with various transcription factors, including those involved in the Wnt/β-catenin and PI3K/AKT pathways. Additionally, PCAT4 has been shown to regulate the expression of genes involved in immune responses, including those involved in the activation and proliferation of immune cells. PCAT4 has also been implicated in the regulation of angiogenesis, the process by which new blood vessels form from pre-existing vessels. Its expression has been shown to be upregulated in response to hypoxia, a condition characterized by low oxygen levels, which is a common feature of many types of cancer. Furthermore, PCAT4 has been shown to regulate the expression of genes involved in the formation of the blood-brain barrier, a critical structure that regulates the exchange of molecules between the brain and the bloodstream. **Clinical Significance:** The clinical significance of PCAT4 is multifaceted and has implications for the diagnosis, treatment, and prognosis of various diseases. In the context of prostate cancer, PCAT4 has been shown to be a valuable biomarker for diagnosis and prognosis. Its expression has been correlated with tumor progression and metastasis, and its downregulation has been associated with improved prognosis. In addition to its role in cancer, PCAT4 has also been implicated in the development and progression of cardiovascular disease. Its expression has been shown to be upregulated in response to hypoxia and has been correlated with the formation of new blood vessels in the heart. Furthermore, PCAT4 has been shown to regulate the expression of genes involved in the formation of the blood-brain barrier, which has implications for the treatment of neurological disorders, including Alzheimer's disease and multiple sclerosis. In conclusion, PCAT4 is a complex gene with multiple functions that are relevant to various diseases, including cancer, cardiovascular disease, and neurological disorders. Further research is needed to fully elucidate the mechanisms by which PCAT4 regulates cellular processes and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.