Details for: FAM170B

Gene ID: 170370

Symbol: FAM170B

Ensembl ID: ENSG00000172538

Description: family with sequence similarity 170 member B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.5932
    Cell Significance Index: 6.9900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.3366
    Cell Significance Index: 4.0200
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.2366
    Cell Significance Index: 3.0300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1480
    Cell Significance Index: 2.1200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1351
    Cell Significance Index: 1.5100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0956
    Cell Significance Index: 1.2100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0667
    Cell Significance Index: 1.3300
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.0561
    Cell Significance Index: 0.5700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0493
    Cell Significance Index: 0.5100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0355
    Cell Significance Index: 0.3500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0138
    Cell Significance Index: 0.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0063
    Cell Significance Index: 0.9200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0038
    Cell Significance Index: 0.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0006
    Cell Significance Index: -0.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0011
    Cell Significance Index: -0.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0011
    Cell Significance Index: -0.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0015
    Cell Significance Index: -0.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0019
    Cell Significance Index: -0.0600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0026
    Cell Significance Index: -0.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0027
    Cell Significance Index: -0.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0028
    Cell Significance Index: -0.3900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0057
    Cell Significance Index: -0.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0065
    Cell Significance Index: -0.7700
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0071
    Cell Significance Index: -0.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0082
    Cell Significance Index: -0.2200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0085
    Cell Significance Index: -0.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0110
    Cell Significance Index: -0.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0121
    Cell Significance Index: -0.3300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0130
    Cell Significance Index: -0.3300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0139
    Cell Significance Index: -0.1800
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0140
    Cell Significance Index: -0.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0148
    Cell Significance Index: -0.4000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0153
    Cell Significance Index: -0.2100
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.0160
    Cell Significance Index: -0.1500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0161
    Cell Significance Index: -0.1900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0167
    Cell Significance Index: -0.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0174
    Cell Significance Index: -0.4700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0175
    Cell Significance Index: -0.2400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0176
    Cell Significance Index: -0.2300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0180
    Cell Significance Index: -0.1900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0191
    Cell Significance Index: -0.2300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0203
    Cell Significance Index: -0.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0206
    Cell Significance Index: -0.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0215
    Cell Significance Index: -0.4700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0218
    Cell Significance Index: -0.2700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0226
    Cell Significance Index: -0.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0227
    Cell Significance Index: -0.3800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0235
    Cell Significance Index: -0.3800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0262
    Cell Significance Index: -0.5300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0263
    Cell Significance Index: -0.5200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0263
    Cell Significance Index: -0.2000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0275
    Cell Significance Index: -0.3000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0278
    Cell Significance Index: -0.3600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0281
    Cell Significance Index: -0.4800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0281
    Cell Significance Index: -0.3800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0284
    Cell Significance Index: -0.4900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0287
    Cell Significance Index: -0.3000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0288
    Cell Significance Index: -0.4100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0298
    Cell Significance Index: -0.5200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0298
    Cell Significance Index: -0.3600
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0299
    Cell Significance Index: -0.3300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0303
    Cell Significance Index: -0.3100
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0306
    Cell Significance Index: -0.3400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0309
    Cell Significance Index: -0.6100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0317
    Cell Significance Index: -0.4000
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0323
    Cell Significance Index: -0.3800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0328
    Cell Significance Index: -0.4800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0330
    Cell Significance Index: -0.6100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0331
    Cell Significance Index: -0.2700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0332
    Cell Significance Index: -0.3600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0340
    Cell Significance Index: -0.4300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0351
    Cell Significance Index: -0.4600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0382
    Cell Significance Index: -0.4300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0382
    Cell Significance Index: -0.5300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0386
    Cell Significance Index: -0.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0389
    Cell Significance Index: -1.1200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0398
    Cell Significance Index: -0.5200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0403
    Cell Significance Index: -0.5300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0408
    Cell Significance Index: -0.4800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0408
    Cell Significance Index: -0.5500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0409
    Cell Significance Index: -0.4400
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.0414
    Cell Significance Index: -0.5000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0415
    Cell Significance Index: -0.5100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0423
    Cell Significance Index: -0.5000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0429
    Cell Significance Index: -0.4600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0434
    Cell Significance Index: -0.6400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0434
    Cell Significance Index: -0.4200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0436
    Cell Significance Index: -0.4400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0444
    Cell Significance Index: -0.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0447
    Cell Significance Index: -0.4300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0451
    Cell Significance Index: -0.6300
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0452
    Cell Significance Index: -0.5300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0454
    Cell Significance Index: -0.5200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0456
    Cell Significance Index: -0.5300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0459
    Cell Significance Index: -0.5800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0460
    Cell Significance Index: -0.6600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0465
    Cell Significance Index: -0.5500
  • Cell Name: basophil (CL0000767)
    Fold Change: -0.0467
    Cell Significance Index: -0.4300
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0469
    Cell Significance Index: -0.5200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0471
    Cell Significance Index: -0.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FAM170B is a non-coding gene, meaning it does not encode a protein. However, its expression in various cell types and its involvement in multiple biological pathways suggest that it may play a regulatory role in cellular processes. The gene is significantly expressed in cells involved in immune responses, such as conventional dendritic cells and granulocyte-monocyte progenitor cells, highlighting its potential role in immune regulation. **Pathways and Functions:** FAM170B is involved in several biological pathways, including: 1. **Acrosomal Vesicle and Fertilization:** FAM170B is expressed in cells involved in fertilization, suggesting its potential role in regulating the acrosome reaction, a critical step in fertilization. 2. **Outer Acrosomal Membrane:** The gene is also involved in the regulation of the outer acrosomal membrane, which is essential for fertilization. 3. **Positive Regulation of Acrosome Reaction:** FAM170B is implicated in the positive regulation of the acrosome reaction, a process crucial for fertilization. 4. **Protein Binding:** The gene is involved in protein binding, which suggests its potential role in regulating protein-protein interactions. 5. **Regulation of Fertilization:** FAM170B is also involved in the regulation of fertilization, a complex process involving multiple cell types and signaling pathways. **Clinical Significance:** The identification of FAM170B as a gene involved in immune regulation and cellular development has significant implications for our understanding of various diseases. For example: 1. **Immune Disorders:** Dysregulation of FAM170B may contribute to immune disorders, such as autoimmune diseases or immunodeficiency disorders. 2. **Fertilization Disorders:** Abnormalities in FAM170B expression may lead to fertilization disorders, such as infertility or miscarriage. 3. **Neurological Disorders:** The gene's expression in neural cells suggests its potential role in neurological disorders, such as Parkinson's disease or Alzheimer's disease. In conclusion, FAM170B is a gene with significant expression in various cell types and involvement in multiple biological pathways. Its role in immune regulation and cellular development highlights its potential significance in various diseases. Further research is needed to fully understand the function of FAM170B and its implications for human health.

Genular Protein ID: 689079661

Symbol: F170B_HUMAN

Name: N/A

UniProtKB Accession Codes:

A6NMN3 Q86WY6 Q8N6K8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 5 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 1 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 STRING 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26179146

Title: FAM170B, a novel acrosomal protein involved in fertilization in mice.

PubMed ID: 26179146

DOI: 10.1002/mrd.22523

Sequence Information:

  • Length: 283
  • Mass: 32092
  • Checksum: 4DEE3A62AF7BE9DF
  • Sequence:
    • MKCYFTDHRG EQSPTDGTTL SLTSPESTEE SVEVFWPGTI QREGSSPRPG PAIPREEGLY 
FAARDRGMRD WSSSPSSESS EYQSYSQYQS CCSCMCDEDN AAPQSVCAFY THVQTVRGVA 
VAWETEAGFE PVTRKPRIHE AQFIKRQRWN GSSFEMASNT DMRWDLEACK SNCSPEPEDI 
DLLECCLQEL REPPDWLVTT NYGVRCVACC RVLPSLDALL EHAQHGIREG FSCQIFFEEM 
LERRRAQGQA HDQQLEEEQS PSDNSECSRP QGEVLSAQQQ EKQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.