Details for: HTR3D

Gene ID: 200909

Symbol: HTR3D

Ensembl ID: ENSG00000186090

Description: 5-hydroxytryptamine receptor 3D

Associated with

  • Neuronal system
    (R-HSA-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-HSA-112314)
  • Transmission across chemical synapses
    (R-HSA-112315)
  • Chemical synaptic transmission
    (GO:0007268)
  • Excitatory extracellular ligand-gated monoatomic ion channel activity
    (GO:0005231)
  • Excitatory postsynaptic potential
    (GO:0060079)
  • Inorganic cation transmembrane transport
    (GO:0098662)
  • Monoatomic ion transmembrane transport
    (GO:0034220)
  • Neuron projection
    (GO:0043005)
  • Plasma membrane
    (GO:0005886)
  • Postsynaptic membrane
    (GO:0045211)
  • Protein binding
    (GO:0005515)
  • Regulation of membrane potential
    (GO:0042391)
  • Serotonin-activated cation-selective channel complex
    (GO:1904602)
  • Serotonin-gated cation-selective signaling pathway
    (GO:0140227)
  • Serotonin-gated monoatomic cation channel activity
    (GO:0022850)
  • Serotonin receptor signaling pathway
    (GO:0007210)
  • Synapse
    (GO:0045202)
  • Transmembrane transporter complex
    (GO:1902495)
  • Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
    (GO:1904315)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1344
    Cell Significance Index: 1.9300
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0869
    Cell Significance Index: 1.0500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0624
    Cell Significance Index: 0.7900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0456
    Cell Significance Index: 0.5300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0367
    Cell Significance Index: 0.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0164
    Cell Significance Index: 0.4400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0110
    Cell Significance Index: 0.2400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0066
    Cell Significance Index: 0.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0066
    Cell Significance Index: 0.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0040
    Cell Significance Index: 0.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0037
    Cell Significance Index: 0.1100
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.0033
    Cell Significance Index: 0.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0026
    Cell Significance Index: 0.4700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0016
    Cell Significance Index: 0.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0015
    Cell Significance Index: 0.4400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0012
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0010
    Cell Significance Index: 0.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0009
    Cell Significance Index: 0.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0002
    Cell Significance Index: 0.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: 0.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0000
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0002
    Cell Significance Index: -0.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0002
    Cell Significance Index: 0.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0004
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0004
    Cell Significance Index: -0.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0005
    Cell Significance Index: -0.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0005
    Cell Significance Index: -0.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0007
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0007
    Cell Significance Index: -0.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0010
    Cell Significance Index: -0.1400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0015
    Cell Significance Index: -0.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0023
    Cell Significance Index: -0.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0030
    Cell Significance Index: -0.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0031
    Cell Significance Index: -0.1100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0032
    Cell Significance Index: -0.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0038
    Cell Significance Index: -0.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0039
    Cell Significance Index: -0.2600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0046
    Cell Significance Index: -0.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0055
    Cell Significance Index: -0.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0064
    Cell Significance Index: -0.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0065
    Cell Significance Index: -0.3400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0066
    Cell Significance Index: -0.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0070
    Cell Significance Index: -0.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0078
    Cell Significance Index: -0.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0078
    Cell Significance Index: -0.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0079
    Cell Significance Index: -0.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0085
    Cell Significance Index: -0.3200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0093
    Cell Significance Index: -0.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0101
    Cell Significance Index: -0.2700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0101
    Cell Significance Index: -0.1000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0102
    Cell Significance Index: -0.0900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0102
    Cell Significance Index: -0.2900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0104
    Cell Significance Index: -0.2600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0105
    Cell Significance Index: -0.1400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0110
    Cell Significance Index: -0.1600
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0111
    Cell Significance Index: -0.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0115
    Cell Significance Index: -0.2500
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0119
    Cell Significance Index: -0.1300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0123
    Cell Significance Index: -0.1800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0125
    Cell Significance Index: -0.2700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0125
    Cell Significance Index: -0.2100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0130
    Cell Significance Index: -0.2600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0130
    Cell Significance Index: -0.2600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0131
    Cell Significance Index: -0.2600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0135
    Cell Significance Index: -0.2000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0137
    Cell Significance Index: -0.2700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0139
    Cell Significance Index: -0.3400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0140
    Cell Significance Index: -0.3400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0143
    Cell Significance Index: -0.2800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0144
    Cell Significance Index: -0.3000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0148
    Cell Significance Index: -0.2000
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0149
    Cell Significance Index: -0.1400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0150
    Cell Significance Index: -0.3600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0152
    Cell Significance Index: -0.3000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0156
    Cell Significance Index: -0.1200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0158
    Cell Significance Index: -0.2700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0160
    Cell Significance Index: -0.2100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0162
    Cell Significance Index: -0.2800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0165
    Cell Significance Index: -0.2000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0167
    Cell Significance Index: -0.2200
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0167
    Cell Significance Index: -0.1900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0168
    Cell Significance Index: -0.1900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0169
    Cell Significance Index: -0.2200
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0169
    Cell Significance Index: -0.1600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0170
    Cell Significance Index: -0.2200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0171
    Cell Significance Index: -0.2900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0176
    Cell Significance Index: -0.2100
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0180
    Cell Significance Index: -0.2000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0184
    Cell Significance Index: -0.1800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0190
    Cell Significance Index: -0.1800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0192
    Cell Significance Index: -0.2400
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0193
    Cell Significance Index: -0.2300
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.0200
    Cell Significance Index: -0.2200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0201
    Cell Significance Index: -0.2600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0202
    Cell Significance Index: -0.2700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0202
    Cell Significance Index: -0.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serotonin receptor subtype:** HTR3D is a subtype of serotonin receptors, specifically classified as a 5-HT3 receptor, which is activated by the neurotransmitter serotonin (5-HT). 2. **Transmembrane protein:** The 5-HT3D receptor is a transmembrane protein, consisting of seven transmembrane domains, which facilitates the binding of serotonin to the receptor. 3. **ligand-gated ion channel:** The 5-HT3D receptor acts as a ligand-gated ion channel, allowing the flow of cations (positively charged ions) across the neuronal membrane, modulating neurotransmitter release and excitability. **Pathways and Functions:** 1. **Neurotransmitter signaling:** The 5-HT3D receptor plays a crucial role in regulating neurotransmitter release and excitability, influencing synaptic transmission and neuronal communication. 2. **Regulation of membrane potential:** The receptor modulates the resting membrane potential of neurons, influencing their excitability and firing patterns. 3. **Chemical synaptic transmission:** The 5-HT3D receptor is involved in chemical synaptic transmission, facilitating the release of neurotransmitters and the transmission of signals across synapses. 4. **Neuroprotection and neurotoxicity:** The receptor has been implicated in neuroprotection and neurotoxicity, with its activation contributing to the release of neurotrophic factors and its inhibition associated with neurodegeneration. **Signaling Pathways:** 1. **Serotonin receptor signaling pathway:** The 5-HT3D receptor is part of the serotonin receptor signaling pathway, which regulates various physiological processes, including mood, appetite, and sleep. 2. **G protein-coupled receptor signaling pathway:** The receptor is also coupled to G proteins, which activate downstream signaling pathways, influencing cellular responses to serotonin. 3. **Ion channel signaling pathway:** The 5-HT3D receptor acts as an ion channel, modulating the flow of cations across the neuronal membrane and influencing cellular excitability. **Clinical Significance:** 1. **Cancer:** The 5-HT3D receptor has been implicated in cancer progression, with its activation contributing to the release of growth factors and the promotion of tumor growth. 2. **Neurological disorders:** The receptor has been associated with various neurological disorders, including Parkinson's disease, Huntington's disease, and multiple sclerosis, where its dysregulation contributes to disease pathology. 3. **Cardiovascular conditions:** The 5-HT3D receptor has been implicated in cardiovascular conditions, such as hypertension and cardiac arrhythmias, where its dysregulation contributes to disease progression. 4. **Psychiatric disorders:** The receptor has been associated with psychiatric disorders, including depression, anxiety, and schizophrenia, where its dysregulation contributes to disease pathology. In conclusion, the HTR3D gene encodes for a serotonin receptor subtype that plays a critical role in various physiological and pathological processes within the nervous system. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and cardiovascular conditions. Further research is necessary to fully understand the function and clinical significance of the 5-HT3D receptor, with potential therapeutic implications for the treatment of these diseases.

Genular Protein ID: 759974763

Symbol: 5HT3D_HUMAN

Name: Serotonin receptor 3D

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12801637

Title: Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E.

PubMed ID: 12801637

DOI: 10.1016/s0378-1119(03)00503-1

PubMed ID: 17392525

Title: Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E.

PubMed ID: 17392525

DOI: 10.1124/mol.106.032144

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 454
  • Mass: 50191
  • Checksum: 8B12F6CC31C4446C
  • Sequence:
  • MQKHSPGPPA LALLSQSLLT TGNGDTLIIN CPGFGQHRVD PAAFQAVFDR KAIGPVTNYS 
    VATHVNISFT LSAIWNCYSR IHTFNCHHAR PWHNQFVQWN PDECGGIKKS GMATENLWLS 
    DVFIEESVDQ TPAGLMASMS IVKATSNTIS QCGWSASANW TPSISPSMDR ARAWRRMSRS 
    FQIHHRTSFR TRREWVLLGI QKRTIKVTVA TNQYEQAIFH VAIRRRCRPS PYVVNFLVPS 
    GILIAIDALS FYLPLESGNC APFKMTVLLG YSVFLLMMND LLPATSTSSH ASLVAPLALM 
    QTPLPAGVYF ALCLSLMVGS LLETIFITHL LHVATTQPLP LPRWLHSLLL HCTGQGRCCP 
    TAPQKGNKGP GLTPTHLPGV KEPEVSAGQM PGPGEAELTG GSEWTRAQRE HEAQKQHSVE 
    LWVQFSHAMD ALLFRLYLLF MASSIITVIC LWNT

Genular Protein ID: 175849036

Symbol: F6WC43_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 279
  • Mass: 30463
  • Checksum: CB896346C137B4BA
  • Sequence:
  • MASMSIVKAT SNTISQCGWS ASANWTPSIS PSMDRGERSP SALSPTQVAI RRRCRPSPYV 
    VNFLVPSGIL IAIDALSFYL PLESGNCAPF KMTVLLGYSV FLLMMNDLLP ATSTSSHASL 
    VRPHPSRDQK RGVYFALCLS LMVGSLLETI FITHLLHVAT TQPLPLPRWL HSLLLHCTGQ 
    GRCCPTAPQK GNKGPGLTPT HLPGVKEPEV SAGQMPGPGE AELTGGSEWT RAQREHEAQK 
    QHSVELWVQF SHAMDALLFR LYLLFMASSI ITVICLWNT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.