Details for: F13B

Gene ID: 2165

Symbol: F13B

Ensembl ID: ENSG00000143278

Description: coagulation factor XIII B chain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 11.0819
    Cell Significance Index: 186.3900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4161
    Cell Significance Index: 34.3000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.3581
    Cell Significance Index: 20.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9327
    Cell Significance Index: 185.0900
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.7828
    Cell Significance Index: 2.0700
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.5447
    Cell Significance Index: 5.0600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4770
    Cell Significance Index: 8.0400
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.2524
    Cell Significance Index: 1.5600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.2193
    Cell Significance Index: 2.1700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1504
    Cell Significance Index: 1.9000
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.0916
    Cell Significance Index: 0.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0592
    Cell Significance Index: 1.5900
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.0382
    Cell Significance Index: 0.2200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0369
    Cell Significance Index: 0.5300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.0199
    Cell Significance Index: 0.2100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0191
    Cell Significance Index: 0.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0167
    Cell Significance Index: 0.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0152
    Cell Significance Index: 0.3300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0133
    Cell Significance Index: 0.1600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0115
    Cell Significance Index: 0.1500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0106
    Cell Significance Index: 0.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0056
    Cell Significance Index: 0.6400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0049
    Cell Significance Index: 0.0700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0038
    Cell Significance Index: 0.0500
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0034
    Cell Significance Index: 0.0400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0007
    Cell Significance Index: 0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0004
    Cell Significance Index: -0.6300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0005
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0007
    Cell Significance Index: -0.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0010
    Cell Significance Index: -0.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0013
    Cell Significance Index: -0.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0014
    Cell Significance Index: -0.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0015
    Cell Significance Index: -0.7000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0026
    Cell Significance Index: -0.0300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0027
    Cell Significance Index: -0.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0049
    Cell Significance Index: -0.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0057
    Cell Significance Index: -0.8300
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0062
    Cell Significance Index: -0.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0062
    Cell Significance Index: -0.6500
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0071
    Cell Significance Index: -0.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0072
    Cell Significance Index: -0.8900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0075
    Cell Significance Index: -0.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0080
    Cell Significance Index: -0.1700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0106
    Cell Significance Index: -0.2700
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0115
    Cell Significance Index: -0.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0116
    Cell Significance Index: -0.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0127
    Cell Significance Index: -0.7100
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.0130
    Cell Significance Index: -0.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0137
    Cell Significance Index: -0.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0142
    Cell Significance Index: -0.6300
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0145
    Cell Significance Index: -0.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0146
    Cell Significance Index: -0.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0151
    Cell Significance Index: -0.5700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0153
    Cell Significance Index: -0.5000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0157
    Cell Significance Index: -0.5000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0160
    Cell Significance Index: -0.3200
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0171
    Cell Significance Index: -0.1800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0180
    Cell Significance Index: -0.2500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0182
    Cell Significance Index: -0.3800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0191
    Cell Significance Index: -0.4800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0196
    Cell Significance Index: -0.4200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0199
    Cell Significance Index: -0.6300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0200
    Cell Significance Index: -0.5000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0205
    Cell Significance Index: -0.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0205
    Cell Significance Index: -0.4000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0216
    Cell Significance Index: -0.3700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0231
    Cell Significance Index: -0.5000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0237
    Cell Significance Index: -0.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0238
    Cell Significance Index: -0.6300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0239
    Cell Significance Index: -0.4800
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0241
    Cell Significance Index: -0.1900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0253
    Cell Significance Index: -0.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0255
    Cell Significance Index: -0.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0256
    Cell Significance Index: -0.6400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0259
    Cell Significance Index: -0.5100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0262
    Cell Significance Index: -0.3000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0265
    Cell Significance Index: -0.4500
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0270
    Cell Significance Index: -0.3700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0273
    Cell Significance Index: -0.5400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0274
    Cell Significance Index: -0.2600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0285
    Cell Significance Index: -0.3800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0291
    Cell Significance Index: -0.7100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0297
    Cell Significance Index: -0.5800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0298
    Cell Significance Index: -0.4100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0300
    Cell Significance Index: -0.3400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0319
    Cell Significance Index: -0.4800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0327
    Cell Significance Index: -0.4200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0330
    Cell Significance Index: -0.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0330
    Cell Significance Index: -0.6900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0332
    Cell Significance Index: -0.7100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0336
    Cell Significance Index: -0.5800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0338
    Cell Significance Index: -0.4500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0345
    Cell Significance Index: -0.5100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0352
    Cell Significance Index: -0.5700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0352
    Cell Significance Index: -0.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural homology:** F13B shares structural homology with coagulation factor XIII A (F13A), its activated form, which is essential for cross-linking fibrin clots. 2. **Post-translational modification:** F13B undergoes a series of post-translational modifications, including proteolytic cleavage and disulfide bond formation, to generate its active form. 3. **Cellular localization:** F13B is primarily expressed in endothelial cells, epithelial cells, and hepatocytes, suggesting its involvement in maintaining tissue integrity and regulating cellular processes. **Pathways and Functions:** 1. **Blood coagulation:** F13B plays a central role in the coagulation cascade, specifically in the formation and stabilization of fibrin clots. Its activated form (F13A) cross-links fibrin molecules, creating a more robust and resistant clot. 2. **Fibrin clot formation:** F13B is essential for the formation of fibrin clots, which are critical for hemostasis, wound healing, and maintaining tissue integrity. 3. **Hemostasis:** F13B contributes to the regulation of hemostasis by stabilizing blood clots and preventing excessive bleeding. 4. **Cellular processes:** F13B is involved in various cellular processes, including cell adhesion, migration, and differentiation, highlighting its broader functional scope. **Clinical Significance:** 1. **Thrombotic disorders:** Mutations or deficiencies in F13B have been associated with thrombotic disorders, such as thrombosis, venous thromboembolism, and arterial thrombosis. 2. **Hemophilia:** F13B is involved in the regulation of hemostasis, and its deficiency has been linked to hemophilia, a bleeding disorder characterized by impaired coagulation. 3. **Cancer:** F13B has been implicated in cancer progression, where its dysregulation can contribute to tumor growth, metastasis, and resistance to therapy. 4. **Inflammatory diseases:** F13B has been shown to play a role in inflammatory diseases, such as atherosclerosis and rheumatoid arthritis, where its dysregulation can contribute to tissue damage and disease progression. In conclusion, coagulation factor XIII B chain (F13B) is a multifunctional protein that plays a critical role in hemostasis, fibrin clot formation, and cellular processes. Its dysregulation has been implicated in various clinical disorders, highlighting the importance of further research into the mechanisms underlying its functions and its potential therapeutic applications.

Genular Protein ID: 772502726

Symbol: F13B_HUMAN

Name: Coagulation factor XIII B chain

UniProtKB Accession Codes:

P05160 A8K3E5 Q5VYL5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2271707

Title: Nucleotide sequence of the gene for the b subunit of human factor XIII.

PubMed ID: 2271707

DOI: 10.1021/bi00503a007

PubMed ID: 3021194

Title: Amino acid sequence of the b subunit of human factor XIII, a protein composed of ten repetitive segments.

PubMed ID: 3021194

DOI: 10.1021/bi00364a027

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 2339067

Title: Complete cDNA sequence encoding the B subunit of human factor XIII.

PubMed ID: 2339067

DOI: 10.1093/nar/18.9.2817

PubMed ID: 4405643

Title: Human Factor XIII from plasma and platelets. Molecular weights, subunit structures, proteolytic activation, and cross-linking of fibrinogen and fibrin.

PubMed ID: 4405643

DOI: 10.1016/s0021-9258(19)44312-3

PubMed ID: 11313256

Title: Truncated mutant B subunit for factor XIII causes its deficiency due to impaired intracellular transportation.

PubMed ID: 11313256

DOI: 10.1182/blood.v97.9.2667

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21742792

Title: Factor XIII: a coagulation factor with multiple plasmatic and cellular functions.

PubMed ID: 21742792

DOI: 10.1152/physrev.00016.2010

PubMed ID: 8324218

Title: Two genetic defects in a patient with complete deficiency of the b-subunit for coagulation factor XIII.

PubMed ID: 8324218

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 20331752

Title: Mutations affecting disulphide bonds contribute to a fairly common prevalence of F13B gene defects: results of a genetic study in 14 families with factor XIII B deficiency.

PubMed ID: 20331752

DOI: 10.1111/j.1365-2516.2010.02207.x

PubMed ID: 26247044

Title: Structural and functional influences of coagulation factor XIII subunit B heterozygous missense mutants.

PubMed ID: 26247044

DOI: 10.1002/mgg3.138

Sequence Information:

  • Length: 661
  • Mass: 75511
  • Checksum: 57A2FD2A0E35B812
  • Sequence:
    • MRLKNLTFII ILIISGELYA EEKPCGFPHV ENGRIAQYYY TFKSFYFPMS IDKKLSFFCL 
AGYTTESGRQ EEQTTCTTEG WSPEPRCFKK CTKPDLSNGY ISDVKLLYKI QENMRYGCAS 
GYKTTGGKDE EVVQCLSDGW SSQPTCRKEH ETCLAPELYN GNYSTTQKTF KVKDKVQYEC 
ATGYYTAGGK KTEEVECLTY GWSLTPKCTK LKCSSLRLIE NGYFHPVKQT YEEGDVVQFF 
CHENYYLSGS DLIQCYNFGW YPESPVCEGR RNRCPPPPLP INSKIQTHST TYRHGEIVHI 
ECELNFEIHG SAEIRCEDGK WTEPPKCIEG QEKVACEEPP FIENGAANLH SKIYYNGDKV 
TYACKSGYLL HGSNEITCNR GKWTLPPECV ENNENCKHPP VVMNGAVADG ILASYATGSS 
VEYRCNEYYL LRGSKISRCE QGKWSSPPVC LEPCTVNVDY MNRNNIEMKW KYEGKVLHGD 
LIDFVCKQGY DLSPLTPLSE LSVQCNRGEV KYPLCTRKES KGMCTSPPLI KHGVIISSTV 
DTYENGSSVE YRCFDHHFLE GSREAYCLDG MWTTPPLCLE PCTLSFTEME KNNLLLKWDF 
DNRPHILHGE YIEFICRGDT YPAELYITGS ILRMQCDRGQ LKYPRCIPRQ STLSYQEPLR 
T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.