Details for: F13B

Gene ID: 2165

Symbol: F13B

Ensembl ID: ENSG00000143278

Description: coagulation factor XIII B chain

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.38
    Marker Score: 2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1176
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.57
    Marker Score: 1561
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 861
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 491
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.16
    Marker Score: 7432
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4819
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 507
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.09
    Marker Score: 4721
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.05
    Marker Score: 3454
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.03
    Marker Score: 5526
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48055
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 513
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.98
    Marker Score: 670
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 378
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 330
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.88
    Marker Score: 5356
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 495
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.81
    Marker Score: 476
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1175
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 467
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.7
    Marker Score: 781
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.7
    Marker Score: 1320
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.66
    Marker Score: 248
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 522
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.61
    Marker Score: 592
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 177.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.47
    Marker Score: 175
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.46
    Marker Score: 927
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.43
    Marker Score: 411
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.41
    Marker Score: 440
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.37
    Marker Score: 222
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.35
    Marker Score: 545
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.31
    Marker Score: 330
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.31
    Marker Score: 536
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.31
    Marker Score: 638.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.27
    Marker Score: 4283
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.24
    Marker Score: 213
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.2
    Marker Score: 198
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.19
    Marker Score: 88
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.18
    Marker Score: 203
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.18
    Marker Score: 85
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.14
    Marker Score: 43
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 53
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.11
    Marker Score: 60
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.11
    Marker Score: 132
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.11
    Marker Score: 70
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.1
    Marker Score: 21
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.09
    Marker Score: 62
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.08
    Marker Score: 43.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.07
    Marker Score: 55
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.07
    Marker Score: 428
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.06
    Marker Score: 118
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.06
    Marker Score: 149
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.06
    Marker Score: 56
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.05
    Marker Score: 28.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.04
    Marker Score: 16.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.04
    Marker Score: 79
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.04
    Marker Score: 111
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.04
    Marker Score: 142.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.04
    Marker Score: 17.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.03
    Marker Score: 34
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.03
    Marker Score: 17

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Other Information

**Key characteristics:** - F13B is a glycoprotein with a molecular weight of approximately 500 kDa. - It is produced by a single gene, F13B, which is located on chromosome 15q21.1. - F13B is a member of the coagulation factor family, which is responsible for blood clot formation. **Pathways and functions:** - F13B is involved in the coagulation cascade, a complex series of reactions that lead to blood clot formation. - It is a key factor in the formation of fibrin clots, which are essential for hemostasis and wound healing. - F13B is also involved in the regulation of blood pressure. - It acts as a cofactor for factor IX, which is another coagulation factor. - It is also involved in the regulation of inflammation and thrombosis. **Clinical significance:** - Mutations in the F13B gene have been linked to several clotting disorders, including hemophilia A and von Willebrand disease. - These disorders are caused by mutations in the F13A gene, which encodes the F13A protein. - F13B mutations can also lead to bleeding disorders, such as von Willebrand disease. - F13B is a promising target for the treatment of clotting disorders.

Genular Protein ID: 772502726

Symbol: F13B_HUMAN

Name: Coagulation factor XIII B chain

UniProtKB Accession Codes:

P05160 A8K3E5 Q5VYL5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2271707

Title: Nucleotide sequence of the gene for the b subunit of human factor XIII.

PubMed ID: 2271707

DOI: 10.1021/bi00503a007

PubMed ID: 3021194

Title: Amino acid sequence of the b subunit of human factor XIII, a protein composed of ten repetitive segments.

PubMed ID: 3021194

DOI: 10.1021/bi00364a027

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 2339067

Title: Complete cDNA sequence encoding the B subunit of human factor XIII.

PubMed ID: 2339067

DOI: 10.1093/nar/18.9.2817

PubMed ID: 4405643

Title: Human Factor XIII from plasma and platelets. Molecular weights, subunit structures, proteolytic activation, and cross-linking of fibrinogen and fibrin.

PubMed ID: 4405643

DOI: 10.1016/s0021-9258(19)44312-3

PubMed ID: 11313256

Title: Truncated mutant B subunit for factor XIII causes its deficiency due to impaired intracellular transportation.

PubMed ID: 11313256

DOI: 10.1182/blood.v97.9.2667

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21742792

Title: Factor XIII: a coagulation factor with multiple plasmatic and cellular functions.

PubMed ID: 21742792

DOI: 10.1152/physrev.00016.2010

PubMed ID: 8324218

Title: Two genetic defects in a patient with complete deficiency of the b-subunit for coagulation factor XIII.

PubMed ID: 8324218

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 20331752

Title: Mutations affecting disulphide bonds contribute to a fairly common prevalence of F13B gene defects: results of a genetic study in 14 families with factor XIII B deficiency.

PubMed ID: 20331752

DOI: 10.1111/j.1365-2516.2010.02207.x

PubMed ID: 26247044

Title: Structural and functional influences of coagulation factor XIII subunit B heterozygous missense mutants.

PubMed ID: 26247044

DOI: 10.1002/mgg3.138

Sequence Information:

  • Length: 661
  • Mass: 75511
  • Checksum: 57A2FD2A0E35B812
  • Sequence:
    • MRLKNLTFII ILIISGELYA EEKPCGFPHV ENGRIAQYYY TFKSFYFPMS IDKKLSFFCL 
AGYTTESGRQ EEQTTCTTEG WSPEPRCFKK CTKPDLSNGY ISDVKLLYKI QENMRYGCAS 
GYKTTGGKDE EVVQCLSDGW SSQPTCRKEH ETCLAPELYN GNYSTTQKTF KVKDKVQYEC 
ATGYYTAGGK KTEEVECLTY GWSLTPKCTK LKCSSLRLIE NGYFHPVKQT YEEGDVVQFF 
CHENYYLSGS DLIQCYNFGW YPESPVCEGR RNRCPPPPLP INSKIQTHST TYRHGEIVHI 
ECELNFEIHG SAEIRCEDGK WTEPPKCIEG QEKVACEEPP FIENGAANLH SKIYYNGDKV 
TYACKSGYLL HGSNEITCNR GKWTLPPECV ENNENCKHPP VVMNGAVADG ILASYATGSS 
VEYRCNEYYL LRGSKISRCE QGKWSSPPVC LEPCTVNVDY MNRNNIEMKW KYEGKVLHGD 
LIDFVCKQGY DLSPLTPLSE LSVQCNRGEV KYPLCTRKES KGMCTSPPLI KHGVIISSTV 
DTYENGSSVE YRCFDHHFLE GSREAYCLDG MWTTPPLCLE PCTLSFTEME KNNLLLKWDF 
DNRPHILHGE YIEFICRGDT YPAELYITGS ILRMQCDRGQ LKYPRCIPRQ STLSYQEPLR 
T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.