Details for: FCGR2A

Gene ID: 2212

Symbol: FCGR2A

Ensembl ID: ENSG00000143226

Description: Fc gamma receptor IIa

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.22
    Marker Score: 3679
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.51
    Marker Score: 4891
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.35
    Marker Score: 131150
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.27
    Marker Score: 58133
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.2
    Marker Score: 898
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.01
    Marker Score: 1107
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.94
    Marker Score: 11774
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.89
    Marker Score: 4901
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.8
    Marker Score: 4490
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.7
    Marker Score: 4099
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.65
    Marker Score: 6837.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.64
    Marker Score: 3336
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.61
    Marker Score: 1608
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1155
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.5
    Marker Score: 1817
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.46
    Marker Score: 1457
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.4
    Marker Score: 582
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.24
    Marker Score: 842
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.15
    Marker Score: 1170
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4793
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.12
    Marker Score: 1246
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.09
    Marker Score: 2074
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.04
    Marker Score: 1901
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.04
    Marker Score: 260
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.02
    Marker Score: 368
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1
    Marker Score: 1051
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71794
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48019
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.99
    Marker Score: 11498
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 498
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5284
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 365
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.88
    Marker Score: 582
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.88
    Marker Score: 13727
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.85
    Marker Score: 357
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.85
    Marker Score: 437
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.84
    Marker Score: 365
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.83
    Marker Score: 1084
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 596
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1252
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1186
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 672
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.7
    Marker Score: 699
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.68
    Marker Score: 187
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.66
    Marker Score: 200
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.66
    Marker Score: 3458
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.64
    Marker Score: 306
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.61
    Marker Score: 195
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.6
    Marker Score: 208
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.6
    Marker Score: 364
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.58
    Marker Score: 289
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.57
    Marker Score: 255
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.57
    Marker Score: 340
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 354.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.52
    Marker Score: 333
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.52
    Marker Score: 301
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.51
    Marker Score: 405
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.5
    Marker Score: 209
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5
    Marker Score: 354
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.48
    Marker Score: 331
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.48
    Marker Score: 330
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.43
    Marker Score: 190
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.42
    Marker Score: 278
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.41
    Marker Score: 143
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.39
    Marker Score: 245
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.38
    Marker Score: 106
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.38
    Marker Score: 119
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.36
    Marker Score: 95
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.36
    Marker Score: 2320
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.35
    Marker Score: 213
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.35
    Marker Score: 337
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.35
    Marker Score: 186
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.34
    Marker Score: 114
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.34
    Marker Score: 121
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.34
    Marker Score: 365
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.33
    Marker Score: 193
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.33
    Marker Score: 162
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.32
    Marker Score: 147
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.32
    Marker Score: 735
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.32
    Marker Score: 160
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.31
    Marker Score: 164
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.3
    Marker Score: 89
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.29
    Marker Score: 91
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.29
    Marker Score: 144
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.28
    Marker Score: 212
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.28
    Marker Score: 55
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.28
    Marker Score: 166
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.27
    Marker Score: 82
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.27
    Marker Score: 353
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.26
    Marker Score: 145
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 156

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Other Information

**Key characteristics:** * It is a member of the Fc gamma receptor family, which are expressed on the surface of immune cells. * It is a cell surface receptor that is responsible for triggering intracellular signaling pathways involved in the immune response. * It is expressed in high levels on macrophages, which are professional phagocytes that play a crucial role in the immune response against pathogens. * It is also expressed on other immune cells, including monocytes, dendritic cells, and classical and non-classical monocyte subsets. **Pathways and functions:** * Activation of FcGR2A is triggered by the binding of its ligand, IgG antibodies. * This binding activates the Fcgamma receptor, leading to the recruitment of the immune complex into the cell. * The activated FcGR2A then recruits and activates the adaptor protein FcGR3a, which in turn activates the intracellular signaling pathway. * This pathway involves the phosphorylation of various targets, including those involved in the regulation of actin dynamics, cell signaling, and apoptosis. * The activated FcGR2A also plays a role in the regulation of inflammation and immune responses through the production of inflammatory cytokines and chemokines. **Clinical significance:** * Mutations in the FCGR2A gene have been linked to an increased risk of leishmaniasis, a chronic infectious disease caused by the protozoan parasite Leishmania parasites. * In leishmaniasis, the activation of FcGR2A on macrophages and dendritic cells is crucial for the inflammatory response against the parasite. * Targeting FcGR2A signaling has emerged as a potential therapeutic strategy for leishmaniasis, as it can inhibit the inflammatory response and prevent disease progression. **Additional notes:** * The FCGR2A gene is also involved in other immune responses, including the regulation of allergic responses and autoimmune disorders. * It is a promising target for the development of novel therapeutic interventions for inflammatory diseases, including cancer and autoimmune disorders.

Genular Protein ID: 1311819160

Symbol: FCG2A_HUMAN

Name: Low affinity immunoglobulin gamma Fc region receptor II-a

UniProtKB Accession Codes:

P12318 Q8WUN1 Q8WW64

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 ELM 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 6 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2824655

Title: Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII).

PubMed ID: 2824655

DOI: 10.1084/jem.166.6.1668

PubMed ID: 2529342

Title: Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes.

PubMed ID: 2529342

DOI: 10.1084/jem.170.4.1369

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2965389

Title: Molecular cloning of a human immunoglobulin G Fc receptor.

PubMed ID: 2965389

DOI: 10.1073/pnas.85.7.2240

PubMed ID: 3402431

Title: Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning.

PubMed ID: 3402431

DOI: 10.1002/j.1460-2075.1988.tb02913.x

PubMed ID: 2526077

Title: Identification of multiple isoforms of the low-affinity human IgG Fc receptor.

PubMed ID: 2526077

DOI: 10.1007/bf02421463

PubMed ID: 10397151

Title: Biochemical analysis and crystallisation of Fc gamma RIIa, the low affinity receptor for IgG.

PubMed ID: 10397151

DOI: 10.1016/s0165-2478(99)00025-5

PubMed ID: 8327512

Title: Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils.

PubMed ID: 8327512

DOI: 10.1073/pnas.90.13.6305

PubMed ID: 8132624

Title: Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells.

PubMed ID: 8132624

DOI: 10.1016/s0021-9258(17)37050-3

PubMed ID: 8756631

Title: In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.

PubMed ID: 8756631

DOI: 10.1128/mcb.16.9.4735

PubMed ID: 11711607

Title: Effector function activities of a panel of mutants of a broadly neutralizing antibody against human immunodeficiency virus type 1.

PubMed ID: 11711607

DOI: 10.1128/jvi.75.24.12161-12168.2001

PubMed ID: 12690104

Title: SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signaling.

PubMed ID: 12690104

DOI: 10.1074/jbc.m302907200

PubMed ID: 10331870

Title: Crystal structure of the human leukocyte Fc receptor, Fc gammaRIIa.

PubMed ID: 10331870

DOI: 10.1038/8241

PubMed ID: 11397093

Title: Molecular basis for immune complex recognition: a comparison of Fc-receptor structures.

PubMed ID: 11397093

DOI: 10.1006/jmbi.2001.4670

PubMed ID: 19011614

Title: Structural recognition and functional activation of FcgammaR by innate pentraxins.

PubMed ID: 19011614

DOI: 10.1038/nature07468

PubMed ID: 8636449

Title: Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans.

PubMed ID: 8636449

DOI: 10.1172/jci118552

Sequence Information:

  • Length: 317
  • Mass: 35001
  • Checksum: 07F73F3BB282DFF6
  • Sequence:
    • MTMETQMSQN VCPRNLWLLQ PLTVLLLLAS ADSQAAAPPK AVLKLEPPWI NVLQEDSVTL 
TCQGARSPES DSIQWFHNGN LIPTHTQPSY RFKANNNDSG EYTCQTGQTS LSDPVHLTVL 
SEWLVLQTPH LEFQEGETIM LRCHSWKDKP LVKVTFFQNG KSQKFSHLDP TFSIPQANHS 
HSGDYHCTGN IGYTLFSSKP VTITVQVPSM GSSSPMGIIV AVVIATAVAA IVAAVVALIY 
CRKKRISANS TDPVKAAQFE PPGRQMIAIR KRQLEETNND YETADGGYMT LNPRAPTDDD 
KNIYLTLPPN DHVNSNN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.