Details for: CELA3B

Gene ID: 23436

Symbol: CELA3B

Ensembl ID: ENSG00000219073

Description: chymotrypsin like elastase 3B

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 14.72
    Marker Score: 5,719
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 6.21
    Marker Score: 3,501
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 5.04
    Marker Score: 3,553
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.57
    Marker Score: 5,422
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.22
    Marker Score: 2,236
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.87
    Marker Score: 2,083
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.65
    Marker Score: 1,620
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,161
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.42
    Marker Score: 2,684
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.35
    Marker Score: 851
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.3
    Marker Score: 293
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 845
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.17
    Marker Score: 1,219
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1
    Marker Score: 415
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,813
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,037
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.99
    Marker Score: 15,505
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,344
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.93
    Marker Score: 428
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,288
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 322
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.8
    Marker Score: 465
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.76
    Marker Score: 332
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 456
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,975
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.69
    Marker Score: 149
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 452
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.56
    Marker Score: 2,968
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.51
    Marker Score: 571
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.5
    Marker Score: 224
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.5
    Marker Score: 491
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 273
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.45
    Marker Score: 728
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.38
    Marker Score: 773
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.38
    Marker Score: 181
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.34
    Marker Score: 141
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.31
    Marker Score: 296
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.31
    Marker Score: 186
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.25
    Marker Score: 62
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.24
    Marker Score: 107
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.24
    Marker Score: 408
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.22
    Marker Score: 463
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.21
    Marker Score: 55
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.17
    Marker Score: 38
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.17
    Marker Score: 57
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.16
    Marker Score: 65
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.15
    Marker Score: 245
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.15
    Marker Score: 728
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.14
    Marker Score: 37
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.14
    Marker Score: 37
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.14
    Marker Score: 37
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.13
    Marker Score: 35
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.13
    Marker Score: 32
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.13
    Marker Score: 37
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.13
    Marker Score: 36
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.12
    Marker Score: 36
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.12
    Marker Score: 36
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.12
    Marker Score: 35
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.12
    Marker Score: 69
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.12
    Marker Score: 105
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.12
    Marker Score: 36
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.12
    Marker Score: 37
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.11
    Marker Score: 94
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.11
    Marker Score: 38
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.1
    Marker Score: 33
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.1
    Marker Score: 37
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1
    Marker Score: 97
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.1
    Marker Score: 51
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.1
    Marker Score: 44
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.09
    Marker Score: 38
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.09
    Marker Score: 105
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.09
    Marker Score: 55
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.09
    Marker Score: 584
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.09
    Marker Score: 38

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Homology:** CELA3B shares structural homology with other chymotrypsin-like elastases, such as elastase, cathepsin G, and tryptase. This similarity indicates that CELA3B may possess similar enzymatic properties and functions. 2. **Serine-Type Endopeptidase Activity:** CELA3B exhibits serine-type endopeptidase activity, which involves the hydrolysis of peptide bonds in proteins. This activity is crucial for various cellular processes, including protein degradation, signaling, and cell migration. 3. **Extracellular Space Regulation:** CELA3B is involved in regulating the extracellular space by degrading matrix proteins and regulating the activity of other proteases. 4. **Cell Signaling:** CELA3B may also participate in cell signaling pathways, influencing cell growth, differentiation, and survival. **Pathways and Functions:** 1. **Proteolysis:** CELA3B is involved in the degradation of various proteins, including matrix proteins, growth factors, and cytokines. This process is essential for tissue remodeling, cell migration, and wound healing. 2. **Extracellular Space Regulation:** CELA3B regulates the extracellular space by degrading matrix proteins, such as collagen and elastin. This process is crucial for maintaining tissue structure and function. 3. **Cell Signaling:** CELA3B may participate in cell signaling pathways, influencing cell growth, differentiation, and survival. For example, it can regulate the activity of growth factors and cytokines. 4. **Inflammation:** CELA3B has been implicated in inflammatory processes, where it can degrade pro-inflammatory cytokines and chemokines, reducing inflammation and tissue damage. **Clinical Significance:** CEL A3B has been implicated in various diseases, including: 1. **Pancreatitis:** CELA3B has been associated with pancreatitis, a condition characterized by inflammation of the pancreas. Elevated levels of CELA3B have been observed in patients with pancreatitis, suggesting its involvement in the pathogenesis of the disease. 2. **Cardiovascular Disease:** CELA3B has been implicated in cardiovascular disease, where it can degrade matrix proteins and regulate inflammation. 3. **Cancer:** CELA3B has been associated with cancer, where it can degrade matrix proteins and regulate cell growth and differentiation. In conclusion, CELA3B is a serine-type endopeptidase enzyme that plays a crucial role in various physiological processes, including proteolysis, extracellular space regulation, and cell signaling. Its expression in multiple cell types and involvement in various diseases make it an important target for therapeutic interventions. Further studies are needed to elucidate the mechanisms of CELA3B and its clinical significance in human disease.

Genular Protein ID: 886599566

Symbol: CEL3B_HUMAN

Name: Chymotrypsin-like elastase family member 3B

UniProtKB Accession Codes:

P08861 B2RE44 P11423 Q5VU28 Q5VU29 Q5VU30

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2826474

Title: Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning.

PubMed ID: 2826474

DOI: 10.1016/s0021-9258(19)57291-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3477287

Title: Primary structure of human pancreatic protease E determined by sequence analysis of the cloned mRNA.

PubMed ID: 3477287

DOI: 10.1021/bi00386a030

PubMed ID: 2675835

Title: Generation of a subunit III-like protein by autolysis of human and porcine proproteinase E in a binary complex with procarboxypeptidase A.

PubMed ID: 2675835

DOI: 10.1016/0006-291x(89)91104-2

PubMed ID: 3178837

Title: Characterization of two glycoproteins of human pancreatic juice: P35, a truncated protease E and P19, precursor of protein X.

PubMed ID: 3178837

DOI: 10.1016/s0006-291x(88)80842-8

PubMed ID: 2753124

Title: Identification of a procarboxypeptidase A-truncated protease E binary complex in human pancreatic juice.

PubMed ID: 2753124

DOI: 10.1016/0014-5793(89)80712-4

PubMed ID: 2737288

Title: Localization and characterization of the glycosylation site of human pancreatic elastase 1.

PubMed ID: 2737288

DOI: 10.1016/0014-5793(89)80640-4

PubMed ID: 10620133

Title: Human elastase 1: evidence for expression in the skin and the identification of a frequent frameshift polymorphism.

PubMed ID: 10620133

DOI: 10.1046/j.1523-1747.2000.00825.x

Sequence Information:

  • Length: 270
  • Mass: 29263
  • Checksum: F738C5F8F5195D8C
  • Sequence:
    • MMLRLLSSLL LVAVASGYGP PSSRPSSRVV NGEDAVPYSW PWQVSLQYEK SGSFYHTCGG 
SLIAPDWVVT AGHCISSSRT YQVVLGEYDR AVKEGPEQVI PINSGDLFVH PLWNRSCVAC 
GNDIALIKLS RSAQLGDAVQ LASLPPAGDI LPNETPCYIT GWGRLYTNGP LPDKLQEALL 
PVVDYEHCSR WNWWGSSVKK TMVCAGGDIR SGCNGDSGGP LNCPTEDGGW QVHGVTSFVS 
AFGCNTRRKP TVFTRVSAFI DWIEETIASH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.