Details for: GABRR1

Gene ID: 2569

Symbol: GABRR1

Ensembl ID: ENSG00000146276

Description: gamma-aminobutyric acid type A receptor subunit rho1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 5.6
    Marker Score: 3103
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.17
    Marker Score: 1135.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.96
    Marker Score: 2709
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.33
    Marker Score: 757
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.19
    Marker Score: 626
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71810
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48034
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.98
    Marker Score: 6488
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.9
    Marker Score: 377
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.8
    Marker Score: 529
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.76
    Marker Score: 537
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.74
    Marker Score: 333
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.73
    Marker Score: 1382
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 423
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.56
    Marker Score: 1156
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.56
    Marker Score: 8731
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.54
    Marker Score: 1101
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.45
    Marker Score: 263
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.43
    Marker Score: 137
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.43
    Marker Score: 251
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.39
    Marker Score: 141.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.38
    Marker Score: 844.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.38
    Marker Score: 154
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.36
    Marker Score: 219
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.34
    Marker Score: 383
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.31
    Marker Score: 1302
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.31
    Marker Score: 492
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.31
    Marker Score: 125
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.3
    Marker Score: 143
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.3
    Marker Score: 86
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.28
    Marker Score: 164
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.27
    Marker Score: 161
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.27
    Marker Score: 362
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.27
    Marker Score: 3557
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.26
    Marker Score: 316
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.26
    Marker Score: 81
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.21
    Marker Score: 102
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.21
    Marker Score: 744
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2
    Marker Score: 1193
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.2
    Marker Score: 572
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.19
    Marker Score: 38
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.19
    Marker Score: 48
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.18
    Marker Score: 225
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.18
    Marker Score: 122
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.18
    Marker Score: 39
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.18
    Marker Score: 43
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.17
    Marker Score: 166
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.17
    Marker Score: 691
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.17
    Marker Score: 150
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.16
    Marker Score: 183
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.16
    Marker Score: 158
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.16
    Marker Score: 553
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.16
    Marker Score: 229
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.16
    Marker Score: 381
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.16
    Marker Score: 51
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.16
    Marker Score: 71.5
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.15
    Marker Score: 450
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.15
    Marker Score: 38
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.15
    Marker Score: 38
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.15
    Marker Score: 43
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.14
    Marker Score: 66
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.14
    Marker Score: 40
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.14
    Marker Score: 80
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.14
    Marker Score: 43
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.14
    Marker Score: 39
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.13
    Marker Score: 154
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.13
    Marker Score: 37
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.13
    Marker Score: 130.5
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.13
    Marker Score: 42
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.13
    Marker Score: 140
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.13
    Marker Score: 40
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.12
    Marker Score: 40
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.12
    Marker Score: 288
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.12
    Marker Score: 509
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 54
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.12
    Marker Score: 35
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.12
    Marker Score: 143
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.12
    Marker Score: 35
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.12
    Marker Score: 100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.11
    Marker Score: 40
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.11
    Marker Score: 125
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.11
    Marker Score: 284
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.11
    Marker Score: 42

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Other Information

**Key characteristics:** - GBRR1 is a type of G protein-coupled receptor (GPCR). - It is expressed in a wide range of cell types, including neurons, astrocytes, and immune cells. - GBRR1 is a key modulator of synaptic transmission, influencing the opening and closing of chloride ion channels in presynaptic neurons. - It is also involved in regulating neuronal excitability, learning and memory, and epilepsy. **Pathways and functions:** - GBRR1 is a ligand-gated ion channel that opens upon binding of GABA. - This opens chloride channels in the presynaptic terminal, leading to a decrease in the resting membrane potential and an increase in the likelihood of action potential generation. - The activation of GBRR1 also modulates the activity of other ion channels and signaling pathways, affecting synaptic plasticity and neuronal excitability. **Clinical significance:** - Mutations in the GABRR1 gene have been linked to several neurological disorders, including epilepsy, anxiety, depression, and schizophrenia. - Drugs that target GBRR1 are being investigated as potential treatments for these disorders. - Understanding the role of GBRR1 in synaptic transmission and neuronal function provides insights into the development of novel therapeutic strategies for neurological diseases. **Additional notes:** - GBRR1 is a well-characterized receptor, with a well-defined structure and function. - It is a key target for neurotransmitter research, and its dysregulation is implicated in several neurological disorders. - GBRR1 is a promising drug target for treating neurological diseases, but further research is needed to develop effective therapeutic agents.

Genular Protein ID: 4204931018

Symbol: GBRR1_HUMAN

Name: Gamma-aminobutyric acid receptor subunit rho-1

UniProtKB Accession Codes:

P24046 A1L401 B4DJK8 B4DQT5 B7ZBQ7 Q9BX06

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 6 EMDB 5 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRINTS 4 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 5 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1849271

Title: Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina.

PubMed ID: 1849271

DOI: 10.1073/pnas.88.7.2673

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 479
  • Mass: 55883
  • Checksum: C0C1985F16C18231
  • Sequence:
    • MLAVPNMRFG IFLLWWGWVL ATESRMHWPG REVHEMSKKG RPQRQRREVH EDAHKQVSPI 
LRRSPDITKS PLTKSEQLLR IDDHDFSMRP GFGGPAIPVG VDVQVESLDS ISEVDMDFTM 
TLYLRHYWKD ERLSFPSTNN LSMTFDGRLV KKIWVPDMFF VHSKRSFIHD TTTDNVMLRV 
QPDGKVLYSL RVTVTAMCNM DFSRFPLDTQ TCSLEIESYA YTEDDLMLYW KKGNDSLKTD 
ERISLSQFLI QEFHTTTKLA FYSSTGWYNR LYINFTLRRH IFFFLLQTYF PATLMVMLSW 
VSFWIDRRAV PARVPLGITT VLTMSTIITG VNASMPRVSY IKAVDIYLWV SFVFVFLSVL 
EYAAVNYLTT VQERKEQKLR EKLPCTSGLP PPRTAMLDGN YSDGEVNDLD NYMPENGEKP 
DRMMVQLTLA SERSSPQRKS QRSSYVSMRI DTHAIDKYSR IIFPAAYILF NLIYWSIFS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.