Details for: GFRA2

Gene ID: 2675

Symbol: GFRA2

Ensembl ID: ENSG00000168546

Description: GDNF family receptor alpha 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 5.15
    Marker Score: 4123
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.92
    Marker Score: 3640
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.63
    Marker Score: 3378
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169209
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3
    Marker Score: 80246
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.28
    Marker Score: 4953
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19755
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.23
    Marker Score: 1891
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.21
    Marker Score: 407
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.18
    Marker Score: 1181
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.16
    Marker Score: 1403
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.16
    Marker Score: 1300
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.05
    Marker Score: 663.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.98
    Marker Score: 589
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.96
    Marker Score: 3227
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.96
    Marker Score: 309
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5343
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.93
    Marker Score: 8872
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9
    Marker Score: 30469
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.89
    Marker Score: 2090
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.84
    Marker Score: 378
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.81
    Marker Score: 258
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 621
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.81
    Marker Score: 482.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.81
    Marker Score: 387
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.81
    Marker Score: 2312
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.81
    Marker Score: 5362
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.78
    Marker Score: 246
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.67
    Marker Score: 175
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.67
    Marker Score: 298
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.66
    Marker Score: 751
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.65
    Marker Score: 815
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.65
    Marker Score: 9780
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.65
    Marker Score: 2636
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.63
    Marker Score: 368
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.61
    Marker Score: 738
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.61
    Marker Score: 2525
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.61
    Marker Score: 573
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.57
    Marker Score: 374.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.56
    Marker Score: 4780
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.55
    Marker Score: 2936
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.54
    Marker Score: 5580
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.53
    Marker Score: 506
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.51
    Marker Score: 160
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.5
    Marker Score: 707
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.5
    Marker Score: 19076
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.47
    Marker Score: 790
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.46
    Marker Score: 489
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.46
    Marker Score: 3495
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.45
    Marker Score: 132
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.43
    Marker Score: 241
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.41
    Marker Score: 479
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.41
    Marker Score: 8132
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.4
    Marker Score: 139
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4
    Marker Score: 808
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.4
    Marker Score: 190
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.38
    Marker Score: 145
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.37
    Marker Score: 457
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.35
    Marker Score: 4640
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.34
    Marker Score: 162
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.33
    Marker Score: 1537
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.32
    Marker Score: 548
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.32
    Marker Score: 215
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.32
    Marker Score: 149
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.31
    Marker Score: 224
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.31
    Marker Score: 11391
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.3
    Marker Score: 96
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.29
    Marker Score: 89
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.29
    Marker Score: 322
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.29
    Marker Score: 249
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.28
    Marker Score: 1658
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.27
    Marker Score: 157
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.26
    Marker Score: 531
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.26
    Marker Score: 1697
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.26
    Marker Score: 109
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.26
    Marker Score: 138
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.25
    Marker Score: 136
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.25
    Marker Score: 1049
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.25
    Marker Score: 278
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.25
    Marker Score: 221
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.25
    Marker Score: 162
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.24
    Marker Score: 102
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.24
    Marker Score: 285
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.23
    Marker Score: 708
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.23
    Marker Score: 150
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.22
    Marker Score: 643

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Other Information

## Summary GFRA2 is a transmembrane receptor protein that is highly expressed in various cell types in the central nervous system (CNS). It is a key regulator of neural development and function, with important roles in axonal guidance, glial cell survival, and neurite outgrowth. ## Key characteristics * **Type:** Membrane protein * **Ensembl ID:** ENSG00000168546 * **Protein length:** 197 amino acids * **Subcellular localization:** Extracellular * **Expression:** High expression in the following cell types: * Pulmonary interstitial fibroblast * Cardiac endothelial cell * Kidney proximal convoluted tubule epithelial cell * Mural cell * L2/3-6 intratelencephalic projecting glutamatergic neuron * Caudal ganglionic eminence derived GABAergic cortical interneuron * Cardiac muscle myoblast * L5 extratelencephalic projecting glutamatergic cortical neuron * Primary sensory neuron (sensu Teleostei) * Kupffer cell ## Pathways and functions GFRA2 is involved in a variety of signaling pathways, including: * **Axon guidance:** GFRA2 is a key component of the developing cerebral cortex, where it is expressed in neurons and glial cells. It plays a crucial role in guiding migrating neurons along the developing cerebral cortex, both in the early stages of neural tube formation and later in the process of layer formation. * **Developmental biology:** GFRA2 is also expressed in the developing cardiovascular and renal tissues. It is involved in the specification of cardiac and renal cell fate and contributes to the development of the cardiovascular and renal systems. * **Neurotrophic factor signaling:** GFRA2 is a receptor for GDNF, a neurotrophic factor that is essential for the survival and growth of neurons. It is expressed in a variety of neuronal cell types, and its expression is upregulated in neurons that are injured or diseased. * **MAPK signaling:** GFRA2 is also a receptor for the MAPK signaling pathway, a major signaling pathway that is involved in a variety of cellular processes, including cell growth, differentiation, and survival. ## Clinical significance Mutations in GFRA2 have been linked to a number of human diseases, including cerebral palsy, intellectual disability, and cardiovascular disease. These mutations can disrupt the signaling pathways mediated by GFRA2, leading to neuronal dysfunction and disease. GFRA2 is a promising target for the treatment of a variety of neurological disorders. By blocking the activity of GFRA2, it is possible to prevent the neuronal damage and death that is caused by these diseases.

Genular Protein ID: 3614853570

Symbol: GFRA2_HUMAN

Name: GDNF family receptor alpha-2

UniProtKB Accession Codes:

O00451 E9PD47 O15316 O15328 Q58J92 Q6GTR9 Q7Z5C2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 3 Ensembl 4 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PIRSF 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 5 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9182803

Title: TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.

PubMed ID: 9182803

DOI: 10.1016/s0896-6273(00)80318-9

PubMed ID: 9259272

Title: Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha.

PubMed ID: 9259272

DOI: 10.1093/hmg/6.8.1267

PubMed ID: 9177201

Title: Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins.

PubMed ID: 9177201

DOI: 10.1073/pnas.94.12.6238

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23333276

Title: SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRalpha1 and RET.

PubMed ID: 23333276

DOI: 10.1016/j.celrep.2012.12.011

Sequence Information:

  • Length: 464
  • Mass: 51544
  • Checksum: 8BC61529530FF21F
  • Sequence:
    • MILANVFCLF FFLDETLRSL ASPSSLQGPE LHGWRPPVDC VRANELCAAE SNCSSRYRTL 
RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMK KELQCLQIYW SIHLGLTEGE 
EFYEASPYEP VTSRLSDIFR LASIFSGTGA DPVVSAKSNH CLDAAKACNL NDNCKKLRSS 
YISICNREIS PTERCNRRKC HKALRQFFDR VPSEYTYRML FCSCQDQACA ERRRQTILPS 
CSYEDKEKPN CLDLRGVCRT DHLCRSRLAD FHANCRASYQ TVTSCPADNY QACLGSYAGM 
IGFDMTPNYV DSSPTGIVVS PWCSCRGSGN MEEECEKFLR DFTENPCLRN AIQAFGNGTD 
VNVSPKGPSF QATQAPRVEK TPSLPDDLSD STSLGTSVIT TCTSVQEQGL KANNSKELSM 
CFTELTTNII PGSNKVIKPN SGPSRARPSA ALTVLSVLML KLAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.