Details for: SNORD43

Gene ID: 26807

Symbol: SNORD43

Ensembl ID: ENSG00000263764

Description: small nucleolar RNA, C/D box 43

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 7.6799
    Cell Significance Index: -3.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4354
    Cell Significance Index: 5.9400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1998
    Cell Significance Index: 2.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0764
    Cell Significance Index: 2.2000
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.0168
    Cell Significance Index: 0.2000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0160
    Cell Significance Index: 0.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0059
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0081
    Cell Significance Index: -1.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0135
    Cell Significance Index: -1.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0217
    Cell Significance Index: -0.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0555
    Cell Significance Index: -2.8900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0561
    Cell Significance Index: -0.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0588
    Cell Significance Index: -2.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0601
    Cell Significance Index: -2.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0782
    Cell Significance Index: -1.7000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0883
    Cell Significance Index: -1.0200
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0969
    Cell Significance Index: -0.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1097
    Cell Significance Index: -2.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1221
    Cell Significance Index: -3.9100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1292
    Cell Significance Index: -1.2500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1375
    Cell Significance Index: -1.4500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1569
    Cell Significance Index: -2.6800
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1621
    Cell Significance Index: -1.7200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1775
    Cell Significance Index: -2.2800
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1875
    Cell Significance Index: -2.5500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1954
    Cell Significance Index: -2.9300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1976
    Cell Significance Index: -2.3700
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1985
    Cell Significance Index: -2.1500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2078
    Cell Significance Index: -2.7200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2099
    Cell Significance Index: -2.3500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2176
    Cell Significance Index: -2.8000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.2237
    Cell Significance Index: -1.8500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2270
    Cell Significance Index: -3.1200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.2328
    Cell Significance Index: -2.6300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2398
    Cell Significance Index: -3.1300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2423
    Cell Significance Index: -3.2700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2428
    Cell Significance Index: -2.5800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2509
    Cell Significance Index: -2.5300
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.2576
    Cell Significance Index: -2.7200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2587
    Cell Significance Index: -3.1800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2589
    Cell Significance Index: -2.9800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2625
    Cell Significance Index: -2.6800
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2642
    Cell Significance Index: -3.0700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2694
    Cell Significance Index: -3.4000
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2717
    Cell Significance Index: -3.2300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2725
    Cell Significance Index: -3.2200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.2733
    Cell Significance Index: -3.0000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2778
    Cell Significance Index: -2.9000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2797
    Cell Significance Index: -3.6500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2819
    Cell Significance Index: -3.3600
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.2839
    Cell Significance Index: -3.1300
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.2854
    Cell Significance Index: -3.1600
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2891
    Cell Significance Index: -3.1500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2897
    Cell Significance Index: -3.4200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2905
    Cell Significance Index: -2.9500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2920
    Cell Significance Index: -3.5400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.2950
    Cell Significance Index: -3.7000
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.2957
    Cell Significance Index: -3.7100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2991
    Cell Significance Index: -3.1500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.3004
    Cell Significance Index: -3.7500
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.3031
    Cell Significance Index: -2.9900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3094
    Cell Significance Index: -3.5600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3103
    Cell Significance Index: -3.0300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3110
    Cell Significance Index: -2.9200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.3122
    Cell Significance Index: -2.9100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3148
    Cell Significance Index: -3.4300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.3180
    Cell Significance Index: -3.6400
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.3217
    Cell Significance Index: -3.4600
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.3222
    Cell Significance Index: -3.4900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.3228
    Cell Significance Index: -3.0200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3301
    Cell Significance Index: -3.7200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3304
    Cell Significance Index: -4.3900
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.3320
    Cell Significance Index: -2.7400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.3332
    Cell Significance Index: -3.2000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3383
    Cell Significance Index: -3.9200
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.3386
    Cell Significance Index: -3.1100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.3386
    Cell Significance Index: -3.6300
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.3403
    Cell Significance Index: -3.8100
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.3693
    Cell Significance Index: -3.2300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.3815
    Cell Significance Index: -3.0900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.4055
    Cell Significance Index: -3.1200
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.4121
    Cell Significance Index: -3.6300
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.4221
    Cell Significance Index: -3.8100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.4261
    Cell Significance Index: -4.0400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.4519
    Cell Significance Index: -3.7300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.4932
    Cell Significance Index: -3.0600
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.4945
    Cell Significance Index: -3.4300
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.5494
    Cell Significance Index: -3.8700
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.5767
    Cell Significance Index: -4.8700
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.6374
    Cell Significance Index: -6.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD43 is a 69-nucleotide-long snoRNA, characterized by the presence of a C/D box motif. This snoRNA is predominantly expressed in the nucleus, where it is involved in RNA processing, specifically in the modification of ribosomal RNA (rRNA). The C/D box motif is essential for the recognition and binding of SNORD43 to its target rRNA sequences, facilitating the 2'-O-methylation and 2'-O-ribose-1-methylation modifications. These modifications are crucial for the proper folding and function of rRNA, which is essential for protein synthesis. **Pathways and Functions:** SNORD43 is involved in the regulation of RNA processing, specifically in the modification of rRNA. The snoRNA interacts with the ribosomal machinery to facilitate the 2'-O-methylation and 2'-O-ribose-1-methylation modifications of rRNA. These modifications are essential for the proper folding and function of rRNA, which is critical for protein synthesis. Additionally, SNORD43 has been implicated in the regulation of cell growth, differentiation, and survival, suggesting a potential role in the development and maintenance of various cell types. **Clinical Significance:** The clinical significance of SNORD43 remains poorly understood, but its widespread expression across diverse cell types suggests potential roles in various diseases. For example, alterations in SNORD43 expression have been observed in cardiac diseases, such as heart failure and cardiac arrhythmias. Additionally, SNORD43 has been implicated in the pathogenesis of certain cancers, including leukemia and lymphoma. Further studies are necessary to elucidate the functional significance of SNORD43 and its potential role in disease. In conclusion, SNORD43 is a small nucleolar RNA with a complex and multifaceted function. Its widespread expression across diverse cell types suggests potential roles in various biological processes, including RNA processing, cell growth, and differentiation. Further studies are necessary to fully elucidate the functional significance of SNORD43 and its potential role in disease. **Implications for Immunology:** As an immunologist, it is essential to consider the potential implications of SNORD43 for our understanding of immune function. The snoRNA's role in RNA processing and its widespread expression across diverse cell types suggest potential roles in the regulation of immune cell development and function. For example, alterations in SNORD43 expression may contribute to the development of immune-related diseases, such as autoimmune disorders. Further studies are necessary to elucidate the functional significance of SNORD43 in the immune system and its potential role in disease. **Future Directions:** Future studies should focus on elucidating the functional significance of SNORD43 in various cell types and its potential role in disease. The use of advanced molecular biology techniques, such as RNA interference (RNAi) and CRISPR-Cas9 genome editing, will be essential for further understanding the role of SNORD43 in RNA processing and its potential impact on human health. Additionally, the investigation of SNORD43's role in immune-related diseases will provide valuable insights into the regulation of immune cell development and function.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.