Details for: IL36B

Gene ID: 27177

Symbol: IL36B

Ensembl ID: ENSG00000136696

Description: interleukin 36 beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.7963
    Cell Significance Index: 10.4500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.7321
    Cell Significance Index: 4.8600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5331
    Cell Significance Index: 7.7700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2954
    Cell Significance Index: 4.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2426
    Cell Significance Index: 3.3100
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.2201
    Cell Significance Index: 2.6600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0985
    Cell Significance Index: 1.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0772
    Cell Significance Index: 1.6900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0732
    Cell Significance Index: 1.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0648
    Cell Significance Index: 1.1100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.0379
    Cell Significance Index: 1.3900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0319
    Cell Significance Index: 0.3600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0119
    Cell Significance Index: 0.1500
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.0106
    Cell Significance Index: 0.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0090
    Cell Significance Index: 0.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0025
    Cell Significance Index: 0.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0018
    Cell Significance Index: 0.0800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0012
    Cell Significance Index: 0.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0006
    Cell Significance Index: 0.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0004
    Cell Significance Index: 0.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0003
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0006
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0007
    Cell Significance Index: -0.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0008
    Cell Significance Index: -0.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0009
    Cell Significance Index: -0.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0011
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0017
    Cell Significance Index: -0.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0020
    Cell Significance Index: -0.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0023
    Cell Significance Index: -0.3300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0026
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0027
    Cell Significance Index: -0.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0030
    Cell Significance Index: -0.3700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0041
    Cell Significance Index: -0.1300
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0059
    Cell Significance Index: -0.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0073
    Cell Significance Index: -0.4100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0074
    Cell Significance Index: -0.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0076
    Cell Significance Index: -0.5100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0077
    Cell Significance Index: -0.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0080
    Cell Significance Index: -0.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0083
    Cell Significance Index: -0.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0089
    Cell Significance Index: -0.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0100
    Cell Significance Index: -0.4700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0108
    Cell Significance Index: -0.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0109
    Cell Significance Index: -0.4800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0111
    Cell Significance Index: -0.1400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0112
    Cell Significance Index: -0.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0116
    Cell Significance Index: -0.3100
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0117
    Cell Significance Index: -0.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0119
    Cell Significance Index: -0.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0121
    Cell Significance Index: -0.6100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0127
    Cell Significance Index: -0.1600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0130
    Cell Significance Index: -0.2600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0135
    Cell Significance Index: -0.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0137
    Cell Significance Index: -0.3800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0138
    Cell Significance Index: -0.4400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0142
    Cell Significance Index: -0.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0144
    Cell Significance Index: -0.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0149
    Cell Significance Index: -0.2900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0153
    Cell Significance Index: -0.2000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0156
    Cell Significance Index: -0.1700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0167
    Cell Significance Index: -0.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0167
    Cell Significance Index: -0.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0179
    Cell Significance Index: -0.5100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0193
    Cell Significance Index: -0.4700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0194
    Cell Significance Index: -0.4200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0200
    Cell Significance Index: -0.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0200
    Cell Significance Index: -0.5000
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0200
    Cell Significance Index: -0.1500
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.0201
    Cell Significance Index: -0.2400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0202
    Cell Significance Index: -0.2600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0202
    Cell Significance Index: -0.2900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0204
    Cell Significance Index: -0.2300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0206
    Cell Significance Index: -0.2400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0206
    Cell Significance Index: -0.5000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0213
    Cell Significance Index: -0.4200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0217
    Cell Significance Index: -0.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0217
    Cell Significance Index: -0.4600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0222
    Cell Significance Index: -0.4100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0225
    Cell Significance Index: -0.3400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0228
    Cell Significance Index: -0.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0229
    Cell Significance Index: -0.5500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0229
    Cell Significance Index: -0.3000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0230
    Cell Significance Index: -0.4500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0237
    Cell Significance Index: -0.3500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0237
    Cell Significance Index: -0.3200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0240
    Cell Significance Index: -0.3200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0243
    Cell Significance Index: -0.4800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0244
    Cell Significance Index: -0.4900
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0247
    Cell Significance Index: -0.2800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0252
    Cell Significance Index: -0.3000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0253
    Cell Significance Index: -0.2000
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0261
    Cell Significance Index: -0.3100
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0264
    Cell Significance Index: -0.3000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0272
    Cell Significance Index: -0.3300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0273
    Cell Significance Index: -0.3500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0281
    Cell Significance Index: -0.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** IL36B is a type I cytokine, consisting of 139 amino acids, which is secreted by various cell types, including epithelial cells, plasma cells, and mast cells. 2. **Receptor Binding:** IL36B binds to its receptor, IL-1R1, which is expressed on the surface of immune cells, including T-cells and macrophages. 3. **Cytokine Activity:** IL36B exhibits both pro-inflammatory and anti-inflammatory properties, depending on the context and concentration of the cytokine. 4. **Signaling Pathways:** IL36B activates the NF-κB pathway, which regulates the expression of genes involved in inflammation, immune response, and cell survival. 5. **Cellular Expression:** IL36B is expressed in various tissues, including the skin, lungs, and gastrointestinal tract, highlighting its role in maintaining tissue homeostasis. **Pathways and Functions:** 1. **Innate Immune Response:** IL36B plays a crucial role in the innate immune response, particularly in the regulation of neutrophil and macrophage activation. 2. **Cytokine-Mediated Signaling:** IL36B activates the IL-1R1 receptor, leading to the activation of downstream signaling pathways, including NF-κB and MAPK. 3. **Gene Expression Regulation:** IL36B regulates the expression of genes involved in inflammation, immune response, and cell survival, including the expression of pro-inflammatory cytokines. 4. **T-Cell Differentiation:** IL36B modulates T-cell differentiation, influencing the development of Th1 and Th2 responses. 5. **Inflammatory Response:** IL36B contributes to the regulation of inflammatory responses, including the production of pro-inflammatory cytokines and chemokines. **Clinical Significance:** 1. **Inflammatory Disorders:** Dysregulation of IL36B has been implicated in various inflammatory disorders, including psoriasis, acne, and inflammatory bowel disease. 2. **Autoimmune Diseases:** IL36B has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where its dysregulation contributes to immune dysbalance. 3. **Cancer:** IL36B has been found to be overexpressed in certain types of cancer, including colorectal and breast cancer, where it promotes tumor growth and metastasis. 4. **Neurological Disorders:** IL36B has been implicated in neurological disorders, including multiple sclerosis and Alzheimer's disease, where its dysregulation contributes to immune dysbalance and neuroinflammation. In conclusion, IL36B is a complex cytokine that plays a multifaceted role in regulating the immune response, tissue homeostasis, and disease pathogenesis. Further research is needed to fully elucidate the mechanisms by which IL36B modulates immune responses and to explore its therapeutic potential in various diseases.

Genular Protein ID: 1729247036

Symbol: IL36B_HUMAN

Name: Interleukin-36 beta

UniProtKB Accession Codes:

Q9NZH7 Q3MIH0 Q53SR6 Q7RTZ7 Q9UHA5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10744718

Title: Identification and initial characterization of four novel members of the interleukin-1 family.

PubMed ID: 10744718

DOI: 10.1074/jbc.275.14.10308

PubMed ID: 10625660

Title: Four new members expand the IL-1 superfamily.

PubMed ID: 10625660

DOI: 10.1074/jbc.275.2.1169

PubMed ID: 11991722

Title: A sequence-based map of the nine genes of the human interleukin-1 cluster.

PubMed ID: 11991722

DOI: 10.1006/geno.2002.6751

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16646978

Title: The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes.

PubMed ID: 16646978

DOI: 10.1186/ar1946

PubMed ID: 20300079

Title: The effect of the interleukin-1 cytokine family members IL-1F6 and IL-1F8 on adipocyte differentiation.

PubMed ID: 20300079

DOI: 10.1038/oby.2010.55

PubMed ID: 21965679

Title: Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity.

PubMed ID: 21965679

DOI: 10.1074/jbc.m111.267922

PubMed ID: 21242515

Title: IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression.

PubMed ID: 21242515

DOI: 10.4049/jimmunol.1003162

PubMed ID: 21881584

Title: Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis.

PubMed ID: 21881584

DOI: 10.1038/jid.2011.234

PubMed ID: 24829417

Title: IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin.

PubMed ID: 24829417

DOI: 10.4049/jimmunol.1301481

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

Sequence Information:

  • Length: 164
  • Mass: 18522
  • Checksum: F0D2099F4A357A0A
  • Sequence:
    • MNPQREAAPK SYAIRDSRQM VWVLSGNSLI AAPLSRSIKP VTLHLIACRD TEFSDKEKGN 
MVYLGIKGKD LCLFCAEIQG KPTLQLKLQG SQDNIGKDTC WKLVGIHTCI NLDVRESCFM 
GTLDQWGIGV GRKKWKSSFQ HHHLRKKDKD FSSMRTNIGM PGRM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.