Details for: GNGT1

Gene ID: 2792

Symbol: GNGT1

Ensembl ID: ENSG00000127928

Description: G protein subunit gamma transducin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 4.22
    Marker Score: 12039
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4.2
    Marker Score: 2211
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.88
    Marker Score: 859
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.21
    Marker Score: 1156
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.01
    Marker Score: 3816
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.98
    Marker Score: 503
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.73
    Marker Score: 499
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1153
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.49
    Marker Score: 3023
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169859
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.35
    Marker Score: 564
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.26
    Marker Score: 832
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.24
    Marker Score: 841
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.17
    Marker Score: 706
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.17
    Marker Score: 397.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.16
    Marker Score: 612
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.15
    Marker Score: 476
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4787
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.07
    Marker Score: 492
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.05
    Marker Score: 4405
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 1.04
    Marker Score: 336
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71791
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48016
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 498
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5298
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 365
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.89
    Marker Score: 13927
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.87
    Marker Score: 392
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.81
    Marker Score: 255
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.78
    Marker Score: 1085
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 700
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.72
    Marker Score: 1704
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 452
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.69
    Marker Score: 2467
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.68
    Marker Score: 561
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.65
    Marker Score: 237
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.65
    Marker Score: 1124
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.64
    Marker Score: 206
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.63
    Marker Score: 678
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.62
    Marker Score: 475
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.61
    Marker Score: 227
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.6
    Marker Score: 334
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.59
    Marker Score: 280
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.58
    Marker Score: 556
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.57
    Marker Score: 347
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.56
    Marker Score: 145
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.53
    Marker Score: 500
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.51
    Marker Score: 716
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.49
    Marker Score: 524.5
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.47
    Marker Score: 754
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.46
    Marker Score: 514
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.46
    Marker Score: 316
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.46
    Marker Score: 506
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.45
    Marker Score: 182
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.4
    Marker Score: 500
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.4
    Marker Score: 1130
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.4
    Marker Score: 126
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.4
    Marker Score: 1156
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.39
    Marker Score: 390
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.39
    Marker Score: 173
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.39
    Marker Score: 163
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.39
    Marker Score: 431
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.37
    Marker Score: 713
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.37
    Marker Score: 109
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.33
    Marker Score: 940
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.33
    Marker Score: 195
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.32
    Marker Score: 287
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.32
    Marker Score: 62
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.3
    Marker Score: 139
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.3
    Marker Score: 82
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.29
    Marker Score: 92
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.29
    Marker Score: 376
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.29
    Marker Score: 166
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.27
    Marker Score: 208
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.27
    Marker Score: 230
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.26
    Marker Score: 147
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.25
    Marker Score: 146
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.25
    Marker Score: 58
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.25
    Marker Score: 727
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.24
    Marker Score: 77
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.24
    Marker Score: 62
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.23
    Marker Score: 71
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.23
    Marker Score: 136
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.23
    Marker Score: 60
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.23
    Marker Score: 62
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.22
    Marker Score: 54
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.22
    Marker Score: 59

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Other Information

**Key characteristics:** - GNGT1 is a type of G protein-coupled receptor (GPCR). - It is expressed in high levels in the eye, where it is involved in the regulation of aqueous humor balance and the transport of fluid and ions across the blood-aqueous barrier. - It is also expressed in immune cells, where it is involved in the regulation of inflammation and immune responses. **Pathways and functions:** - GNGT1 is a key regulator of water and electrolyte transport in the eye. - It is involved in the regulation of the aqueous humor balance and the transport of fluid and ions across the blood-aqueous barrier. - It is also involved in the regulation of inflammation and immune responses. - In the eye, GNGT1 is expressed in retinal rod cells, where it is involved in the regulation of aqueous humor balance. - In immune cells, GNGT1 is expressed in myeloid and lymphoid cells, where it is involved in the regulation of inflammation and immune responses. **Clinical significance:** - Mutations in GNGT1 have been linked to a number of eye diseases, including retinal degenerative diseases and glaucoma. - GNGT1 is a potential therapeutic target for these diseases. **Additional information:** - GNGT1 is a member of the G protein-coupled receptor family. - It is a transmembrane protein with seven transmembrane domains. - It is a highly conserved protein, with a similar sequence in mammals and birds.

Genular Protein ID: 49023388

Symbol: GBG1_HUMAN

Name: Guanine nucleotide-binding protein G(T) subunit gamma-T1

UniProtKB Accession Codes:

P63211 A4D1H2 O43835 Q08447 Q16026 Q6LCP6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 4 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 29 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8500562

Title: Structure of the bovine transducin gamma subunit gene and analysis of promoter function in transgenic mice.

PubMed ID: 8500562

DOI: 10.1006/exer.1993.1063

PubMed ID: 8661128

Title: Gene structure and chromosome localization to 7q21.3 of the human rod photoreceptor transducin gamma-subunit gene (GNGT1).

PubMed ID: 8661128

DOI: 10.1006/geno.1996.0346

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 74
  • Mass: 8496
  • Checksum: B12B42BE00DB1C05
  • Sequence:
    • MPVINIEDLT EKDKLKMEVD QLKKEVTLER MLVSKCCEEV RDYVEERSGE DPLVKGIPED 
KNPFKELKGG CVIS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.