Details for: GNS

Gene ID: 2799

Symbol: GNS

Ensembl ID: ENSG00000135677

Description: glucosamine (N-acetyl)-6-sulfatase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.87
    Marker Score: 68678
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.03
    Marker Score: 5117
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.88
    Marker Score: 3654
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.75
    Marker Score: 4688
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.73
    Marker Score: 44330
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.72
    Marker Score: 96030
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.7
    Marker Score: 1704
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.65
    Marker Score: 1992
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.61
    Marker Score: 1842
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.58
    Marker Score: 13872
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.56
    Marker Score: 3766
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.53
    Marker Score: 3816
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.5
    Marker Score: 5330
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.48
    Marker Score: 2095
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167106
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.43
    Marker Score: 712
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.42
    Marker Score: 2882.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.37
    Marker Score: 553
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.36
    Marker Score: 2005
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.36
    Marker Score: 50006
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.34
    Marker Score: 559
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.29
    Marker Score: 713
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.29
    Marker Score: 2581
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.29
    Marker Score: 7819
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.28
    Marker Score: 721
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.28
    Marker Score: 1352.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.27
    Marker Score: 19890
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.26
    Marker Score: 758
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.26
    Marker Score: 2091
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.26
    Marker Score: 305
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.25
    Marker Score: 4852
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.23
    Marker Score: 282
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.21
    Marker Score: 12503
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.21
    Marker Score: 4929
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.2
    Marker Score: 4127
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.2
    Marker Score: 288
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.19
    Marker Score: 1206
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.18
    Marker Score: 4894
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.18
    Marker Score: 72372
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.16
    Marker Score: 2633
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.14
    Marker Score: 10731
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.14
    Marker Score: 2796
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.13
    Marker Score: 1746
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.11
    Marker Score: 9533
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.11
    Marker Score: 10534
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.09
    Marker Score: 12726
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.09
    Marker Score: 21631
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.08
    Marker Score: 1575
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.08
    Marker Score: 9391.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.08
    Marker Score: 41024
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.08
    Marker Score: 720
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.06
    Marker Score: 4383
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.05
    Marker Score: 8052
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.04
    Marker Score: 1083
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.03
    Marker Score: 255
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.03
    Marker Score: 1108
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.02
    Marker Score: 1933
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.01
    Marker Score: 1421
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71669
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1
    Marker Score: 465
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47896
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.99
    Marker Score: 211
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.99
    Marker Score: 891
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.98
    Marker Score: 1060
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30387
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.98
    Marker Score: 33837.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.97
    Marker Score: 462
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.97
    Marker Score: 14540
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.97
    Marker Score: 1074
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.95
    Marker Score: 997
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2394
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.94
    Marker Score: 842
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.92
    Marker Score: 1492
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.91
    Marker Score: 1072
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.91
    Marker Score: 837
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2714
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.9
    Marker Score: 540
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.9
    Marker Score: 261
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.9
    Marker Score: 3783
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.9
    Marker Score: 5867
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.89
    Marker Score: 462
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.89
    Marker Score: 559
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.89
    Marker Score: 306
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.89
    Marker Score: 472
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.88
    Marker Score: 285
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.88
    Marker Score: 764
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.87
    Marker Score: 1406
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.87
    Marker Score: 574
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.87
    Marker Score: 2209
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.86
    Marker Score: 952
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.85
    Marker Score: 192
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.85
    Marker Score: 662
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.84
    Marker Score: 409
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.84
    Marker Score: 4410
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4781
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 635.5

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Other Information

**Key characteristics** * The GNS gene is located on chromosome 15q21.1. * The protein is a transmembrane protein that is expressed on the surface of cells. * The protein is a glycoprotein that is composed of 140 amino acids. * The protein is a member of the sulfotransferase family of enzymes. * The protein is involved in the degradation of glucosamine and its derivatives. * The protein is also involved in the regulation of inflammation and cell migration. **Pathways and functions** The GNS gene product is involved in a variety of pathways, including: * The degradation of glucosamine and its derivatives * The regulation of inflammation * The regulation of cell migration **Clinical significance** Mutations in the GNS gene have been linked to a number of human diseases, including: * Sanfilippo syndrome, a rare genetic disorder that is characterized by a build-up of glycosaminoglycans in the eyes and other tissues. * Mucopolysaccharidoses, a group of genetic disorders that are characterized by a build-up of glycosaminoglycans in the joints, eyes, and other tissues. * Kidney diseases, including nephropathies and glomerulonephritis. * Inflammation disorders, such as rheumatoid arthritis and psoriasis. **Additional information** * The GNS gene is also involved in the regulation of cell migration. * The protein is also involved in the formation of the extracellular matrix, which is a network of proteins and polysaccharides that helps to hold cells together. * The GNS gene is a promising target for the treatment of a variety of diseases, including Sanfilippo syndrome and mucopolysaccharidoses.

Genular Protein ID: 1763514887

Symbol: GNS_HUMAN

Name: N-acetylglucosamine-6-sulfatase

UniProtKB Accession Codes:

P15586 B4DYH8 Q53F05

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1463457

Title: A cDNA clone for human glucosamine-6-sulphatase reveals differences between arylsulphatases and non-arylsulphatases.

PubMed ID: 1463457

DOI: 10.1042/bj2880539

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3196333

Title: Human glucosamine-6-sulfatase cDNA reveals homology with steroid sulfatase.

PubMed ID: 3196333

DOI: 10.1016/s0006-291x(88)80035-4

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 12573255

Title: Genomic basis of mucopolysaccharidosis type IIID (MIM 252940) revealed by sequencing of GNS encoding N-acetylglucosamine-6-sulfatase.

PubMed ID: 12573255

DOI: 10.1016/s0888-7543(02)00014-9

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 20232353

Title: Mucopolysaccharidosis type IIID: 12 new patients and 15 novel mutations.

PubMed ID: 20232353

DOI: 10.1002/humu.21234

Sequence Information:

  • Length: 552
  • Mass: 62082
  • Checksum: 85094043F6E64468
  • Sequence:
    • MRLLPLAPGR LRRGSPRHLP SCSPALLLLV LGGCLGVFGV AAGTRRPNVV LLLTDDQDEV 
LGGMTPLKKT KALIGEMGMT FSSAYVPSAL CCPSRASILT GKYPHNHHVV NNTLEGNCSS 
KSWQKIQEPN TFPAILRSMC GYQTFFAGKY LNEYGAPDAG GLEHVPLGWS YWYALEKNSK 
YYNYTLSING KARKHGENYS VDYLTDVLAN VSLDFLDYKS NFEPFFMMIA TPAPHSPWTA 
APQYQKAFQN VFAPRNKNFN IHGTNKHWLI RQAKTPMTNS SIQFLDNAFR KRWQTLLSVD 
DLVEKLVKRL EFTGELNNTY IFYTSDNGYH TGQFSLPIDK RQLYEFDIKV PLLVRGPGIK 
PNQTSKMLVA NIDLGPTILD IAGYDLNKTQ MDGMSLLPIL RGASNLTWRS DVLVEYQGEG 
RNVTDPTCPS LSPGVSQCFP DCVCEDAYNN TYACVRTMSA LWNLQYCEFD DQEVFVEVYN 
LTADPDQITN IAKTIDPELL GKMNYRLMML QSCSGPTCRT PGVFDPGYRF DPRLMFSNRG 
SVRTRRFSKH LL

Genular Protein ID: 483117319

Symbol: Q7Z3X3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z3X3

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 EC 1 EMBL 2 GO 4 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 1 PROSITE 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SUPFAM 1

Sequence Information:

  • Length: 496
  • Mass: 56346
  • Checksum: B53BDD56AD7322F6
  • Sequence:
    • MDNYLLLQTP LKKTKALIGE MGMTFSSAYV PSALCCPSRA SILTGKYPHN HHVVNNTLEG 
NCSSKSWQKI QEPNTFPAIL RSMCGYQTFF AGKYLNEYGA PDAGGLEHVP LGWSYWYALE 
KNSKYYNYTL SINGKARKHG ENYSVDYLTD VLANVSLDFL DYKSNFEPFF MMIATPAPHS 
PWTAAPQYQK AFQNVFAPRN KNFNIHGTNK HWLIRQAKTP MTNSSIQFLD NAFRKRWQTL 
LSVDDLVEKL VKRLEFTGEL NNTYIFYTSD NGYHTGQFSL PIDKRQLYEF DIKVPLLVRG 
PGIKPNQTSK MLVANIDLGP TILDIAGYDL NKTQMDGMSL LPILRGASNL TWRSDVLVEY 
QGEGRNVTDP TCPSLSPGVS QCFPDCACED AYNNTYACVR TMSALWNLQY CEFDDQEVFV 
EVYNLTADPD QITNIAKTID PELLGKMNYR LMMLQSCSGP TCRTPGVFDP GYRFDPRLMF 
SNRGSVRTRR FSKHLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.