Details for: GOLGA2

Gene ID: 2801

Symbol: GOLGA2

Ensembl ID: ENSG00000167110

Description: golgin A2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.9
    Marker Score: 1268
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.87
    Marker Score: 4272
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.67
    Marker Score: 826
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.59
    Marker Score: 742
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.59
    Marker Score: 2183
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.53
    Marker Score: 1042
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.47
    Marker Score: 2171
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.46
    Marker Score: 5009
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.45
    Marker Score: 1527
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.45
    Marker Score: 2561
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.42
    Marker Score: 16014
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.31
    Marker Score: 489
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.3
    Marker Score: 11319.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.3
    Marker Score: 1084
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.29
    Marker Score: 372
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.24
    Marker Score: 43048.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.24
    Marker Score: 12788
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.23
    Marker Score: 517
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.23
    Marker Score: 41709
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.23
    Marker Score: 9120
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.21
    Marker Score: 279
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.2
    Marker Score: 844
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.2
    Marker Score: 1321
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.17
    Marker Score: 10117
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.17
    Marker Score: 9156
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.17
    Marker Score: 683
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.14
    Marker Score: 1764
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.13
    Marker Score: 7239
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.13
    Marker Score: 2389
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.12
    Marker Score: 252
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.11
    Marker Score: 575
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.11
    Marker Score: 4649
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.11
    Marker Score: 40948
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.11
    Marker Score: 4515
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.11
    Marker Score: 2902
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.1
    Marker Score: 2507
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.1
    Marker Score: 1144
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.1
    Marker Score: 4581
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.09
    Marker Score: 310
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.09
    Marker Score: 2072
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.09
    Marker Score: 268
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.08
    Marker Score: 1889
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.08
    Marker Score: 1033
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.08
    Marker Score: 678.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.07
    Marker Score: 1384
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.06
    Marker Score: 3334.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.05
    Marker Score: 579
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.05
    Marker Score: 1048
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.04
    Marker Score: 603
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.03
    Marker Score: 589
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.03
    Marker Score: 8848
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.02
    Marker Score: 8982
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.02
    Marker Score: 878
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.01
    Marker Score: 5323
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.01
    Marker Score: 9499
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.01
    Marker Score: 62088
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.01
    Marker Score: 3898
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1
    Marker Score: 476
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1
    Marker Score: 6509
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1
    Marker Score: 1234
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71618
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47841
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.99
    Marker Score: 1594
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.99
    Marker Score: 431
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.99
    Marker Score: 1315
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.99
    Marker Score: 1138
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.99
    Marker Score: 398
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.98
    Marker Score: 603
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30371
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.97
    Marker Score: 3593
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.97
    Marker Score: 889
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.97
    Marker Score: 3731
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.97
    Marker Score: 282
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.96
    Marker Score: 4007
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.96
    Marker Score: 304
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.96
    Marker Score: 1123
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.96
    Marker Score: 354
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.95
    Marker Score: 9073
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.95
    Marker Score: 556
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.95
    Marker Score: 388
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.95
    Marker Score: 1144
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.94
    Marker Score: 657
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.94
    Marker Score: 6142.5
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.94
    Marker Score: 643
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.94
    Marker Score: 35741
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2381
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.93
    Marker Score: 3600
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.93
    Marker Score: 424
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.93
    Marker Score: 1692
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.92
    Marker Score: 1737
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.92
    Marker Score: 1235
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 473
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.92
    Marker Score: 219
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.91
    Marker Score: 986
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.91
    Marker Score: 3585
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14213
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 429
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.91
    Marker Score: 3911
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.91
    Marker Score: 1396
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.9
    Marker Score: 960

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Other Information

**Key characteristics:** * GOGA2 is a transmembrane protein with a cytoplasmic domain and a single transmembrane domain. * It is highly expressed in various cell types, including those in the respiratory tract, urinary tract, and mammary gland. * It is involved in the regulation of cell cycle progression, apoptosis, and protein transport. **Pathways and functions:** * Golgin A2 is involved in the **asparagine n-linked glycosylation pathway**, which is responsible for the addition of a glycosyl group to asparagine residues in proteins. This pathway is crucial for the stability and function of various cellular proteins. * It also plays a role in the **cell cycle**, regulating the progression from G1 to S phase and the G2 to M phase transitions. * Golgin A2 is involved in the **mitotic prophase** by facilitating the formation of the contractile ring complex, which is responsible for chromosome segregation. * It also participates in the **post-translational protein modification** pathway, where it is involved in the regulation of protein stability and function. * Golgin A2 is also involved in the **vesicle-mediated transport** of proteins from the endoplasmic reticulum to the Golgi apparatus. **Clinical significance:** * Mutations in the GOLGA2 gene have been linked to the development of several human diseases, including Alzheimer's disease (AD). * In AD, Golgin A2 is thought to be involved in the regulation of protein transport and the maintenance of cellular homeostasis. * Studies have shown that mutations in GOLGA2 can lead to the accumulation of misfolded or abnormal proteins, which is associated with the development of AD-like symptoms. * Therefore, targeting Golgin A2 signaling could be a potential therapeutic strategy for the treatment of AD. **Additional notes:** * Golgin A2 is a multi-functional protein that can interact with various proteins involved in cell cycle regulation, apoptosis, and protein transport. * It is a highly conserved protein, with similar sequences found in organisms from yeast to humans. * Further research is needed to fully understand the role of Golgin A2 in human health and disease.

Genular Protein ID: 2924870405

Symbol: GOGA2_HUMAN

Name: Golgin subfamily A member 2

UniProtKB Accession Codes:

Q08379 A0A0C4DGS5 Q6GRM9 Q9BRB0 Q9NYF9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 32 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 7 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8315394

Title: Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex.

PubMed ID: 8315394

DOI: 10.1084/jem.178.1.49

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11306556

Title: The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b.

PubMed ID: 11306556

DOI: 10.1093/embo-reports/kve065

PubMed ID: 11781572

Title: The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment.

PubMed ID: 11781572

DOI: 10.1038/ncb1201-1101

PubMed ID: 15003503

Title: Golgi fragmentation during Fas-mediated apoptosis is associated with the rapid loss of GM130.

PubMed ID: 15003503

DOI: 10.1016/j.bbrc.2004.02.015

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16489344

Title: GM130 and GRASP65-dependent lateral cisternal fusion allows uniform Golgi-enzyme distribution.

PubMed ID: 16489344

DOI: 10.1038/ncb1366

PubMed ID: 17314401

Title: The biogenesis of the Golgi ribbon: the roles of membrane input from the ER and of GM130.

PubMed ID: 17314401

DOI: 10.1091/mbc.e06-10-0886

PubMed ID: 18323775

Title: ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport.

PubMed ID: 18323775

DOI: 10.1038/emboj.2008.40

PubMed ID: 18045989

Title: The Golgi protein GM130 regulates centrosome morphology and function.

PubMed ID: 18045989

DOI: 10.1091/mbc.e07-08-0847

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19242490

Title: Microtubule nucleation at the cis-side of the Golgi apparatus requires AKAP450 and GM130.

PubMed ID: 19242490

DOI: 10.1038/emboj.2009.47

PubMed ID: 19109421

Title: GM130-dependent control of Cdc42 activity at the Golgi regulates centrosome organization.

PubMed ID: 19109421

DOI: 10.1091/mbc.e08-08-0834

PubMed ID: 20421892

Title: PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130.

PubMed ID: 20421892

DOI: 10.1038/cr.2010.56

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26165940

Title: GM130 regulates Golgi-derived spindle assembly by activating TPX2 and capturing microtubules.

PubMed ID: 26165940

DOI: 10.1016/j.cell.2015.06.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26742501

Title: GOLGA2, encoding a master regulator of golgi apparatus, is mutated in a patient with a neuromuscular disorder.

PubMed ID: 26742501

DOI: 10.1007/s00439-015-1632-8

PubMed ID: 30237576

Title: Autozygome and high throughput confirmation of disease genes candidacy.

PubMed ID: 30237576

DOI: 10.1038/s41436-018-0138-x

PubMed ID: 26363069

Title: Structural basis for the interaction between the Golgi reassembly-stacking protein GRASP65 and the Golgi matrix protein GM130.

PubMed ID: 26363069

DOI: 10.1074/jbc.m115.657940

PubMed ID: 34424553

Title: Bi-allelic loss of function variants in GOLGA2 are associated with a complex neurological phenotype: Report of a second family.

PubMed ID: 34424553

DOI: 10.1111/cge.14053

Sequence Information:

  • Length: 1002
  • Mass: 113086
  • Checksum: BD067145C5092237
  • Sequence:
    • MWPQPRLPPR PAMSEETRQS KLAAAKKKLR EYQQRNSPGV PTGAKKKKKI KNGSNPETTT 
SGGCHSPEDT PKDNAATLQP SDDTVLPGGV PSPGASLTSM AASQNHDADN VPNLMDETKT 
FSSTESLRQL SQQLNGLVCE SATCVNGEGP ASSANLKDLE SRYQQLAVAL DSSYVTNKQL 
NITIEKLKQQ NQEITDQLEE EKKECHQKQG ALREQLQVHI QTIGILVSEK AELQTALAHT 
QHAARQKEGE SEDLASRLQY SRRRVGELER ALSAVSTQQK KADRYNKELT KERDALRLEL 
YKNTQSNEDL KQEKSELEEK LRVLVTEKAG MQLNLEELQK KLEMTELLLQ QFSSRCEAPD 
ANQQLQQAME ERAQLEAHLG QVMESVRQLQ MERDKYAENL KGESAMWRQR MQQMSEQVHT 
LREEKECSMS RVQELETSLA ELRNQMAEPP PPEPPAGPSE VEQQLQAEAE HLRKELEGLA 
GQLQAQVQDN EGLSRLNREQ EERLLELERA AELWGEQAEA RRQILETMQN DRTTISRALS 
QNRELKEQLA ELQSGFVKLT NENMEITSAL QSEQHVKREL GKKLGELQEK LSELKETVEL 
KSQEAQSLQQ QRDQYLGHLQ QYVAAYQQLT SEKEVLHNQL LLQTQLVDQL QQQEAQGKAV 
AEMARQELQE TQERLEAATQ QNQQLRAQLS LMAHPGEGDG LDREEEEDEE EEEEEAVAVP 
QPMPSIPEDL ESREAMVAFF NSAVASAEEE QARLRGQLKE QRVRCRRLAH LLASAQKEPE 
AAAPAPGTGG DSVCGETHRA LQGAMEKLQS RFMELMQEKA DLKERVEELE HRCIQLSGET 
DTIGEYIALY QSQRAVLKER HREKEEYISR LAQDKEEMKV KLLELQELVL RLVGDRNEWH 
GRFLAAAQNP ADEPTSGAPA PQELGAANQQ GDLCEVSLAG SVEPAQGEAR EGSPRDNPTA 
QQIMQLLREM QNPRERPGLG SNPCIPFFYR ADENDEVKIT VI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.