Details for: IGHV4 30 2

Gene ID: 28398

Symbol: IGHV4 30 2

Ensembl ID: ENSG00000231475

Description: immunoglobulin heavy variable 4-30-2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.4604
    Cell Significance Index: 6.6900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2870
    Cell Significance Index: 4.4400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2096
    Cell Significance Index: 3.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0577
    Cell Significance Index: -5.8900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0625
    Cell Significance Index: -1.5200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0747
    Cell Significance Index: -1.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0750
    Cell Significance Index: -2.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0876
    Cell Significance Index: -5.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0948
    Cell Significance Index: -4.4200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1205
    Cell Significance Index: -1.4900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1816
    Cell Significance Index: -4.6400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1904
    Cell Significance Index: -2.1300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2085
    Cell Significance Index: -2.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2091
    Cell Significance Index: -5.6900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2207
    Cell Significance Index: -2.6200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2486
    Cell Significance Index: -3.1500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2752
    Cell Significance Index: -5.3800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2985
    Cell Significance Index: -4.8400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3039
    Cell Significance Index: -3.8400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.3114
    Cell Significance Index: -3.6800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3194
    Cell Significance Index: -5.4600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3246
    Cell Significance Index: -6.0000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3260
    Cell Significance Index: -4.4700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3342
    Cell Significance Index: -3.8500
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.3496
    Cell Significance Index: -2.9800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3538
    Cell Significance Index: -9.0200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3612
    Cell Significance Index: -4.9900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3648
    Cell Significance Index: -4.7200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.3819
    Cell Significance Index: -4.6100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.4088
    Cell Significance Index: -4.8100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.4126
    Cell Significance Index: -5.3000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4211
    Cell Significance Index: -10.5000
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.4364
    Cell Significance Index: -4.4300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.4392
    Cell Significance Index: -4.7900
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.4400
    Cell Significance Index: -2.9300
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.4429
    Cell Significance Index: -4.9200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.4528
    Cell Significance Index: -4.8100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.4548
    Cell Significance Index: -5.5300
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.4567
    Cell Significance Index: -4.8800
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.4719
    Cell Significance Index: -5.1700
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.4729
    Cell Significance Index: -4.9200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.4793
    Cell Significance Index: -5.0900
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.4836
    Cell Significance Index: -4.9100
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.4860
    Cell Significance Index: -4.5100
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.4957
    Cell Significance Index: -4.9000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.4999
    Cell Significance Index: -5.3900
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.5018
    Cell Significance Index: -5.8300
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.5019
    Cell Significance Index: -4.9100
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.5056
    Cell Significance Index: -5.5300
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.5105
    Cell Significance Index: -5.5200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.5174
    Cell Significance Index: -6.3000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.5245
    Cell Significance Index: -5.6400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.5251
    Cell Significance Index: -4.9300
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.5275
    Cell Significance Index: -6.2700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.5304
    Cell Significance Index: -6.3600
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.5313
    Cell Significance Index: -5.1000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.5437
    Cell Significance Index: -6.0200
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.5453
    Cell Significance Index: -5.6100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.5456
    Cell Significance Index: -7.1600
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.5574
    Cell Significance Index: -6.0100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.5577
    Cell Significance Index: -6.5900
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.5749
    Cell Significance Index: -4.6200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.5776
    Cell Significance Index: -5.6300
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.5839
    Cell Significance Index: -4.8200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.5841
    Cell Significance Index: -6.1500
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.5899
    Cell Significance Index: -5.7600
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.5910
    Cell Significance Index: -5.2800
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.5931
    Cell Significance Index: -6.3100
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.5955
    Cell Significance Index: -5.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.6045
    Cell Significance Index: -5.8100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.6116
    Cell Significance Index: -7.6400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.6162
    Cell Significance Index: -5.3900
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.6223
    Cell Significance Index: -5.7500
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.6231
    Cell Significance Index: -5.6600
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.6247
    Cell Significance Index: -5.8200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.6263
    Cell Significance Index: -6.3100
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.6311
    Cell Significance Index: -7.1700
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.6348
    Cell Significance Index: -5.7300
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.6363
    Cell Significance Index: -5.5900
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.6388
    Cell Significance Index: -6.8300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.6470
    Cell Significance Index: -5.4600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.6543
    Cell Significance Index: -7.5900
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: -0.6553
    Cell Significance Index: -5.8700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.6613
    Cell Significance Index: -7.6100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.6687
    Cell Significance Index: -5.7500
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.6738
    Cell Significance Index: -6.0100
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.6794
    Cell Significance Index: -5.1300
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.6828
    Cell Significance Index: -6.7400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.6856
    Cell Significance Index: -7.6600
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.6869
    Cell Significance Index: -6.2600
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.7019
    Cell Significance Index: -5.7600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.7035
    Cell Significance Index: -9.2000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.7076
    Cell Significance Index: -5.7300
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: -0.7203
    Cell Significance Index: -5.7500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.7232
    Cell Significance Index: -8.0100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.7243
    Cell Significance Index: -7.6800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.7269
    Cell Significance Index: -9.6600
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.7281
    Cell Significance Index: -5.7100
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.7313
    Cell Significance Index: -5.5800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.7361
    Cell Significance Index: -9.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene structure:** The IGHV4-30-2 gene is a heavy chain variable region gene located on chromosome 14q32.1. It is composed of three exons (V, D, and J) that undergo V(D)J recombination to generate a diverse repertoire of immunoglobulin heavy chains. 2. **Expression patterns:** IGHV4-30-2 is expressed in a wide range of cell types, including goblet cells, granulocyte-monocyte progenitor cells, T cells, and neoplastic cells. This suggests that the IGHV4-30-2 gene plays a role in the development and function of these cells. 3. **Cellular specificity:** The expression of IGHV4-30-2 is highly specific to certain cell types, such as goblet cells and intestinal crypt stem cells. This suggests that the gene may be involved in the maintenance of epithelial homeostasis and immune surveillance. **Pathways and Functions:** 1. **Immunoglobulin class switching:** IGHV4-30-2 is a member of the immunoglobulin heavy chain superfamily, which plays a critical role in class switching between IgM, IgG, IgA, and IgE. The IGHV4-30-2 gene is involved in the transition from IgM to IgG class switching. 2. **Antigen recognition:** The IGHV4-30-2 gene is responsible for encoding the variable region of the heavy chain, which recognizes and binds to specific antigens. This interaction is essential for the activation of B cells and the initiation of an immune response. 3. **Cellular differentiation:** IGHV4-30-2 is also involved in the differentiation of B cells into plasma cells, which are responsible for producing large amounts of antibodies. 4. **Immune tolerance:** The IGHV4-30-2 gene may play a role in immune tolerance, as it is expressed in cells that are involved in the maintenance of immune homeostasis, such as goblet cells and intestinal crypt stem cells. **Clinical Significance:** 1. **Autoimmune diseases:** Alterations in IGHV4-30-2 expression have been implicated in various autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Understanding the role of this gene in these diseases may provide new therapeutic targets. 2. **Cancer:** The IGHV4-30-2 gene is overexpressed in certain types of cancer, such as follicular lymphoma and chronic lymphocytic leukemia. This suggests that the gene may play a role in the development and progression of these diseases. 3. **Immune disorders:** Abnormal expression of IGHV4-30-2 has been observed in patients with immune disorders, such as immunodeficiency and autoimmune disorders. This highlights the importance of this gene in maintaining immune homeostasis. 4. **Vaccine development:** The IGHV4-30-2 gene may be useful in the development of vaccines, as it is involved in the recognition and binding of antigens. Understanding the role of this gene in antigen recognition may provide new insights into vaccine design. In conclusion, the IGHV4-30-2 gene is a critical component of the adaptive immune system, and its unique structure and expression patterns have significant implications for our understanding of immune function and disease. Further research is needed to fully elucidate the role of this gene in immune homeostasis and disease, and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.