Details for: IGHV4 30 2

Gene ID: 28398

Symbol: IGHV4 30 2

Ensembl ID: ENSG00000231475

Description: immunoglobulin heavy variable 4-30-2

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10,808
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 875
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.26
    Marker Score: 2,172
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,575
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.21
    Marker Score: 3,639
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,726
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 802
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,815
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,400
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 737
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.8
    Marker Score: 4,547
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,258
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1,181
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.71
    Marker Score: 687
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.66
    Marker Score: 381
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 438
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.47
    Marker Score: 649
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.45
    Marker Score: 351
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 384
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.39
    Marker Score: 511
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.32
    Marker Score: 420
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.27
    Marker Score: 302
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.23
    Marker Score: 487
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.22
    Marker Score: 129
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.21
    Marker Score: 509
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.21
    Marker Score: 119
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.17
    Marker Score: 187
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.17
    Marker Score: 430
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.17
    Marker Score: 140
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.16
    Marker Score: 153
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.16
    Marker Score: 137
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.16
    Marker Score: 139
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.15
    Marker Score: 102
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.15
    Marker Score: 184
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.15
    Marker Score: 51
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.15
    Marker Score: 98
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.15
    Marker Score: 110
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.14
    Marker Score: 186
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.14
    Marker Score: 1,619
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.13
    Marker Score: 92
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.13
    Marker Score: 56
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.13
    Marker Score: 120
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.12
    Marker Score: 28
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.12
    Marker Score: 56
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.12
    Marker Score: 55
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.12
    Marker Score: 50
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.11
    Marker Score: 135
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.09
    Marker Score: 91
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.09
    Marker Score: 57
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.08
    Marker Score: 89
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.08
    Marker Score: 165
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.08
    Marker Score: 42
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.08
    Marker Score: 70
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.08
    Marker Score: 74
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.07
    Marker Score: 70
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.07
    Marker Score: 196
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.07
    Marker Score: 35
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.07
    Marker Score: 36
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 136
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.06
    Marker Score: 31
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.06
    Marker Score: 99
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.06
    Marker Score: 90
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.05
    Marker Score: 83
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.04
    Marker Score: 36
  • Cell Name: enucleated reticulocyte (CL0002422)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.04
    Marker Score: 174
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.04
    Marker Score: 30
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.04
    Marker Score: 30
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.04
    Marker Score: 42
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.04
    Marker Score: 9
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.03
    Marker Score: 61
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.03
    Marker Score: 44
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.02
    Marker Score: 17

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene structure:** The IGHV4-30-2 gene is a heavy chain variable region gene located on chromosome 14q32.1. It is composed of three exons (V, D, and J) that undergo V(D)J recombination to generate a diverse repertoire of immunoglobulin heavy chains. 2. **Expression patterns:** IGHV4-30-2 is expressed in a wide range of cell types, including goblet cells, granulocyte-monocyte progenitor cells, T cells, and neoplastic cells. This suggests that the IGHV4-30-2 gene plays a role in the development and function of these cells. 3. **Cellular specificity:** The expression of IGHV4-30-2 is highly specific to certain cell types, such as goblet cells and intestinal crypt stem cells. This suggests that the gene may be involved in the maintenance of epithelial homeostasis and immune surveillance. **Pathways and Functions:** 1. **Immunoglobulin class switching:** IGHV4-30-2 is a member of the immunoglobulin heavy chain superfamily, which plays a critical role in class switching between IgM, IgG, IgA, and IgE. The IGHV4-30-2 gene is involved in the transition from IgM to IgG class switching. 2. **Antigen recognition:** The IGHV4-30-2 gene is responsible for encoding the variable region of the heavy chain, which recognizes and binds to specific antigens. This interaction is essential for the activation of B cells and the initiation of an immune response. 3. **Cellular differentiation:** IGHV4-30-2 is also involved in the differentiation of B cells into plasma cells, which are responsible for producing large amounts of antibodies. 4. **Immune tolerance:** The IGHV4-30-2 gene may play a role in immune tolerance, as it is expressed in cells that are involved in the maintenance of immune homeostasis, such as goblet cells and intestinal crypt stem cells. **Clinical Significance:** 1. **Autoimmune diseases:** Alterations in IGHV4-30-2 expression have been implicated in various autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Understanding the role of this gene in these diseases may provide new therapeutic targets. 2. **Cancer:** The IGHV4-30-2 gene is overexpressed in certain types of cancer, such as follicular lymphoma and chronic lymphocytic leukemia. This suggests that the gene may play a role in the development and progression of these diseases. 3. **Immune disorders:** Abnormal expression of IGHV4-30-2 has been observed in patients with immune disorders, such as immunodeficiency and autoimmune disorders. This highlights the importance of this gene in maintaining immune homeostasis. 4. **Vaccine development:** The IGHV4-30-2 gene may be useful in the development of vaccines, as it is involved in the recognition and binding of antigens. Understanding the role of this gene in antigen recognition may provide new insights into vaccine design. In conclusion, the IGHV4-30-2 gene is a critical component of the adaptive immune system, and its unique structure and expression patterns have significant implications for our understanding of immune function and disease. Further research is needed to fully elucidate the role of this gene in immune homeostasis and disease, and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.