Details for: TRBV18

Gene ID: 28569

Symbol: TRBV18

Ensembl ID: ENSG00000276557

Description: T cell receptor beta variable 18

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.8711
    Cell Significance Index: 4.7500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0708
    Cell Significance Index: 0.7100
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.0394
    Cell Significance Index: 0.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0129
    Cell Significance Index: -2.5800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0135
    Cell Significance Index: -0.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0250
    Cell Significance Index: -3.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0279
    Cell Significance Index: -2.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0492
    Cell Significance Index: -2.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0537
    Cell Significance Index: -1.8800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0618
    Cell Significance Index: -0.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0636
    Cell Significance Index: -1.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0655
    Cell Significance Index: -3.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0673
    Cell Significance Index: -2.2100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0695
    Cell Significance Index: -1.1800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0700
    Cell Significance Index: -0.9600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0722
    Cell Significance Index: -1.7500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0728
    Cell Significance Index: -0.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0744
    Cell Significance Index: -0.8400
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0777
    Cell Significance Index: -0.5800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0821
    Cell Significance Index: -2.6200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0942
    Cell Significance Index: -1.1900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0944
    Cell Significance Index: -2.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0997
    Cell Significance Index: -2.1600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1101
    Cell Significance Index: -1.0300
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1139
    Cell Significance Index: -0.9700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1162
    Cell Significance Index: -1.7000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1196
    Cell Significance Index: -1.7000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1199
    Cell Significance Index: -1.3400
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1204
    Cell Significance Index: -1.0000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1217
    Cell Significance Index: -1.1700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1248
    Cell Significance Index: -2.4400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1288
    Cell Significance Index: -2.1700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1292
    Cell Significance Index: -1.3400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1293
    Cell Significance Index: -1.5200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1300
    Cell Significance Index: -2.5700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1302
    Cell Significance Index: -1.6100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1303
    Cell Significance Index: -2.7700
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1315
    Cell Significance Index: -1.1100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1361
    Cell Significance Index: -2.2100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1406
    Cell Significance Index: -1.4200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1407
    Cell Significance Index: -2.6000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1449
    Cell Significance Index: -1.2500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1523
    Cell Significance Index: -1.5800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1539
    Cell Significance Index: -2.2700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1556
    Cell Significance Index: -2.6600
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1556
    Cell Significance Index: -1.0700
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1605
    Cell Significance Index: -2.5800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1618
    Cell Significance Index: -2.7900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1635
    Cell Significance Index: -1.4300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1635
    Cell Significance Index: -1.9600
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1636
    Cell Significance Index: -1.7400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1677
    Cell Significance Index: -1.5900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1679
    Cell Significance Index: -2.5500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1704
    Cell Significance Index: -2.3400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1708
    Cell Significance Index: -2.2100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1736
    Cell Significance Index: -2.5200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1768
    Cell Significance Index: -2.4800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1793
    Cell Significance Index: -2.0800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1795
    Cell Significance Index: -1.7500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1813
    Cell Significance Index: -1.8400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1817
    Cell Significance Index: -2.3900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1819
    Cell Significance Index: -2.1400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1824
    Cell Significance Index: -2.5300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1831
    Cell Significance Index: -2.4100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1905
    Cell Significance Index: -2.6700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1914
    Cell Significance Index: -2.7900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1937
    Cell Significance Index: -2.4200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1986
    Cell Significance Index: -2.1400
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.2012
    Cell Significance Index: -1.7300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2021
    Cell Significance Index: -2.5500
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.2022
    Cell Significance Index: -1.9800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2024
    Cell Significance Index: -2.6000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.2025
    Cell Significance Index: -2.0400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2032
    Cell Significance Index: -2.2900
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.2091
    Cell Significance Index: -2.4100
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.2097
    Cell Significance Index: -1.9400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2100
    Cell Significance Index: -2.4400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2103
    Cell Significance Index: -2.4200
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2112
    Cell Significance Index: -2.5100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2121
    Cell Significance Index: -2.5800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2124
    Cell Significance Index: -2.5100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2126
    Cell Significance Index: -2.7800
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2126
    Cell Significance Index: -2.4200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2130
    Cell Significance Index: -2.8300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2133
    Cell Significance Index: -2.7900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.2140
    Cell Significance Index: -1.7100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2140
    Cell Significance Index: -2.5400
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.2145
    Cell Significance Index: -1.9300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2147
    Cell Significance Index: -2.4700
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2170
    Cell Significance Index: -2.2400
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.2186
    Cell Significance Index: -1.7700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2216
    Cell Significance Index: -2.0800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2234
    Cell Significance Index: -2.6400
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2236
    Cell Significance Index: -2.4500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2240
    Cell Significance Index: -2.4400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2245
    Cell Significance Index: -2.7600
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2249
    Cell Significance Index: -2.4600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2266
    Cell Significance Index: -2.5100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2269
    Cell Significance Index: -2.7000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2278
    Cell Significance Index: -2.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV18 shares several key characteristics with other TRB genes. It is located on chromosome 7, which is a major histocompatibility complex (MHC) region that encodes for the T cell receptor alpha (TRAA) and beta (TRAB) chains. The TRBV18 gene encodes for a variable region that is approximately 95% identical to TRBV17, suggesting a high degree of sequence homology. This similarity is likely due to the conserved nature of the T cell receptor complex across different species. **Pathways and Functions:** The T cell receptor complex, including TRBV18, is part of the adaptive immune response. Upon recognition of antigens, the T cell receptor complex is activated, leading to the activation of downstream signaling pathways. These pathways involve the activation of various kinases, such as Lck and ZAP-70, which phosphorylate and activate downstream targets, including the transcription factor NF-AT. The activation of NF-AT leads to the transcription of genes involved in the immune response, including cytokines, chemokines, and adhesion molecules. TRBV18 is also involved in the regulation of T cell development and function. It is expressed in various cell types, including T cells, granulocytes, and epithelial cells, suggesting a role in the regulation of immune responses in different tissues. Furthermore, TRBV18 has been shown to be involved in the regulation of T cell proliferation and differentiation, highlighting its importance in the development of immune responses. **Clinical Significance:** TRBV18 has been implicated in various diseases, including autoimmune disorders, allergies, and cancer. In autoimmune disorders, such as multiple sclerosis and type 1 diabetes, TRBV18 has been shown to be involved in the regulation of T cell responses and the development of autoimmunity. In allergies, TRBV18 has been implicated in the regulation of IgE production and the development of allergic responses. In cancer, TRBV18 has been shown to be involved in the regulation of T cell responses and the development of immunosuppression. For example, in colorectal cancer, TRBV18 has been shown to be expressed in tumor cells and has been implicated in the regulation of immune responses to cancer. In addition, TRBV18 has been shown to be involved in the regulation of epithelial cell function and the development of gastrointestinal disorders. For example, in inflammatory bowel disease, TRBV18 has been shown to be expressed in epithelial cells and has been implicated in the regulation of immune responses to the gut microbiome. In conclusion, TRBV18 is a gene that plays a critical role in the adaptive immune response. Its involvement in various diseases, including autoimmune disorders, allergies, and cancer, highlights its importance in the regulation of immune responses. Further research is needed to fully understand the function and clinical significance of TRBV18, but its role in the regulation of T cell responses and epithelial cell function is clear.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.