Details for: TRBV17

Gene ID: 28570

Symbol: TRBV17

Ensembl ID: ENSG00000277880

Description: T cell receptor beta variable 17 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.7430
    Cell Significance Index: 69.8900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.9999
    Cell Significance Index: 16.2000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.6271
    Cell Significance Index: 8.6000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.5446
    Cell Significance Index: 9.3100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.3118
    Cell Significance Index: 4.0400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.1987
    Cell Significance Index: 2.1100
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.1915
    Cell Significance Index: 2.5200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.1250
    Cell Significance Index: 1.2100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0214
    Cell Significance Index: 0.3100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.0212
    Cell Significance Index: 0.3600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0145
    Cell Significance Index: 0.1800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.0053
    Cell Significance Index: 0.0500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.0015
    Cell Significance Index: 0.0200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0006
    Cell Significance Index: 0.0100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0002
    Cell Significance Index: -0.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0003
    Cell Significance Index: -0.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0006
    Cell Significance Index: -0.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0011
    Cell Significance Index: -0.1700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0019
    Cell Significance Index: -0.0400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0027
    Cell Significance Index: -0.0300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0034
    Cell Significance Index: -0.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0036
    Cell Significance Index: -0.1000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0041
    Cell Significance Index: -0.0500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0051
    Cell Significance Index: -0.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0052
    Cell Significance Index: -0.2300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0053
    Cell Significance Index: -0.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0055
    Cell Significance Index: -0.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0057
    Cell Significance Index: -0.3200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0058
    Cell Significance Index: -0.0800
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0059
    Cell Significance Index: -0.0700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0060
    Cell Significance Index: -0.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0061
    Cell Significance Index: -0.2300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0062
    Cell Significance Index: -0.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0063
    Cell Significance Index: -0.2000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0064
    Cell Significance Index: -0.0800
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0066
    Cell Significance Index: -0.0700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0067
    Cell Significance Index: -0.0700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0071
    Cell Significance Index: -0.0800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0071
    Cell Significance Index: -0.0600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0073
    Cell Significance Index: -0.0900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0076
    Cell Significance Index: -0.0900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0076
    Cell Significance Index: -0.0800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0077
    Cell Significance Index: -0.1100
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0078
    Cell Significance Index: -0.0500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0084
    Cell Significance Index: -0.1100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0086
    Cell Significance Index: -0.1700
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0087
    Cell Significance Index: -0.0900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0090
    Cell Significance Index: -0.1900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0090
    Cell Significance Index: -0.1800
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0091
    Cell Significance Index: -0.0900
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0092
    Cell Significance Index: -0.0900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0094
    Cell Significance Index: -0.1000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0098
    Cell Significance Index: -0.1200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0103
    Cell Significance Index: -0.0900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0103
    Cell Significance Index: -0.1300
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0104
    Cell Significance Index: -0.0900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0109
    Cell Significance Index: -0.1300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0113
    Cell Significance Index: -0.2200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0125
    Cell Significance Index: -0.1600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0128
    Cell Significance Index: -0.1200
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0133
    Cell Significance Index: -0.1300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0133
    Cell Significance Index: -0.1800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0134
    Cell Significance Index: -0.1800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0137
    Cell Significance Index: -0.1300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0142
    Cell Significance Index: -0.1600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0143
    Cell Significance Index: -0.1500
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0144
    Cell Significance Index: -0.1300
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0146
    Cell Significance Index: -0.1300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0155
    Cell Significance Index: -0.1800
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.0156
    Cell Significance Index: -0.1700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0156
    Cell Significance Index: -0.2000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0160
    Cell Significance Index: -0.1500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0163
    Cell Significance Index: -0.1800
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0167
    Cell Significance Index: -0.1700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0169
    Cell Significance Index: -0.1100
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0174
    Cell Significance Index: -0.2000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0179
    Cell Significance Index: -0.1800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0179
    Cell Significance Index: -0.2200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0182
    Cell Significance Index: -0.1400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0197
    Cell Significance Index: -0.1700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0199
    Cell Significance Index: -0.2200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0200
    Cell Significance Index: -0.2500
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0205
    Cell Significance Index: -0.1100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0208
    Cell Significance Index: -0.2600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0211
    Cell Significance Index: -0.2000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0214
    Cell Significance Index: -0.1000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0217
    Cell Significance Index: -0.1900
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0219
    Cell Significance Index: -0.2300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0222
    Cell Significance Index: -0.1700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0232
    Cell Significance Index: -0.1400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0255
    Cell Significance Index: -0.1600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0258
    Cell Significance Index: -0.3200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0306
    Cell Significance Index: -0.3500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0367
    Cell Significance Index: -0.2000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0376
    Cell Significance Index: -0.3100
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0479
    Cell Significance Index: -0.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-functional nature:** TRBV17 is a non-functional gene, meaning it does not contribute to the development or function of T cells, a crucial component of the adaptive immune system. 2. **Widespread expression:** TRBV17 is significantly expressed in various hematopoietic cells, including erythrocytes, megakaryocytes, and precursor B cells, suggesting a potential role in hematopoiesis or cell development. 3. **Cell type specificity:** TRBV17 is predominantly expressed in CD8-positive, alpha-beta T cells, early T lineage precursors, and progenitor cells, indicating a specific role in T cell development and maturation. **Pathways and Functions:** 1. **Adaptive immune response:** TRBV17 is involved in the adaptive immune response, although its non-functional nature suggests that it may not contribute to T cell receptor-mediated recognition and activation. 2. **Cell surface receptor signaling pathway:** TRBV17 is part of the cell surface receptor signaling pathway, which is essential for the transmission of signals from the T cell receptor to the interior of the cell. 3. **Plasma membrane and T cell receptor complex:** TRBV17 is located on the plasma membrane and interacts with the T cell receptor complex, suggesting a role in T cell receptor-mediated signaling. **Clinical Significance:** 1. **Hematological disorders:** The non-functional nature of TRBV17 raises questions about its potential role in hematological disorders, such as immunodeficiency or leukemia. 2. **Immunological tolerance:** TRBV17 may play a role in immunological tolerance, as its non-functional nature may prevent excessive or inappropriate T cell activation. 3. **Cancer research:** TRBV17's expression in megakaryocytes and precursor B cells suggests a potential role in cancer research, particularly in the study of hematopoietic malignancies. In conclusion, TRBV17 is a non-functional gene that is significantly expressed in various hematopoietic cells. Its widespread expression and cell type specificity suggest a potential role in T cell development and maturation, as well as a possible contribution to hematological disorders or immunological tolerance. Further research is necessary to fully understand the functions and clinical significance of TRBV17.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.