Details for: TRBV12 3

Gene ID: 28577

Symbol: TRBV12 3

Ensembl ID: ENSG00000274752

Description: T cell receptor beta variable 12-3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.3374
    Cell Significance Index: 1.8400
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.0722
    Cell Significance Index: 0.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0203
    Cell Significance Index: -4.0700
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0236
    Cell Significance Index: -0.2200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0271
    Cell Significance Index: -0.4600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0331
    Cell Significance Index: -0.4500
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0338
    Cell Significance Index: -0.2800
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0356
    Cell Significance Index: -0.3300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0390
    Cell Significance Index: -0.4600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0455
    Cell Significance Index: -0.4600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0487
    Cell Significance Index: -0.7100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0634
    Cell Significance Index: -0.5400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0766
    Cell Significance Index: -1.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0826
    Cell Significance Index: -2.2100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0909
    Cell Significance Index: -1.3300
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0930
    Cell Significance Index: -0.6400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0998
    Cell Significance Index: -2.5500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1044
    Cell Significance Index: -0.9900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1149
    Cell Significance Index: -1.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1223
    Cell Significance Index: -5.7500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1261
    Cell Significance Index: -1.4900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1299
    Cell Significance Index: -3.3100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1472
    Cell Significance Index: -1.2700
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1483
    Cell Significance Index: -1.7600
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1488
    Cell Significance Index: -1.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1529
    Cell Significance Index: -1.4700
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1566
    Cell Significance Index: -1.7500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1587
    Cell Significance Index: -1.6100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1630
    Cell Significance Index: -1.3200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1678
    Cell Significance Index: -3.2800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1716
    Cell Significance Index: -2.2200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1754
    Cell Significance Index: -2.1700
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1766
    Cell Significance Index: -1.4900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1799
    Cell Significance Index: -3.3300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1809
    Cell Significance Index: -2.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2000
    Cell Significance Index: -5.3400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2018
    Cell Significance Index: -2.5500
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2021
    Cell Significance Index: -1.9700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2047
    Cell Significance Index: -2.3800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2100
    Cell Significance Index: -2.8800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2106
    Cell Significance Index: -3.6000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2121
    Cell Significance Index: -2.2000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2148
    Cell Significance Index: -2.3500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2164
    Cell Significance Index: -2.1700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2173
    Cell Significance Index: -3.6600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2181
    Cell Significance Index: -2.8700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2187
    Cell Significance Index: -3.7700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.2223
    Cell Significance Index: -2.2400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2294
    Cell Significance Index: -2.7900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2324
    Cell Significance Index: -3.0500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2324
    Cell Significance Index: -2.3700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.2332
    Cell Significance Index: -2.5600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2352
    Cell Significance Index: -3.0700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2365
    Cell Significance Index: -2.9600
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.2379
    Cell Significance Index: -1.7700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2382
    Cell Significance Index: -3.0600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2433
    Cell Significance Index: -2.9900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2438
    Cell Significance Index: -2.7700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2458
    Cell Significance Index: -2.9100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.2490
    Cell Significance Index: -2.6400
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.2499
    Cell Significance Index: -2.4500
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2501
    Cell Significance Index: -2.7400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2532
    Cell Significance Index: -2.2200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2559
    Cell Significance Index: -2.6200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2580
    Cell Significance Index: -3.0100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.2602
    Cell Significance Index: -2.3900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.2632
    Cell Significance Index: -2.8300
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.2657
    Cell Significance Index: -2.3900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2671
    Cell Significance Index: -3.0100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2671
    Cell Significance Index: -2.8800
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.2690
    Cell Significance Index: -2.9000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2702
    Cell Significance Index: -3.1100
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.2734
    Cell Significance Index: -2.3300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2820
    Cell Significance Index: -3.1500
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.2825
    Cell Significance Index: -2.8200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.2843
    Cell Significance Index: -2.6300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2847
    Cell Significance Index: -3.3500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2872
    Cell Significance Index: -2.5300
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.2878
    Cell Significance Index: -2.4100
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.2878
    Cell Significance Index: -2.3800
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2891
    Cell Significance Index: -3.0700
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2915
    Cell Significance Index: -3.0100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2919
    Cell Significance Index: -2.9800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.2928
    Cell Significance Index: -2.5600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2939
    Cell Significance Index: -3.1000
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.2964
    Cell Significance Index: -3.0700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3013
    Cell Significance Index: -3.5600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3065
    Cell Significance Index: -3.4000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3072
    Cell Significance Index: -4.2600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.3081
    Cell Significance Index: -2.3700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3081
    Cell Significance Index: -4.6800
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.3083
    Cell Significance Index: -2.5500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.3124
    Cell Significance Index: -2.4300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3129
    Cell Significance Index: -3.6000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.3134
    Cell Significance Index: -5.0400
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.3142
    Cell Significance Index: -3.0700
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.3149
    Cell Significance Index: -2.9800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3173
    Cell Significance Index: -4.1500
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.3237
    Cell Significance Index: -2.4700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3249
    Cell Significance Index: -3.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TRBV12-3 gene is a member of the T cell receptor beta variable (TRBV) family, which is responsible for encoding the variable region of the T cell receptor beta chain. This region is critical for recognizing and binding to antigenic peptides presented by major histocompatibility complex (MHC) molecules. The TRBV12-3 gene is characterized by its high degree of polymorphism, allowing for the generation of a diverse repertoire of T cell receptors. Its expression is restricted to cells of the immune system, including T cells, hematopoietic cells, and certain non-lymphoid cells. **Pathways and Functions:** The TRBV12-3 gene is involved in various signaling pathways that regulate T cell activation, proliferation, and differentiation. These pathways include: 1. **Adaptive immune response:** The TRBV12-3 gene plays a crucial role in the adaptive immune response by recognizing and binding to antigenic peptides presented by MHC molecules. 2. **Cell surface receptor signaling pathway:** The TRBV12-3 gene is involved in the signaling cascade that occurs upon T cell receptor engagement with antigenic peptides. 3. **Costimulation by the CD28 family:** The TRBV12-3 gene is required for the activation of T cells through the CD28 co-receptor. 4. **Downstream TCR signaling:** The TRBV12-3 gene is involved in the downstream signaling events that occur after T cell receptor engagement. 5. **Phosphorylation of CD3 and TCR zeta chains:** The TRBV12-3 gene is required for the phosphorylation of CD3 and TCR zeta chains, which is a critical step in T cell activation. **Clinical Significance:** Dysregulation of the TRBV12-3 gene has been implicated in various immune-related disorders and cancers, including: 1. **Autoimmune diseases:** Alterations in the TRBV12-3 gene have been associated with autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** The TRBV12-3 gene has been implicated in the development and progression of certain cancers, including leukemia and lymphoma. 3. **Infectious diseases:** The TRBV12-3 gene plays a crucial role in the adaptive immune response to infectious diseases, and its dysregulation can lead to impaired immune function. In conclusion, the TRBV12-3 gene is a critical component of the adaptive immune response, influencing cell surface receptor signaling, costimulation, and downstream signaling pathways. Its dysregulation has been implicated in various immune-related disorders and cancers, highlighting the importance of this gene in maintaining immune homeostasis.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.