Details for: TRBV6 4

Gene ID: 28603

Symbol: TRBV6 4

Ensembl ID: ENSG00000211713

Description: T cell receptor beta variable 6-4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 1.8912
    Cell Significance Index: 20.0900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0517
    Cell Significance Index: 0.5400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0275
    Cell Significance Index: 0.1500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.0017
    Cell Significance Index: 0.0200
  • Cell Name: lung resident memory CD4-positive, alpha-beta T cell (CL4033038)
    Fold Change: -0.0013
    Cell Significance Index: -0.0100
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0045
    Cell Significance Index: -0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0083
    Cell Significance Index: -1.6700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0131
    Cell Significance Index: -0.2300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0132
    Cell Significance Index: -0.1800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0200
    Cell Significance Index: -0.2300
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0217
    Cell Significance Index: -0.1800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0231
    Cell Significance Index: -0.5600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0269
    Cell Significance Index: -0.4600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0271
    Cell Significance Index: -0.3200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0323
    Cell Significance Index: -0.5400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0331
    Cell Significance Index: -0.4800
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0340
    Cell Significance Index: -0.4100
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0345
    Cell Significance Index: -0.3100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0356
    Cell Significance Index: -0.5300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0366
    Cell Significance Index: -0.3700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0373
    Cell Significance Index: -0.9500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0378
    Cell Significance Index: -0.3500
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0390
    Cell Significance Index: -0.4000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0408
    Cell Significance Index: -0.5600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0424
    Cell Significance Index: -0.4600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0434
    Cell Significance Index: -0.4500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0458
    Cell Significance Index: -0.3900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0464
    Cell Significance Index: -0.6600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0474
    Cell Significance Index: -0.6600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0569
    Cell Significance Index: -0.8300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0577
    Cell Significance Index: -0.5400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0612
    Cell Significance Index: -0.5800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0618
    Cell Significance Index: -0.6700
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0685
    Cell Significance Index: -0.6300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0692
    Cell Significance Index: -0.4500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0696
    Cell Significance Index: -0.9000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0697
    Cell Significance Index: -0.9200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0711
    Cell Significance Index: -0.7500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0716
    Cell Significance Index: -1.4000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0719
    Cell Significance Index: -1.1700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0734
    Cell Significance Index: -0.9600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0736
    Cell Significance Index: -1.3600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0736
    Cell Significance Index: -0.9300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0737
    Cell Significance Index: -0.9700
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0744
    Cell Significance Index: -0.6400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0744
    Cell Significance Index: -1.1300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0748
    Cell Significance Index: -0.9200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0749
    Cell Significance Index: -0.7600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0773
    Cell Significance Index: -0.9200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0785
    Cell Significance Index: -0.9100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0789
    Cell Significance Index: -0.8600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0792
    Cell Significance Index: -0.9500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0794
    Cell Significance Index: -1.0900
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0822
    Cell Significance Index: -0.9200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0841
    Cell Significance Index: -0.9900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0842
    Cell Significance Index: -1.1800
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0847
    Cell Significance Index: -1.0300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0849
    Cell Significance Index: -0.8800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0864
    Cell Significance Index: -1.1100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0888
    Cell Significance Index: -0.7100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0895
    Cell Significance Index: -0.7100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0902
    Cell Significance Index: -0.7300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0904
    Cell Significance Index: -0.7800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0905
    Cell Significance Index: -1.0200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0912
    Cell Significance Index: -1.0100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0917
    Cell Significance Index: -0.9300
  • Cell Name: respiratory suprabasal cell (CL4033048)
    Fold Change: -0.0918
    Cell Significance Index: -0.8300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0923
    Cell Significance Index: -0.9800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0924
    Cell Significance Index: -0.9800
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0927
    Cell Significance Index: -0.7900
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0929
    Cell Significance Index: -0.8400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0931
    Cell Significance Index: -1.0400
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0945
    Cell Significance Index: -0.6500
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0950
    Cell Significance Index: -0.8400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0953
    Cell Significance Index: -0.9600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0957
    Cell Significance Index: -0.9200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0965
    Cell Significance Index: -1.2600
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0965
    Cell Significance Index: -1.0000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0978
    Cell Significance Index: -1.0400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0980
    Cell Significance Index: -1.0000
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0980
    Cell Significance Index: -1.1300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1009
    Cell Significance Index: -1.0300
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1016
    Cell Significance Index: -0.9400
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1023
    Cell Significance Index: -1.0000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1030
    Cell Significance Index: -1.1100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1032
    Cell Significance Index: -1.0300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1033
    Cell Significance Index: -0.9700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1038
    Cell Significance Index: -1.3800
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.1062
    Cell Significance Index: -0.4000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1064
    Cell Significance Index: -1.2600
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1068
    Cell Significance Index: -0.9700
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.1083
    Cell Significance Index: -0.2900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1087
    Cell Significance Index: -1.0600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1089
    Cell Significance Index: -1.0000
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1100
    Cell Significance Index: -1.1400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1117
    Cell Significance Index: -1.2900
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1125
    Cell Significance Index: -0.9400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1138
    Cell Significance Index: -0.9600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1149
    Cell Significance Index: -1.2100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1151
    Cell Significance Index: -1.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TRBV6-4 gene is characterized by its involvement in the adaptive immune response, specifically in the activation and regulation of T cells. The gene is expressed in a range of immune cells, including mucosal invariant T cells, which are unique to the mucosal-associated lymphoid tissues (MALT) and play a critical role in mucosal immunity. The TRBV6-4 gene is also expressed in central memory CD4-positive T cells, which are a subset of T cells that have undergone extensive differentiation and are characterized by their ability to maintain long-term immunity. Furthermore, the gene is expressed in alpha-beta T cells, which are a major subset of T cells involved in cell-mediated immunity. **Pathways and Functions:** The TRBV6-4 gene is involved in several key pathways and functions, including: 1. **Adaptive Immune Response**: The TRBV6-4 gene plays a critical role in the adaptive immune response, influencing the activation and regulation of T cells. 2. **Cell Surface Receptor Signaling**: The gene is involved in cell surface receptor signaling, influencing the interaction between T cells and antigens. 3. **Plasma Membrane Interactions**: The TRBV6-4 gene is also involved in plasma membrane interactions, influencing the organization and function of the T cell receptor complex. 4. **T Cell Receptor Complex Formation**: The gene is essential for the formation of the T cell receptor complex, which is critical for T cell activation and function. **Clinical Significance:** The TRBV6-4 gene has significant clinical implications for the understanding and treatment of autoimmune and infectious diseases. For example: 1. **Immunodeficiency Disorders**: Alterations in the TRBV6-4 gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Autoimmune Diseases**: The gene has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer**: The TRBV6-4 gene has been associated with cancer, including T cell lymphoma and leukemia. 4. **Vaccine Development**: Understanding the function and clinical significance of TRBV6-4 is essential for the development of novel vaccines and immunotherapies. In conclusion, the TRBV6-4 gene plays a critical role in the adaptive immune response, influencing cell surface receptor signaling, plasma membrane interactions, and T cell receptor complex formation. Further research is necessary to elucidate the full extent of the gene's function and clinical significance, with potential implications for the treatment of autoimmune and infectious diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.