Details for: TRBV2

Gene ID: 28620

Symbol: TRBV2

Ensembl ID: ENSG00000226660

Description: T cell receptor beta variable 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.6474
    Cell Significance Index: 3.5300
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.4066
    Cell Significance Index: 3.3700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0005
    Cell Significance Index: -0.0200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0054
    Cell Significance Index: -0.0600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0364
    Cell Significance Index: -0.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0437
    Cell Significance Index: -4.4600
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0689
    Cell Significance Index: -0.2100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0834
    Cell Significance Index: -2.0200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1168
    Cell Significance Index: -1.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1482
    Cell Significance Index: -3.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1517
    Cell Significance Index: -7.1300
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1877
    Cell Significance Index: -1.5200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1885
    Cell Significance Index: -2.2600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1892
    Cell Significance Index: -4.8200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2033
    Cell Significance Index: -2.4000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2168
    Cell Significance Index: -2.1900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2302
    Cell Significance Index: -4.5000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2374
    Cell Significance Index: -3.2300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2429
    Cell Significance Index: -4.4900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2467
    Cell Significance Index: -4.1900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2531
    Cell Significance Index: -4.1000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2576
    Cell Significance Index: -4.4400
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.2692
    Cell Significance Index: -2.3200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2702
    Cell Significance Index: -3.7100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2743
    Cell Significance Index: -4.4100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2854
    Cell Significance Index: -2.9600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2873
    Cell Significance Index: -4.8400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2903
    Cell Significance Index: -2.4500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.2909
    Cell Significance Index: -2.5100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2918
    Cell Significance Index: -2.7300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2928
    Cell Significance Index: -3.1900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3013
    Cell Significance Index: -5.1500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3089
    Cell Significance Index: -4.5600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3119
    Cell Significance Index: -3.0400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3142
    Cell Significance Index: -3.6500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3161
    Cell Significance Index: -3.9100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3207
    Cell Significance Index: -4.8700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.3269
    Cell Significance Index: -4.2000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3367
    Cell Significance Index: -4.7200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3398
    Cell Significance Index: -4.6600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3400
    Cell Significance Index: -3.4500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.3417
    Cell Significance Index: -4.9800
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.3431
    Cell Significance Index: -2.3600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3449
    Cell Significance Index: -3.2700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3457
    Cell Significance Index: -4.5500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3468
    Cell Significance Index: -4.8100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3472
    Cell Significance Index: -3.2600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.3527
    Cell Significance Index: -3.3900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3545
    Cell Significance Index: -4.3100
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.3567
    Cell Significance Index: -3.0400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3582
    Cell Significance Index: -4.7000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.3604
    Cell Significance Index: -3.0700
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.3622
    Cell Significance Index: -3.8400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3645
    Cell Significance Index: -4.4800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.3652
    Cell Significance Index: -3.6800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3655
    Cell Significance Index: -4.7300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.3664
    Cell Significance Index: -4.3500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.3673
    Cell Significance Index: -4.3400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3714
    Cell Significance Index: -4.6400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.3715
    Cell Significance Index: -4.8500
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.3721
    Cell Significance Index: -3.1100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.3738
    Cell Significance Index: -4.0300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.3744
    Cell Significance Index: -4.4300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.3760
    Cell Significance Index: -2.9300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3793
    Cell Significance Index: -5.0400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.3845
    Cell Significance Index: -4.5700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.3847
    Cell Significance Index: -4.3700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.3864
    Cell Significance Index: -4.2100
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.3870
    Cell Significance Index: -3.8800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.3913
    Cell Significance Index: -4.3000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.3917
    Cell Significance Index: -4.2900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3918
    Cell Significance Index: -4.6300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3936
    Cell Significance Index: -4.5300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3947
    Cell Significance Index: -4.0300
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.3992
    Cell Significance Index: -4.4400
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.3993
    Cell Significance Index: -4.4400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.4000
    Cell Significance Index: -4.4300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4050
    Cell Significance Index: -4.6600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.4069
    Cell Significance Index: -4.9500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.4073
    Cell Significance Index: -4.5900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.4080
    Cell Significance Index: -4.2300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.4130
    Cell Significance Index: -4.2200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.4135
    Cell Significance Index: -4.6200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.4148
    Cell Significance Index: -4.1400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.4167
    Cell Significance Index: -4.2500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4171
    Cell Significance Index: -4.4000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.4191
    Cell Significance Index: -4.6400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.4196
    Cell Significance Index: -3.6700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.4201
    Cell Significance Index: -5.6000
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.4216
    Cell Significance Index: -3.9000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.4228
    Cell Significance Index: -4.4900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.4238
    Cell Significance Index: -4.1000
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.4257
    Cell Significance Index: -4.3800
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.4266
    Cell Significance Index: -4.6600
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.4269
    Cell Significance Index: -4.9600
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.4271
    Cell Significance Index: -4.6400
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.4279
    Cell Significance Index: -3.8500
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.4303
    Cell Significance Index: -4.5100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.4311
    Cell Significance Index: -5.1300
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.4312
    Cell Significance Index: -4.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Genomic Location:** The TRBV2 gene is located on chromosome 7q34, within the TCR locus. This region is a hotspot for genetic variation, resulting in diverse TCR repertoires. 2. **Expression Patterns:** TRBV2 is expressed in various hematopoietic cells, including T cells, granulocytes, monocytes, and goblet cells. Its expression is also observed in early T lineage precursors, intestinal crypt stem cells, and absorptive cells. 3. **Molecular Structure:** The TRBV2 gene encodes a variable region of the TCR beta chain, which is composed of five immunoglobulin-like domains. This structure allows for the recognition of peptide-MHC complexes and the initiation of T cell activation. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRBV2 is integral to the adaptive immune response, enabling T cells to recognize and respond to specific pathogens. The TCR complex, comprising TRBV2, TRBV1, TRBD2, and TRBC2, recognizes peptide-MHC complexes, triggering T cell activation and proliferation. 2. **Cell Surface Receptor Signaling Pathway:** The TRBV2 gene is involved in the signaling pathway of cell surface receptors, regulating T cell activation, proliferation, and differentiation. 3. **Plasma Membrane and TCR Complex:** TRBV2 is embedded in the plasma membrane, where it interacts with other TCR components to form the TCR complex. This complex is essential for the recognition of peptide-MHC complexes and the initiation of T cell responses. **Clinical Significance:** 1. **Autoimmune Diseases:** Dysregulation of TRBV2 expression and function has been implicated in autoimmune diseases, such as multiple sclerosis and type 1 diabetes. Altered TCR repertoires may contribute to the development of these conditions. 2. **Cancer Immunotherapy:** TRBV2 has been identified as a potential target for cancer immunotherapy. By manipulating TCR repertoires, researchers aim to enhance anti-tumor immune responses and improve cancer treatment outcomes. 3. **Infectious Diseases:** TRBV2 plays a critical role in the recognition of pathogens, making it an essential component of the immune response against infections. Alterations in TRBV2 expression and function may contribute to the development of vaccine-resistant pathogens. In conclusion, TRBV2 is a vital component of the adaptive immune system, playing a crucial role in the recognition and response to pathogens. Further research into the complexities of TRBV2 will provide valuable insights into the development of novel immunotherapies and our understanding of immune-mediated diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.