Details for: TRAV38 1

Gene ID: 28644

Symbol: TRAV38 1

Ensembl ID: ENSG00000211816

Description: T cell receptor alpha variable 38-1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.58
    Marker Score: 1,331
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.96
    Marker Score: 1,032
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 501
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 231
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.51
    Marker Score: 452
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 475
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.44
    Marker Score: 270
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.36
    Marker Score: 211
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.27
    Marker Score: 486
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.23
    Marker Score: 399
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.19
    Marker Score: 88
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.19
    Marker Score: 157
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.16
    Marker Score: 231
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.16
    Marker Score: 170
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.15
    Marker Score: 135
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.14
    Marker Score: 82
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.14
    Marker Score: 440
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.12
    Marker Score: 96
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.11
    Marker Score: 118
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.1
    Marker Score: 187
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.09
    Marker Score: 392
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.09
    Marker Score: 905
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.09
    Marker Score: 129
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.08
    Marker Score: 196
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.07
    Marker Score: 3,705
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.07
    Marker Score: 52
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.07
    Marker Score: 73
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 133
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.06
    Marker Score: 47
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.06
    Marker Score: 46
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.06
    Marker Score: 52
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.06
    Marker Score: 38
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.05
    Marker Score: 52
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.05
    Marker Score: 38
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.05
    Marker Score: 54
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.05
    Marker Score: 581
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.04
    Marker Score: 125
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.04
    Marker Score: 37
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.04
    Marker Score: 33
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.04
    Marker Score: 52
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.04
    Marker Score: 90
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.03
    Marker Score: 35
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.03
    Marker Score: 109
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.03
    Marker Score: 42
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.01
    Marker Score: 32
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 17
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0
    Marker Score: 19
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0
    Marker Score: 19
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0
    Marker Score: 17
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0
    Marker Score: 19
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 62

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location:** TRAV38.1 is located on the T cell receptor complex, which is a critical region for the assembly and expression of T cell receptors. 2. **Expression:** TRAV38.1 is significantly expressed in various immune cells, including effector CD8-positive T cells, central memory CD4-positive T cells, and precursor B cells. 3. **Cell types:** TRAV38.1 is expressed in granulocyte monocyte progenitor cells, early T lineage precursors, and megakaryocyte-erythroid progenitor cells, indicating its role in the development and function of multiple immune cell types. 4. **Pathways:** TRAV38.1 is involved in the adaptive immune response, extracellular space, immunoglobulin production, and T cell receptor complex pathways. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRAV38.1 plays a crucial role in the adaptive immune response by contributing to the recognition and elimination of pathogens. The variable region of the T cell receptor alpha chain, including TRAV38.1, is responsible for antigen recognition and binding. 2. **T Cell Receptor Complex:** TRAV38.1 is a critical component of the T cell receptor complex, which assembles and expresses the T cell receptor alpha chain. This complex is essential for the recognition of antigens and the activation of T cells. 3. **Extracellular Space:** TRAV38.1 is involved in the extracellular space, where it interacts with other molecules and cells to facilitate immune responses. 4. **Immunoglobulin Production:** TRAV38.1 is also involved in immunoglobulin production, which is a critical aspect of the adaptive immune response. The expression of TRAV38.1 in precursor B cells suggests its role in the development of B cells and the production of immunoglobulins. **Clinical Significance:** 1. **Immunodeficiency:** Mutations or deletions in the TRAV38.1 gene can lead to immunodeficiency, making individuals susceptible to infections and diseases. 2. **Autoimmune Diseases:** The expression of TRAV38.1 in certain immune cells suggests its role in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer:** The involvement of TRAV38.1 in the adaptive immune response and T cell receptor complex pathways makes it a potential target for cancer therapy. 4. **Vaccine Development:** Understanding the function of TRAV38.1 can inform the development of vaccines that target specific T cell receptors and enhance immune responses. In conclusion, TRAV38.1 is a critical gene that plays a pivotal role in the adaptive immune response. Its widespread expression across various immune cells and involvement in multiple pathways and functions make it an essential component of the immune system. Further research on TRAV38.1 can provide valuable insights into the development of new immunotherapies and vaccines, as well as our understanding of immunodeficiency and autoimmune diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.