Details for: TRAV38 1

Gene ID: 28644

Symbol: TRAV38 1

Ensembl ID: ENSG00000211816

Description: T cell receptor alpha variable 38-1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.2835
    Cell Significance Index: 2.3500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1082
    Cell Significance Index: 0.5900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.0002
    Cell Significance Index: 0.0000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0192
    Cell Significance Index: -0.2200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0214
    Cell Significance Index: -0.2000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0297
    Cell Significance Index: -0.7200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0389
    Cell Significance Index: -0.6600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0398
    Cell Significance Index: -0.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0413
    Cell Significance Index: -1.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0418
    Cell Significance Index: -1.3700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0441
    Cell Significance Index: -0.6000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0443
    Cell Significance Index: -0.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0460
    Cell Significance Index: -1.2300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0515
    Cell Significance Index: -0.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0519
    Cell Significance Index: -1.5300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0590
    Cell Significance Index: -0.8600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0622
    Cell Significance Index: -0.5300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0673
    Cell Significance Index: -1.7200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0685
    Cell Significance Index: -1.1800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0698
    Cell Significance Index: -0.8300
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0727
    Cell Significance Index: -0.5000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0729
    Cell Significance Index: -0.5900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0778
    Cell Significance Index: -1.2600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0791
    Cell Significance Index: -0.7400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0796
    Cell Significance Index: -1.1600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0839
    Cell Significance Index: -1.1500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0923
    Cell Significance Index: -1.8100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0924
    Cell Significance Index: -1.5800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0928
    Cell Significance Index: -0.8800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0957
    Cell Significance Index: -1.2600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0962
    Cell Significance Index: -1.1900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0974
    Cell Significance Index: -1.2600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0977
    Cell Significance Index: -0.9800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0985
    Cell Significance Index: -1.8200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0985
    Cell Significance Index: -1.4000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1003
    Cell Significance Index: -1.0400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1020
    Cell Significance Index: -0.9800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1021
    Cell Significance Index: -1.5500
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1037
    Cell Significance Index: -1.1000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1069
    Cell Significance Index: -1.0900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1089
    Cell Significance Index: -0.9400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1147
    Cell Significance Index: -1.3500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1153
    Cell Significance Index: -1.4400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1155
    Cell Significance Index: -1.3400
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1173
    Cell Significance Index: -0.9800
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1175
    Cell Significance Index: -1.0100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1200
    Cell Significance Index: -1.2900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1211
    Cell Significance Index: -1.2200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1218
    Cell Significance Index: -1.4600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1220
    Cell Significance Index: -1.5000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1234
    Cell Significance Index: -1.6200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1238
    Cell Significance Index: -1.7000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1259
    Cell Significance Index: -1.4300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1264
    Cell Significance Index: -1.6800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1269
    Cell Significance Index: -2.0400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1279
    Cell Significance Index: -1.6700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1294
    Cell Significance Index: -1.4100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1295
    Cell Significance Index: -1.4900
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1297
    Cell Significance Index: -1.2000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1299
    Cell Significance Index: -1.4700
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.1318
    Cell Significance Index: -1.5400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1341
    Cell Significance Index: -1.4200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1350
    Cell Significance Index: -2.2700
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1351
    Cell Significance Index: -1.3700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1351
    Cell Significance Index: -1.5700
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1357
    Cell Significance Index: -1.4300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1360
    Cell Significance Index: -1.5700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1378
    Cell Significance Index: -1.7700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1384
    Cell Significance Index: -1.6400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1384
    Cell Significance Index: -1.5600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1391
    Cell Significance Index: -1.5000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1392
    Cell Significance Index: -1.4200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1401
    Cell Significance Index: -1.4300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1418
    Cell Significance Index: -1.5700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1422
    Cell Significance Index: -1.6800
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.1425
    Cell Significance Index: -1.3400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1427
    Cell Significance Index: -1.1100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1436
    Cell Significance Index: -1.4000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1440
    Cell Significance Index: -1.2200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1441
    Cell Significance Index: -1.2600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1448
    Cell Significance Index: -2.0300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1454
    Cell Significance Index: -1.7300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1457
    Cell Significance Index: -1.7300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1459
    Cell Significance Index: -1.3700
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1460
    Cell Significance Index: -1.5600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1476
    Cell Significance Index: -1.1800
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1487
    Cell Significance Index: -1.5400
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1497
    Cell Significance Index: -1.6400
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1501
    Cell Significance Index: -1.7300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1504
    Cell Significance Index: -1.6800
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1508
    Cell Significance Index: -1.3700
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1512
    Cell Significance Index: -1.8400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1513
    Cell Significance Index: -1.6100
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1523
    Cell Significance Index: -1.3700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1526
    Cell Significance Index: -1.2900
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.1532
    Cell Significance Index: -1.5600
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1543
    Cell Significance Index: -1.5400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1546
    Cell Significance Index: -1.4200
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1550
    Cell Significance Index: -1.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location:** TRAV38.1 is located on the T cell receptor complex, which is a critical region for the assembly and expression of T cell receptors. 2. **Expression:** TRAV38.1 is significantly expressed in various immune cells, including effector CD8-positive T cells, central memory CD4-positive T cells, and precursor B cells. 3. **Cell types:** TRAV38.1 is expressed in granulocyte monocyte progenitor cells, early T lineage precursors, and megakaryocyte-erythroid progenitor cells, indicating its role in the development and function of multiple immune cell types. 4. **Pathways:** TRAV38.1 is involved in the adaptive immune response, extracellular space, immunoglobulin production, and T cell receptor complex pathways. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRAV38.1 plays a crucial role in the adaptive immune response by contributing to the recognition and elimination of pathogens. The variable region of the T cell receptor alpha chain, including TRAV38.1, is responsible for antigen recognition and binding. 2. **T Cell Receptor Complex:** TRAV38.1 is a critical component of the T cell receptor complex, which assembles and expresses the T cell receptor alpha chain. This complex is essential for the recognition of antigens and the activation of T cells. 3. **Extracellular Space:** TRAV38.1 is involved in the extracellular space, where it interacts with other molecules and cells to facilitate immune responses. 4. **Immunoglobulin Production:** TRAV38.1 is also involved in immunoglobulin production, which is a critical aspect of the adaptive immune response. The expression of TRAV38.1 in precursor B cells suggests its role in the development of B cells and the production of immunoglobulins. **Clinical Significance:** 1. **Immunodeficiency:** Mutations or deletions in the TRAV38.1 gene can lead to immunodeficiency, making individuals susceptible to infections and diseases. 2. **Autoimmune Diseases:** The expression of TRAV38.1 in certain immune cells suggests its role in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer:** The involvement of TRAV38.1 in the adaptive immune response and T cell receptor complex pathways makes it a potential target for cancer therapy. 4. **Vaccine Development:** Understanding the function of TRAV38.1 can inform the development of vaccines that target specific T cell receptors and enhance immune responses. In conclusion, TRAV38.1 is a critical gene that plays a pivotal role in the adaptive immune response. Its widespread expression across various immune cells and involvement in multiple pathways and functions make it an essential component of the immune system. Further research on TRAV38.1 can provide valuable insights into the development of new immunotherapies and vaccines, as well as our understanding of immunodeficiency and autoimmune diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.