Details for: TRAV24

Gene ID: 28659

Symbol: TRAV24

Ensembl ID: ENSG00000211805

Description: T cell receptor alpha variable 24

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1797
    Cell Significance Index: 0.9800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1548
    Cell Significance Index: 1.7300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.1012
    Cell Significance Index: 1.2800
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.0459
    Cell Significance Index: 0.3800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0144
    Cell Significance Index: 0.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0017
    Cell Significance Index: -0.6100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0019
    Cell Significance Index: -0.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0047
    Cell Significance Index: -0.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0056
    Cell Significance Index: -0.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0084
    Cell Significance Index: -1.1600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0153
    Cell Significance Index: -0.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0188
    Cell Significance Index: -1.0600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0193
    Cell Significance Index: -0.2300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0247
    Cell Significance Index: -0.4200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0249
    Cell Significance Index: -0.2100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0266
    Cell Significance Index: -0.6500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0279
    Cell Significance Index: -0.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0281
    Cell Significance Index: -1.3200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0287
    Cell Significance Index: -0.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0299
    Cell Significance Index: -0.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0302
    Cell Significance Index: -0.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0311
    Cell Significance Index: -0.9900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0313
    Cell Significance Index: -0.3700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0321
    Cell Significance Index: -0.5400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0323
    Cell Significance Index: -0.4700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0344
    Cell Significance Index: -0.3700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0392
    Cell Significance Index: -0.4900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0413
    Cell Significance Index: -0.4000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0438
    Cell Significance Index: -0.7100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0459
    Cell Significance Index: -0.5800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0471
    Cell Significance Index: -0.6100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0483
    Cell Significance Index: -1.2300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0491
    Cell Significance Index: -1.0600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0500
    Cell Significance Index: -0.6900
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0522
    Cell Significance Index: -0.5800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0539
    Cell Significance Index: -1.0600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0547
    Cell Significance Index: -1.0900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0548
    Cell Significance Index: -1.1000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0561
    Cell Significance Index: -1.1100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0574
    Cell Significance Index: -0.5800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0576
    Cell Significance Index: -0.7400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0590
    Cell Significance Index: -0.7300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0604
    Cell Significance Index: -0.8600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0617
    Cell Significance Index: -0.8600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0617
    Cell Significance Index: -0.6700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0633
    Cell Significance Index: -0.6000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0646
    Cell Significance Index: -0.5500
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0658
    Cell Significance Index: -0.4500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0701
    Cell Significance Index: -1.3700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0704
    Cell Significance Index: -0.5700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0705
    Cell Significance Index: -1.0900
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0707
    Cell Significance Index: -0.7300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0719
    Cell Significance Index: -0.7300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0733
    Cell Significance Index: -0.7600
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0744
    Cell Significance Index: -0.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0763
    Cell Significance Index: -1.4100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0802
    Cell Significance Index: -0.7500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0812
    Cell Significance Index: -0.9600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0813
    Cell Significance Index: -1.0700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0818
    Cell Significance Index: -0.8200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0821
    Cell Significance Index: -0.6500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0822
    Cell Significance Index: -1.0200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0823
    Cell Significance Index: -1.0600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0828
    Cell Significance Index: -1.1000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0830
    Cell Significance Index: -1.2100
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0838
    Cell Significance Index: -1.0500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0848
    Cell Significance Index: -1.4500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0848
    Cell Significance Index: -1.0700
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0858
    Cell Significance Index: -0.8500
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0858
    Cell Significance Index: -0.8400
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0869
    Cell Significance Index: -0.9000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0870
    Cell Significance Index: -1.0500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0879
    Cell Significance Index: -1.0200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0893
    Cell Significance Index: -1.0500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0903
    Cell Significance Index: -1.1100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0918
    Cell Significance Index: -1.0400
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0922
    Cell Significance Index: -0.8400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0923
    Cell Significance Index: -0.9300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0937
    Cell Significance Index: -1.2300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0938
    Cell Significance Index: -1.0900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0942
    Cell Significance Index: -1.2300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0947
    Cell Significance Index: -1.0900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0949
    Cell Significance Index: -0.9300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0961
    Cell Significance Index: -1.0400
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0962
    Cell Significance Index: -1.0200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0962
    Cell Significance Index: -1.1700
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0969
    Cell Significance Index: -0.8100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0973
    Cell Significance Index: -0.8400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0978
    Cell Significance Index: -0.6800
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0980
    Cell Significance Index: -1.0700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0995
    Cell Significance Index: -1.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0999
    Cell Significance Index: -0.9600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1009
    Cell Significance Index: -1.2100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1016
    Cell Significance Index: -1.1300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1024
    Cell Significance Index: -1.2100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1033
    Cell Significance Index: -0.9700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1034
    Cell Significance Index: -1.1900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1037
    Cell Significance Index: -1.2300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1045
    Cell Significance Index: -1.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression pattern:** TRAV24 is expressed in a variety of cell types, including alpha-beta T cells, granulocyte-monocyte progenitor cells, and neoplastic cells. This widespread expression suggests that TRAV24 is involved in the development and function of multiple immune cell types. 2. **T cell receptor complex:** TRAV24 is part of the TCR complex, which is essential for the recognition of antigens by T cells. The TCR complex consists of the alpha, beta, gamma, and delta chains, which assemble to form a functional TCR. 3. **Adaptive immune response:** TRAV24 is involved in the adaptive immune response, which is characterized by specific, targeted responses to pathogens. The adaptive immune response involves the activation of immune cells, such as T cells and B cells, which recognize and eliminate pathogens. **Pathways and Functions:** 1. **T cell activation:** TRAV24 is involved in the activation of T cells, which is a critical step in the adaptive immune response. Activated T cells can recognize and kill infected cells or produce cytokines that recruit other immune cells to the site of infection. 2. **Antigen recognition:** TRAV24 is essential for the recognition of antigens by T cells. The TCR complex recognizes specific peptide-MHC complexes presented by antigen-presenting cells, which triggers the activation of T cells. 3. **Immune cell development:** TRAV24 is involved in the development of immune cells, including alpha-beta T cells and granulocyte-monocyte progenitor cells. The expression of TRAV24 is critical for the proper formation and function of these cells. **Clinical Significance:** 1. **Immune-related disorders:** Alterations in TRAV24 expression have been implicated in various immune-related disorders, including autoimmune diseases and cancer. For example, changes in TRAV24 expression have been observed in patients with multiple sclerosis and rheumatoid arthritis. 2. **Cancer immunotherapy:** TRAV24 is a potential target for cancer immunotherapy. The expression of TRAV24 is often lost in cancer cells, which can lead to the loss of T cell recognition and the activation of anti-tumor immune responses. 3. **Immunotherapy for infectious diseases:** TRAV24 is involved in the recognition of pathogens by T cells, which is critical for the control of infectious diseases. The expression of TRAV24 is often altered in patients with infectious diseases, which can impact the efficacy of immunotherapies. In conclusion, TRAV24 is a crucial gene involved in the adaptive immune response, particularly in the recognition and targeting of pathogens. The expression of TRAV24 is widespread across various cell types, and its dysfunction has been implicated in various immune-related disorders. Further research is needed to fully understand the mechanisms by which TRAV24 regulates the adaptive immune response and to explore its potential as a therapeutic target for immune-related diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.