Details for: TRAV23DV6

Gene ID: 28660

Symbol: TRAV23DV6

Ensembl ID: ENSG00000211803

Description: T cell receptor alpha variable 23/delta variable 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.3661
    Cell Significance Index: 12.3500
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.2135
    Cell Significance Index: 2.5600
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0017
    Cell Significance Index: 0.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0238
    Cell Significance Index: -0.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0398
    Cell Significance Index: -2.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0469
    Cell Significance Index: -2.2100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0652
    Cell Significance Index: -1.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0690
    Cell Significance Index: -4.4500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0816
    Cell Significance Index: -1.1600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0843
    Cell Significance Index: -1.4200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1031
    Cell Significance Index: -1.4300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1116
    Cell Significance Index: -1.3900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1143
    Cell Significance Index: -1.6900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1238
    Cell Significance Index: -1.3400
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1348
    Cell Significance Index: -1.3200
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1532
    Cell Significance Index: -1.5800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1660
    Cell Significance Index: -4.2300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1719
    Cell Significance Index: -2.3600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1742
    Cell Significance Index: -4.4500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1757
    Cell Significance Index: -1.7000
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1794
    Cell Significance Index: -1.6600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1826
    Cell Significance Index: -2.9300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.2073
    Cell Significance Index: -1.6400
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.2124
    Cell Significance Index: -1.9400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2179
    Cell Significance Index: -4.2600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2229
    Cell Significance Index: -3.6100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2245
    Cell Significance Index: -3.4100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2366
    Cell Significance Index: -3.0400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2390
    Cell Significance Index: -3.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2391
    Cell Significance Index: -4.4200
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2500
    Cell Significance Index: -4.0200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2564
    Cell Significance Index: -4.4200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2623
    Cell Significance Index: -2.6500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2717
    Cell Significance Index: -3.9600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2733
    Cell Significance Index: -3.2300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2748
    Cell Significance Index: -2.5800
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.2779
    Cell Significance Index: -2.3900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2815
    Cell Significance Index: -3.3500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2873
    Cell Significance Index: -2.9800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2907
    Cell Significance Index: -3.8200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.3222
    Cell Significance Index: -2.7800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.3261
    Cell Significance Index: -3.2700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3285
    Cell Significance Index: -3.8100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3286
    Cell Significance Index: -3.8800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3332
    Cell Significance Index: -4.2100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3375
    Cell Significance Index: -5.7700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.3384
    Cell Significance Index: -2.9600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.3387
    Cell Significance Index: -4.1200
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.3439
    Cell Significance Index: -2.8500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3439
    Cell Significance Index: -5.3200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3488
    Cell Significance Index: -4.5900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.3501
    Cell Significance Index: -4.5700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3529
    Cell Significance Index: -3.4400
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.3579
    Cell Significance Index: -3.2200
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.3619
    Cell Significance Index: -4.6400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.3639
    Cell Significance Index: -4.3200
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.3642
    Cell Significance Index: -2.5100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3695
    Cell Significance Index: -4.9100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3716
    Cell Significance Index: -4.5200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3720
    Cell Significance Index: -4.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.3735
    Cell Significance Index: -3.5900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3767
    Cell Significance Index: -4.6300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.3804
    Cell Significance Index: -3.2100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.3827
    Cell Significance Index: -3.5800
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.3848
    Cell Significance Index: -3.9900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3850
    Cell Significance Index: -4.0900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3862
    Cell Significance Index: -6.5600
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.3865
    Cell Significance Index: -3.5800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3876
    Cell Significance Index: -4.4600
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.3888
    Cell Significance Index: -4.0900
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.3896
    Cell Significance Index: -4.2000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.3942
    Cell Significance Index: -4.1800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.3954
    Cell Significance Index: -4.0400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3963
    Cell Significance Index: -4.5600
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.3965
    Cell Significance Index: -4.5700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3969
    Cell Significance Index: -4.6900
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.3985
    Cell Significance Index: -4.1000
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.3988
    Cell Significance Index: -4.7400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4020
    Cell Significance Index: -4.3800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.4031
    Cell Significance Index: -4.0900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.4040
    Cell Significance Index: -4.0700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.4046
    Cell Significance Index: -4.5200
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.4047
    Cell Significance Index: -3.8900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.4055
    Cell Significance Index: -4.5700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.4065
    Cell Significance Index: -4.2800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.4066
    Cell Significance Index: -3.8600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4067
    Cell Significance Index: -4.2900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.4069
    Cell Significance Index: -4.5100
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.4072
    Cell Significance Index: -4.4700
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.4073
    Cell Significance Index: -4.5600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.4077
    Cell Significance Index: -4.4200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.4116
    Cell Significance Index: -5.6000
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.4126
    Cell Significance Index: -4.6800
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.4164
    Cell Significance Index: -4.4300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.4183
    Cell Significance Index: -4.8600
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.4238
    Cell Significance Index: -4.5700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.4251
    Cell Significance Index: -4.3400
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.4265
    Cell Significance Index: -3.6400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.4293
    Cell Significance Index: -3.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TRAV23DV6 gene is a member of the TCR alpha variable (TRAV) family, which is responsible for encoding the variable region of the alpha chain of the TCR. The delta variable (TRVD) domain, in this case, is associated with a specific TCR repertoire. The expression of TRAV23DV6 is significantly enriched in various T cell subsets, including naive and activated T cells, suggesting its involvement in the regulation of immune responses. The gene's expression is also notable for its presence in platelets, which highlights its potential role in immune-related functions beyond T cell-mediated immunity. **Pathways and Functions:** TRAV23DV6 is integral to the adaptive immune response, specifically through its involvement in peptide antigen binding and recognition. The TCR complex, which includes TRAV23DV6, interacts with major histocompatibility complex (MHC) molecules to recognize peptide antigens. This interaction triggers the activation of T cells, leading to the initiation of an immune response. The gene's expression in various T cell subsets suggests its role in the regulation of immune responses, including the activation of T-helper 22 cells and the proliferation of cytotoxic T cells. Furthermore, the expression of TRAV23DV6 in platelets suggests a potential role in immune-related functions beyond T cell-mediated immunity. Platelet TCRs have been shown to recognize and bind to various ligands, including peptides and MHC molecules, which may contribute to the regulation of platelet function and immune responses. **Clinical Significance:** The TRAV23DV6 gene has significant implications for our understanding of immune-related disorders. The gene's expression in various T cell subsets and platelets highlights its potential role in the regulation of immune responses and the development of immune-related diseases. For example, alterations in TRAV23DV6 expression have been associated with various immune-related disorders, including autoimmune diseases and cancer. Furthermore, the gene's expression in platelets may contribute to the pathogenesis of thrombotic disorders, which are often associated with immune-related mechanisms. In conclusion, the TRAV23DV6 gene is a critical component of the adaptive immune system, playing a pivotal role in the recognition and binding to peptide antigens. Its expression in various T cell subsets and platelets highlights its potential role in the regulation of immune responses and the development of immune-related diseases. Further research is necessary to fully elucidate the functions and clinical significance of TRAV23DV6.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.