Details for: TRAV2

Gene ID: 28691

Symbol: TRAV2

Ensembl ID: ENSG00000211776

Description: T cell receptor alpha variable 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.5631
    Cell Significance Index: -1.7300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.4686
    Cell Significance Index: 2.5600
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.2679
    Cell Significance Index: 2.4100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0781
    Cell Significance Index: 1.9500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0050
    Cell Significance Index: 0.0500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0040
    Cell Significance Index: -0.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0156
    Cell Significance Index: -3.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0366
    Cell Significance Index: -1.7200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0615
    Cell Significance Index: -1.4900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0691
    Cell Significance Index: -1.1600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0694
    Cell Significance Index: -1.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0732
    Cell Significance Index: -1.9900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0858
    Cell Significance Index: -1.1900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0913
    Cell Significance Index: -1.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0929
    Cell Significance Index: -2.4900
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0936
    Cell Significance Index: -1.0200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0976
    Cell Significance Index: -1.1900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1027
    Cell Significance Index: -1.4600
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1031
    Cell Significance Index: -1.0100
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1074
    Cell Significance Index: -1.1300
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1131
    Cell Significance Index: -1.0400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1183
    Cell Significance Index: -3.0200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1240
    Cell Significance Index: -1.4700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1329
    Cell Significance Index: -1.8300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1343
    Cell Significance Index: -1.0600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1355
    Cell Significance Index: -1.6000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1360
    Cell Significance Index: -2.3100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1375
    Cell Significance Index: -1.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1420
    Cell Significance Index: -3.2800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1430
    Cell Significance Index: -2.3000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1530
    Cell Significance Index: -2.2300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1531
    Cell Significance Index: -2.4800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1560
    Cell Significance Index: -2.3700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1568
    Cell Significance Index: -1.8800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1569
    Cell Significance Index: -2.7100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1632
    Cell Significance Index: -3.1900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1672
    Cell Significance Index: -1.5200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1673
    Cell Significance Index: -1.6900
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1702
    Cell Significance Index: -1.1300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1721
    Cell Significance Index: -3.1800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1853
    Cell Significance Index: -2.6900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1891
    Cell Significance Index: -2.6500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1904
    Cell Significance Index: -2.5900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1909
    Cell Significance Index: -2.4700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1943
    Cell Significance Index: -1.2200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1948
    Cell Significance Index: -2.4100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1959
    Cell Significance Index: -2.3100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1969
    Cell Significance Index: -2.4600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1974
    Cell Significance Index: -2.5900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1977
    Cell Significance Index: -2.0500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1977
    Cell Significance Index: -2.5400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2017
    Cell Significance Index: -2.4000
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.2045
    Cell Significance Index: -1.1800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2095
    Cell Significance Index: -2.4300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2127
    Cell Significance Index: -1.9900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2169
    Cell Significance Index: -2.7400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2175
    Cell Significance Index: -2.1200
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.2181
    Cell Significance Index: -2.3300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2200
    Cell Significance Index: -2.6000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2226
    Cell Significance Index: -2.9300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2267
    Cell Significance Index: -2.3000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2277
    Cell Significance Index: -2.6200
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.2329
    Cell Significance Index: -2.4700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2333
    Cell Significance Index: -2.1900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2343
    Cell Significance Index: -2.8800
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2351
    Cell Significance Index: -2.8600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2382
    Cell Significance Index: -2.4700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2389
    Cell Significance Index: -3.1800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2394
    Cell Significance Index: -2.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2414
    Cell Significance Index: -2.3200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2415
    Cell Significance Index: -2.2900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2427
    Cell Significance Index: -3.0100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.2435
    Cell Significance Index: -2.9600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2444
    Cell Significance Index: -3.1900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2447
    Cell Significance Index: -2.7100
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.2472
    Cell Significance Index: -1.7000
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.2486
    Cell Significance Index: -2.0600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2492
    Cell Significance Index: -2.9300
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.2516
    Cell Significance Index: -2.9000
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.2536
    Cell Significance Index: -2.8400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.2538
    Cell Significance Index: -2.1900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2548
    Cell Significance Index: -2.4200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2571
    Cell Significance Index: -2.6300
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.2577
    Cell Significance Index: -2.8000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2581
    Cell Significance Index: -3.0500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2582
    Cell Significance Index: -2.9100
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.2584
    Cell Significance Index: -2.3900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2596
    Cell Significance Index: -2.9000
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.2599
    Cell Significance Index: -2.5400
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2601
    Cell Significance Index: -2.9600
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.2605
    Cell Significance Index: -2.2400
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.2624
    Cell Significance Index: -2.2400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.2661
    Cell Significance Index: -3.2100
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.2670
    Cell Significance Index: -3.1200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2683
    Cell Significance Index: -2.8300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2685
    Cell Significance Index: -3.1200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.2695
    Cell Significance Index: -1.0200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2708
    Cell Significance Index: -2.9200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2712
    Cell Significance Index: -3.2200
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.2756
    Cell Significance Index: -3.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** TRAV2 is located on the X chromosome and is significantly expressed in various cell types, including glutamatergic neurons, oligodendrocyte precursor cells, microglial cells, blood vessel endothelial cells, hematopoietic cells, goblet cells, granulocyte-monocyte progenitor cells, leukocytes, neoplastic cells, and abnormal cells. 2. **Function:** TRAV2 encodes for a variable region of the TCR alpha chain, which is crucial for recognizing and binding to specific antigens. 3. **Diversity:** The TRAV2 gene contributes to the vast diversity of TCRs, with multiple TRAV genes (TRAV1-TRAV22) encoding for distinct variable regions, thereby generating an enormous repertoire of TCRs. 4. **Regulation:** The expression and diversity of TRAV2 are tightly regulated by various mechanisms, including gene conversion, somatic hypermutation, and selection processes. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRAV2 plays a central role in the adaptive immune response, enabling T cells to recognize and respond to specific antigens. 2. **T Cell Receptor Complex:** The TRAV2-encoded variable region forms part of the TCR complex, which interacts with the TCR beta chain and MHC molecules to initiate immune responses. 3. **Immune Response Signaling:** The recognition of antigens by TCRs triggers a cascade of signaling events, including activation of transcription factors, cytokine production, and cell proliferation. 4. **Immune Regulation:** TRAV2 also contributes to the regulation of immune responses, modulating the activity of T cells and influencing the balance between different immune cell subsets. **Clinical Significance:** 1. **Autoimmune Diseases:** Dysregulation of TRAV2 expression and diversity has been implicated in various autoimmune diseases, including rheumatoid arthritis, multiple sclerosis, and type 1 diabetes. 2. **Cancer:** Aberrant expression of TRAV2 has been observed in certain types of cancer, including leukemia and lymphoma, suggesting a potential role in tumor immune evasion and progression. 3. **Immunotherapy:** Understanding the complex mechanisms of TRAV2 may provide insights into the development of novel immunotherapies, targeting specific TCRs or modulating immune responses to enhance anti-tumor efficacy. 4. **Gene Therapy:** TRAV2 has been identified as a potential target for gene therapy approaches aimed at restoring immune function in patients with immunodeficiency disorders or cancer. In conclusion, TRAV2 is a critical component of the T cell receptor complex, playing a pivotal role in shaping the adaptive immune response and regulating immune function. Further research into the complexities of TRAV2 will likely uncover novel therapeutic strategies for the treatment of autoimmune diseases, cancer, and immunodeficiency disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.