Details for: IGLV3 12

Gene ID: 28802

Symbol: IGLV3 12

Ensembl ID: ENSG00000211667

Description: immunoglobulin lambda variable 3-12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.0066
    Cell Significance Index: 10.4200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2552
    Cell Significance Index: 3.7200
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.0784
    Cell Significance Index: 0.9000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0020
    Cell Significance Index: 0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0028
    Cell Significance Index: -0.5700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0179
    Cell Significance Index: -0.2900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0212
    Cell Significance Index: -0.5400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0223
    Cell Significance Index: -0.5400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0240
    Cell Significance Index: -0.2700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0246
    Cell Significance Index: -0.2600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0263
    Cell Significance Index: -0.3400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0264
    Cell Significance Index: -0.3000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0267
    Cell Significance Index: -0.3200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0281
    Cell Significance Index: -0.5500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0287
    Cell Significance Index: -0.5300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0303
    Cell Significance Index: -0.3300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0329
    Cell Significance Index: -0.3500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0345
    Cell Significance Index: -0.4700
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0348
    Cell Significance Index: -0.5600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0375
    Cell Significance Index: -0.5700
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0387
    Cell Significance Index: -0.3300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0389
    Cell Significance Index: -0.4600
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0390
    Cell Significance Index: -0.2600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0391
    Cell Significance Index: -0.4800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0392
    Cell Significance Index: -0.5500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0393
    Cell Significance Index: -0.5400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0398
    Cell Significance Index: -0.5200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0406
    Cell Significance Index: -0.4800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0406
    Cell Significance Index: -0.5400
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0416
    Cell Significance Index: -0.3800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0427
    Cell Significance Index: -0.5600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0447
    Cell Significance Index: -0.5400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0454
    Cell Significance Index: -0.5800
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0461
    Cell Significance Index: -0.4900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0469
    Cell Significance Index: -0.4400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0469
    Cell Significance Index: -0.5700
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0469
    Cell Significance Index: -0.5700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0470
    Cell Significance Index: -0.5200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0470
    Cell Significance Index: -0.5200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0471
    Cell Significance Index: -0.6200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0474
    Cell Significance Index: -0.5500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0478
    Cell Significance Index: -0.5500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0479
    Cell Significance Index: -0.6800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0483
    Cell Significance Index: -0.5600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0484
    Cell Significance Index: -0.5200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0491
    Cell Significance Index: -0.5800
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0495
    Cell Significance Index: -0.4500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0496
    Cell Significance Index: -0.4700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0500
    Cell Significance Index: -0.5100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0501
    Cell Significance Index: -0.5400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0506
    Cell Significance Index: -0.4700
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0509
    Cell Significance Index: -0.5400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0513
    Cell Significance Index: -0.5400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0518
    Cell Significance Index: -0.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0520
    Cell Significance Index: -0.5000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0521
    Cell Significance Index: -0.4400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0522
    Cell Significance Index: -0.5300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0522
    Cell Significance Index: -0.6700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0523
    Cell Significance Index: -0.5100
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0524
    Cell Significance Index: -0.4900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0526
    Cell Significance Index: -0.5300
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0526
    Cell Significance Index: -0.5700
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0527
    Cell Significance Index: -0.4700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0530
    Cell Significance Index: -0.5500
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0531
    Cell Significance Index: -0.5300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0533
    Cell Significance Index: -0.6300
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0542
    Cell Significance Index: -0.5100
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0545
    Cell Significance Index: -0.5700
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0560
    Cell Significance Index: -0.5300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0562
    Cell Significance Index: -0.5700
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0562
    Cell Significance Index: -0.4900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0569
    Cell Significance Index: -0.5300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0574
    Cell Significance Index: -0.5800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0578
    Cell Significance Index: -0.4500
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0581
    Cell Significance Index: -0.4800
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0584
    Cell Significance Index: -0.5400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0592
    Cell Significance Index: -0.5000
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0593
    Cell Significance Index: -0.5300
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0597
    Cell Significance Index: -0.4800
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0598
    Cell Significance Index: -0.5300
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0601
    Cell Significance Index: -0.5400
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0603
    Cell Significance Index: -0.5000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0605
    Cell Significance Index: -0.4900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0606
    Cell Significance Index: -0.5300
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0622
    Cell Significance Index: -0.5200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0626
    Cell Significance Index: -0.5400
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.0637
    Cell Significance Index: -0.5600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0647
    Cell Significance Index: -0.5700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0676
    Cell Significance Index: -0.5400
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0682
    Cell Significance Index: -0.5600
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0684
    Cell Significance Index: -0.5500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0702
    Cell Significance Index: -1.2100
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.0703
    Cell Significance Index: -0.5400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0712
    Cell Significance Index: -0.5300
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.0722
    Cell Significance Index: -0.4700
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: -0.0724
    Cell Significance Index: -0.3400
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0728
    Cell Significance Index: -0.6200
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0749
    Cell Significance Index: -0.6500
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: -0.0779
    Cell Significance Index: -0.5400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0793
    Cell Significance Index: -0.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin lambda variable region**: The IGLV3-12 gene encodes a variable region of the lambda light chain of immunoglobulins, which is essential for antibody production and recognition of antigens. 2. **High expression in immune cells**: The IGLV3-12 gene is highly expressed in various immune cells, including T cells, B cells, mast cells, and intestinal epithelial cells. 3. **Tissue-specific expression**: The IGLV3-12 gene is also expressed in non-immune cells, such as goblet cells and absorptive cells, suggesting its potential role in maintaining tissue homeostasis. 4. **Adaptive immune response**: The IGLV3-12 gene is involved in the adaptive immune response, which is a specific and targeted response to pathogens and foreign substances. **Pathways and Functions:** 1. **Immunoglobulin production**: The IGLV3-12 gene plays a crucial role in the production of immunoglobulins, which are essential for recognizing and binding to antigens. 2. **Antigen recognition**: The variable region encoded by the IGLV3-12 gene is responsible for recognizing and binding to antigens, leading to the activation of immune cells. 3. **Adaptive immune response**: The IGLV3-12 gene is involved in the adaptive immune response, which is a specific and targeted response to pathogens and foreign substances. 4. **Immune cell activation**: The IGLV3-12 gene is expressed in various immune cells, including T cells and B cells, and plays a crucial role in their activation and differentiation. **Clinical Significance:** 1. **Immunodeficiency disorders**: Alterations in the IGLV3-12 gene may contribute to immunodeficiency disorders, such as immunoglobulin deficiency, which is characterized by impaired antibody production. 2. **Cancer**: The IGLV3-12 gene is overexpressed in certain types of cancer, such as multiple myeloma, suggesting its potential role in tumorigenesis. 3. **Autoimmune diseases**: The IGLV3-12 gene may contribute to autoimmune diseases, such as rheumatoid arthritis, which is characterized by impaired immune regulation and excessive antibody production. 4. **Infectious diseases**: The IGLV3-12 gene is involved in the immune response to infectious diseases, such as tuberculosis, which is characterized by impaired antibody production and immune regulation. In conclusion, the IGLV3-12 gene plays a crucial role in the adaptive immune response, immunoglobulin production, and antigen recognition. Its expression in various immune cells and non-immune cells highlights its potential role in maintaining tissue homeostasis. Further research is needed to fully understand the clinical significance of the IGLV3-12 gene and its implications in immunodeficiency disorders, cancer, autoimmune diseases, and infectious diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.