Details for: IGLV1 36

Gene ID: 28826

Symbol: IGLV1 36

Ensembl ID: ENSG00000211655

Description: immunoglobulin lambda variable 1-36

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0012
    Cell Significance Index: -0.0100
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0122
    Cell Significance Index: -0.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0298
    Cell Significance Index: -1.3900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0601
    Cell Significance Index: -0.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0697
    Cell Significance Index: -13.9800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1408
    Cell Significance Index: -1.7800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1660
    Cell Significance Index: -1.8900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1679
    Cell Significance Index: -1.8300
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.2190
    Cell Significance Index: -2.3100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2455
    Cell Significance Index: -2.6100
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2466
    Cell Significance Index: -2.8000
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.2654
    Cell Significance Index: -2.5300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2968
    Cell Significance Index: -7.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3058
    Cell Significance Index: -8.1800
  • Cell Name: collagen secreting cell (CL0000667)
    Fold Change: -0.3551
    Cell Significance Index: -1.9800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3636
    Cell Significance Index: -7.1100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.4194
    Cell Significance Index: -7.1700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4404
    Cell Significance Index: -8.1400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4620
    Cell Significance Index: -11.7700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.5051
    Cell Significance Index: -8.1800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.5279
    Cell Significance Index: -7.6700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.5288
    Cell Significance Index: -6.0900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.5393
    Cell Significance Index: -5.5100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.5972
    Cell Significance Index: -8.1900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.6066
    Cell Significance Index: -6.7800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.6091
    Cell Significance Index: -6.4700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.6144
    Cell Significance Index: -8.1700
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.6166
    Cell Significance Index: -6.5600
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.6217
    Cell Significance Index: -4.1400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.6228
    Cell Significance Index: -6.7200
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.6289
    Cell Significance Index: -5.3600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.6354
    Cell Significance Index: -7.1600
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.6396
    Cell Significance Index: -5.2800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.6535
    Cell Significance Index: -7.2400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.6566
    Cell Significance Index: -7.7600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.6589
    Cell Significance Index: -8.1500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.6615
    Cell Significance Index: -7.8100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6680
    Cell Significance Index: -8.3300
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.6714
    Cell Significance Index: -6.4500
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.6746
    Cell Significance Index: -6.9400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.6764
    Cell Significance Index: -8.4500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.6778
    Cell Significance Index: -7.8000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.6919
    Cell Significance Index: -8.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6980
    Cell Significance Index: -8.3200
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.7021
    Cell Significance Index: -6.3500
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.7058
    Cell Significance Index: -6.8800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.7332
    Cell Significance Index: -6.8100
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.7360
    Cell Significance Index: -6.8000
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.7398
    Cell Significance Index: -9.0000
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.7451
    Cell Significance Index: -7.8100
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.7484
    Cell Significance Index: -6.5800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.7527
    Cell Significance Index: -9.7400
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.7540
    Cell Significance Index: -7.8100
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.7541
    Cell Significance Index: -6.0600
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.7696
    Cell Significance Index: -7.1700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.7782
    Cell Significance Index: -7.2800
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.7834
    Cell Significance Index: -8.3700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.7841
    Cell Significance Index: -8.7600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.7969
    Cell Significance Index: -6.9700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.8039
    Cell Significance Index: -10.5500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.8126
    Cell Significance Index: -6.5800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.8372
    Cell Significance Index: -7.8600
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.8408
    Cell Significance Index: -8.2100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.8423
    Cell Significance Index: -9.7700
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.8476
    Cell Significance Index: -7.8400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.8520
    Cell Significance Index: -13.7000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.8640
    Cell Significance Index: -11.1000
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.8697
    Cell Significance Index: -7.7700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.8775
    Cell Significance Index: -11.4600
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.8777
    Cell Significance Index: -8.7600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.8781
    Cell Significance Index: -9.7300
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.8782
    Cell Significance Index: -9.1000
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.8812
    Cell Significance Index: -11.1600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.8861
    Cell Significance Index: -9.3300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.8877
    Cell Significance Index: -10.4900
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.8935
    Cell Significance Index: -7.9700
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.8972
    Cell Significance Index: -8.1500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.8985
    Cell Significance Index: -6.9900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.8985
    Cell Significance Index: -15.2600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.9007
    Cell Significance Index: -13.6800
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.9024
    Cell Significance Index: -9.6000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.9062
    Cell Significance Index: -9.1300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.9086
    Cell Significance Index: -9.7700
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.9100
    Cell Significance Index: -7.8400
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.9205
    Cell Significance Index: -8.2000
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: -0.9306
    Cell Significance Index: -7.8500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.9330
    Cell Significance Index: -8.9700
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.9353
    Cell Significance Index: -8.8500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.9388
    Cell Significance Index: -13.3400
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.9404
    Cell Significance Index: -8.6000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.9433
    Cell Significance Index: -11.6000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.9436
    Cell Significance Index: -11.1500
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.9446
    Cell Significance Index: -8.8000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.9468
    Cell Significance Index: -12.4600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.9474
    Cell Significance Index: -13.1000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.9578
    Cell Significance Index: -13.0300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.9619
    Cell Significance Index: -9.1200
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.9625
    Cell Significance Index: -7.3900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.9631
    Cell Significance Index: -9.7300
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.9660
    Cell Significance Index: -8.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Structure:** The IGLV1 36 gene is a single-exon gene, encoding a variable region of the lambda light chain. 2. **Protein Function:** The lambda light chain is a critical component of the Ig molecule, which recognizes and binds to specific antigens. 3. **Immunoglobulin Class:** The IGLV1 36 gene is associated with the lambda class of immunoglobulins, which are a subset of Ig molecules that recognize antigens through the lambda heavy chain. 4. **Significant Expression:** The IGLV1 36 gene is significantly expressed in various immune cells, including macrophages, T cells, and hematopoietic cells. **Pathways and Functions:** 1. **Adaptive Immune Response:** The IGLV1 36 gene plays a crucial role in the adaptive immune response, providing specificity and diversity to the immune system. 2. **Immunoglobulin Production:** The IGLV1 36 gene is involved in the production of lambda light chains, which are essential for the assembly of Ig molecules. 3. **Plasma Membrane:** The lambda light chain is translocated to the plasma membrane, where it interacts with the heavy chain and other components of the Ig molecule. 4. **Immune Cell Signaling:** The IGLV1 36 gene is involved in the signaling pathways of immune cells, including T cells and macrophages. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations in the IGLV1 36 gene have been associated with immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA). 2. **Autoimmune Diseases:** Alterations in the IGLV1 36 gene have been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer:** The IGLV1 36 gene has been implicated in cancer, particularly in the development of lymphomas and leukemias. 4. **Infectious Diseases:** The IGLV1 36 gene plays a critical role in the immune response to infections, such as tuberculosis and HIV. In conclusion, the IGLV1 36 gene is a vital component of the human immune system, playing a crucial role in the adaptive immune response, immunoglobulin production, and immune cell signaling. Its dysregulation has been implicated in various clinical disorders, including immunodeficiency, autoimmune diseases, cancer, and infectious diseases. Further research is necessary to fully understand the complex functions of the IGLV1 36 gene and its role in the human immune system.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.