IGKV2D 28 | ENSG00000242534 | NCBI 28883

Details for: IGKV2D 28

Gene ID: 28883

Symbol: IGKV2D 28

Ensembl ID: ENSG00000242534

Description: immunoglobulin kappa variable 2D-28

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.2249
Cell Significance Index: 3.4800
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.0244
Cell Significance Index: 0.3600
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0121
Cell Significance Index: -1.5500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0606
Cell Significance Index: -2.8300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1053
Cell Significance Index: -8.0800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1157
Cell Significance Index: -3.1500
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1486
Cell Significance Index: -3.6000
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2359
Cell Significance Index: -6.0100
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.2377
Cell Significance Index: -5.9400
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2574
Cell Significance Index: -9.4500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2697
Cell Significance Index: -7.2200
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: -0.2872
Cell Significance Index: -3.3200
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.2922
Cell Significance Index: -3.3200
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.3355
Cell Significance Index: -5.7400
Cell Name: peg cell (CL4033014)
Fold Change: -0.3515
Cell Significance Index: -8.1200
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.3655
Cell Significance Index: -5.9200
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.3775
Cell Significance Index: -7.3800
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.3843
Cell Significance Index: -5.2700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.4377
Cell Significance Index: -8.0900
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.4505
Cell Significance Index: -6.5400
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.4550
Cell Significance Index: -5.0900
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.4850
Cell Significance Index: -3.2300
Cell Name: monocyte (CL0000576)
Fold Change: -0.4993
Cell Significance Index: -5.7500
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.5177
Cell Significance Index: -5.5000
Cell Name: stromal cell (CL0000499)
Fold Change: -0.5598
Cell Significance Index: -5.7200
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.5611
Cell Significance Index: -8.0700
Cell Name: granulocyte (CL0000094)
Fold Change: -0.5679
Cell Significance Index: -6.8500
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.5709
Cell Significance Index: -6.1600
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.5788
Cell Significance Index: -6.8400
Cell Name: platelet (CL0000233)
Fold Change: -0.6051
Cell Significance Index: -6.2300
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.6088
Cell Significance Index: -7.5300
Cell Name: fibroblast (CL0000057)
Fold Change: -0.6103
Cell Significance Index: -5.7300
Cell Name: intermediate monocyte (CL0002393)
Fold Change: -0.6274
Cell Significance Index: -5.8500
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.6275
Cell Significance Index: -5.1800
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.6317
Cell Significance Index: -8.1000
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.6487
Cell Significance Index: -7.3100
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.6492
Cell Significance Index: -8.4000
Cell Name: blood cell (CL0000081)
Fold Change: -0.6594
Cell Significance Index: -5.6200
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.6769
Cell Significance Index: -5.4400
Cell Name: fibroblast of lung (CL0002553)
Fold Change: -0.6781
Cell Significance Index: -8.0600
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.6847
Cell Significance Index: -8.3300
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.6865
Cell Significance Index: -7.6000
Cell Name: T cell (CL0000084)
Fold Change: -0.6911
Cell Significance Index: -8.1600
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.6982
Cell Significance Index: -8.2200
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -0.7043
Cell Significance Index: -6.1600
Cell Name: glial cell (CL0000125)
Fold Change: -0.7138
Cell Significance Index: -7.8200
Cell Name: plasma cell (CL0000786)
Fold Change: -0.7152
Cell Significance Index: -7.9900
Cell Name: memory B cell (CL0000787)
Fold Change: -0.7238
Cell Significance Index: -7.7000
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.7239
Cell Significance Index: -9.3000
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.7294
Cell Significance Index: -7.1100
Cell Name: myofibroblast cell (CL0000186)
Fold Change: -0.7403
Cell Significance Index: -7.7600
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.7420
Cell Significance Index: -9.8600
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.7536
Cell Significance Index: -9.8900
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.7553
Cell Significance Index: -7.2500
Cell Name: naive B cell (CL0000788)
Fold Change: -0.7608
Cell Significance Index: -8.0100
Cell Name: pericyte (CL0000669)
Fold Change: -0.7610
Cell Significance Index: -9.1300
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.7633
Cell Significance Index: -9.0200
Cell Name: neutrophil (CL0000775)
Fold Change: -0.7633
Cell Significance Index: -9.5400
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.7649
Cell Significance Index: -9.8500
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.7775
Cell Significance Index: -7.9300
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: -0.7816
Cell Significance Index: -6.1300
Cell Name: transitional stage B cell (CL0000818)
Fold Change: -0.7831
Cell Significance Index: -6.8800
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.7979
Cell Significance Index: -9.2600
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.8055
Cell Significance Index: -9.2700
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: -0.8070
Cell Significance Index: -7.2100
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.8089
Cell Significance Index: -7.2200
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.8108
Cell Significance Index: -8.9800
Cell Name: plasmablast (CL0000980)
Fold Change: -0.8135
Cell Significance Index: -7.5500
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.8157
Cell Significance Index: -7.8400
Cell Name: secretory cell (CL0000151)
Fold Change: -0.8162
Cell Significance Index: -5.6600
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: -0.8307
Cell Significance Index: -7.0100
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: -0.8309
Cell Significance Index: -7.5000
Cell Name: ciliated cell (CL0000064)
Fold Change: -0.8368
Cell Significance Index: -9.0600
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.8375
Cell Significance Index: -10.1100
Cell Name: germinal center B cell (CL0000844)
Fold Change: -0.8392
Cell Significance Index: -5.9300
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: -0.8426
Cell Significance Index: -8.4100
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: -0.8464
Cell Significance Index: -7.8200
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: -0.8572
Cell Significance Index: -5.9400
Cell Name: intestine goblet cell (CL0019031)
Fold Change: -0.8601
Cell Significance Index: -7.4100
Cell Name: leukocyte (CL0000738)
Fold Change: -0.8655
Cell Significance Index: -14.7000
Cell Name: T follicular helper cell (CL0002038)
Fold Change: -0.8724
Cell Significance Index: -9.2500
Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
Fold Change: -0.8752
Cell Significance Index: -8.4200
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.8768
Cell Significance Index: -9.6300
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: -0.8782
Cell Significance Index: -6.0400
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: -0.8862
Cell Significance Index: -9.3400
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.8882
Cell Significance Index: -9.5500
Cell Name: immature B cell (CL0000816)
Fold Change: -0.8899
Cell Significance Index: -8.4200
Cell Name: IgM plasma cell (CL0000986)
Fold Change: -0.8947
Cell Significance Index: -6.8700
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: -0.8955
Cell Significance Index: -9.2800
Cell Name: club cell (CL0000158)
Fold Change: -0.9059
Cell Significance Index: -9.8700
Cell Name: B-2 B cell (CL0000822)
Fold Change: -0.9116
Cell Significance Index: -8.0800
Cell Name: naive T cell (CL0000898)
Fold Change: -0.9126
Cell Significance Index: -8.2900
Cell Name: B cell (CL0000236)
Fold Change: -0.9148
Cell Significance Index: -10.8100
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.9244
Cell Significance Index: -9.3800
Cell Name: mast cell (CL0000097)
Fold Change: -0.9415
Cell Significance Index: -12.3900
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.9435
Cell Significance Index: -9.8500
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.9499
Cell Significance Index: -12.4000
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: -0.9554
Cell Significance Index: -7.8400
Cell Name: macrophage (CL0000235)
Fold Change: -0.9628
Cell Significance Index: -9.8300
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: -0.9641
Cell Significance Index: -7.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** 1. **Immunoglobulin structure**: IGKV2D28 is a kappa light chain variable region, which is a critical component of the immunoglobulin molecule. 2. **Cellular expression**: This gene is expressed in various cell types, including double-negative thymocytes, granulocyte-monocyte progenitor cells, goblet cells, T cells, hematopoietic cells, fallopian tube secretory epithelial cells, and intestinal crypt stem cells. 3. **Immune-related pathways**: IGKV2D28 is involved in multiple immune-related pathways, including antigen binding, B cell receptor signaling, complement activation, and phagocytosis. 4. **Disease association**: Dysregulation of IGKV2D28 has been implicated in various diseases, including infectious diseases, autoimmune disorders, and cancer. **Pathways and Functions** 1. **Adaptive immune response**: IGKV2D28 plays a critical role in the adaptive immune response by encoding a kappa light chain variable region that binds to antigens, leading to B cell activation and antibody production. 2. **B cell receptor signaling**: IGKV2D28 is involved in B cell receptor signaling, which is essential for B cell activation, differentiation, and survival. 3. **Complement activation**: IGKV2D28 is also involved in complement activation, which is a critical mechanism for eliminating pathogens and foreign substances from the body. 4. **Phagocytosis**: IGKV2D28 is involved in phagocytosis, which is the process by which cells engulf and internalize pathogens and foreign substances. 5. **Antigen binding**: IGKV2D28 is involved in antigen binding, which is the process by which the immunoglobulin molecule recognizes and binds to antigens. 6. **Signaling by the B cell receptor**: IGKV2D28 is involved in signaling by the B cell receptor, which is essential for B cell activation and differentiation. **Clinical Significance** 1. **Infectious diseases**: Dysregulation of IGKV2D28 has been implicated in various infectious diseases, including Leishmania infection, which is a significant public health problem in many developing countries. 2. **Autoimmune disorders**: IGKV2D28 has also been implicated in autoimmune disorders, including rheumatoid arthritis and lupus, which are characterized by the production of autoantibodies. 3. **Cancer**: Dysregulation of IGKV2D28 has been implicated in various types of cancer, including lymphoma and leukemia, which are characterized by the production of abnormal immunoglobulins. 4. **Therapeutic potential**: The dysregulation of IGKV2D28 has been identified as a potential therapeutic target for various diseases, including infectious diseases, autoimmune disorders, and cancer. In conclusion, the IGKV2D28 gene plays a critical role in the adaptive immune system and is involved in multiple immune-related pathways, including antigen binding, B cell receptor signaling, and complement activation. Its dysregulation has been implicated in various diseases, including infectious diseases, autoimmune disorders, and cancer, highlighting its potential as a therapeutic target.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.