Details for: IGKV2D 24

Gene ID: 28885

Symbol: IGKV2D 24

Ensembl ID: ENSG00000241566

Description: immunoglobulin kappa variable 2D-24 (non-functional)

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: macrophage (CL0000235)
    Fold Change: 5.14
    Marker Score: 5,719
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 876
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.17
    Marker Score: 2,965
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7,677
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 802
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 1
    Marker Score: 5,703
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,392
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.96
    Marker Score: 1,563
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,733
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,279
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.69
    Marker Score: 550
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 236
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.55
    Marker Score: 276
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.54
    Marker Score: 330
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 216
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.24
    Marker Score: 137
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.17
    Marker Score: 172
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.17
    Marker Score: 117
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.17
    Marker Score: 89
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.16
    Marker Score: 156
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.16
    Marker Score: 103
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.13
    Marker Score: 286
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.12
    Marker Score: 166
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.12
    Marker Score: 112
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.09
    Marker Score: 274
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.09
    Marker Score: 99
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.08
    Marker Score: 127
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.08
    Marker Score: 99
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.08
    Marker Score: 99
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 138
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.06
    Marker Score: 57
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 73
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.06
    Marker Score: 74
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.06
    Marker Score: 70
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.05
    Marker Score: 44
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.05
    Marker Score: 188
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.04
    Marker Score: 31
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.04
    Marker Score: 106
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.03
    Marker Score: 41
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.02
    Marker Score: 30
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.01
    Marker Score: 25
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.01
    Marker Score: 119
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 12
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0
    Marker Score: 18
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 24
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 19
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 12

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IGKV2D 24 is characterized by the following features: * **Non-functional**: IGKV2D 24 does not encode a functional immunoglobulin protein, which is essential for recognizing and binding to specific antigens. * **Kappa variable gene**: IGKV2D 24 is a member of the kappa variable gene family, which is responsible for encoding the variable region of the immunoglobulin heavy chain. * **Widespread expression**: IGKV2D 24 is expressed in various cell types, including immune cells, epithelial cells, and stem cells. **Pathways and Functions** IGKV2D 24 is involved in several pathways and functions, including: * **Adaptive immune response**: IGKV2D 24 may play a role in regulating the adaptive immune response by influencing the expression of other immunoglobulin genes or by interacting with other immune-related proteins. * **Immunoglobulin complex formation**: IGKV2D 24 may contribute to the formation of immunoglobulin complexes, which are essential for recognizing and binding to specific antigens. * **Immunoglobulin production**: IGKV2D 24 may influence the production of immunoglobulins by regulating the expression of other immunoglobulin genes or by interacting with other proteins involved in immunoglobulin synthesis. * **Plasma membrane**: IGKV2D 24 is expressed on the plasma membrane of various cells, suggesting that it may play a role in cell signaling or cell-cell interactions. **Clinical Significance** IGKV2D 24 has several clinical implications, including: * **Autoimmune diseases**: Abnormal expression of IGKV2D 24 has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. * **Cancer**: IGKV2D 24 is overexpressed in various types of cancer, including colorectal cancer and lymphoma. * **Infectious diseases**: IGKV2D 24 may play a role in the regulation of the immune response to infectious diseases, such as tuberculosis and HIV. * **Immunodeficiency**: IGKV2D 24 may contribute to immunodeficiency by influencing the expression of other immunoglobulin genes or by interacting with other proteins involved in immune function. In conclusion, IGKV2D 24 is a non-functional immunoglobulin kappa variable gene that plays a crucial role in the adaptive immune response. Its widespread expression in various cell types suggests that it may have multiple functions, including regulating immune responses, maintaining tissue homeostasis, and influencing the development of autoimmune diseases and cancer. Further research is needed to fully understand the role of IGKV2D 24 in the immune system and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.