Details for: IGKV2D 24

Gene ID: 28885

Symbol: IGKV2D 24

Ensembl ID: ENSG00000241566

Description: immunoglobulin kappa variable 2D-24 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1145
    Cell Significance Index: 1.2800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0497
    Cell Significance Index: 0.6500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0238
    Cell Significance Index: 0.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0027
    Cell Significance Index: -0.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0116
    Cell Significance Index: -0.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0156
    Cell Significance Index: -0.7300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0205
    Cell Significance Index: -0.2600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0210
    Cell Significance Index: -0.7700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0275
    Cell Significance Index: -0.3800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0279
    Cell Significance Index: -0.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0284
    Cell Significance Index: -0.7600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0292
    Cell Significance Index: -0.7500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0296
    Cell Significance Index: -0.3500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0330
    Cell Significance Index: -0.6500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0355
    Cell Significance Index: -0.4600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0362
    Cell Significance Index: -0.3700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0374
    Cell Significance Index: -0.7500
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0433
    Cell Significance Index: -0.4400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0456
    Cell Significance Index: -0.5100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0460
    Cell Significance Index: -0.7500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0474
    Cell Significance Index: -0.6500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0520
    Cell Significance Index: -0.6500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0537
    Cell Significance Index: -1.0500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0542
    Cell Significance Index: -0.6700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0568
    Cell Significance Index: -0.7300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0582
    Cell Significance Index: -0.6700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0610
    Cell Significance Index: -0.8100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0612
    Cell Significance Index: -0.6500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0646
    Cell Significance Index: -0.6600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0660
    Cell Significance Index: -0.7100
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0666
    Cell Significance Index: -0.5900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0672
    Cell Significance Index: -1.0200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0680
    Cell Significance Index: -0.7900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0682
    Cell Significance Index: -0.7300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0695
    Cell Significance Index: -0.9200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0705
    Cell Significance Index: -0.7500
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0706
    Cell Significance Index: -0.6600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0714
    Cell Significance Index: -0.8400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0719
    Cell Significance Index: -0.8100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0726
    Cell Significance Index: -0.8700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0727
    Cell Significance Index: -1.0600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0730
    Cell Significance Index: -0.7700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0732
    Cell Significance Index: -0.9000
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0734
    Cell Significance Index: -0.6400
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0736
    Cell Significance Index: -0.4900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0738
    Cell Significance Index: -0.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0739
    Cell Significance Index: -1.3700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0746
    Cell Significance Index: -1.0600
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.0749
    Cell Significance Index: -0.7400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0749
    Cell Significance Index: -1.0500
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0750
    Cell Significance Index: -0.7800
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0758
    Cell Significance Index: -0.8300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0770
    Cell Significance Index: -0.7200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0773
    Cell Significance Index: -0.8900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0781
    Cell Significance Index: -1.0200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0795
    Cell Significance Index: -0.9400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0796
    Cell Significance Index: -0.9400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0829
    Cell Significance Index: -0.9800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0836
    Cell Significance Index: -0.9700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0846
    Cell Significance Index: -1.1100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0855
    Cell Significance Index: -0.9000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0874
    Cell Significance Index: -1.0400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0875
    Cell Significance Index: -0.8300
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0933
    Cell Significance Index: -0.8100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0935
    Cell Significance Index: -0.9500
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0937
    Cell Significance Index: -1.0800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0939
    Cell Significance Index: -1.0400
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0942
    Cell Significance Index: -0.8100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0948
    Cell Significance Index: -0.8400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0950
    Cell Significance Index: -0.9900
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0957
    Cell Significance Index: -0.8800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0959
    Cell Significance Index: -0.9000
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0962
    Cell Significance Index: -0.9100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0962
    Cell Significance Index: -1.0200
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0969
    Cell Significance Index: -0.7900
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0971
    Cell Significance Index: -0.7800
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0977
    Cell Significance Index: -1.0300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0997
    Cell Significance Index: -1.0100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1001
    Cell Significance Index: -0.8000
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1027
    Cell Significance Index: -0.9500
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1048
    Cell Significance Index: -1.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1061
    Cell Significance Index: -1.0200
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1062
    Cell Significance Index: -1.1000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1096
    Cell Significance Index: -1.0200
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -0.1103
    Cell Significance Index: -0.8100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1104
    Cell Significance Index: -1.1200
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1115
    Cell Significance Index: -1.0700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1134
    Cell Significance Index: -1.0100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1150
    Cell Significance Index: -1.2400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1159
    Cell Significance Index: -1.0000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1171
    Cell Significance Index: -1.1800
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1173
    Cell Significance Index: -1.0000
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1195
    Cell Significance Index: -1.0000
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.1196
    Cell Significance Index: -1.2300
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1209
    Cell Significance Index: -1.0300
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: -0.1211
    Cell Significance Index: -0.7000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1221
    Cell Significance Index: -1.1900
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1225
    Cell Significance Index: -1.2200
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1230
    Cell Significance Index: -1.0400
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -0.1236
    Cell Significance Index: -1.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IGKV2D 24 is characterized by the following features: * **Non-functional**: IGKV2D 24 does not encode a functional immunoglobulin protein, which is essential for recognizing and binding to specific antigens. * **Kappa variable gene**: IGKV2D 24 is a member of the kappa variable gene family, which is responsible for encoding the variable region of the immunoglobulin heavy chain. * **Widespread expression**: IGKV2D 24 is expressed in various cell types, including immune cells, epithelial cells, and stem cells. **Pathways and Functions** IGKV2D 24 is involved in several pathways and functions, including: * **Adaptive immune response**: IGKV2D 24 may play a role in regulating the adaptive immune response by influencing the expression of other immunoglobulin genes or by interacting with other immune-related proteins. * **Immunoglobulin complex formation**: IGKV2D 24 may contribute to the formation of immunoglobulin complexes, which are essential for recognizing and binding to specific antigens. * **Immunoglobulin production**: IGKV2D 24 may influence the production of immunoglobulins by regulating the expression of other immunoglobulin genes or by interacting with other proteins involved in immunoglobulin synthesis. * **Plasma membrane**: IGKV2D 24 is expressed on the plasma membrane of various cells, suggesting that it may play a role in cell signaling or cell-cell interactions. **Clinical Significance** IGKV2D 24 has several clinical implications, including: * **Autoimmune diseases**: Abnormal expression of IGKV2D 24 has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. * **Cancer**: IGKV2D 24 is overexpressed in various types of cancer, including colorectal cancer and lymphoma. * **Infectious diseases**: IGKV2D 24 may play a role in the regulation of the immune response to infectious diseases, such as tuberculosis and HIV. * **Immunodeficiency**: IGKV2D 24 may contribute to immunodeficiency by influencing the expression of other immunoglobulin genes or by interacting with other proteins involved in immune function. In conclusion, IGKV2D 24 is a non-functional immunoglobulin kappa variable gene that plays a crucial role in the adaptive immune response. Its widespread expression in various cell types suggests that it may have multiple functions, including regulating immune responses, maintaining tissue homeostasis, and influencing the development of autoimmune diseases and cancer. Further research is needed to fully understand the role of IGKV2D 24 in the immune system and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.