IGKV1D 39 | ENSG00000251546 | NCBI 28893

Details for: IGKV1D 39

Gene ID: 28893

Symbol: IGKV1D 39

Ensembl ID: ENSG00000251546

Description: immunoglobulin kappa variable 1D-39

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 4.1548
Cell Significance Index: -12.7600
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0381
Cell Significance Index: -0.5900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1063
Cell Significance Index: -10.8600
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1290
Cell Significance Index: -3.1300
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.1976
Cell Significance Index: -2.8800
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.3073
Cell Significance Index: -3.4400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3095
Cell Significance Index: -14.4300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3508
Cell Significance Index: -9.3900
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.4434
Cell Significance Index: -3.6600
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.4751
Cell Significance Index: -9.2900
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.4952
Cell Significance Index: -8.0200
Cell Name: stromal cell (CL0000499)
Fold Change: -0.5021
Cell Significance Index: -5.1300
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.5438
Cell Significance Index: -7.9000
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.5613
Cell Significance Index: -14.3000
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.5774
Cell Significance Index: -9.8700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.5795
Cell Significance Index: -10.7100
Cell Name: monocyte (CL0000576)
Fold Change: -0.6153
Cell Significance Index: -7.0800
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.6271
Cell Significance Index: -8.6000
Cell Name: leukocyte (CL0000738)
Fold Change: -0.6577
Cell Significance Index: -11.1700
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.7172
Cell Significance Index: -9.3800
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.7253
Cell Significance Index: -4.8300
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.7478
Cell Significance Index: -6.0100
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.7486
Cell Significance Index: -9.2600
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.7578
Cell Significance Index: -8.0500
Cell Name: granulocyte (CL0000094)
Fold Change: -0.7743
Cell Significance Index: -9.3400
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.7921
Cell Significance Index: -8.5400
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.8026
Cell Significance Index: -9.1000
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.8242
Cell Significance Index: -9.1300
Cell Name: platelet (CL0000233)
Fold Change: -0.8243
Cell Significance Index: -8.4800
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.8314
Cell Significance Index: -10.9100
Cell Name: plasma cell (CL0000786)
Fold Change: -0.8414
Cell Significance Index: -9.4000
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.8457
Cell Significance Index: -9.9500
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.8580
Cell Significance Index: -10.1400
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.8681
Cell Significance Index: -9.9900
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.8703
Cell Significance Index: -11.1600
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.8803
Cell Significance Index: -8.4500
Cell Name: intermediate monocyte (CL0002393)
Fold Change: -0.9038
Cell Significance Index: -8.4200
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: -0.9065
Cell Significance Index: -8.1200
Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -0.9123
Cell Significance Index: -14.6700
Cell Name: blood cell (CL0000081)
Fold Change: -0.9128
Cell Significance Index: -7.7800
Cell Name: memory B cell (CL0000787)
Fold Change: -0.9212
Cell Significance Index: -9.8000
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.9223
Cell Significance Index: -11.2200
Cell Name: glial cell (CL0000125)
Fold Change: -0.9310
Cell Significance Index: -10.2000
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.9373
Cell Significance Index: -8.3600
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: -0.9389
Cell Significance Index: -8.6800
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.9413
Cell Significance Index: -12.1800
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.9525
Cell Significance Index: -11.2600
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.9531
Cell Significance Index: -10.7400
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.9539
Cell Significance Index: -11.0700
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -0.9547
Cell Significance Index: -8.3500
Cell Name: neutrophil (CL0000775)
Fold Change: -0.9558
Cell Significance Index: -11.9400
Cell Name: pericyte (CL0000669)
Fold Change: -0.9682
Cell Significance Index: -11.6100
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.9723
Cell Significance Index: -12.9200
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.9859
Cell Significance Index: -10.8700
Cell Name: transitional stage B cell (CL0000818)
Fold Change: -0.9891
Cell Significance Index: -8.6900
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: -0.9996
Cell Significance Index: -8.9300
Cell Name: fibroblast (CL0000057)
Fold Change: -1.0002
Cell Significance Index: -9.3900
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: -1.0031
Cell Significance Index: -8.4700
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: -1.0054
Cell Significance Index: -10.1300
Cell Name: naive B cell (CL0000788)
Fold Change: -1.0067
Cell Significance Index: -10.6000
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: -1.0087
Cell Significance Index: -9.9500
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: -1.0108
Cell Significance Index: -9.8700
Cell Name: natural killer cell (CL0000623)
Fold Change: -1.0130
Cell Significance Index: -11.2200
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -1.0196
Cell Significance Index: -9.8000
Cell Name: T cell (CL0000084)
Fold Change: -1.0316
Cell Significance Index: -12.1800
Cell Name: classical monocyte (CL0000860)
Fold Change: -1.0354
Cell Significance Index: -9.6400
Cell Name: macrophage (CL0000235)
Fold Change: -1.0500
Cell Significance Index: -10.7200
Cell Name: T follicular helper cell (CL0002038)
Fold Change: -1.0516
Cell Significance Index: -11.1500
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: -1.0586
Cell Significance Index: -10.9700
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -1.0617
Cell Significance Index: -11.2800
Cell Name: plasmablast (CL0000980)
Fold Change: -1.0627
Cell Significance Index: -9.8600
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: -1.0658
Cell Significance Index: -8.6300
Cell Name: intestine goblet cell (CL0019031)
Fold Change: -1.0667
Cell Significance Index: -9.1900
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -1.0764
Cell Significance Index: -11.2000
Cell Name: melanocyte of skin (CL1000458)
Fold Change: -1.0852
Cell Significance Index: -15.2100
Cell Name: helper T cell (CL0000912)
Fold Change: -1.0898
Cell Significance Index: -15.4900
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: -1.0902
Cell Significance Index: -8.5500
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: -1.0911
Cell Significance Index: -10.8900
Cell Name: dendritic cell, human (CL0001056)
Fold Change: -1.0973
Cell Significance Index: -10.1200
Cell Name: duct epithelial cell (CL0000068)
Fold Change: -1.0986
Cell Significance Index: -15.1900
Cell Name: dendritic cell (CL0000451)
Fold Change: -1.1069
Cell Significance Index: -14.4500
Cell Name: B-2 B cell (CL0000822)
Fold Change: -1.1091
Cell Significance Index: -9.8300
Cell Name: IgM plasma cell (CL0000986)
Fold Change: -1.1109
Cell Significance Index: -8.5300
Cell Name: immature B cell (CL0000816)
Fold Change: -1.1213
Cell Significance Index: -10.6100
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -1.1243
Cell Significance Index: -10.0100
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -1.1265
Cell Significance Index: -11.4300
Cell Name: B-1 B cell (CL0000819)
Fold Change: -1.1296
Cell Significance Index: -9.8500
Cell Name: respiratory basal cell (CL0002633)
Fold Change: -1.1302
Cell Significance Index: -11.1500
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -1.1396
Cell Significance Index: -14.6400
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -1.1473
Cell Significance Index: -13.3300
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -1.1593
Cell Significance Index: -14.9300
Cell Name: B cell (CL0000236)
Fold Change: -1.1636
Cell Significance Index: -13.7500
Cell Name: mast cell (CL0000097)
Fold Change: -1.1771
Cell Significance Index: -15.4900
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -1.1898
Cell Significance Index: -10.8800
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -1.1924
Cell Significance Index: -17.4400
Cell Name: naive T cell (CL0000898)
Fold Change: -1.1955
Cell Significance Index: -10.8600
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -1.1958
Cell Significance Index: -13.0800
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: -1.2015
Cell Significance Index: -9.8600
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: -1.2022
Cell Significance Index: -11.1200
Cell Name: pro-B cell (CL0000826)
Fold Change: -1.2137
Cell Significance Index: -13.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** IGKV1D-39 is a member of the immunoglobulin kappa (IgK) family, which is characterized by the presence of a variable domain that is responsible for antigen recognition. The IgK family is involved in the production of kappa light chains, which are essential components of antibodies. IGKV1D-39 is a specific member of this family, with a unique sequence that is distinct from other IgK family members. The gene's expression is tightly regulated, with significant expression in immune cells and tissues. **Pathways and Functions** IGKV1D-39 is involved in several key immune-related pathways, including: 1. **Adaptive Immune Response**: IGKV1D-39 plays a crucial role in the adaptive immune response, particularly in the generation of antibodies against pathogens. The gene's expression is linked to the activation of B cells and the production of antibodies. 2. **Anti-inflammatory Response**: IGKV1D-39 is also involved in anti-inflammatory responses, particularly in the context of Leishmania parasite infection. The gene's expression is linked to the regulation of immune responses and the suppression of inflammation. 3. **Complement Cascade**: IGKV1D-39 is involved in the regulation of the complement cascade, particularly in the context of Leishmania parasite infection. The gene's expression is linked to the activation of complement cascade and the generation of second messengers. 4. **Cell Surface Interactions**: IGKV1D-39 is also involved in cell surface interactions, particularly in the context of vascular wall interactions. The gene's expression is linked to the regulation of cell adhesion and migration. **Clinical Significance** IGKV1D-39 has significant clinical implications, particularly in the context of Leishmania parasite infection and other immune-related diseases. The gene's expression is linked to the regulation of immune responses and the generation of antibodies, making it a potential target for therapeutic interventions. Additionally, IGKV1D-39's involvement in the complement cascade and anti-inflammatory responses makes it a potential target for the treatment of autoimmune diseases and other inflammatory conditions. In conclusion, IGKV1D-39 is a critical gene that plays a significant role in the adaptive immune response, anti-inflammatory responses, and the regulation of complement cascade. Its expression is tightly regulated, with significant expression in immune cells and tissues. The gene's involvement in these key immune-related pathways makes it a potential target for therapeutic interventions, particularly in the context of Leishmania parasite infection and other immune-related diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.