Details for: IGKV6 21

Gene ID: 28906

Symbol: IGKV6 21

Ensembl ID: ENSG00000211611

Description: immunoglobulin kappa variable 6-21 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0129
    Cell Significance Index: 0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0083
    Cell Significance Index: -6.2600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1273
    Cell Significance Index: -3.1800
  • Cell Name: lymphocyte of B lineage (CL0000945)
    Fold Change: -0.1454
    Cell Significance Index: -1.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2244
    Cell Significance Index: -10.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2353
    Cell Significance Index: -10.9700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2506
    Cell Significance Index: -6.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2510
    Cell Significance Index: -13.0400
  • Cell Name: collagen secreting cell (CL0000667)
    Fold Change: -0.3011
    Cell Significance Index: -1.6800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3066
    Cell Significance Index: -6.0000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3372
    Cell Significance Index: -8.5900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3504
    Cell Significance Index: -5.9900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3901
    Cell Significance Index: -7.2100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4198
    Cell Significance Index: -4.8300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.4383
    Cell Significance Index: -6.0100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.4542
    Cell Significance Index: -5.9400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.4576
    Cell Significance Index: -6.0100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.4794
    Cell Significance Index: -5.6400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4807
    Cell Significance Index: -7.7900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.5026
    Cell Significance Index: -5.1400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.5054
    Cell Significance Index: -6.5400
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.5109
    Cell Significance Index: -4.7600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.5200
    Cell Significance Index: -6.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5361
    Cell Significance Index: -12.3900
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.5414
    Cell Significance Index: -5.7600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.5472
    Cell Significance Index: -5.9000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.5543
    Cell Significance Index: -5.9600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.5564
    Cell Significance Index: -6.2700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.5582
    Cell Significance Index: -6.5900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.5641
    Cell Significance Index: -5.9900
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.5686
    Cell Significance Index: -6.2100
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.5714
    Cell Significance Index: -6.2600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.5721
    Cell Significance Index: -7.3500
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.5781
    Cell Significance Index: -6.4000
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.5803
    Cell Significance Index: -5.9700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.6015
    Cell Significance Index: -6.0600
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.6058
    Cell Significance Index: -5.8200
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.6105
    Cell Significance Index: -6.5200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.6166
    Cell Significance Index: -6.0100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.6194
    Cell Significance Index: -8.5900
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.6239
    Cell Significance Index: -4.1600
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.6400
    Cell Significance Index: -5.4600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.6404
    Cell Significance Index: -7.1600
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.6424
    Cell Significance Index: -5.7300
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.6440
    Cell Significance Index: -5.9500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.6507
    Cell Significance Index: -7.6900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6510
    Cell Significance Index: -13.0700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.6541
    Cell Significance Index: -7.7300
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.6699
    Cell Significance Index: -5.9900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.6711
    Cell Significance Index: -6.8100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.6779
    Cell Significance Index: -8.8500
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.6795
    Cell Significance Index: -6.0500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.6820
    Cell Significance Index: -5.9700
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.6835
    Cell Significance Index: -6.0100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.6847
    Cell Significance Index: -6.3800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.6920
    Cell Significance Index: -7.3000
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.6947
    Cell Significance Index: -5.9900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.6988
    Cell Significance Index: -7.7400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.7061
    Cell Significance Index: -8.5900
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.7087
    Cell Significance Index: -6.9200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.7124
    Cell Significance Index: -12.1000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.7157
    Cell Significance Index: -8.1300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.7243
    Cell Significance Index: -6.8000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.7247
    Cell Significance Index: -7.6300
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.7328
    Cell Significance Index: -8.1500
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.7404
    Cell Significance Index: -5.9500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.7414
    Cell Significance Index: -8.6000
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.7436
    Cell Significance Index: -6.9000
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.7439
    Cell Significance Index: -7.7100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.7456
    Cell Significance Index: -8.5800
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.7570
    Cell Significance Index: -6.1300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.7632
    Cell Significance Index: -8.1200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.7672
    Cell Significance Index: -9.8800
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.7749
    Cell Significance Index: -8.0300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.7762
    Cell Significance Index: -6.5500
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.7777
    Cell Significance Index: -6.4200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.7785
    Cell Significance Index: -7.7700
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.7800
    Cell Significance Index: -8.2700
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.7809
    Cell Significance Index: -8.2300
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.7833
    Cell Significance Index: -8.2900
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.7844
    Cell Significance Index: -8.6100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.7868
    Cell Significance Index: -7.3600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.7931
    Cell Significance Index: -9.5100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.7953
    Cell Significance Index: -11.3000
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.7963
    Cell Significance Index: -7.3900
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.8020
    Cell Significance Index: -8.5600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.8057
    Cell Significance Index: -7.4000
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.8074
    Cell Significance Index: -7.6400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.8115
    Cell Significance Index: -9.5900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.8218
    Cell Significance Index: -11.1800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.8266
    Cell Significance Index: -10.1600
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: -0.8307
    Cell Significance Index: -5.8600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.8338
    Cell Significance Index: -7.9100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.8381
    Cell Significance Index: -11.0300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.8483
    Cell Significance Index: -7.1700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.8498
    Cell Significance Index: -11.7500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.8563
    Cell Significance Index: -10.1900
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: -0.8586
    Cell Significance Index: -5.9500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.8677
    Cell Significance Index: -8.3400
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.8709
    Cell Significance Index: -5.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IGKV6 21 is a member of the immunoglobulin kappa (IgK) family, which is involved in the production of antibodies against pathogens. However, unlike other IgK genes, IGKV6 21 is non-functional and does not encode a functional protein. Despite this, it is expressed in various cell types, including those involved in immune responses, such as T cells and mast cells. IGKV6 21 is also expressed in non-immune cells, including goblet cells and absorptive cells in the gut. **Pathways and Functions** IGKV6 21's expression is associated with several key pathways, including: 1. **Adaptive Immune Response**: IGKV6 21 is expressed in T cells, which are central to the adaptive immune response. While the gene's non-functional status suggests it may not contribute to antibody production, its expression in T cells may indicate a role in regulating immune responses or cell differentiation. 2. **Immune Response**: IGKV6 21 is also expressed in goblet cells, which produce mucins that play a crucial role in immune responses, particularly in the gut. 3. **Extracellular Space**: IGKV6 21 is expressed in cells that interact with the extracellular space, such as mast cells and hematopoietic cells. 4. **Immunoglobulin Complex**: IGKV6 21 is associated with immunoglobulin complexes, which are formed when antibodies bind to antigens. **Functions** Despite its non-functional status, IGKV6 21 may play a role in regulating immune responses or modulating cell differentiation. Its expression in T cells and goblet cells suggests that it may influence the development of immune cells or the production of mucins in the gut. IGKV6 21's association with mast cells and hematopoietic cells further suggests that it may play a role in regulating immune responses or cell proliferation. **Clinical Significance** IGKV6 21's non-functional status and widespread expression in various cell types make it a potential candidate for studying immune responses and cell differentiation. Its expression in neoplastic cells and abnormal cells also suggests that it may be involved in cancer development or progression. Further research is needed to fully understand IGKV6 21's functional significance and clinical relevance. In conclusion, IGKV6 21 is a non-functional gene that plays a complex role in the adaptive immune response. Its widespread expression in various cell types, including immune cells and non-immune cells, suggests that it may influence immune responses, cell differentiation, or cancer development. Further research is needed to fully understand IGKV6 21's functional significance and clinical relevance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.