Details for: IGKV6 21

Gene ID: 28906

Symbol: IGKV6 21

Ensembl ID: ENSG00000211611

Description: immunoglobulin kappa variable 6-21 (non-functional)

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 2.54
    Marker Score: 4,376
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,691
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.07
    Marker Score: 709
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,807
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,336
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 499
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.86
    Marker Score: 432
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.8
    Marker Score: 1,305
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1,192
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.72
    Marker Score: 699
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.66
    Marker Score: 530
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.55
    Marker Score: 889
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.5
    Marker Score: 479
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.44
    Marker Score: 564
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 387
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.3
    Marker Score: 251
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.26
    Marker Score: 588
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.26
    Marker Score: 346
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.26
    Marker Score: 285
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.25
    Marker Score: 1,059
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.18
    Marker Score: 567
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.15
    Marker Score: 133
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.12
    Marker Score: 52
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.12
    Marker Score: 27
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.11
    Marker Score: 77
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.1
    Marker Score: 238
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.1
    Marker Score: 81
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.09
    Marker Score: 62
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.08
    Marker Score: 91
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.08
    Marker Score: 91
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.05
    Marker Score: 42
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.05
    Marker Score: 39
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.05
    Marker Score: 40
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.05
    Marker Score: 64
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.05
    Marker Score: 573
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.05
    Marker Score: 63
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.04
    Marker Score: 33
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.02
    Marker Score: 46
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.02
    Marker Score: 41
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.01
    Marker Score: 30
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.01
    Marker Score: 25
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.01
    Marker Score: 27
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.01
    Marker Score: 31
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0
    Marker Score: 21
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0
    Marker Score: 22

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IGKV6 21 is a member of the immunoglobulin kappa (IgK) family, which is involved in the production of antibodies against pathogens. However, unlike other IgK genes, IGKV6 21 is non-functional and does not encode a functional protein. Despite this, it is expressed in various cell types, including those involved in immune responses, such as T cells and mast cells. IGKV6 21 is also expressed in non-immune cells, including goblet cells and absorptive cells in the gut. **Pathways and Functions** IGKV6 21's expression is associated with several key pathways, including: 1. **Adaptive Immune Response**: IGKV6 21 is expressed in T cells, which are central to the adaptive immune response. While the gene's non-functional status suggests it may not contribute to antibody production, its expression in T cells may indicate a role in regulating immune responses or cell differentiation. 2. **Immune Response**: IGKV6 21 is also expressed in goblet cells, which produce mucins that play a crucial role in immune responses, particularly in the gut. 3. **Extracellular Space**: IGKV6 21 is expressed in cells that interact with the extracellular space, such as mast cells and hematopoietic cells. 4. **Immunoglobulin Complex**: IGKV6 21 is associated with immunoglobulin complexes, which are formed when antibodies bind to antigens. **Functions** Despite its non-functional status, IGKV6 21 may play a role in regulating immune responses or modulating cell differentiation. Its expression in T cells and goblet cells suggests that it may influence the development of immune cells or the production of mucins in the gut. IGKV6 21's association with mast cells and hematopoietic cells further suggests that it may play a role in regulating immune responses or cell proliferation. **Clinical Significance** IGKV6 21's non-functional status and widespread expression in various cell types make it a potential candidate for studying immune responses and cell differentiation. Its expression in neoplastic cells and abnormal cells also suggests that it may be involved in cancer development or progression. Further research is needed to fully understand IGKV6 21's functional significance and clinical relevance. In conclusion, IGKV6 21 is a non-functional gene that plays a complex role in the adaptive immune response. Its widespread expression in various cell types, including immune cells and non-immune cells, suggests that it may influence immune responses, cell differentiation, or cancer development. Further research is needed to fully understand IGKV6 21's functional significance and clinical relevance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.