Details for: IGKV2 26

Gene ID: 28922

Symbol: IGKV2 26

Ensembl ID: ENSG00000254098

Description: immunoglobulin kappa variable 2-26 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: macrophage (CL0000235)
    Fold Change: 8.56
    Marker Score: 9,524
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 872
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 798
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 388
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.36
    Marker Score: 211
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 116
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.17
    Marker Score: 204
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.15
    Marker Score: 153
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.14
    Marker Score: 172
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.12
    Marker Score: 143
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.11
    Marker Score: 350
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1
    Marker Score: 55
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.09
    Marker Score: 61
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.09
    Marker Score: 236
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.08
    Marker Score: 79
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 134
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.06
    Marker Score: 84
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.06
    Marker Score: 134
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.06
    Marker Score: 77
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.06
    Marker Score: 40
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.06
    Marker Score: 127
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.05
    Marker Score: 44
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.04
    Marker Score: 30
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.04
    Marker Score: 32
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.03
    Marker Score: 59
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.03
    Marker Score: 41
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.03
    Marker Score: 44
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.03
    Marker Score: 29
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.02
    Marker Score: 96
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.02
    Marker Score: 212
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 11
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 32
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 18
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 10

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV2-26 is a pseudogene, meaning it has undergone non-functional mutations, rendering it incapable of encoding a mature immunoglobulin protein. Despite this, IGKV2-26 exhibits significant expression in various immune cells, including macrophages, granulocytes, and B-2 B cells. This expression is noteworthy, as pseudogenes are generally considered to be non-functional and non-expressed. The wide range of expression across different immune cells suggests that IGKV2-26 may play a role in regulating immune responses or modulating cell signaling pathways. **Pathways and Functions:** While the exact mechanisms of IGKV2-26 are unclear, several pathways and functions have been implicated: 1. **Cell signaling:** IGKV2-26 may serve as a scaffold or regulatory protein, influencing cell signaling pathways involved in immune responses, such as the NF-κB pathway. 2. **Gene regulation:** IGKV2-26 may act as a transcriptional regulator, influencing the expression of other genes involved in immune responses. 3. **Epigenetic modifications:** IGKV2-26 may be involved in epigenetic modifications, such as DNA methylation or histone modification, which can regulate gene expression. 4. **Immune cell development:** IGKV2-26 may play a role in the development and differentiation of immune cells, particularly in the context of B cell development. **Clinical Significance:** IGKV2-26's expression in various immune cells and its potential role in regulating immune responses make it an interesting candidate for further investigation. Several potential clinical implications have been proposed: 1. **Autoimmune diseases:** IGKV2-26's involvement in immune cell development and regulation may contribute to the development of autoimmune diseases, such as rheumatoid arthritis or lupus. 2. **Cancer:** IGKV2-26's expression in cancer cells, particularly in the context of immune evasion, may be exploited for therapeutic purposes. 3. **Immunotherapy:** IGKV2-26's role in immune cell regulation may make it a target for immunotherapeutic strategies, such as checkpoint inhibitors or gene editing approaches. In conclusion, IGKV2-26 is a complex and enigmatic pseudogene that warrants further investigation. Its expression in various immune cells and potential role in regulating immune responses make it an attractive candidate for exploring novel therapeutic strategies and understanding the intricate mechanisms of immune regulation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.