Details for: IGKV2 26

Gene ID: 28922

Symbol: IGKV2 26

Ensembl ID: ENSG00000254098

Description: immunoglobulin kappa variable 2-26 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 4.6693
    Cell Significance Index: 52.1900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.0715
    Cell Significance Index: 25.9600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.0552
    Cell Significance Index: 14.4700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8658
    Cell Significance Index: 12.5700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.3464
    Cell Significance Index: 4.2900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3084
    Cell Significance Index: 4.5000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.1883
    Cell Significance Index: 2.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1144
    Cell Significance Index: 3.0600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0447
    Cell Significance Index: 0.5400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0276
    Cell Significance Index: 0.3500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0012
    Cell Significance Index: 0.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0035
    Cell Significance Index: -0.7000
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0047
    Cell Significance Index: -0.0600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0132
    Cell Significance Index: -0.2200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0152
    Cell Significance Index: -0.1800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0153
    Cell Significance Index: -0.1600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0160
    Cell Significance Index: -0.2000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0209
    Cell Significance Index: -0.3100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0217
    Cell Significance Index: -0.2800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0219
    Cell Significance Index: -0.3700
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0229
    Cell Significance Index: -0.2300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0243
    Cell Significance Index: -0.3300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0322
    Cell Significance Index: -0.6300
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0323
    Cell Significance Index: -0.3500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0334
    Cell Significance Index: -0.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0335
    Cell Significance Index: -2.1600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0467
    Cell Significance Index: -0.7100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0471
    Cell Significance Index: -0.5000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0497
    Cell Significance Index: -0.8500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0514
    Cell Significance Index: -0.4100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0519
    Cell Significance Index: -0.5300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0531
    Cell Significance Index: -0.8600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0535
    Cell Significance Index: -0.7600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0539
    Cell Significance Index: -0.7600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0541
    Cell Significance Index: -0.7100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0551
    Cell Significance Index: -1.4100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0575
    Cell Significance Index: -0.7900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0609
    Cell Significance Index: -0.6800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0611
    Cell Significance Index: -0.7900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0613
    Cell Significance Index: -0.7300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0635
    Cell Significance Index: -0.6900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0642
    Cell Significance Index: -0.7700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0645
    Cell Significance Index: -0.7700
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0655
    Cell Significance Index: -0.6900
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0665
    Cell Significance Index: -0.6000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0673
    Cell Significance Index: -0.7300
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0677
    Cell Significance Index: -0.7400
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0685
    Cell Significance Index: -0.7900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0689
    Cell Significance Index: -0.7800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0692
    Cell Significance Index: -0.7300
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0694
    Cell Significance Index: -0.7100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0704
    Cell Significance Index: -0.8700
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0705
    Cell Significance Index: -0.7300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0724
    Cell Significance Index: -0.7700
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0724
    Cell Significance Index: -0.6600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0727
    Cell Significance Index: -0.7800
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0729
    Cell Significance Index: -0.7300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0742
    Cell Significance Index: -0.7700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0746
    Cell Significance Index: -0.7000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0780
    Cell Significance Index: -0.7500
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0786
    Cell Significance Index: -0.8200
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0789
    Cell Significance Index: -0.7200
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0790
    Cell Significance Index: -0.7000
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0792
    Cell Significance Index: -0.8300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0809
    Cell Significance Index: -0.8700
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0815
    Cell Significance Index: -0.7100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0823
    Cell Significance Index: -0.7800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0829
    Cell Significance Index: -0.9800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0840
    Cell Significance Index: -0.4500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0851
    Cell Significance Index: -0.7500
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0853
    Cell Significance Index: -0.7400
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: -0.0853
    Cell Significance Index: -0.4000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0855
    Cell Significance Index: -0.9000
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0884
    Cell Significance Index: -0.7100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0886
    Cell Significance Index: -0.7500
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.0906
    Cell Significance Index: -0.5900
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0919
    Cell Significance Index: -0.8700
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0929
    Cell Significance Index: -0.8400
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0931
    Cell Significance Index: -0.6200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0935
    Cell Significance Index: -1.2200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0940
    Cell Significance Index: -0.9600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0940
    Cell Significance Index: -1.1100
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.0987
    Cell Significance Index: -0.4900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0999
    Cell Significance Index: -1.1500
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -0.1049
    Cell Significance Index: -0.7700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1056
    Cell Significance Index: -1.1900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1066
    Cell Significance Index: -1.2600
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1085
    Cell Significance Index: -1.1000
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.1090
    Cell Significance Index: -0.7700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1111
    Cell Significance Index: -1.2300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1132
    Cell Significance Index: -0.8700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1169
    Cell Significance Index: -2.1600
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: -0.1244
    Cell Significance Index: -0.6600
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1333
    Cell Significance Index: -1.3300
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.1339
    Cell Significance Index: -1.4200
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1356
    Cell Significance Index: -1.2400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1395
    Cell Significance Index: -1.3600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1414
    Cell Significance Index: -1.2200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1436
    Cell Significance Index: -1.5900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1455
    Cell Significance Index: -1.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV2-26 is a pseudogene, meaning it has undergone non-functional mutations, rendering it incapable of encoding a mature immunoglobulin protein. Despite this, IGKV2-26 exhibits significant expression in various immune cells, including macrophages, granulocytes, and B-2 B cells. This expression is noteworthy, as pseudogenes are generally considered to be non-functional and non-expressed. The wide range of expression across different immune cells suggests that IGKV2-26 may play a role in regulating immune responses or modulating cell signaling pathways. **Pathways and Functions:** While the exact mechanisms of IGKV2-26 are unclear, several pathways and functions have been implicated: 1. **Cell signaling:** IGKV2-26 may serve as a scaffold or regulatory protein, influencing cell signaling pathways involved in immune responses, such as the NF-κB pathway. 2. **Gene regulation:** IGKV2-26 may act as a transcriptional regulator, influencing the expression of other genes involved in immune responses. 3. **Epigenetic modifications:** IGKV2-26 may be involved in epigenetic modifications, such as DNA methylation or histone modification, which can regulate gene expression. 4. **Immune cell development:** IGKV2-26 may play a role in the development and differentiation of immune cells, particularly in the context of B cell development. **Clinical Significance:** IGKV2-26's expression in various immune cells and its potential role in regulating immune responses make it an interesting candidate for further investigation. Several potential clinical implications have been proposed: 1. **Autoimmune diseases:** IGKV2-26's involvement in immune cell development and regulation may contribute to the development of autoimmune diseases, such as rheumatoid arthritis or lupus. 2. **Cancer:** IGKV2-26's expression in cancer cells, particularly in the context of immune evasion, may be exploited for therapeutic purposes. 3. **Immunotherapy:** IGKV2-26's role in immune cell regulation may make it a target for immunotherapeutic strategies, such as checkpoint inhibitors or gene editing approaches. In conclusion, IGKV2-26 is a complex and enigmatic pseudogene that warrants further investigation. Its expression in various immune cells and potential role in regulating immune responses make it an attractive candidate for exploring novel therapeutic strategies and understanding the intricate mechanisms of immune regulation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.