Details for: IGKV2 24

Gene ID: 28923

Symbol: IGKV2 24

Ensembl ID: ENSG00000241294

Description: immunoglobulin kappa variable 2-24

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1293
    Cell Significance Index: 2.0000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0355
    Cell Significance Index: 0.4500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0393
    Cell Significance Index: -0.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0749
    Cell Significance Index: -15.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0803
    Cell Significance Index: -5.1800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1022
    Cell Significance Index: -2.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1166
    Cell Significance Index: -13.3600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1512
    Cell Significance Index: -4.0500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2046
    Cell Significance Index: -2.4700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2065
    Cell Significance Index: -5.2600
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.2347
    Cell Significance Index: -2.6600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2478
    Cell Significance Index: -3.0100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2547
    Cell Significance Index: -4.9800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2716
    Cell Significance Index: -5.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2750
    Cell Significance Index: -12.8200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2877
    Cell Significance Index: -4.6600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2940
    Cell Significance Index: -5.0300
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.2980
    Cell Significance Index: -3.3300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3003
    Cell Significance Index: -3.7200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3021
    Cell Significance Index: -4.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3136
    Cell Significance Index: -8.9900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3206
    Cell Significance Index: -3.0100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3342
    Cell Significance Index: -4.3300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3343
    Cell Significance Index: -4.5900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3548
    Cell Significance Index: -4.6400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3566
    Cell Significance Index: -5.1100
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.3661
    Cell Significance Index: -3.1200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3735
    Cell Significance Index: -8.6300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.3739
    Cell Significance Index: -3.8200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3757
    Cell Significance Index: -5.2100
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.3962
    Cell Significance Index: -2.8000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.3994
    Cell Significance Index: -4.7200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.4147
    Cell Significance Index: -5.1800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4215
    Cell Significance Index: -4.7900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.4279
    Cell Significance Index: -5.0400
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.4391
    Cell Significance Index: -4.6900
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.4427
    Cell Significance Index: -4.5000
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.4452
    Cell Significance Index: -4.5800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4502
    Cell Significance Index: -5.1800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.4528
    Cell Significance Index: -3.9600
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.4644
    Cell Significance Index: -4.7900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.4746
    Cell Significance Index: -4.4100
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.4789
    Cell Significance Index: -5.1000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.4841
    Cell Significance Index: -5.1500
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.4854
    Cell Significance Index: -4.3300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.4878
    Cell Significance Index: -5.2300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.4895
    Cell Significance Index: -5.2000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.4907
    Cell Significance Index: -5.5300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.4947
    Cell Significance Index: -5.4300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.4950
    Cell Significance Index: -5.5300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.4985
    Cell Significance Index: -5.3600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.4999
    Cell Significance Index: -5.3900
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.5004
    Cell Significance Index: -5.2900
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.5036
    Cell Significance Index: -5.5000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.5040
    Cell Significance Index: -5.5800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.5059
    Cell Significance Index: -4.7100
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.5110
    Cell Significance Index: -4.9900
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.5201
    Cell Significance Index: -5.2800
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.5226
    Cell Significance Index: -3.4800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.5273
    Cell Significance Index: -5.8400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.5285
    Cell Significance Index: -6.2400
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.5307
    Cell Significance Index: -5.2400
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.5342
    Cell Significance Index: -5.0600
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.5344
    Cell Significance Index: -5.1300
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.5345
    Cell Significance Index: -5.4600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.5354
    Cell Significance Index: -6.4200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.5357
    Cell Significance Index: -7.0500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.5382
    Cell Significance Index: -6.3600
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.5438
    Cell Significance Index: -4.9400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.5448
    Cell Significance Index: -7.1500
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.5462
    Cell Significance Index: -4.8800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.5463
    Cell Significance Index: -5.1100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.5466
    Cell Significance Index: -6.2900
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.5536
    Cell Significance Index: -4.5700
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.5549
    Cell Significance Index: -5.1700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.5585
    Cell Significance Index: -5.8800
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.5590
    Cell Significance Index: -5.7900
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: -0.5632
    Cell Significance Index: -5.0500
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.5634
    Cell Significance Index: -5.9100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.5639
    Cell Significance Index: -5.4200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.5680
    Cell Significance Index: -5.3900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.5757
    Cell Significance Index: -6.5400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.5763
    Cell Significance Index: -6.8100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.5788
    Cell Significance Index: -5.7100
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.5791
    Cell Significance Index: -5.3500
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.5805
    Cell Significance Index: -5.1000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.5805
    Cell Significance Index: -5.8900
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.5820
    Cell Significance Index: -6.3100
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.5823
    Cell Significance Index: -4.6800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.5829
    Cell Significance Index: -5.1900
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.5845
    Cell Significance Index: -6.1600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.5846
    Cell Significance Index: -5.8900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.5854
    Cell Significance Index: -6.2200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.5862
    Cell Significance Index: -6.8000
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.5867
    Cell Significance Index: -6.0800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.5923
    Cell Significance Index: -6.2800
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.5938
    Cell Significance Index: -6.3500
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.5978
    Cell Significance Index: -6.3800
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.6020
    Cell Significance Index: -4.9400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.6035
    Cell Significance Index: -8.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin kappa variable region**: The IGKV2 24 gene encodes a unique kappa variable region, which is essential for the production of antibodies. 2. **High expression in immune cells**: The gene is highly expressed in T cells, granulocyte-monocyte progenitor cells, and goblet cells, indicating its significant role in immune responses. 3. **Broad tissue expression**: The gene is also expressed in goblet cells, fallopian tube secretory epithelial cells, and intestinal crypt stem cells, suggesting its involvement in mucosal immunity. **Pathways and Functions:** 1. **Adaptive immune response**: The IGKV2 24 gene is involved in the adaptive immune response, which is a specific and targeted response to pathogens. 2. **Immunoglobulin production**: The gene plays a crucial role in the production of antibodies, which are essential for neutralizing pathogens and eliminating infected cells. 3. **Immunoglobulin complex formation**: The kappa variable region encoded by the IGKV2 24 gene contributes to the formation of immunoglobulin complexes, which are essential for complement activation and immune effector functions. 4. **Immune regulation**: The gene may also play a role in regulating immune responses, potentially modulating the activity of immune cells and influencing the severity of autoimmune diseases. **Clinical Significance:** 1. **Autoimmune diseases**: Alterations in the IGKV2 24 gene have been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, suggesting its potential role in disease pathogenesis. 2. **Cancer**: The gene may also contribute to cancer development, as aberrant expression of the kappa variable region has been observed in certain types of tumors. 3. **Infectious diseases**: The IGKV2 24 gene plays a critical role in the production of antibodies against pathogens, making it a potential target for vaccine development and therapeutic interventions. 4. **Mucosal immunity**: The gene's expression in goblet cells and intestinal crypt stem cells highlights its importance in mucosal immunity, which is essential for protecting against infections and maintaining gut homeostasis. In conclusion, the IGKV2 24 gene is a critical component of the adaptive immune system, playing a pivotal role in the production of antibodies and regulation of immune responses. Its clinical significance extends to autoimmune diseases, cancer, infectious diseases, and mucosal immunity, highlighting the need for further research into its functions and potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.