Details for: IGKV2 24

Gene ID: 28923

Symbol: IGKV2 24

Ensembl ID: ENSG00000241294

Description: immunoglobulin kappa variable 2-24

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 1.94
    Marker Score: 3,347
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,690
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.11
    Marker Score: 738
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,787
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,330
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.91
    Marker Score: 1,176
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.83
    Marker Score: 482
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.76
    Marker Score: 384
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1,192
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.72
    Marker Score: 699
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.65
    Marker Score: 616
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.63
    Marker Score: 506
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.61
    Marker Score: 371
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.59
    Marker Score: 967
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 152
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.56
    Marker Score: 433
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.51
    Marker Score: 2,135
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 384
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.4
    Marker Score: 1,232
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.37
    Marker Score: 208
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.36
    Marker Score: 150
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.35
    Marker Score: 387
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.33
    Marker Score: 218
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.32
    Marker Score: 342
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.31
    Marker Score: 709
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.28
    Marker Score: 127
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.28
    Marker Score: 280
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.24
    Marker Score: 320
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.22
    Marker Score: 184
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.21
    Marker Score: 92
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.21
    Marker Score: 273
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.2
    Marker Score: 174
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.2
    Marker Score: 137
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.19
    Marker Score: 470
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.19
    Marker Score: 472
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.19
    Marker Score: 100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.18
    Marker Score: 126
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.18
    Marker Score: 157
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.17
    Marker Score: 40
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.17
    Marker Score: 168
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.17
    Marker Score: 209
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.16
    Marker Score: 42
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.15
    Marker Score: 46
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.14
    Marker Score: 83
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.14
    Marker Score: 64
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.13
    Marker Score: 42
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.13
    Marker Score: 45
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.12
    Marker Score: 102
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.12
    Marker Score: 32
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.11
    Marker Score: 44
  • Cell Name: group 2 innate lymphoid cell, human (CL0001081)
    Fold Change: 0.11
    Marker Score: 46
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.11
    Marker Score: 46
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.11
    Marker Score: 126
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.1
    Marker Score: 126
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.1
    Marker Score: 67
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.1
    Marker Score: 34
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.1
    Marker Score: 44
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.09
    Marker Score: 64
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.09
    Marker Score: 1,047
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.09
    Marker Score: 44
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.09
    Marker Score: 104
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.09
    Marker Score: 78
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.08
    Marker Score: 63
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.08
    Marker Score: 46
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.08
    Marker Score: 72
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 83
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.07
    Marker Score: 46
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 138
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.07
    Marker Score: 46
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.07
    Marker Score: 41
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.06
    Marker Score: 51
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.06
    Marker Score: 43
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.06
    Marker Score: 45
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.06
    Marker Score: 41
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.06
    Marker Score: 40
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.06
    Marker Score: 154
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.06
    Marker Score: 44
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.05
    Marker Score: 40
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.05
    Marker Score: 101
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.05
    Marker Score: 49
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.05
    Marker Score: 90
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.05
    Marker Score: 86
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.05
    Marker Score: 41

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin kappa variable region**: The IGKV2 24 gene encodes a unique kappa variable region, which is essential for the production of antibodies. 2. **High expression in immune cells**: The gene is highly expressed in T cells, granulocyte-monocyte progenitor cells, and goblet cells, indicating its significant role in immune responses. 3. **Broad tissue expression**: The gene is also expressed in goblet cells, fallopian tube secretory epithelial cells, and intestinal crypt stem cells, suggesting its involvement in mucosal immunity. **Pathways and Functions:** 1. **Adaptive immune response**: The IGKV2 24 gene is involved in the adaptive immune response, which is a specific and targeted response to pathogens. 2. **Immunoglobulin production**: The gene plays a crucial role in the production of antibodies, which are essential for neutralizing pathogens and eliminating infected cells. 3. **Immunoglobulin complex formation**: The kappa variable region encoded by the IGKV2 24 gene contributes to the formation of immunoglobulin complexes, which are essential for complement activation and immune effector functions. 4. **Immune regulation**: The gene may also play a role in regulating immune responses, potentially modulating the activity of immune cells and influencing the severity of autoimmune diseases. **Clinical Significance:** 1. **Autoimmune diseases**: Alterations in the IGKV2 24 gene have been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, suggesting its potential role in disease pathogenesis. 2. **Cancer**: The gene may also contribute to cancer development, as aberrant expression of the kappa variable region has been observed in certain types of tumors. 3. **Infectious diseases**: The IGKV2 24 gene plays a critical role in the production of antibodies against pathogens, making it a potential target for vaccine development and therapeutic interventions. 4. **Mucosal immunity**: The gene's expression in goblet cells and intestinal crypt stem cells highlights its importance in mucosal immunity, which is essential for protecting against infections and maintaining gut homeostasis. In conclusion, the IGKV2 24 gene is a critical component of the adaptive immune system, playing a pivotal role in the production of antibodies and regulation of immune responses. Its clinical significance extends to autoimmune diseases, cancer, infectious diseases, and mucosal immunity, highlighting the need for further research into its functions and potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.